LOCUS       NM_001205266             337 bp    mRNA    linear   PRI 08-APR-2024
DEFINITION  Homo sapiens defensin beta 4B (DEFB4B), mRNA.
ACCESSION   NM_001205266 XM_002342811
VERSION     NM_001205266.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 337)
  AUTHORS   Borchers,N.S., Santos-Valente,E., Toncheva,A.A., Wehkamp,J.,
            Franke,A., Gaertner,V.D., Nordkild,P., Genuneit,J., Jensen,B.A.H.
            and Kabesch,M.
  TITLE     Human beta-Defensin 2 Mutations Are Associated With Asthma and
            Atopy in Children and Its Application Prevents Atopic Asthma in a
            Mouse Model
  JOURNAL   Front Immunol 12, 636061 (2021)
   PUBMED   33717182
  REMARK    GeneRIF: Human beta-Defensin 2 Mutations Are Associated With Asthma
            and Atopy in Children and Its Application Prevents Atopic Asthma in
            a Mouse Model.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 337)
  AUTHORS   Wang,Y., Anderson,E.P. and Tatakis,D.N.
  TITLE     Whole transcriptome analysis of smoker palatal mucosa identifies
            multiple downregulated innate immunity genes
  JOURNAL   J Periodontol 91 (6), 756-766 (2020)
   PUBMED   31682009
  REMARK    GeneRIF: DEFB4B expression is significantly downregulated in
            healthy palatal mucosa of smokers
REFERENCE   3  (bases 1 to 337)
  AUTHORS   Bals,R., Wang,X., Wu,Z., Freeman,T., Bafna,V., Zasloff,M. and
            Wilson,J.M.
  TITLE     Human beta-defensin 2 is a salt-sensitive peptide antibiotic
            expressed in human lung
  JOURNAL   J Clin Invest 102 (5), 874-880 (1998)
   PUBMED   9727055
  REMARK    GeneRIF: The encoded peptide has antimicrobial activity against
            E.coli, S. aureus, and P. aeruginosa.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC130360.4.
            
            On Feb 24, 2021 this sequence version replaced NM_001205266.1.
            
            Summary: Defensins form a family of microbicidal and cytotoxic
            peptides made by neutrophils. Members of the defensin family are
            highly similar in protein sequence. This gene encodes defensin,
            beta 4, an antibiotic peptide which is locally regulated by
            inflammation. [provided by RefSeq, Oct 2014].
            
            ##Evidence-Data-START##
            Transcript exon combination :: BE714502.1, BE181080.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2154405, SAMN03465420
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match                 :: ENST00000318157.3/
                                                  ENSP00000424598.1
            Protein has antimicrobial activity :: PMID: 9727055
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-94                AC130360.4         104877-104970       c
            95-337              AC130360.4         102962-103204       c
FEATURES             Location/Qualifiers
     source          1..337
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p23.1"
     gene            1..337
                     /gene="DEFB4B"
                     /gene_synonym="DEFB4P"
                     /note="defensin beta 4B"
                     /db_xref="GeneID:100289462"
                     /db_xref="HGNC:HGNC:30193"
     exon            1..94
                     /gene="DEFB4B"
                     /gene_synonym="DEFB4P"
                     /inference="alignment:Splign:2.1.0"
     CDS             37..231
                     /gene="DEFB4B"
                     /gene_synonym="DEFB4P"
                     /note="defensin, beta 4, pseudogene; beta defensin 2"
                     /codon_start=1
                     /product="beta-defensin 4B precursor"
                     /protein_id="NP_001192195.1"
                     /db_xref="CCDS:CCDS55193.1"
                     /db_xref="GeneID:100289462"
                     /db_xref="HGNC:HGNC:30193"
                     /translation="MRVLYLLFSFLFIFLMPLPGVFGGIGDPVTCLKSGAICHPVFCP
                     RRYKQIGTCGLPGTKCCKKP"
     exon            95..337
                     /gene="DEFB4B"
                     /gene_synonym="DEFB4P"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agactcagct cctggtgaag ctcccagcca tcagccatga gggtcttgta tctcctcttc
       61 tcgttcctct tcatatttct gatgcctctt ccaggtgttt ttggtggtat aggcgatcct
      121 gttacctgcc ttaagagtgg agccatatgt catccagtct tttgccctag aaggtataaa
      181 caaattggca cctgtggtct ccctggaaca aaatgctgca aaaagccatg aggaggccaa
      241 gaagctgctg tggctgatgc ggattcagaa agggctccct catcagagac gtgcgacatg
      301 taaaccaaat taaactatgg tgtccaaaga tacgcaa
//
