LOCUS       NM_001037499             312 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens defensin beta 114 (DEFB114), mRNA.
ACCESSION   NM_001037499 XM_930162 XM_941743
VERSION     NM_001037499.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 312)
  AUTHORS   Yu,H., Dong,J., Gu,Y., Liu,H., Xin,A., Shi,H., Sun,F., Zhang,Y.,
            Lin,D. and Diao,H.
  TITLE     The novel human beta-defensin 114 regulates lipopolysaccharide
            (LPS)-mediated inflammation and protects sperm from motility loss
  JOURNAL   J Biol Chem 288 (17), 12270-12282 (2013)
   PUBMED   23482568
  REMARK    GeneRIF: Human beta-defensin 114 regulates lipopolysaccharide
            (LPS)-mediated inflammation and protects sperm from motility loss.
            It also has antimicrobial activity against E. coli, S. aureus, and
            C. albicans.
REFERENCE   2  (bases 1 to 312)
  AUTHORS   Patil,A.A., Cai,Y., Sang,Y., Blecha,F. and Zhang,G.
  TITLE     Cross-species analysis of the mammalian beta-defensin gene family:
            presence of syntenic gene clusters and preferential expression in
            the male reproductive tract
  JOURNAL   Physiol Genomics 23 (1), 5-17 (2005)
   PUBMED   16033865
REFERENCE   3  (bases 1 to 312)
  AUTHORS   Schutte,B.C., Mitros,J.P., Bartlett,J.A., Walters,J.D., Jia,H.P.,
            Welsh,M.J., Casavant,T.L. and McCray,P.B. Jr.
  TITLE     Discovery of five conserved beta -defensin gene clusters using a
            computational search strategy
  JOURNAL   Proc Natl Acad Sci U S A 99 (4), 2129-2133 (2002)
   PUBMED   11854508
  REMARK    Erratum:[Proc Natl Acad Sci U S A 2002 Oct 29;99(22):14611]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL138879.10.
            
            On Mar 15, 2019 this sequence version replaced NM_001037499.1.
            
            Summary: Defensins form a family of antimicrobial and cytotoxic
            peptides made by neutrophils. Defensins are short, processed
            peptide molecules that are classified by structure into three
            groups: alpha-defensins, beta-defensins and theta-defensins. All
            beta-defensin genes are densely clustered in four to five syntenic
            chromosomal regions. The protein encoded by this gene is a
            beta-defensin with antimicrobial activity against E. coli, S.
            aureus, and C. albicans. The encoded protein also binds and
            neutralizes lipopolysaccharide (LPS), a factor involved in
            inflammatory diseases and male reproductive issues. [provided by
            RefSeq, Nov 2014].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match                 :: ENST00000322066.4/
                                                  ENSP00000312702.3
            Protein has antimicrobial activity :: PMID: 23482568
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-114               AL138879.10        13030-13143         c
            115-312             AL138879.10        9228-9425           c
FEATURES             Location/Qualifiers
     source          1..312
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p12.3"
     gene            1..312
                     /gene="DEFB114"
                     /gene_synonym="DEFB-14; DEFB14"
                     /note="defensin beta 114"
                     /db_xref="GeneID:245928"
                     /db_xref="HGNC:HGNC:18095"
                     /db_xref="MIM:615243"
     exon            1..114
                     /gene="DEFB114"
                     /gene_synonym="DEFB-14; DEFB14"
                     /inference="alignment:Splign:2.1.0"
     CDS             60..269
                     /gene="DEFB114"
                     /gene_synonym="DEFB-14; DEFB14"
                     /note="defensin, beta 14; beta-defensin 14; beta-defensin
                     114"
                     /codon_start=1
                     /product="beta-defensin 114 precursor"
                     /protein_id="NP_001032588.1"
                     /db_xref="CCDS:CCDS34474.1"
                     /db_xref="GeneID:245928"
                     /db_xref="HGNC:HGNC:18095"
                     /db_xref="MIM:615243"
                     /translation="MRIFYYLHFLCYVTFILPATCTLVNADRCTKRYGRCKRDCLESE
                     KQIDICSLPRKICCTEKLYEEDDMF"
     exon            115..312
                     /gene="DEFB114"
                     /gene_synonym="DEFB-14; DEFB14"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaaagttcta tagtctctat attctgttat caagtctttc aacaacttct ttctacagaa
       61 tgaggatctt ttactatctc cattttctgt gttatgtgac cttcattcta ccagccacat
      121 gtaccttggt gaatgctgat cgttgcacca aacgttacgg tcgttgtaaa agagactgtc
      181 ttgagagtga aaagcaaata gacatatgtt ccttaccaag aaaaatttgc tgcactgaga
      241 aattgtatga agaagatgat atgttttgaa aagaaaggca tacctctgaa caaagaagtt
      301 acatgtgcac ca
//
