LOCUS       NM_001011878             362 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens defensin beta 121 (DEFB121), transcript variant 1,
            mRNA.
ACCESSION   NM_001011878
VERSION     NM_001011878.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 362)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 362)
  AUTHORS   Radhakrishnan,Y., Hamil,K.G., Yenugu,S., Young,S.L., French,F.S.
            and Hall,S.H.
  TITLE     Identification, characterization, and evolution of a primate
            beta-defensin gene cluster
  JOURNAL   Genes Immun 6 (3), 203-210 (2005)
   PUBMED   15772680
  REMARK    GeneRIF: This gene is thought to encode a peptide that displays
            antimicrobial activity.
REFERENCE   3  (bases 1 to 362)
  AUTHORS   Schutte,B.C., Mitros,J.P., Bartlett,J.A., Walters,J.D., Jia,H.P.,
            Welsh,M.J., Casavant,T.L. and McCray,P.B. Jr.
  TITLE     Discovery of five conserved beta -defensin gene clusters using a
            computational search strategy
  JOURNAL   Proc Natl Acad Sci U S A 99 (4), 2129-2133 (2002)
   PUBMED   11854508
  REMARK    Erratum:[Proc Natl Acad Sci U S A 2002 Oct 29;99(22):14611]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC130609.1 and AI476463.1.
            
            On May 17, 2019 this sequence version replaced NM_001011878.2.
            
            Summary: This gene encodes a member of the beta subfamily of
            defensins. Beta-defensins are antimicrobial peptides that protect
            tissues and organs from infection by a variety of microorganisms.
            This gene is found in a cluster with other beta-defensin genes on
            the long arm of chromosome 20. Two transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Nov 2014].
            
            Transcript Variant: This variant (1) represents the shorter
            transcript but encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC130609.1, AY501000.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match                 :: ENST00000376314.3/
                                                  ENSP00000417128.1
            Protein has antimicrobial activity :: PMID: 15772680
            RefSeq Select criteria             :: based on longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-338               BC130609.1         52-389
            339-362             AI476463.1         6-29                c
FEATURES             Location/Qualifiers
     source          1..362
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q11.21"
     gene            1..362
                     /gene="DEFB121"
                     /gene_synonym="DEFB21; ESC42RELC"
                     /note="defensin beta 121"
                     /db_xref="GeneID:245934"
                     /db_xref="HGNC:HGNC:18101"
                     /db_xref="MIM:616075"
     exon            1..121
                     /gene="DEFB121"
                     /gene_synonym="DEFB21; ESC42RELC"
                     /inference="alignment:Splign:2.1.0"
     CDS             64..294
                     /gene="DEFB121"
                     /gene_synonym="DEFB21; ESC42RELC"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; defensin, beta 21; beta-defensin 121;
                     epididymis secretory sperm binding protein; beta-defensin
                     21"
                     /codon_start=1
                     /product="beta-defensin 121 isoform 1 precursor"
                     /protein_id="NP_001011878.1"
                     /db_xref="CCDS:CCDS33456.1"
                     /db_xref="GeneID:245934"
                     /db_xref="HGNC:HGNC:18101"
                     /db_xref="MIM:616075"
                     /translation="MKLLLLLLTVTLLLAQVTPVMKCWGKSGRCRTTCKESEVYYILC
                     KTEAKCCVDPKYVPVKPKLTDTNTSLESTSAV"
     exon            122..362
                     /gene="DEFB121"
                     /gene_synonym="DEFB21; ESC42RELC"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggagtcctct gtctgtttta ccagttgaga agcctcctat ccctccctga tcattcatca
       61 ttcatgaagc tccttcttct gcttttgact gttactctgc tcctggccca ggtcacccca
      121 gtcatgaaat gttggggcaa gtcaggcagg tgcagaacaa catgtaaaga aagtgaagta
      181 tactatatat tatgcaaaac tgaggctaag tgctgtgtgg atcccaagta tgtacctgta
      241 aaaccaaaat taacagacac aaatacaagc ctggaatcaa cttctgcagt ctgacacctc
      301 tcttccaacc ttgagtctca acatcatggg atcctgcagt tctattaaat cattcttggc
      361 aa
//
