LOCUS       NM_001037730             267 bp    mRNA    linear   PRI 03-APR-2024
DEFINITION  Homo sapiens defensin beta 115 (DEFB115), mRNA.
ACCESSION   NM_001037730
VERSION     NM_001037730.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 267)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 267)
  AUTHORS   Patil,A.A., Cai,Y., Sang,Y., Blecha,F. and Zhang,G.
  TITLE     Cross-species analysis of the mammalian beta-defensin gene family:
            presence of syntenic gene clusters and preferential expression in
            the male reproductive tract
  JOURNAL   Physiol Genomics 23 (1), 5-17 (2005)
   PUBMED   16033865
  REMARK    GeneRIF: The encoded protein is thought to display antimicrobial
            activity.
REFERENCE   3  (bases 1 to 267)
  AUTHORS   Schutte,B.C., Mitros,J.P., Bartlett,J.A., Walters,J.D., Jia,H.P.,
            Welsh,M.J., Casavant,T.L. and McCray,P.B. Jr.
  TITLE     Discovery of five conserved beta -defensin gene clusters using a
            computational search strategy
  JOURNAL   Proc Natl Acad Sci U S A 99 (4), 2129-2133 (2002)
   PUBMED   11854508
  REMARK    Erratum:[Proc Natl Acad Sci U S A 2002 Oct 29;99(22):14611]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DQ012019.1.
            
            Summary: Defensins form a family of antimicrobial and cytotoxic
            peptides made by neutrophils. Defensins are short, processed
            peptide molecules that are classified by structure into three
            groups: alpha-defensins, beta-defensins and theta-defensins. All
            beta-defensin genes are densely clustered in four to five syntenic
            chromosomal regions. [provided by RefSeq, Oct 2014].
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ012019.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match                 :: ENST00000400552.1/
                                                  ENSP00000383398.1
            Protein has antimicrobial activity :: PMID: 16033865
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..267
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q11.21"
     gene            1..267
                     /gene="DEFB115"
                     /gene_synonym="DEFB-15"
                     /note="defensin beta 115"
                     /db_xref="GeneID:245929"
                     /db_xref="HGNC:HGNC:18096"
     CDS             1..267
                     /gene="DEFB115"
                     /gene_synonym="DEFB-15"
                     /note="defensin, beta 15; beta-defensin 115; beta-defensin
                     15"
                     /codon_start=1
                     /product="beta-defensin 115 precursor"
                     /protein_id="NP_001032819.1"
                     /db_xref="CCDS:CCDS42859.1"
                     /db_xref="GeneID:245929"
                     /db_xref="HGNC:HGNC:18096"
                     /translation="MLPDHFSPLSGDIKLSVLALVVLVVLAQTAPDGWIRRCYYGTGR
                     CRKSCKEIERKKEKCGEKHICCVPKEKDKLSHIHDQKETSELYI"
     exon            1..94
                     /gene="DEFB115"
                     /gene_synonym="DEFB-15"
                     /inference="alignment:Splign:2.1.0"
     exon            95..267
                     /gene="DEFB115"
                     /gene_synonym="DEFB-15"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgctgccag atcatttctc acccctctca ggagacatta aactctctgt cctggcctta
       61 gttgtccttg tggtcctggc tcagactgcc ccagatggat ggatcagaag gtgctattat
      121 ggaactggca gatgcaggaa atcatgcaaa gaaattgaga ggaagaaaga aaaatgtggg
      181 gaaaaacata tttgctgtgt ccctaaagaa aaggataaac tatcacacat tcacgaccaa
      241 aaagagacaa gtgagctata tatctag
//
