LOCUS       NM_054112               1175 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens defensin beta 118 (DEFB118), mRNA.
ACCESSION   NM_054112
VERSION     NM_054112.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1175)
  AUTHORS   Hou,J., Liu,H.Y., Diao,H. and Yu,H.
  TITLE     The truncated human beta-defensin 118 can modulate
            lipopolysaccharide mediated inflammatory response in RAW264.7
            macrophages
  JOURNAL   Peptides 136, 170438 (2021)
   PUBMED   33181266
  REMARK    GeneRIF: The truncated human beta-defensin 118 can modulate
            lipopolysaccharide mediated inflammatory response in RAW264.7
            macrophages.
REFERENCE   2  (bases 1 to 1175)
  AUTHORS   Lin,Q., Xie,K., Chen,D., Yu,B., Mao,X., Yu,J., Luo,J., Zheng,P.,
            Luo,Y., Yan,H. and He,J.
  TITLE     Expression and Functional Characterization of a Novel Antimicrobial
            Peptide: Human Beta-Defensin 118
  JOURNAL   Biomed Res Int 2020, 1395304 (2020)
   PUBMED   33224970
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1175)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1175)
  AUTHORS   Yenugu,S., Hamil,K.G., Radhakrishnan,Y., French,F.S. and Hall,S.H.
  TITLE     The androgen-regulated epididymal sperm-binding protein, human
            beta-defensin 118 (DEFB118) (formerly ESC42), is an antimicrobial
            beta-defensin
  JOURNAL   Endocrinology 145 (7), 3165-3173 (2004)
   PUBMED   15033915
  REMARK    GeneRIF: DEFB118 may contribute to epididymal innate immunity and
            provide antimicrobial activity against microorganisms attacking
            sperm in the male and female reproductive tracts.
REFERENCE   5  (bases 1 to 1175)
  AUTHORS   Kao,C.Y., Chen,Y., Zhao,Y.H. and Wu,R.
  TITLE     ORFeome-based search of airway epithelial cell-specific novel human
            [beta]-defensin genes
  JOURNAL   Am J Respir Cell Mol Biol 29 (1), 71-80 (2003)
   PUBMED   12600824
REFERENCE   6  (bases 1 to 1175)
  AUTHORS   Schutte,B.C., Mitros,J.P., Bartlett,J.A., Walters,J.D., Jia,H.P.,
            Welsh,M.J., Casavant,T.L. and McCray,P.B. Jr.
  TITLE     Discovery of five conserved beta -defensin gene clusters using a
            computational search strategy
  JOURNAL   Proc Natl Acad Sci U S A 99 (4), 2129-2133 (2002)
   PUBMED   11854508
  REMARK    Erratum:[Proc Natl Acad Sci U S A 2002 Oct 29;99(22):14611]
REFERENCE   7  (bases 1 to 1175)
  AUTHORS   Liu,Q., Hamil,K.G., Sivashanmugam,P., Grossman,G.,
            Soundararajan,R., Rao,A.J., Richardson,R.T., Zhang,Y.L.,
            O'Rand,M.G., Petrusz,P., French,F.S. and Hall,S.H.
  TITLE     Primate epididymis-specific proteins: characterization of ESC42, a
            novel protein containing a trefoil-like motif in monkey and human
  JOURNAL   Endocrinology 142 (10), 4529-4539 (2001)
   PUBMED   11564719
REFERENCE   8  (bases 1 to 1175)
  AUTHORS   van Wetering,S., Sterk,P.J., Rabe,K.F. and Hiemstra,P.S.
  TITLE     Defensins: key players or bystanders in infection, injury, and
            repair in the lung?
  JOURNAL   J Allergy Clin Immunol 104 (6), 1131-1138 (1999)
   PUBMED   10588992
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL031650.22, BC035677.1 and
            AF347073.1.
            
            On May 17, 2019 this sequence version replaced NM_054112.2.
            
            Summary: This gene encodes a member of the beta subfamily of
            defensins. Beta-defensins are antimicrobial peptides that protect
            tissues and organs from infection by a variety of microorganisms.
            Expression of this gene is regulated by androgen, and the encoded
            protein binds to sperm and exhibits antibacterial activity against
            E. coli. This gene is found in a cluster with other beta-defensin
            genes on the long arm of chromosome 20. [provided by RefSeq, Nov
            2014].
