LOCUS       NM_001040448             485 bp    mRNA    linear   PRI 05-OCT-2024
DEFINITION  Homo sapiens defensin beta 131A (DEFB131A), mRNA.
ACCESSION   NM_001040448 XM_927560 XM_939534
VERSION     NM_001040448.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 485)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 485)
  AUTHORS   Kim,J.H., Kim,K.H., Kim,H.J., Lee,J. and Myung,S.C.
  TITLE     Expression of Beta-Defensin 131 Promotes an Innate Immune Response
            in Human Prostate Epithelial Cells
  JOURNAL   PLoS One 10 (12), e0144776 (2015)
   PUBMED   26649771
  REMARK    GeneRIF: DEFB131 induces cytokine and chemokine upregulation
            through the TLR2/NF-kappaB signaling pathway in RWPE-1 cells during
            bacterial infection and promotes an innate immune response
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 485)
  AUTHORS   Patil,A.A., Cai,Y., Sang,Y., Blecha,F. and Zhang,G.
  TITLE     Cross-species analysis of the mammalian beta-defensin gene family:
            presence of syntenic gene clusters and preferential expression in
            the male reproductive tract
  JOURNAL   Physiol Genomics 23 (1), 5-17 (2005)
   PUBMED   16033865
  REMARK    GeneRIF: The protein encoded by this gene is thought to display
            antimicrobial activity.
REFERENCE   4  (bases 1 to 485)
  AUTHORS   Kao,C.Y., Chen,Y., Zhao,Y.H. and Wu,R.
  TITLE     ORFeome-based search of airway epithelial cell-specific novel human
            [beta]-defensin genes
  JOURNAL   Am J Respir Cell Mol Biol 29 (1), 71-80 (2003)
   PUBMED   12600824
REFERENCE   5  (bases 1 to 485)
  AUTHORS   Schutte,B.C., Mitros,J.P., Bartlett,J.A., Walters,J.D., Jia,H.P.,
            Welsh,M.J., Casavant,T.L. and McCray,P.B. Jr.
  TITLE     Discovery of five conserved beta -defensin gene clusters using a
            computational search strategy
  JOURNAL   Proc Natl Acad Sci U S A 99 (4), 2129-2133 (2002)
   PUBMED   11854508
  REMARK    Erratum:[Proc Natl Acad Sci U S A 2002 Oct 29;99(22):14611]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC116655.7 and AF529414.1.
            
            On Apr 30, 2021 this sequence version replaced NM_001040448.2.
            
            Summary: Defensins are cysteine-rich cationic polypeptides that are
            important in the immunologic response to invading microorganisms.
            The antimicrobial protein encoded by this gene is secreted and is a
            member of the beta defensin protein family. Beta defensin genes are
            found in several clusters throughout the genome, with this gene
            mapping to a cluster at 4p16. [provided by RefSeq, Nov 2014].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR279858.1117.1, AF529414.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142348, SAMEA2144835
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match                 :: ENST00000334879.2/
                                                  ENSP00000335538.1
            Protein has antimicrobial activity :: PMID: 16033865
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-120               AC116655.7         124608-124727       c
            121-178             AF529414.1         1-58
            179-485             AC116655.7         118475-118781       c
FEATURES             Location/Qualifiers
     source          1..485
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p16.1"
     gene            1..485
                     /gene="DEFB131A"
                     /gene_synonym="DEFB-31; DEFB131"
                     /note="defensin beta 131A"
                     /db_xref="GeneID:644414"
                     /db_xref="HGNC:HGNC:18108"
     exon            1..178
                     /gene="DEFB131A"
                     /gene_synonym="DEFB-31; DEFB131"
                     /inference="alignment:Splign:2.1.0"
     CDS             121..333
                     /gene="DEFB131A"
                     /gene_synonym="DEFB-31; DEFB131"
                     /note="beta-defensin 131; defensin beta 131; defensin,
                     beta 31; beta-defensin 31; beta-defensin 131A"
                     /codon_start=1
                     /product="beta-defensin 131A precursor"
                     /protein_id="NP_001035538.2"
                     /db_xref="CCDS:CCDS43213.1"
                     /db_xref="GeneID:644414"
                     /db_xref="HGNC:HGNC:18108"
                     /translation="MRVLFFVFGVLSLMFTVPPARSFISNDECPSEYYHCRLKCNADE
                     HAIRYCADFSICCKLKIIEIDGQKKW"
     exon            179..485
                     /gene="DEFB131A"
                     /gene_synonym="DEFB-31; DEFB131"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cttgctcctg aaaggttcaa taatcactca acaactcacc tcttcagaga actgaatgta
       61 cacagaagtc ctcttcatct cagctactga ttctctctaa cctgctttac ctattcaacc
      121 atgagggtct tgttttttgt ctttggagtc ctttccttga tgttcacagt tcctccagcc
      181 agaagcttca tttctaatga tgaatgtcct tcagaatatt atcattgcag actgaagtgc
      241 aatgctgatg aacatgcaat tagatactgt gctgacttca gcatctgctg caaactgaag
      301 atcattgaaa ttgacggaca aaagaagtgg tgaaaattct aactccatct tcttcagact
      361 ccgggacaaa aaacatgtct taaactctct tatctatgaa taattaacat gatagatgaa
      421 aattattata attgcatgtt tagatggtca ggtgaaaatg aatataaatt ttataaatgc
      481 ttcca
//
