LOCUS       NM_207469               2133 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens defensin beta 132 (DEFB132), mRNA.
ACCESSION   NM_207469
VERSION     NM_207469.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2133)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2133)
  AUTHORS   Lin,Y.Q., Li,J.Y., Wang,H.Y., Liu,J., Zhang,C.L., Wang,W.T.,
            Liu,J., Li,N. and Jin,S.H.
  TITLE     Cloning and identification of a novel sperm binding protein,
            HEL-75, with antibacterial activity and expressed in the human
            epididymis
  JOURNAL   Hum Reprod 23 (9), 2086-2094 (2008)
   PUBMED   18343807
  REMARK    GeneRIF: HEL-75 is a new beta-defensin expressed in the epididymis
            and on sperm. The encoded protein displays antimicrobial activity
            against E. coli.
REFERENCE   3  (bases 1 to 2133)
  AUTHORS   Li,J.Y., Wang,H.Y., Liu,J., Liu,Q., Zhang,J.S., Wan,F.C., Liu,F.J.,
            Jin,S.H. and Zhang,Y.L.
  TITLE     Transcriptome analysis of a cDNA library from adult human
            epididymis
  JOURNAL   DNA Res 15 (3), 115-122 (2008)
   PUBMED   18390568
REFERENCE   4  (bases 1 to 2133)
  AUTHORS   Hollox,E.J. and Armour,J.A.
  TITLE     Directional and balancing selection in human beta-defensins
  JOURNAL   BMC Evol Biol 8, 113 (2008)
   PUBMED   18416833
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2133)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   6  (bases 1 to 2133)
  AUTHORS   Rodriguez-Jimenez,F.J., Krause,A., Schulz,S., Forssmann,W.G.,
            Conejo-Garcia,J.R., Schreeb,R. and Motzkus,D.
  TITLE     Distribution of new human beta-defensin genes clustered on
            chromosome 20 in functionally different segments of epididymis
  JOURNAL   Genomics 81 (2), 175-183 (2003)
   PUBMED   12620395
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL034548.25, AY358708.1,
            BC137292.1 and BE044548.1.
            
            On Nov 22, 2018 this sequence version replaced NM_207469.2.
            
            Summary: Defensins are cysteine-rich cationic polypeptides that are
            important in the immunologic response to invading microorganisms.
            The protein encoded by this gene is secreted and is a member of the
            beta defensin protein family. This protein binds spermatozoa and
            has antimicrobial activity against E. coli. Beta defensin genes are
            found in several clusters throughout the genome, with this gene
            mapping to a cluster at 20p13. [provided by RefSeq, Nov 2014].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY358708.1, EF426755.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142680, SAMEA2145122
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match                 :: ENST00000382376.4/
                                                  ENSP00000371813.3
            Protein has antimicrobial activity :: PMID: 18343807
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                AL034548.25        12399-12410
            13-887              AY358708.1         1-875
            888-1016            BC137292.1         870-998
            1017-1332           AY358708.1         1004-1319
            1333-1590           AY358708.1         1321-1578
            1591-2133           BE044548.1         10-552              c
FEATURES             Location/Qualifiers
     source          1..2133
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20p13"
     gene            1..2133
                     /gene="DEFB132"
                     /gene_synonym="BD-32; DEFB-32; DEFB32; HEL-75; KFLL827;
                     UNQ827"
                     /note="defensin beta 132"
                     /db_xref="GeneID:400830"
                     /db_xref="HGNC:HGNC:33806"
     exon            1..113
                     /gene="DEFB132"
                     /gene_synonym="BD-32; DEFB-32; DEFB32; HEL-75; KFLL827;
                     UNQ827"
                     /inference="alignment:Splign:2.1.0"
     CDS             56..343
                     /gene="DEFB132"