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC035677.1, SRR5189667.351993.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match                 :: ENST00000253381.3/
                                                  ENSP00000253381.2
            Protein has antimicrobial activity :: PMID: 15033915
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                AL031650.22        82144-82160
            18-24               BC035677.1         1-7
            25-613              AF347073.1         1-589
            614-1175            BC035677.1         598-1159
FEATURES             Location/Qualifiers
     source          1..1175
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q11.21"
     gene            1..1175
                     /gene="DEFB118"
                     /gene_synonym="C20orf63; DEFB-18; ESC42; ESP13.6"
                     /note="defensin beta 118"
                     /db_xref="GeneID:117285"
                     /db_xref="HGNC:HGNC:16196"
                     /db_xref="MIM:607650"
     exon            1..108
                     /gene="DEFB118"
                     /gene_synonym="C20orf63; DEFB-18; ESC42; ESP13.6"
                     /inference="alignment:Splign:2.1.0"
     CDS             51..422
                     /gene="DEFB118"
                     /gene_synonym="C20orf63; DEFB-18; ESC42; ESP13.6"
                     /note="defensin, beta 18; epididymus specific clone 42;
                     epididymis secretory sperm binding protein; epididymal
                     secretory protein 13.6"
                     /codon_start=1
                     /product="defensin beta 118 precursor"
                     /protein_id="NP_473453.1"
                     /db_xref="CCDS:CCDS13177.1"
                     /db_xref="GeneID:117285"
                     /db_xref="HGNC:HGNC:16196"
                     /db_xref="MIM:607650"
                     /translation="MKLLLLALPMLVLLPQVIPAYSGEKKCWNRSGHCRKQCKDGEAV
                     KDTCKNLRACCIPSNEDHRRVPATSPTPLSDSTPGIIDDILTVRFTTDYFEVSSKKDM
                     VEESEAGRGTETSLPNVHHSS"
     exon            109..1175
                     /gene="DEFB118"
                     /gene_synonym="C20orf63; DEFB-18; ESC42; ESP13.6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acacagtatt ctgaactcct ggatctacca cctcctgctt cccaaggacc atgaaactcc
       61 tgctgctggc tcttcctatg cttgtgctcc taccccaagt gatcccagcc tatagtggtg
      121 aaaaaaaatg ctggaacaga tcagggcact gcaggaaaca atgcaaagat ggagaagcag
      181 tgaaagatac atgcaaaaat cttcgagctt gctgcattcc atccaatgaa gaccacaggc
      241 gagttcctgc gacatctccc acacccttga gtgactcaac accaggaatt attgatgata
      301 ttttaacagt aaggttcacg acagactact ttgaagtaag cagcaagaaa gatatggttg
      361 aagagtctga ggcgggaagg ggaactgaga cctctcttcc aaatgttcac catagctcat
      421 gacttcctct cggctatcac tcacccctgt cctcagagtg ataaactaag tcacatacag
      481 ataaagcact gaaaacacca cagtgaccct cccacccccc accaatatgt aattctatta
      541 atagaaacag ctgtgtaaag aagtctaaaa ttttcactat ttccaatgat aaactcttca
      601 gtgctcttct tgaaatgtca cattatttcc acaacaagtt ataacctatt tttagtattt
      661 cttgtttgct agtgacctat gcacaacttc aatagcttag ttagctattc caacaacaat
      721 ttcttcatgt atcgttctgt cttctcaaca gctgtcttca tggcagcata agtggtcatg
      781 atcaaaattc taaatctttg catctgtgag agtagctact atgacactaa aagctttttt
      841 tctagaacag gagacacttc aggtgaaagc attcattctc ctactaacta tggccttgga
      901 gccaggtttt atctctcact gtaggaaatt ggccgcccca ggtgtgagct atgaagactc
      961 ctttttgccc cagtggcttt ggggttgaaa tgctgtcgaa aagcttttat ggctctgtag
     1021 acccatcttt ttgaccaagc cttgatcaca catggacatc caagggtaat catggacccc
     1081 caattgtggg tgaaaggatg gatcatttat ctacctgatt actgagagct ttatttgtct
     1141 ccctctgata gcaaaaaaaa aaaaaaaaaa aaaaa
//
