LOCUS       NM_003472               3142 bp    mRNA    linear   PRI 15-OCT-2024
DEFINITION  Homo sapiens DEK proto-oncogene (DEK), transcript variant 1, mRNA.
ACCESSION   NM_003472
VERSION     NM_003472.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3142)
  AUTHORS   Hopper,M.A., Dropik,A.R., Walker,J.S., Novak,J.P., Laverty,M.S.,
            Manske,M.K., Wu,X., Wenzl,K., Krull,J.E., Sarangi,V., Maurer,M.J.,
            Yang,Z.Z., Del Busso,M.D., Habermann,T.M., Link,B.K., Rimsza,L.M.,
            Witzig,T.E., Ansell,S.M., Cerhan,J.R., Jevremovic,D. and Novak,A.J.
  TITLE     DEK regulates B-cell proliferative capacity and is associated with
            aggressive disease in low-grade B-cell lymphomas
  JOURNAL   Blood Cancer J 14 (1), 172 (2024)
   PUBMED   39384745
  REMARK    GeneRIF: DEK regulates B-cell proliferative capacity and is
            associated with aggressive disease in low-grade B-cell lymphomas.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3142)
  AUTHORS   Pierzynska-Mach,A., Cainero,I., Oneto,M., Ferrando-May,E.,
            Lanzano,L. and Diaspro,A.
  TITLE     Imaging-based study demonstrates how the DEK nanoscale distribution
            differentially correlates with epigenetic marks in a breast cancer
            model
  JOURNAL   Sci Rep 13 (1), 12749 (2023)
   PUBMED   37550322
  REMARK    GeneRIF: Imaging-based study demonstrates how the DEK nanoscale
            distribution differentially correlates with epigenetic marks in a
            breast cancer model.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3142)
  AUTHORS   Wilcher,K.E., Page,E.R.H. and Privette Vinnedge,L.M.
  TITLE     The impact of the chromatin binding DEK protein in hematopoiesis
            and acute myeloid leukemia
  JOURNAL   Exp Hematol 123, 18-27 (2023)
   PUBMED   37172756
  REMARK    GeneRIF: The impact of the chromatin binding DEK protein in
            hematopoiesis and acute myeloid leukemia.
            Review article
REFERENCE   4  (bases 1 to 3142)
  AUTHORS   Habiburrahman,M., Sutopo,S. and Wardoyo,M.P.
  TITLE     Role of DEK in carcinogenesis, diagnosis, prognosis, and
            therapeutic outcome of breast cancer: An evidence-based clinical
            review
  JOURNAL   Crit Rev Oncol Hematol 181, 103897 (2023)
   PUBMED   36535490
  REMARK    GeneRIF: Role of DEK in carcinogenesis, diagnosis, prognosis, and
            therapeutic outcome of breast cancer: An evidence-based clinical
            review.
            Review article
REFERENCE   5  (bases 1 to 3142)
  AUTHORS   Ozcelik,E., Kalayci,A., Celik,B., Avci,A., Akyol,H., Kilic,I.B.,
            Guzel,T., Cetin,M., Ozturk,M.T., Caliskaner,Z.O., Tombaz,M.,
            Yoleri,D., Konu,O. and Kandilci,A.
  TITLE     Doxorubicin induces prolonged DNA damage signal in cells
            overexpressing DEK isoform-2
  JOURNAL   PLoS One 17 (10), e0275476 (2022)
   PUBMED   36190960
  REMARK    GeneRIF: Doxorubicin induces prolonged DNA damage signal in cells
            overexpressing DEK isoform-2.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3142)
  AUTHORS   Forero,L., Zwirner,N.W., Fink,C.W., Fernandez-Vina,M.A. and
            Stastny,P.
  TITLE     Juvenile arthritis, HLA-A2 and binding of DEK oncogene-peptides
  JOURNAL   Hum Immunol 59 (7), 443-450 (1998)
   PUBMED   9684994
REFERENCE   7  (bases 1 to 3142)
  AUTHORS   Fu,G.K., Grosveld,G. and Markovitz,D.M.
