LOCUS       NM_001037804             240 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens defensin beta 130A (DEFB130A), mRNA.
ACCESSION   NM_001037804
VERSION     NM_001037804.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 240)
  AUTHORS   Terkawi,M.A., Takano,R., Furukawa,A., Murakoshi,F. and Kato,K.
  TITLE     Involvement of beta-defensin 130 (DEFB130) in the macrophage
            microbicidal mechanisms for killing Plasmodium falciparum
  JOURNAL   Sci Rep 7, 41772 (2017)
   PUBMED   28181499
  REMARK    GeneRIF: these results suggest that DEFB130 might be one of the
            macrophage effector molecules for eliminating malarial parasites.
            Our data broaden our knowledge of the immunological response of
            macrophages to iRBCs and shed light on a new target for therapeutic
            intervention.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 240)
  AUTHORS   Patil,A.A., Cai,Y., Sang,Y., Blecha,F. and Zhang,G.
  TITLE     Cross-species analysis of the mammalian beta-defensin gene family:
            presence of syntenic gene clusters and preferential expression in
            the male reproductive tract
  JOURNAL   Physiol Genomics 23 (1), 5-17 (2005)
   PUBMED   16033865
  REMARK    GeneRIF: The protein encoded by this gene is thought to display
            antimicrobial activity.
REFERENCE   3  (bases 1 to 240)
  AUTHORS   Schutte,B.C., Mitros,J.P., Bartlett,J.A., Walters,J.D., Jia,H.P.,
            Welsh,M.J., Casavant,T.L. and McCray,P.B. Jr.
  TITLE     Discovery of five conserved beta -defensin gene clusters using a
            computational search strategy
  JOURNAL   Proc Natl Acad Sci U S A 99 (4), 2129-2133 (2002)
   PUBMED   11854508
  REMARK    Erratum:[Proc Natl Acad Sci U S A 2002 Oct 29;99(22):14611]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DQ012022.1.
            
            Summary: Defensins are cysteine-rich cationic polypeptides that are
            important in the immunologic response to invading microorganisms.
            The antimicrobial protein encoded by this gene is secreted and is a
            member of the beta defensin protein family. Beta defensin genes are
            found in several clusters throughout the genome, with this gene
            mapping to a cluster at 8p23. [provided by RefSeq, Nov 2014].
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ012022.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match                 :: ENST00000400079.1/
                                                  ENSP00000382951.1
            Protein has antimicrobial activity :: PMID: 16033865
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..240
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p23.1"
     gene            1..240
                     /gene="DEFB130A"
                     /gene_synonym="DEFB-30; DEFB130; DEFB130L; DEFB30"
                     /note="defensin beta 130A"
                     /db_xref="GeneID:245940"
                     /db_xref="HGNC:HGNC:18107"
     CDS             1..240
                     /gene="DEFB130A"
                     /gene_synonym="DEFB-30; DEFB130; DEFB130L; DEFB30"
                     /note="defensin, beta 30; beta-defensin 130; beta-defensin
                     30; defensin beta 130; beta-defensin 130A"
                     /codon_start=1
                     /product="beta-defensin 130A precursor"
                     /protein_id="NP_001032893.1"
                     /db_xref="CCDS:CCDS43714.1"
                     /db_xref="GeneID:245940"
                     /db_xref="HGNC:HGNC:18107"
                     /translation="MKLHSLISVLLLFVTLIPKGKTGVIPGQKQCIALKGVCRDKLCS
                     TLDDTIGICNEGKKCCRRWWILEPYPTPVPKGKSP"
     exon            1..58
                     /gene="DEFB130A"
                     /gene_synonym="DEFB-30; DEFB130; DEFB130L; DEFB30"
                     /inference="alignment:Splign:2.1.0"
     exon            59..240
                     /gene="DEFB130A"
                     /gene_synonym="DEFB-30; DEFB130; DEFB130L; DEFB30"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgaaactcc attcccttat ttctgttctc ctcctctttg tgactttaat accaaaagga
       61 aagactggcg ttattccagg acaaaaacag tgtattgctt tgaaaggggt gtgcagagac
      121 aaactatgca gcacactaga tgataccatt ggtatatgta atgaaggaaa aaaatgttgt
      181 agaaggtggt ggatacttga gccctatcca actccggttc ccaaaggaaa atctccttag
//
