LOCUS       NM_207009               2441 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens DENN domain containing 10 (DENND10), transcript
            variant 1, mRNA.
ACCESSION   NM_207009
VERSION     NM_207009.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2441)
  AUTHORS   Healy,M.D., McNally,K.E., Butkovic,R., Chilton,M., Kato,K.,
            Sacharz,J., McConville,C., Moody,E.R.R., Shaw,S.,
            Planelles-Herrero,V.J., Yadav,S.K.N., Ross,J., Borucu,U.,
            Palmer,C.S., Chen,K.E., Croll,T.I., Hall,R.J., Caruana,N.J.,
            Ghai,R., Nguyen,T.H.D., Heesom,K.J., Saitoh,S., Berger,I.,
            Schaffitzel,C., Williams,T.A., Stroud,D.A., Derivery,E.,
            Collins,B.M. and Cullen,P.J.
  TITLE     Structure of the endosomal Commander complex linked to
            Ritscher-Schinzel syndrome
  JOURNAL   Cell 186 (10), 2219-2237 (2023)
   PUBMED   37172566
REFERENCE   2  (bases 1 to 2441)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 2441)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 2441)
  AUTHORS   Zhang,J., Zhang,K., Qi,L., Hu,Q., Shen,Z., Liu,B., Deng,J.,
            Zhang,C. and Zhang,Y.
  TITLE     DENN domain-containing protein FAM45A regulates the homeostasis of
            late/multivesicular endosomes
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1866 (5), 916-929 (2019)
   PUBMED   30771381
  REMARK    GeneRIF: FAM45A defines a novel regulatory step in the homeostasis
            of late endocytic pathway, including endosomal positioning,
            maturation and secretion, possibly through activating Rab proteins
            such as Rab27a/b.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA531569.1, BC022271.1 and AL355598.26.
            
            On Nov 22, 2018 this sequence version replaced NM_207009.3.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.212539.1,
                                           SRR1803614.88193.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000361432.3/ ENSP00000354688.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                DA531569.1         49-67
            20-971              BC022271.1         1-952
            972-972             AL355598.26        103672-103672
            973-1628            BC022271.1         954-1609
            1629-2441           AL355598.26        104329-105141
FEATURES             Location/Qualifiers
     source          1..2441
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q26.11"
     gene            1..2441
                     /gene="DENND10"
                     /gene_synonym="FAM45A"
                     /note="DENN domain containing 10"
                     /db_xref="GeneID:404636"
                     /db_xref="HGNC:HGNC:31793"
     exon            1..85
                     /gene="DENND10"
                     /gene_synonym="FAM45A"
                     /inference="alignment:Splign:2.1.0"
     CDS             31..1104
                     /gene="DENND10"
                     /gene_synonym="FAM45A"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein FAM45A; family with sequence similarity 45 member
                     A; DENN domain-containing protein 10"
                     /codon_start=1
                     /product="DENN domain-containing protein 10 isoform 1"
                     /protein_id="NP_996892.1"
                     /db_xref="CCDS:CCDS7609.1"
                     /db_xref="GeneID:404636"
                     /db_xref="HGNC:HGNC:31793"
                     /translation="MAAAEVADTQLMLGVGLIEKDTNGEVLWVWCYPSTTATLRNLLL
                     RKCCLTDENKLLHPFVFGQYRRTWFYITTIEVPDSSILKKVTHFSIVLTAKDFNPEKY
                     AAFTRILCRMYLKHGSPVKMMESYIAVLTKGICQSEENGSFLSKDFDARKAYLAGSIK
                     DIVSQFGMETVILHTALMLKKRIVVYHPKIEAVQEFTRTLPALVWHRQDWTILHSYVH
                     LNADELEALQMCTGYVAGFVDLEVSNRPDLYDVFVNLAESEITIAPLAKEAMAMGKLH
                     KEMGQLIVQSAEDPEKSESHVIQDIALKTREIFTNLAPFSEVSADGEKRVLNLEALKQ
                     KRFPPATENFLYHLAAAEQMLKI"
     exon            86..282
                     /gene="DENND10"
                     /gene_synonym="FAM45A"
                     /inference="alignment:Splign:2.1.0"
     exon            283..362
                     /gene="DENND10"
                     /gene_synonym="FAM45A"
                     /inference="alignment:Splign:2.1.0"
     exon            363..511
                     /gene="DENND10"
                     /gene_synonym="FAM45A"
                     /inference="alignment:Splign:2.1.0"
     exon            512..623
                     /gene="DENND10"
                     /gene_synonym="FAM45A"
                     /inference="alignment:Splign:2.1.0"