  TITLE     DEK, an autoantigen involved in a chromosomal translocation in
            acute myelogenous leukemia, binds to the HIV-2 enhancer
  JOURNAL   Proc Natl Acad Sci U S A 94 (5), 1811-1815 (1997)
   PUBMED   9050861
REFERENCE   8  (bases 1 to 3142)
  AUTHORS   Murray,K.J., Szer,W., Grom,A.A., Donnelly,P., Levinson,J.E.,
            Giannini,E.H., Glass,D.N. and Szer,I.S.
  TITLE     Antibodies to the 45 kDa DEK nuclear antigen in pauciarticular
            onset juvenile rheumatoid arthritis and iridocyclitis: selective
            association with MHC gene
  JOURNAL   J Rheumatol 24 (3), 560-567 (1997)
   PUBMED   9058666
REFERENCE   9  (bases 1 to 3142)
  AUTHORS   von Lindern,M., Fornerod,M., Soekarman,N., van Baal,S., Jaegle,M.,
            Hagemeijer,A., Bootsma,D. and Grosveld,G.
  TITLE     Translocation t(6;9) in acute non-lymphocytic leukaemia results in
            the formation of a DEK-CAN fusion gene
  JOURNAL   Baillieres Clin Haematol 5 (4), 857-879 (1992)
   PUBMED   1308167
  REMARK    Review article
REFERENCE   10 (bases 1 to 3142)
  AUTHORS   von Lindern,M., Fornerod,M., van Baal,S., Jaegle,M., de Wit,T.,
            Buijs,A. and Grosveld,G.
  TITLE     The translocation (6;9), associated with a specific subtype of
            acute myeloid leukemia, results in the fusion of two genes, dek and
            can, and the expression of a chimeric, leukemia-specific dek-can
            mRNA
  JOURNAL   Mol Cell Biol 12 (4), 1687-1697 (1992)
   PUBMED   1549122
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC035259.1, CN388433.1 and
            AL031774.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 24, 2018 this sequence version replaced NM_003472.3.
            
            Summary: This gene encodes a protein with one SAP domain. This
            protein binds to cruciform and superhelical DNA and induces
            positive supercoils into closed circular DNA, and is also involved
            in splice site selection during mRNA processing. Chromosomal
            aberrations involving this region, increased expression of this
            gene, and the presence of antibodies against this protein are all
            associated with various diseases. Two transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Sep 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.201522.1, BC035259.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467148, SAMN03267770
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000652689.1/ ENSP00000498653.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2821              BC035259.1         11-2831
            2822-2833           CN388433.1         276-287
            2834-3142           AL031774.1         70593-70901
FEATURES             Location/Qualifiers
     source          1..3142
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p22.3"
     gene            1..3142
                     /gene="DEK"
                     /gene_synonym="D6S231E"
                     /note="DEK proto-oncogene"
                     /db_xref="GeneID:7913"
                     /db_xref="HGNC:HGNC:2768"
                     /db_xref="MIM:125264"
     exon            1..146
                     /gene="DEK"
                     /gene_synonym="D6S231E"
                     /inference="alignment:Splign:2.1.0"
     exon            147..300
                     /gene="DEK"
                     /gene_synonym="D6S231E"
                     /inference="alignment:Splign:2.1.0"
     CDS             156..1283
                     /gene="DEK"
                     /gene_synonym="D6S231E"
                     /note="isoform 1 is encoded by transcript variant 1; DEK