                     /gene_synonym="BD-32; DEFB-32; DEFB32; HEL-75; KFLL827;
                     UNQ827"
                     /note="defensin, beta 32; beta-defensin 132; beta-defensin
                     32; defensin HEL-75; RP5-1103G7.6"
                     /codon_start=1
                     /product="beta-defensin 132 precursor"
                     /protein_id="NP_997352.1"
                     /db_xref="CCDS:CCDS12993.1"
                     /db_xref="GeneID:400830"
                     /db_xref="HGNC:HGNC:33806"
                     /translation="MKFLLLVLAALGFLTQVIPASAGGSKCVSNTPGYCRTCCHWGET
                     ALFMCNASRKCCISYSFLPKPDLPQLIGNHWQSRRRNTQRKDKKQQTTVTS"
     exon            114..2133
                     /gene="DEFB132"
                     /gene_synonym="BD-32; DEFB-32; DEFB32; HEL-75; KFLL827;
                     UNQ827"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2103..2108
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DEFB132"
                     /gene_synonym="BD-32; DEFB-32; DEFB32; HEL-75; KFLL827;
                     UNQ827"
                     /note="hexamer: AATAAA"
     polyA_site      2133
                     /gene="DEFB132"
                     /gene_synonym="BD-32; DEFB-32; DEFB32; HEL-75; KFLL827;
                     UNQ827"
                     /note="major polyA site"
ORIGIN      
        1 agagggaccc aactccatta aaccaccacc agctccccaa gccacccctt cagccatgaa
       61 gttcctgctc ctggtcttgg cagccctcgg attcctgacc caggtgatcc cagccagtgc
      121 aggtgggtca aaatgtgtga gtaacacccc aggatactgc aggacatgtt gccactgggg
      181 ggagacagca ttgttcatgt gcaacgcttc cagaaaatgc tgcatcagct actccttcct
      241 gccgaagcct gacctaccac agctcatcgg taaccactgg caatcaagga gaagaaacac
      301 acaaaggaaa gacaagaagc aacaaacgac cgtaacatca taataaccac tgctatcgcc
      361 tccaccaact cagagaaata tcatttccac agttccaatt cctcctacat tgctgagtac
      421 tagccaaggc tcctctttat ggggcagata tctatagcca accccaaaac ttctgtcttc
      481 tatcattctg tcattcatct agtaactaat ttggagtttg tatctatctt acgagaacaa
      541 tcatcatgca gattcgtcca caggggatct gtcagtttgg gtcctccaaa tgaaaaatgt
      601 caagacagaa ttggacatgc aaaagattga ctgggagaac acacctctga tggacaaagg
      661 tgagacagag cagccacagg cagggagagc cttcagactg caacgctggc ctgatacgtg
      721 tcaaaggaga gagggataga ggaggattga atagaaggag actaagactg cagctctaag
      781 aaagtctcag ccaaacagat ggggaggccc aaagcaaggc ttgcccctca gaggagctca
      841 cgcagggcag gaatagccag gttctcatat cccaggggtt cagactttgg ctgagaacag
      901 cccctggaga acatggggtg actgctacca taggtctgga agtatgaggc tgtccaccaa
      961 ctatcccctt gaagcaagtt ctcttgaaag gaaatctaaa cagtgcaccc ccatggctgc
     1021 cacggagtat aaggagggag agaaaggagc tgaaagtcta ggtttggcca gctaggtaga
     1081 ctgacttgtg aggtatttat ttattcattt gagtaacaaa gcagacagaa tacatagcca
     1141 ccattggtag tacaccccaa aagcaaggat ggcatgatgc tggtgactca aacgtgccta
     1201 ctcatggtgt caaattggca taatcctctt gggaagctgt gtggaaataa gcacagagaa
     1261 gcagaactct aattgcttaa tccactaaac attacttctg ggaattggct catcataaat
     1321 tatccaagag aagcacaaag ttatgggcac aaaggttttc catataatat tatttaaaat
     1381 gctgagaaaa tgaaaaaatc taaatggtga aatatatact aatgccatct ataaatacaa
     1441 acaaatagaa tgtttataga ataatggaac ataataacat tattcaaaat tgcatttatg
     1501 ctatagttgt caaaattgtc tccttatatg atacaaaact catgaaaatt atgacttttt
     1561 tgtttggttg gaaagcagaa ttatgcataa atttcctctt acagttcgat gcccattagt
     1621 tttatataac atttatttga cacgtactga cttctatctg agaagaacaa accaaaacac
     1681 tcaggcctaa ataattaaaa acggtcctaa aaactagcaa accagataag aaaagatgtt
     1741 aatgcccatt ccctaactta tgtcttagac caaaattaat tctagatggt tttaaaatga
     1801 cagtgtaaaa gtaaagtatt aaaagattgt gtggtcaaat attcaattta agagcaagga
     1861 aattcttata aatataacaa tagaggcaga actcatgtaa gaataaattg attaggtggt
     1921 attaaatatt aagttcttat gtatgtcaaa agatatcatt ttgaaattca tccatcttat
     1981 tgggtattgc aggagttcat tcctttttgt ttataaatac tcttccgtca tatgaatagt
     2041 attcatttgt atactggttt gttgatggac atttgggttg ttcccagttt atggctatta
     2101 caaataaagc ttctatgaac atttatgtac aaa
//
