LOCUS       NM_001037500             777 bp    mRNA    linear   PRI 10-JUN-2024
DEFINITION  Homo sapiens defensin beta 124 (DEFB124), mRNA.
ACCESSION   NM_001037500
VERSION     NM_001037500.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 777)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 777)
  AUTHORS   Kim,K.H., Lee,J., Han,J.H. and Myung,S.C.
  TITLE     Beta-Defensin 124 Is Required for Efficient Innate Immune Responses
            in Prostate Epithelial RWPE-1 Cells
  JOURNAL   Korean J Urol 55 (6), 417-425 (2014)
   PUBMED   24955228
  REMARK    GeneRIF: The encoded protein is thought to display antimicrobial
            activity and may enhance innate immunity in the prostate.
REFERENCE   3  (bases 1 to 777)
  AUTHORS   Patil,A.A., Cai,Y., Sang,Y., Blecha,F. and Zhang,G.
  TITLE     Cross-species analysis of the mammalian beta-defensin gene family:
            presence of syntenic gene clusters and preferential expression in
            the male reproductive tract
  JOURNAL   Physiol Genomics 23 (1), 5-17 (2005)
   PUBMED   16033865
REFERENCE   4  (bases 1 to 777)
  AUTHORS   Schutte,B.C., Mitros,J.P., Bartlett,J.A., Walters,J.D., Jia,H.P.,
            Welsh,M.J., Casavant,T.L. and McCray,P.B. Jr.
  TITLE     Discovery of five conserved beta -defensin gene clusters using a
            computational search strategy
  JOURNAL   Proc Natl Acad Sci U S A 99 (4), 2129-2133 (2002)
   PUBMED   11854508
  REMARK    Erratum:[Proc Natl Acad Sci U S A 2002 Oct 29;99(22):14611]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL121751.12.
            
            On Sep 21, 2020 this sequence version replaced NM_001037500.1.
            
            Summary: Defensins are cysteine-rich cationic polypeptides that are
            important in the host immunologic response to invading
            microorganisms. This antimicrobial protein is secreted and is a
            member of the beta defensin protein family. Beta defensin genes are
            found in several clusters throughout the genome, with this gene
            mapping to a cluster at 20q11.1. The encoded protein may serve to
            enhance innate immunity in the prostate. [provided by RefSeq, Nov
            2014].
            
            ##Evidence-Data-START##
            CDS exon combination :: DQ119827.1 [ECO:0000331]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG   :: upstream AUG and CDS
                                                  extension is not conserved
            inferred exon combination          :: based on alignments, homology
            MANE Ensembl match                 :: ENST00000317676.3/
                                                  ENSP00000326309.2
            Protein has antimicrobial activity :: PMID: 24955228
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-501               AL121751.12        89780-90280         c
            502-584             AL121751.12        88109-88191         c
            585-777             AL121751.12        80624-80816         c
FEATURES             Location/Qualifiers
     source          1..777
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q11.21"
     gene            1..777
                     /gene="DEFB124"
                     /gene_synonym="DEFB-24"
                     /note="defensin beta 124"
                     /db_xref="GeneID:245937"
                     /db_xref="HGNC:HGNC:18104"
     exon            1..501
                     /gene="DEFB124"
                     /gene_synonym="DEFB-24"
                     /inference="alignment:Splign:2.1.0"
     exon            502..584
                     /gene="DEFB124"
                     /gene_synonym="DEFB-24"
                     /inference="alignment:Splign:2.1.0"
     CDS             527..742
                     /gene="DEFB124"
                     /gene_synonym="DEFB-24"
                     /note="defensin, beta 24; beta-defensin 24; beta-defensin
                     124"
                     /codon_start=1
                     /product="beta-defensin 124 precursor"
                     /protein_id="NP_001032589.1"
                     /db_xref="CCDS:CCDS33457.1"
                     /db_xref="GeneID:245937"
                     /db_xref="HGNC:HGNC:18104"
                     /translation="MTQLLLFLVALLVLGHVPSGRSEFKRCWKGQGACQTYCTRQETY
                     MHLCPDASLCCLSYALKPPPVPKHEYE"
     exon            585..777
                     /gene="DEFB124"
                     /gene_synonym="DEFB-24"
                     /inference="alignment:Splign:2.1.0"
     regulatory      759..764
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DEFB124"
                     /gene_synonym="DEFB-24"
                     /note="hexamer: AATAAA"
     polyA_site      777
                     /gene="DEFB124"
                     /gene_synonym="DEFB-24"
                     /note="major polyA site"
ORIGIN      
        1 gcttctgcca gccctacgca ccgggtgagg gtggcagacg agaaaggaag gatgggggct
       61 ctggattcct gggtctggag ctccatctgc gtccacatct gtccactcca tcaaggggat
      121 gcactaacat attagccccc agaaaaacca cttggggaac ttgctaaatt ttcaggtccc
      181 gccttccaag agaggcggat tccacggtgc tgggggaggg gttcgggaat ctgcgtttta
      241 aacaagtgcc ccaagtgatc ctgatgcagg cggttcactg acctcacttt aagaaactct
      301 gctctggatg aagaattaat tttgggaggt ggcttggagg aagagagagc tcaggaagtc
      361 tgcactgaag aattatgaaa atcttatttt ggcatcattc attcattcac caactgaggc
      421 ttagctgggc ctgggcctga ggtctctgcc actctgtcta ctgtttctat tactgatggc
      481 tgaaaaaaaa aatgctccca gcagcctccc caggagcccc gtggccatga cacagctgct
      541 tctgttcctt gtggctctcc tggttctggg tcatgtgcca tcagggagaa gtgaattcaa
      601 acggtgctgg aagggtcaag gggcctgcca aacttactgc acaaggcaag aaacttacat
      661 gcacctgtgc ccggatgcgt ccctgtgctg tctctcctat gcattgaaac ctccaccggt
      721 ccccaagcat gaatatgagt agctggttcc tgctgtccaa taaaacacag gttgcca
//