                     oncogene (DNA binding); protein DEK"
                     /codon_start=1
                     /product="protein DEK isoform 1"
                     /protein_id="NP_003463.1"
                     /db_xref="CCDS:CCDS34344.1"
                     /db_xref="GeneID:7913"
                     /db_xref="HGNC:HGNC:2768"
                     /db_xref="MIM:125264"
                     /translation="MSASAPAAEGEGTPTQPASEKEPEMPGPREESEEEEDEDDEEEE
                     EEEKEKSLIVEGKREKKKVERLTMQVSSLQREPFTIAQGKGQKLCEIERIHFFLSKKK
                     TDELRNLHKLLYNRPGTVSSLKKNVGQFSGFPFEKGSVQYKKKEEMLKKFRNAMLKSI
                     CEVLDLERSGVNSELVKRILNFLMHPKPSGKPLPKSKKTCSKGSKKERNSSGMARKAK
                     RTKCPEILSDESSSDEDEKKNKEESSDDEDKESEEEPPKKTAKREKPKQKATSKSKKS
                     VKSANVKKADSSTTKKNQNSSKKESESEDSSDDEPLIKKLKKPPTDEELKETIKKLLA
                     SANLEEVTMKQICKKVYENYPTYDLTERKDFIKTTVKELIS"
     exon            301..402
                     /gene="DEK"
                     /gene_synonym="D6S231E"
                     /inference="alignment:Splign:2.1.0"
     exon            403..512
                     /gene="DEK"
                     /gene_synonym="D6S231E"
                     /inference="alignment:Splign:2.1.0"
     exon            513..607
                     /gene="DEK"
                     /gene_synonym="D6S231E"
                     /inference="alignment:Splign:2.1.0"
     exon            608..728
                     /gene="DEK"
                     /gene_synonym="D6S231E"
                     /inference="alignment:Splign:2.1.0"
     exon            729..917
                     /gene="DEK"
                     /gene_synonym="D6S231E"
                     /inference="alignment:Splign:2.1.0"
     exon            918..1053
                     /gene="DEK"
                     /gene_synonym="D6S231E"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1202
                     /gene="DEK"
                     /gene_synonym="D6S231E"
                     /inference="alignment:Splign:2.1.0"
     exon            1203..1271
                     /gene="DEK"
                     /gene_synonym="D6S231E"
                     /inference="alignment:Splign:2.1.0"
     exon            1272..3142
                     /gene="DEK"
                     /gene_synonym="D6S231E"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2801..2806
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DEK"
                     /gene_synonym="D6S231E"
                     /note="hexamer: AATAAA"
     regulatory      2807..2812
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DEK"
                     /gene_synonym="D6S231E"
                     /note="hexamer: AATAAA"
     polyA_site      2821
                     /gene="DEK"
                     /gene_synonym="D6S231E"
                     /note="major polyA site"
     polyA_site      2833
                     /gene="DEK"
                     /gene_synonym="D6S231E"
     regulatory      3115..3120
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DEK"
                     /gene_synonym="D6S231E"
                     /note="hexamer: ATTAAA"
     polyA_site      3142
                     /gene="DEK"
                     /gene_synonym="D6S231E"
ORIGIN      
        1 cttgttgatt ctggggagcc gagcgcgcgg cgcgagcgtc acgccagaca gcggcccgcg
       61 cgccttctcc tcggcgtcgg ccgccgccgc ctcccagaac ctcctcgtgc cctcgcgtgc
      121 caggcccgcg gcggccgaaa tccgcggttc acagcatgtc cgcctcggcc cctgctgcgg
      181 agggggaggg aacccccacc cagcccgcgt ccgagaaaga acccgaaatg cccggtccca
      241 gagaggagag cgaggaggaa gaggacgagg acgacgagga ggaggaggag gaggaaaaag