     exon            624..724
                     /gene="DENND10"
                     /gene_synonym="FAM45A"
                     /inference="alignment:Splign:2.1.0"
     exon            725..832
                     /gene="DENND10"
                     /gene_synonym="FAM45A"
                     /inference="alignment:Splign:2.1.0"
     exon            833..927
                     /gene="DENND10"
                     /gene_synonym="FAM45A"
                     /inference="alignment:Splign:2.1.0"
     exon            928..2441
                     /gene="DENND10"
                     /gene_synonym="FAM45A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2043..2048
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DENND10"
                     /gene_synonym="FAM45A"
                     /note="hexamer: AATAAG"
     polyA_site      2065
                     /gene="DENND10"
                     /gene_synonym="FAM45A"
                     /note="major polyA site"
     regulatory      2212..2217
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DENND10"
                     /gene_synonym="FAM45A"
                     /note="hexamer: AATAAA"
     polyA_site      2229
                     /gene="DENND10"
                     /gene_synonym="FAM45A"
                     /note="major polyA site"
     regulatory      2414..2419
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DENND10"
                     /gene_synonym="FAM45A"
                     /note="hexamer: AATAAA"
     polyA_site      2441
                     /gene="DENND10"
                     /gene_synonym="FAM45A"
ORIGIN      
        1 agccagagct gcgcgccgcg gcggcggaag atggctgcgg ccgaggtggc ggacactcag
       61 ctgatgcttg gagtcgggct gatcgaaaag gacacaaatg gagaagttct gtgggtgtgg
      121 tgttatcctt ccacgacagc cacattaagg aacctgctgc tgagaaaatg ctgccttaca
      181 gatgaaaaca aacttctcca tccctttgtc tttggtcagt acagaagaac atggttttat
      241 atcacaacaa ttgaagttcc agattcttcc attttgaaaa aggtgactca tttttctatt
      301 gtcctgaccg ccaaagattt taacccagag aagtatgctg ccttcactag gatattgtgt
      361 agaatgtacc tgaaacatgg gagcccagtt aaaatgatgg agagttatat tgcagttctc
      421 acaaagggga tatgccagag tgaagaaaac ggctctttcc ttagtaagga ttttgatgcc
      481 cgaaaggcct acctggctgg ctccatcaaa gacattgtat ctcagtttgg aatggaaact
      541 gttatcttac acacagcact gatgctaaag aaaagaattg tggtgtatca ccccaagata
      601 gaagcggtcc aggagttcac caggactctg cctgccctgg tgtggcaccg acaggactgg
      661 accatccttc actcttacgt gcacctcaac gccgatgagc tggaagccct gcagatgtgc
      721 acaggttacg tcgctggatt tgtagacttg gaggtgagca acagaccaga cctctatgat
      781 gtgtttgtga atctggcaga gagtgagatt accattgctc cccttgcaaa agaggccatg
      841 gcaatgggca aactgcacaa agaaatgggt cagctaattg ttcagtctgc agaagatcca
      901 gagaaatcag agagccacgt tatacaggat attgctctaa aaacaagaga aatctttacc
      961 aacctagcac cgttttcaga agtttcggct gatggagaaa agagagtcct taatttggag
     1021 gcgctaaagc aaaaacgatt tccaccagca acagaaaact tcctttatca tctagcagca
     1081 gccgaacaaa tgctgaaaat ctgactgtgt gacagaacgt atcactgatg actgatagaa
     1141 agccctcttt cactctgatt acccactcac tacatgaagt cctgaaaata acagagaaac
     1201 tgttatatct ttttaatgat ttatttgcaa gtattgagat ttgacctgaa aaacaatgaa
     1261 acacatgaac acacttccga ttttctcctc gctgattagc ttcctgcctg ctgtcagtgc
     1321 tggacgaagt gctataacta ctttatgtaa cattacagaa cagctagagg tcctggggta
     1381 agagaaaaaa agcacatcac aacaaatgtg aaagccttca ttattacacg ttccagtttg
     1441 tctcgctgtg taggcataag ctaatggttt attttcagaa agctgcctga aacgttgctt
     1501 tgtattcttc taggaagaac tttaattcct cctgaggaac tctactttct gagccaaact
     1561 gctaattttc tgcggaactg tctagaagat cattcaagag accctgcagt tgcactttct
     1621 cgtaaaagtt aaaaaaaaaa aaaaaaaaaa aaggtttttc ccggcctttg aacattttgc
     1681 ctatgagagt tttgcatata ttttatactt gagtagacaa ctttaataat ccatatttat
     1741 actatcgcag aagtaagcat ttggcaaacg ttcagccatt agcactcatt taaccctgtt
     1801 agcaatattc ttttgaaaaa agtgccagtc cttatgtgat aaactaagaa gcccattgaa
     1861 tataaaagtg tgtaggactg aaacagtgac cttatattat tgctaaggga atatgagatt
     1921 aacttcctac aggggccaaa accagagaaa ggcttccagc aacttcgatg aaagtagttt
     1981 ggccacatgt caagccaatt gtttgtacta tttatgtacc tttttcataa ctggaattgc
     2041 caaataagca tggagatcta aatgatgtac ttgttagtgt attcattcat attgactgta
     2101 aaggattatt tttcactcag tactgatgtc cttggaaatc ttacctggaa acatgtttgc
     2161 aaaaaacatt attgggtctt tcatcttttt cttggtatta catatttgtt caataaaaat
     2221 taaacaccct cccttttttt tgagtgaggg cagggagtac ctgaaataag acaatgttta
     2281 ctaaggcaaa taattgaaaa ttaaatctgc actttatgga aatgaggaat attaacatct
     2341 tttttctcat ttttttgtat tactatatta gctaatgatc aaagttgtta aaattataaa
     2401 tttatgatgc agaaataaaa ttgatatatt ttgatattca a
//
