LOCUS       NM_001033018             237 bp    mRNA    linear   PRI 04-OCT-2024
DEFINITION  Homo sapiens defensin beta 136 (DEFB136), mRNA.
ACCESSION   NM_001033018
VERSION     NM_001033018.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 237)
  AUTHORS   Liu,H., Diao,H., Hou,J., Yu,H. and Wen,H.
  TITLE     Soluble expression and purification of human beta-defensin DEFB136
            in Escherichia coli and identification of its bioactivity
  JOURNAL   Protein Expr Purif 188, 105968 (2021)
   PUBMED   34481960
REFERENCE   2  (bases 1 to 237)
  AUTHORS   Patil,A.A., Cai,Y., Sang,Y., Blecha,F. and Zhang,G.
  TITLE     Cross-species analysis of the mammalian beta-defensin gene family:
            presence of syntenic gene clusters and preferential expression in
            the male reproductive tract
  JOURNAL   Physiol Genomics 23 (1), 5-17 (2005)
   PUBMED   16033865
  REMARK    GeneRIF: The protein encoded by this gene is thought to display
            antimicrobial activity.
REFERENCE   3  (bases 1 to 237)
  AUTHORS   Schutte,B.C., Mitros,J.P., Bartlett,J.A., Walters,J.D., Jia,H.P.,
            Welsh,M.J., Casavant,T.L. and McCray,P.B. Jr.
  TITLE     Discovery of five conserved beta -defensin gene clusters using a
            computational search strategy
  JOURNAL   Proc Natl Acad Sci U S A 99 (4), 2129-2133 (2002)
   PUBMED   11854508
  REMARK    Erratum:[Proc Natl Acad Sci U S A 2002 Oct 29;99(22):14611]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DQ012026.1.
            
            On Oct 21, 2006 this sequence version replaced NM_001033018.1.
            
            Summary: Defensins are cysteine-rich cationic polypeptides that are
            important in the immunologic response to invading microorganisms.
            The antimicrobial protein encoded by this gene is secreted and is a
            member of the beta defensin protein family. Beta defensin genes are
            found in several clusters throughout the genome, with this gene
            mapping to a cluster at 8p23. [provided by RefSeq, Nov 2014].
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ012026.1, AY621333.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match                 :: ENST00000382209.2/
                                                  ENSP00000371644.2
            Protein has antimicrobial activity :: PMID: 16033865
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..237
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p23.1"
     gene            1..237
                     /gene="DEFB136"
                     /gene_synonym="DEFB137"
                     /note="defensin beta 136"
                     /db_xref="GeneID:613210"
                     /db_xref="HGNC:HGNC:34433"
     CDS             1..237
                     /gene="DEFB136"
                     /gene_synonym="DEFB137"
                     /note="beta-defensin 137; beta-defensin 136"
                     /codon_start=1
                     /product="defensin beta 136 precursor"
                     /protein_id="NP_001028190.2"
                     /db_xref="CCDS:CCDS43709.1"
                     /db_xref="GeneID:613210"
                     /db_xref="HGNC:HGNC:34433"
                     /translation="MNLCLSALLFFLVILLPSGKGMFGNDGVKVRTCTSQKAVCFFGC
                     PPGYRWIAFCHNILSCCKNMTRFQPPQAKDPWVH"
     exon            1..55
                     /gene="DEFB136"
                     /gene_synonym="DEFB137"
                     /inference="alignment:Splign:2.1.0"
     exon            56..237
                     /gene="DEFB136"
                     /gene_synonym="DEFB137"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgaacctct gtctttctgc attactcttt ttcctggtga tcttactgcc ttcaggaaaa
       61 ggtatgtttg ggaatgatgg agtcaaagtt cgcacctgca ctagccagaa agccgtatgt
      121 ttcttcgggt gtccgccagg atacaggtgg attgcgttct gccacaatat tctgtcttgc
      181 tgtaaaaata tgacacgttt tcaacccccg caagccaaag atccatgggt tcattaa
//