      301 aaaagagtct catcgtggaa ggcaagaggg aaaagaaaaa agtagagagg ttgacaatgc
      361 aagtctcttc cttacagaga gagccattta caattgcaca aggaaagggg cagaaacttt
      421 gtgaaattga gaggatacat ttttttctaa gtaagaagaa aaccgatgaa cttagaaatc
      481 tacacaaact gctttacaac aggccaggca ctgtgtcctc attaaagaag aatgtgggtc
      541 agttcagtgg ctttccattt gaaaaaggaa gtgtccaata taaaaagaag gaagaaatgt
      601 tgaaaaaatt tagaaatgcc atgttaaaga gcatctgtga ggttcttgat ttggagagat
      661 caggtgtaaa tagtgaacta gtgaagagga tcttgaattt cttaatgcat ccaaagcctt
      721 ctggcaaacc attgccgaaa tctaaaaaaa cttgtagcaa aggcagtaaa aaggaacgga
      781 acagttctgg aatggcaagg aaggctaagc gaaccaaatg tcctgaaatt ctgtcagatg
      841 aatctagtag tgatgaagat gaaaagaaaa acaaggaaga gtcttcagat gatgaagata
      901 aagaaagtga agaggagcca ccaaaaaaga cagccaaaag agaaaaacct aaacagaaag
      961 ctacttctaa aagtaaaaaa tctgtgaaaa gtgccaatgt taagaaagca gatagcagca
     1021 ccaccaagaa gaatcaaaac agttccaaaa aagaaagtga gtctgaggat agttcagatg
     1081 atgaaccttt aattaaaaag ttgaagaaac cccctacaga tgaagagtta aaggaaacaa
     1141 taaagaaatt actggccagt gctaacttgg aagaagtcac aatgaaacag atttgcaaaa
     1201 aggtctatga aaattatcct acttatgatt taactgaaag aaaagatttc ataaaaacaa
     1261 ctgtaaaaga gctaatttct tgagatagag gacagagaag atgactcgtt cccatagatt
     1321 tgaagatctg atttatacca ttataccagc aaagagaatg tatttccttt tctaaatcct
     1381 tgttaagcaa cgttagtaga acttactgct gaccttttta tcttgagtgt tatgtgaatt
     1441 tgagtttgct gttttaaatt gcatttctat gccattttta gtttaaaatc ttgcatggca
     1501 ttaattgttc cttgctttta tagttgtatt ttgtacattt tggatttctt tatataaggt
     1561 catagattct tgagctgttg tggtttttag tgcacttaat attagcttgc ttaaggcata
     1621 cttttaatca agtagaacaa aaactattat caccaggatt tatacataca gagattgtag
     1681 tatttagtat atgaaatatt ttgaatacac atctctgtca gtgtgaaaat tcagcggcag
     1741 tgtgtccatc atattaaaaa tatacaagct acagttgtcc agatcactga attggaactt
     1801 ttctcctgca tgtgtatata tgtcaaattg tcagcatgac aaaagtgaca gatgttattt
     1861 ttgtattttt aaaaaacaat tggttgtata taaagttttt ttatttcttt tgtgcagatc
     1921 actttttaaa ctcacatagg taggtatctt tatagttgta gactatggaa tgtcagtgtt
     1981 cagccaaaca gtatgatgga acagtgaaag tcaattcagt gatggcaaca ctgaaggaac
     2041 agttaccctg ctttgcctcg aaagtgtcat caatttgtaa ttttagtatt aactctgtaa
     2101 aagtgtctgt aggtacgttt tatattatat aaggacagac caaaaatcaa cctatcaaag
     2161 cttcaaaaac tttgggaaag ggtgggatta agtacaagca catttggctt acagtaaatg
     2221 aactgatttt tattaactgc ttttgcccat ataaaatgct gatatttact ggaaacctag
     2281 ccagcttcac gattatgact aaagtaccag attataatgc cagaatataa tgtgcaggca
     2341 atcgtggatg tctctgacaa agtgtgtctc aaaaataata tacttttaca ttaaagaaat
     2401 ttaatgtttc tctggagttg gggctcttgg ctttcagagt ttggttaatc agtgttgatt
     2461 ctagatgatc aacataatgg accactcctg aatgagactt aattttgtct ttcaaattta
     2521 ctgtcttaaa tcagtttatt aaatctgaat tttaaaacat gctgtttatg acacaatgac
     2581 acatttgttg caccaattaa gtgttgaaaa atatctttgc atcatagaac agaaatatat
     2641 aaaaatatat gttgaatgtt aacaggtatt ttcacaggtt tgtttcttga tagttactca
     2701 gacactaggg aaaggtaaat acaagtgaac aaaataagca actaaatgag acctaataat
     2761 tggccttcga ttttaaatat ttgttcttat aaaccttgtc aataaaaata aatctaaatc
     2821 actggtgttt taagtcactt gcatttgata tcttataggt gtatatagca tttccttatg
     2881 gggaataatt ctgaaaaggg atttttaaat tgattcagcc ctataaccta tacaatttgg
     2941 aatactcttt tgtggtaatg gaccattttc ttggagtgac ttcacaaaac tgaataatta
     3001 aggttaattt tatgaccatt tgctataaag aaggtaagta gtcatgcata gagtatttgg
     3061 aagtgaggaa atggagttgt tctgtatgaa agttcttgat gagtacgcac acttattaaa
     3121 tggatgtatc accactacag ta
//
