LOCUS       NM_004942                337 bp    mRNA    linear   PRI 11-OCT-2024
DEFINITION  Homo sapiens defensin beta 4A (DEFB4A), mRNA.
ACCESSION   NM_004942
VERSION     NM_004942.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 337)
  AUTHORS   Strajtenberger,M., Stipic-Markovic,A., Barac,E., Artukovic,M. and
            Lugovic-Mihic,L.
  TITLE     Human beta-defensin 2: a connection between infections and allergic
            skin diseases
  JOURNAL   Acta Dermatovenerol Alp Pannonica Adriat 33 (3), 135-139 (2024)
   PUBMED   39324351
  REMARK    GeneRIF: Human beta-defensin 2: a connection between infections and
            allergic skin diseases.
            Review article
REFERENCE   2  (bases 1 to 337)
  AUTHORS   Wozniak,W., Sechet,E., Kwon,Y.J., Aulner,N., Navarro,L. and
            Sperandio,B.
  TITLE     Identification of human host factors required for beta-defensin-2
            expression in intestinal epithelial cells upon a bacterial
            challenge
  JOURNAL   Sci Rep 14 (1), 15442 (2024)
   PUBMED   38965312
  REMARK    GeneRIF: Identification of human host factors required for
            beta-defensin-2 expression in intestinal epithelial cells upon a
            bacterial challenge.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 337)
  AUTHORS   Gursoy,U.K., Gursoy,M., Loimaranta,V. and Rautava,J.
  TITLE     Salivary Th17 cytokine, human beta-defensin 1-3, and salivary
            scavenger and agglutinin levels in Crohn's disease
  JOURNAL   Clin Oral Investig 28 (1), 108 (2024)
   PUBMED   38246944
  REMARK    GeneRIF: Salivary Th17 cytokine, human beta-defensin 1-3, and
            salivary scavenger and agglutinin levels in Crohn's disease.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 337)
  AUTHORS   Zhang,L. and Li,J.
  TITLE     Molecular Dynamics Simulations on Spike Protein Mutants Binding
            with Human beta Defensin Type 2
  JOURNAL   J Phys Chem B 128 (2), 415-428 (2024)
   PUBMED   38189674
  REMARK    GeneRIF: Molecular Dynamics Simulations on Spike Protein Mutants
            Binding with Human beta Defensin Type 2.
REFERENCE   5  (bases 1 to 337)
  AUTHORS   Schroder,J.M. and Harder,J.
  TITLE     Human beta-defensin-2
  JOURNAL   Int J Biochem Cell Biol 31 (6), 645-651 (1999)
   PUBMED   10404637
  REMARK    GeneRIF: The encoded peptide displays antibacterial activity
            against Gram-negative but not Gram-positive bacteria, including P.
            aeruginosa and E. coli. In addition, this peptide is active against
            C. albicans.
            Review article
REFERENCE   6  (bases 1 to 337)
  AUTHORS   Mathews,M., Jia,H.P., Guthmiller,J.M., Losh,G., Graham,S.,
            Johnson,G.K., Tack,B.F. and McCray,P.B. Jr.
  TITLE     Production of beta-defensin antimicrobial peptides by the oral
            mucosa and salivary glands
  JOURNAL   Infect Immun 67 (6), 2740-2745 (1999)
   PUBMED   10338476
REFERENCE   7  (bases 1 to 337)
  AUTHORS   Liu,L., Wang,L., Jia,H.P., Zhao,C., Heng,H.H., Schutte,B.C.,
            McCray,P.B. Jr. and Ganz,T.
  TITLE     Structure and mapping of the human beta-defensin HBD-2 gene and its
            expression at sites of inflammation
  JOURNAL   Gene 222 (2), 237-244 (1998)
   PUBMED   9831658
REFERENCE   8  (bases 1 to 337)
  AUTHORS   Bals,R., Wang,X., Wu,Z., Freeman,T., Bafna,V., Zasloff,M. and
            Wilson,J.M.
