LOCUS       NM_001037732             403 bp    mRNA    linear   PRI 25-JUL-2020
DEFINITION  Homo sapiens defensin beta 128 (DEFB128), mRNA.
ACCESSION   NM_001037732
VERSION     NM_001037732.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 403)
  AUTHORS   Luck K, Kim DK, Lambourne L, Spirohn K, Begg BE, Bian W, Brignall
            R, Cafarelli T, Campos-Laborie FJ, Charloteaux B, Choi D, Cote AG,
            Daley M, Deimling S, Desbuleux A, Dricot A, Gebbia M, Hardy MF,
            Kishore N, Knapp JJ, Kovacs IA, Lemmens I, Mee MW, Mellor JC,
            Pollis C, Pons C, Richardson AD, Schlabach S, Teeking B, Yadav A,
            Babor M, Balcha D, Basha O, Bowman-Colin C, Chin SF, Choi SG,
            Colabella C, Coppin G, D'Amata C, De Ridder D, De Rouck S,
            Duran-Frigola M, Ennajdaoui H, Goebels F, Goehring L, Gopal A,
            Haddad G, Hatchi E, Helmy M, Jacob Y, Kassa Y, Landini S, Li R, van
            Lieshout N, MacWilliams A, Markey D, Paulson JN, Rangarajan S,
            Rasla J, Rayhan A, Rolland T, San-Miguel A, Shen Y, Sheykhkarimli
            D, Sheynkman GM, Simonovsky E, Tasan M, Tejeda A, Tropepe V,
            Twizere JC, Wang Y, Weatheritt RJ, Weile J, Xia Y, Yang X,
            Yeger-Lotem E, Zhong Q, Aloy P, Bader GD, De Las Rivas J, Gaudet S,
            Hao T, Rak J, Tavernier J, Hill DE, Vidal M, Roth FP and Calderwood
            MA.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 403)
  AUTHORS   Ghatge M, Sharma A, Maity S, Kakkar VV and Vangala RK.
  TITLE     Danger-recognizing proteins, beta-defensin-128 and histatin-3, as
            potential biomarkers of recurrent coronary events
  JOURNAL   Int. J. Mol. Med. 40 (2), 531-538 (2017)
   PUBMED   28627688
  REMARK    GeneRIF: This aim of this study was to identify novel biomarkers
            using comparative global proteome analysis to improve the risk
            assessment for recurrent coronary events. Beta -defensin-128 and
            histatin-3 may be potential biomarkers whch may be used to improve
            risk the stratification for recurrent coronary events.
REFERENCE   3  (bases 1 to 403)
  AUTHORS   Comuzzie AG, Cole SA, Laston SL, Voruganti VS, Haack K, Gibbs RA
            and Butte NF.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS ONE 7 (12), e51954 (2012)
   PUBMED   23251661
REFERENCE   4  (bases 1 to 403)
  AUTHORS   Patil AA, Cai Y, Sang Y, Blecha F and Zhang G.
  TITLE     Cross-species analysis of the mammalian beta-defensin gene family:
            presence of syntenic gene clusters and preferential expression in
            the male reproductive tract
  JOURNAL   Physiol. Genomics 23 (1), 5-17 (2005)
   PUBMED   16033865
REFERENCE   5  (bases 1 to 403)
  AUTHORS   Schulz A, Kluver E, Schulz-Maronde S and Adermann K.
  TITLE     Engineering disulfide bonds of the novel human beta-defensins
            hBD-27 and hBD-28: differences in disulfide formation and
            biological activity among human beta-defensins
  JOURNAL   Biopolymers 80 (1), 34-49 (2005)
   PUBMED   15625724
REFERENCE   6  (bases 1 to 403)
  AUTHORS   Rodriguez-Jimenez FJ, Krause A, Schulz S, Forssmann WG,
            Conejo-Garcia JR, Schreeb R and Motzkus D.
  TITLE     Distribution of new human beta-defensin genes clustered on
            chromosome 20 in functionally different segments of epididymis
  JOURNAL   Genomics 81 (2), 175-183 (2003)
   PUBMED   12620395
  REMARK    GeneRIF: The protein encoded by this gene is thought to display
            antimicrobial activity.
REFERENCE   7  (bases 1 to 403)
  AUTHORS   Schutte BC, Mitros JP, Bartlett JA, Walters JD, Jia HP, Welsh MJ,
            Casavant TL and McCray PB Jr.
  TITLE     Discovery of five conserved beta -defensin gene clusters using a
            computational search strategy
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 99 (4), 2129-2133 (2002)
   PUBMED   11854508
  REMARK    Erratum:[Proc Natl Acad Sci U S A 2002 Oct 29;99(22):14611]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL360078.16, BC140936.1 and
            AF525930.1.
            
            On May 17, 2019 this sequence version replaced NM_001037732.2.
            
            Summary: Defensins are cysteine-rich cationic polypeptides that are
            important in the immunologic response to invading microorganisms.
            The antimicrobial protein encoded by this gene is secreted and is a
            member of the beta defensin protein family. Beta defensin genes are
            found in several clusters throughout the genome, with this gene
            mapping to a cluster at 20p13. [provided by RefSeq, Nov 2014].
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC140936.1, AF525930.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match                 :: ENST00000334391.5/
                                                  ENSP00000335382.4
            Protein has antimicrobial activity :: PMID: 12620395
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-30                AL360078.16        108380-108409       c
            31-168              BC140936.1         1-138
            169-370             AF525930.1         81-282
            371-403             BC140936.1         341-373
FEATURES             Location/Qualifiers
     source          1..403
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20p13"
     gene            1..403
                     /gene="DEFB128"
                     /gene_synonym="DEFB-28; DEFB28; hBD-28"
                     /note="defensin beta 128"
                     /db_xref="GeneID:245939"
                     /db_xref="HGNC:HGNC:18106"
     exon            1..137
                     /gene="DEFB128"
                     /gene_synonym="DEFB-28; DEFB28; hBD-28"
                     /inference="alignment:Splign:2.1.0"
     CDS             89..370
                     /gene="DEFB128"
                     /gene_synonym="DEFB-28; DEFB28; hBD-28"
                     /note="defensin, beta 28; beta-defensin 28; beta-defensin
                     128"
                     /codon_start=1
                     /product="beta-defensin 128 precursor"
                     /protein_id="NP_001032821.1"
                     /db_xref="CCDS:CCDS33430.1"
                     /db_xref="GeneID:245939"
                     /db_xref="HGNC:HGNC:18106"
                     /translation="MKLFLVLIILLFEVLTDGARLKKCFNKVTGYCRKKCKVGERYEI
                     GCLSGKLCCANDEEEKKHVSFKKPHQHSGEKLSVLQDYIILPTITIFTV"
     exon            138..403
                     /gene="DEFB128"
                     /gene_synonym="DEFB-28; DEFB28; hBD-28"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caaaactctg gatcatcttt aaagacctgt ggcacacaga ccactggaca aagttctgct
       61 gcctctttct cttgggaagt ctgtaaatat gaagctgttt ctggttctca ttattctgct
      121 gtttgaggta ctcacagacg gggcaagact caaaaaatgc ttcaataaag taacaggcta
      181 ttgcaggaag aaatgcaagg taggagaaag atatgaaata ggatgtctaa gtgggaaatt
      241 atgttgtgct aatgatgaag aagagaaaaa acatgtgtca tttaagaagc cacatcaaca
      301 ttctggtgag aagctgagtg tgctgcagga ttacatcatc ttacccacca tcaccatttt
      361 cacagtctaa tcctaaatct agcccttgtc tcgctggtct cca
//
