LOCUS       NM_001033017             299 bp    mRNA    linear   PRI 12-JUN-2024
DEFINITION  Homo sapiens defensin beta 135 (DEFB135), mRNA.
ACCESSION   NM_001033017
VERSION     NM_001033017.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 299)
  AUTHORS   Patil,A.A., Cai,Y., Sang,Y., Blecha,F. and Zhang,G.
  TITLE     Cross-species analysis of the mammalian beta-defensin gene family:
            presence of syntenic gene clusters and preferential expression in
            the male reproductive tract
  JOURNAL   Physiol Genomics 23 (1), 5-17 (2005)
   PUBMED   16033865
  REMARK    GeneRIF: The protein encoded by this gene is thought to display
            antimicrobial activity.
REFERENCE   2  (bases 1 to 299)
  AUTHORS   Schutte,B.C., Mitros,J.P., Bartlett,J.A., Walters,J.D., Jia,H.P.,
            Welsh,M.J., Casavant,T.L. and McCray,P.B. Jr.
  TITLE     Discovery of five conserved beta -defensin gene clusters using a
            computational search strategy
  JOURNAL   Proc Natl Acad Sci U S A 99 (4), 2129-2133 (2002)
   PUBMED   11854508
  REMARK    Erratum:[Proc Natl Acad Sci U S A 2002 Oct 29;99(22):14611]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC107918.5.
            
            On Oct 14, 2020 this sequence version replaced NM_001033017.2.
            
            Summary: Defensins are cysteine-rich cationic polypeptides that are
            important in the immunologic response to invading microorganisms.
            The antimicrobial protein encoded by this gene is secreted and is a
            member of the beta defensin protein family. Beta defensin genes are
            found in several clusters throughout the genome, with this gene
            mapping to a cluster at 8p23. [provided by RefSeq, Nov 2014].
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ012025.1, AY621332.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match                 :: ENST00000382208.3/
                                                  ENSP00000371643.2
            Protein has antimicrobial activity :: PMID: 16033865
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-129               AC107918.5         98208-98336
            130-299             AC107918.5         100373-100542
FEATURES             Location/Qualifiers
     source          1..299
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p23.1"
     gene            1..299
                     /gene="DEFB135"
                     /gene_synonym="DEFB136"
                     /note="defensin beta 135"
                     /db_xref="GeneID:613209"
                     /db_xref="HGNC:HGNC:32400"
     exon            1..129
                     /gene="DEFB135"
                     /gene_synonym="DEFB136"
                     /inference="alignment:Splign:2.1.0"
     CDS             66..299
                     /gene="DEFB135"
                     /gene_synonym="DEFB136"
                     /note="beta-defensin 136; beta-defensin 135"
                     /codon_start=1
                     /product="beta-defensin 135 precursor"
                     /protein_id="NP_001028189.2"
                     /db_xref="CCDS:CCDS43710.1"
                     /db_xref="GeneID:613209"
                     /db_xref="HGNC:HGNC:32400"
                     /translation="MATRSVLLALVVLNLLFYVPPGRSGPNVYIQKIFASCWRLQGTC
                     RPKCLKNEQYRILCDTIHLCCVNPKYLPILTGK"
     exon            130..299
                     /gene="DEFB135"
                     /gene_synonym="DEFB136"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtctcttcaa agctgcggag agagtgactc tccgatgagt cacagctgct tctttgctga
       61 ttggtatggc cacaaggagc gtcctcttgg ccctcgtggt ccttaactta ctcttctatg
      121 ttccaccagg tagaagtgga cccaatgtct acatacaaaa aatctttgct tcatgttggc
      181 gactgcaagg tacttgccgg ccaaaatgtc taaaaaacga acaatatcgt attttgtgtg
      241 atactataca tttgtgctgt gtaaacccaa aatatttacc tatactgact gggaaatag
//