  TITLE     Human beta-defensin 2 is a salt-sensitive peptide antibiotic
            expressed in human lung
  JOURNAL   J Clin Invest 102 (5), 874-880 (1998)
   PUBMED   9727055
REFERENCE   9  (bases 1 to 337)
  AUTHORS   Weinberg,A., Krisanaprakornkit,S. and Dale,B.A.
  TITLE     Epithelial antimicrobial peptides: review and significance for oral
            applications
  JOURNAL   Crit Rev Oral Biol Med 9 (4), 399-414 (1998)
   PUBMED   9825219
  REMARK    Review article
REFERENCE   10 (bases 1 to 337)
  AUTHORS   Harder,J., Bartels,J., Christophers,E. and Schroder,J.M.
  TITLE     A peptide antibiotic from human skin
  JOURNAL   Nature 387 (6636), 861 (1997)
   PUBMED   9202117
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC130365.5.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jul 25, 2019 this sequence version replaced NM_004942.3.
            
            Summary: Defensins form a family of microbicidal and cytotoxic
            peptides made by neutrophils. Members of the defensin family are
            highly similar in protein sequence. This gene encodes defensin,
            beta 4, an antibiotic peptide which is locally regulated by
            inflammation. [provided by RefSeq, Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: HY264007.1, BC069285.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2147975, SAMEA2151358
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match                 :: ENST00000302247.3/
                                                  ENSP00000303532.2
            Protein has antimicrobial activity :: PMID: 10404637
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-94                AC130365.5         109315-109408       c
            95-337              AC130365.5         107369-107611       c
FEATURES             Location/Qualifiers
     source          1..337
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p23.1"
     gene            1..337
                     /gene="DEFB4A"
                     /gene_synonym="BD-2; DEFB-2; DEFB102; DEFB2; DEFB4; HBD-2;
                     SAP1"
                     /note="defensin beta 4A"
                     /db_xref="GeneID:1673"
                     /db_xref="HGNC:HGNC:2767"
                     /db_xref="MIM:602215"
     exon            1..94
                     /gene="DEFB4A"
                     /gene_synonym="BD-2; DEFB-2; DEFB102; DEFB2; DEFB4; HBD-2;
                     SAP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             37..231
                     /gene="DEFB4A"
                     /gene_synonym="BD-2; DEFB-2; DEFB102; DEFB2; DEFB4; HBD-2;
                     SAP1"
                     /note="skin-antimicrobial peptide 1; defensin, beta 2;
                     defensin, beta 4; beta-defensin 4A; beta defensin-2"
                     /codon_start=1
                     /product="defensin beta 4A precursor"
                     /protein_id="NP_004933.1"
                     /db_xref="CCDS:CCDS5971.1"
                     /db_xref="GeneID:1673"
                     /db_xref="HGNC:HGNC:2767"
                     /db_xref="MIM:602215"
                     /translation="MRVLYLLFSFLFIFLMPLPGVFGGIGDPVTCLKSGAICHPVFCP
                     RRYKQIGTCGLPGTKCCKKP"
     exon            95..337
                     /gene="DEFB4A"
                     /gene_synonym="BD-2; DEFB-2; DEFB102; DEFB2; DEFB4; HBD-2;
                     SAP1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agactcagct cctggtgaag ctcccagcca tcagccatga gggtcttgta tctcctcttc
       61 tcgttcctct tcatattcct gatgcctctt ccaggtgttt ttggtggtat aggcgatcct
      121 gttacctgcc ttaagagtgg agccatatgt catccagtct tttgccctag aaggtataaa
      181 caaattggca cctgtggtct ccctggaaca aaatgctgca aaaagccatg aggaggccaa
      241 gaagctgctg tggctgatgc ggattcagaa agggctccct catcagagac gtgcgacatg
      301 taaaccaaat taaactatgg tgtccaaaga tacgcaa
//
