LOCUS       NM_153325               1186 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens defensin beta 125 (DEFB125), mRNA.
ACCESSION   NM_153325
VERSION     NM_153325.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1186)
  AUTHORS   Rodriguez-Jimenez,F.J., Krause,A., Schulz,S., Forssmann,W.G.,
            Conejo-Garcia,J.R., Schreeb,R. and Motzkus,D.
  TITLE     Distribution of new human beta-defensin genes clustered on
            chromosome 20 in functionally different segments of epididymis
  JOURNAL   Genomics 81 (2), 175-183 (2003)
   PUBMED   12620395
  REMARK    GeneRIF: The protein encoded by this gene is thought to display
            antimicrobial activity.
REFERENCE   2  (bases 1 to 1186)
  AUTHORS   Schutte,B.C., Mitros,J.P., Bartlett,J.A., Walters,J.D., Jia,H.P.,
            Welsh,M.J., Casavant,T.L. and McCray,P.B. Jr.
  TITLE     Discovery of five conserved beta -defensin gene clusters using a
            computational search strategy
  JOURNAL   Proc Natl Acad Sci U S A 99 (4), 2129-2133 (2002)
   PUBMED   11854508
  REMARK    Erratum:[Proc Natl Acad Sci U S A 2002 Oct 29;99(22):14611]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK311802.1, BC128196.1 and
            AL360078.16.
            
            On May 17, 2019 this sequence version replaced NM_153325.3.
            
            Summary: Defensins are cysteine-rich cationic polypeptides that are
            important in the host immunologic response to invading
            microorganisms. The antimicrobial protein encoded by this gene is
            secreted and is a member of the beta defensin protein family. Beta
            defensin genes are found in several clusters throughout the genome,
            with this gene mapping to a cluster at 20p13. [provided by RefSeq,
            Nov 2014].
            
            ##Evidence-Data-START##
            Transcript exon combination :: DB084490.1, AK311802.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match                 :: ENST00000382410.3/
                                                  ENSP00000371847.2
            Protein has antimicrobial activity :: PMID: 12620395
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-38                AK311802.1         1-38
            39-665              BC128196.1         1-627
            666-1186            AL360078.16        15272-15792
FEATURES             Location/Qualifiers
     source          1..1186
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20p13"
     gene            1..1186
                     /gene="DEFB125"
                     /gene_synonym="DEFB-25"
                     /note="defensin beta 125"
                     /db_xref="GeneID:245938"
                     /db_xref="HGNC:HGNC:18105"
     exon            1..96
                     /gene="DEFB125"
                     /gene_synonym="DEFB-25"
                     /inference="alignment:Splign:2.1.0"
     CDS             39..509
                     /gene="DEFB125"
                     /gene_synonym="DEFB-25"
                     /note="beta defensin 25; beta-defensin 125"
                     /codon_start=1
                     /product="beta-defensin 125 preproprotein"
                     /protein_id="NP_697020.2"
                     /db_xref="CCDS:CCDS12989.2"
                     /db_xref="GeneID:245938"
                     /db_xref="HGNC:HGNC:18105"
                     /translation="MNILMLTFIICGLLTRVTKGSFEPQKCWKNNVGHCRRRCLDTER
                     YILLCRNKLSCCISIISHEYTRRPAFPVIHLEDITLDYSDVDSFTGSPVSMLNDLITF
                     DTTKFGETMTPETNTPETTMPPSEATTPETTMPPSETATSETMPPPSQTALTHN"
     exon            97..1186
                     /gene="DEFB125"
                     /gene_synonym="DEFB-25"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 attcctcagg acacagagct tcctctctcc caggagccat gaatatcctg atgctgacct
       61 tcattatctg tgggttgcta actcgggtga ccaaaggtag ctttgaaccc caaaaatgtt
      121 ggaagaataa tgtaggacat tgcagaagac gatgtttaga tactgaaagg tacatacttc
      181 tttgtaggaa caagctatca tgctgcattt ctataatatc acatgaatat actcgacgac
      241 cagcatttcc tgtgattcac ctagaggata taacattgga ttatagtgat gtggactctt
      301 ttactggttc cccagtatct atgttgaatg atctgataac atttgacaca actaaatttg
      361 gagaaaccat gacacctgag accaatactc ctgagactac tatgccacca tctgaggcca
      421 ctactcccga gactactatg ccaccatctg agactgctac ttccgagact atgccaccac
      481 cttctcagac agctcttact cataattaat taacatttac ttctggtatg gaacaactag
      541 aaatactgct ggaaataata tccaaagagc tgattctacc aatccaattt caccaggaaa
      601 attccatcag ggattggatg accatgggga tggacataat tgctactacc aacacaacag
      661 ccaagagagt tgccttacaa ttagaaatgt gtagacagaa atgtatagaa gatacaagga
      721 ttctcttaat tggacttaaa ttctttatct gtcttcctcc gatgtactca aatatatgag
      781 ctaatttttg tcttaagtga acatttgtat atctatgtat ttttccatgc caaaaacaaa
      841 aacgaagacc attgtttgga gctgcctctt atgactaaga caagaatttt tactttaaca
      901 gtgcctggcc cactactatc gtatatagga gaacatataa aagcatatag aaagttccag
      961 atgaatgttc ccttctctac cctccacctt ttattgtaag ttctgaccct aaatactttt
     1021 ctgtgtcatg acgtcaaatt ttgtttaagg ttctagctgg taactaacag agtcagaagc
     1081 taattctttc attcaacaca agcactgatc taactggata gagataaaag tgggacttgc
     1141 cttgagagta catcatatta aattaaaagc tgcatctcaa attcta
//
