LOCUS       NM_001302695            1099 bp    mRNA    linear   PRI 16-FEB-2024
DEFINITION  Homo sapiens defensin beta 134 (DEFB134), mRNA.
ACCESSION   NM_001302695
VERSION     NM_001302695.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1099)
  AUTHORS   Patil,A.A., Cai,Y., Sang,Y., Blecha,F. and Zhang,G.
  TITLE     Cross-species analysis of the mammalian beta-defensin gene family:
            presence of syntenic gene clusters and preferential expression in
            the male reproductive tract
  JOURNAL   Physiol Genomics 23 (1), 5-17 (2005)
   PUBMED   16033865
  REMARK    GeneRIF: The protein encoded by this gene is thought to display
            antimicrobial activity.
REFERENCE   2  (bases 1 to 1099)
  AUTHORS   Harrington,J.J., Sherf,B., Rundlett,S., Jackson,P.D., Perry,R.,
            Cain,S., Leventhal,C., Thornton,M., Ramachandran,R.,
            Whittington,J., Lerner,L., Costanzo,D., McElligott,K., Boozer,S.,
            Mays,R., Smith,E., Veloso,N., Klika,A., Hess,J., Cothren,K., Lo,K.,
            Offenbacher,J., Danzig,J. and Ducar,M.
  TITLE     Creation of genome-wide protein expression libraries using random
            activation of gene expression
  JOURNAL   Nat Biotechnol 19 (5), 440-445 (2001)
   PUBMED   11329013
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from HY003097.1, BG191747.1,
            BX099413.1 and AC107918.5.
            
            On Aug 13, 2020 this sequence version replaced NM_001302695.1.
            
            Summary: Defensins are cysteine-rich cationic polypeptides that are
            important in the immunologic response to invading microorganisms.
            The antimicrobial protein encoded by this gene is secreted and is a
            member of the beta defensin protein family. Beta defensin genes are
            found in several clusters throughout the genome, with this gene
            mapping to a cluster at 8p23. [provided by RefSeq, Nov 2014].
            
            ##Evidence-Data-START##
            Transcript exon combination :: HY003097.1, HY026830.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2149178, SAMEA2151119
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match                 :: ENST00000382205.6/
                                                  ENSP00000371640.4
            Protein has antimicrobial activity :: PMID: 16033865
            RefSeq Select criteria             :: based on manual assertion,
                                                  conservation, expression,
                                                  longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-556               HY003097.1         3-558
            557-1087            BG191747.1         19-549              c
            1088-1096           BX099413.1         422-430
            1097-1099           AC107918.5         109126-109128       c
FEATURES             Location/Qualifiers
     source          1..1099
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p23.1"
     gene            1..1099
                     /gene="DEFB134"
                     /note="defensin beta 134"
                     /db_xref="GeneID:613211"
                     /db_xref="HGNC:HGNC:32399"
     exon            1..45
                     /gene="DEFB134"
                     /inference="alignment:Splign:2.1.0"
     exon            46..150
                     /gene="DEFB134"
                     /inference="alignment:Splign:2.1.0"
     CDS             93..293
                     /gene="DEFB134"
                     /note="beta-defensin 135; beta-defensin 134"
                     /codon_start=1
                     /product="beta-defensin 134 precursor"
                     /protein_id="NP_001289624.1"
                     /db_xref="CCDS:CCDS34847.1"
                     /db_xref="GeneID:613211"
                     /db_xref="HGNC:HGNC:32399"
                     /translation="MKPLLVVFVFLFLWDPVLAGINSLSSEMHKKCYKNGICRLECYE
                     SEMLVAYCMFQLECCVKGNPAP"
     exon            151..1099
                     /gene="DEFB134"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1081..1086
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DEFB134"
                     /note="hexamer: AATAAA"
     polyA_site      1099
                     /gene="DEFB134"
                     /note="major polyA site"
ORIGIN      
        1 tatatcatct tacatcagca caagaagaag agtgagcata gcacaccgat gtcagaccct
       61 gccactagcc tccttaacag aagttcccag ccatgaagcc tctccttgtt gtgtttgtct
      121 ttcttttcct ttgggatcca gtgctggcag gtataaattc attatcatca gaaatgcaca
      181 agaaatgcta taaaaatggc atctgcagac ttgaatgcta tgagagtgaa atgttagttg
      241 cctactgtat gtttcagctg gagtgctgtg tcaaaggaaa tcctgcaccc tgacataaga
      301 aaccaatgaa tggccactat cctgtaggcc cttgattctg ccatctttca caaaaccagg
      361 gaatttagat caaactgtga caccatgatg tgtccatgac tactggtttt tagcattttt
      421 ataggccagc agactcttgt ggtcttaaat ttaaagagct gagctgtagc cttctttaaa
      481 agagctcggt ttttcacaaa aacaatgtag aagatatttt ctcacctcaa cgtgatgtcc
      541 agtgtgctca tcagcacctg tttctccctc taatcataga ggatattctt attatttaga
      601 aaggcttcaa gggaaacaac ttttgacacc taagtcgtgt cctaccttcg cttcagcttc
      661 gcatttccca tttctgtgaa attcccaact ttagagaagc agatttgcca tggccttctg
      721 acaaccttgt acatctctca cataaaccgc ataggcaggg cttaactaca ggctggcccg
      781 agtctgcact gagtctgacc ctgaagttcc tttggaacag gagaggccat cttgtgatgg
      841 gctggaacaa ggtaatttct catccacctc cctagtttca gttgagcaat ggaacttccc
      901 acctgagccc ctagggttca gctacaggct ataagactgc cgtcctgtgg tttagtgttg
      961 gttccttagc agcagagtga tgccacctct gctgcccgtc atctgactcc tctggatggg
     1021 tgttatcctg tggcttaaga gctaacacca tgctgatctt gctttgctat atgtgtaact
     1081 aataaactgc ctaaatgca
//
