LOCUS       NM_001037729             249 bp    mRNA    linear   PRI 03-FEB-2022
DEFINITION  Homo sapiens defensin beta 113 (DEFB113), mRNA.
ACCESSION   NM_001037729
VERSION     NM_001037729.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 249)
  AUTHORS   Patil AA, Cai Y, Sang Y, Blecha F and Zhang G.
  TITLE     Cross-species analysis of the mammalian beta-defensin gene family:
            presence of syntenic gene clusters and preferential expression in
            the male reproductive tract
  JOURNAL   Physiol. Genomics 23 (1), 5-17 (2005)
   PUBMED   16033865
  REMARK    GeneRIF: The encoded protein is thought to display antimicrobial
            activity.
REFERENCE   2  (bases 1 to 249)
  AUTHORS   Schutte BC, Mitros JP, Bartlett JA, Walters JD, Jia HP, Welsh MJ,
            Casavant TL and McCray PB Jr.
  TITLE     Discovery of five conserved beta -defensin gene clusters using a
            computational search strategy
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 99 (4), 2129-2133 (2002)
   PUBMED   11854508
  REMARK    Erratum:[Proc Natl Acad Sci U S A 2002 Oct 29;99(22):14611]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DQ012017.1.
            
            Summary: Defensins form a family of antimicrobial and cytotoxic
            peptides made by neutrophils. Defensins are short, processed
            peptide molecules that are classified by structure into three
            groups: alpha-defensins, beta-defensins and theta-defensins. All
            beta-defensin genes are densely clustered in four to five syntenic
            chromosomal regions. [provided by RefSeq, Oct 2014].
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ012017.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match                 :: ENST00000398718.1/
                                                  ENSP00000381703.1
            Protein has antimicrobial activity :: PMID: 16033865
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..249
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p12.3"
     gene            1..249
                     /gene="DEFB113"
                     /gene_synonym="DEFB-13"
                     /note="defensin beta 113"
                     /db_xref="GeneID:245927"
                     /db_xref="HGNC:HGNC:18094"
     CDS             1..249
                     /gene="DEFB113"
                     /gene_synonym="DEFB-13"
                     /note="defensin, beta 13; beta-defensin 113; beta-defensin
                     13"
                     /codon_start=1
                     /product="beta-defensin 113 precursor"
                     /protein_id="NP_001032818.1"
                     /db_xref="CCDS:CCDS43472.1"
                     /db_xref="GeneID:245927"
                     /db_xref="HGNC:HGNC:18094"
                     /translation="MKILCIFLTFVFTVSCGPSVPQKKTREVAERKRECQLVRGACKP
                     ECNSWEYVYYYCNVNPCCAVWEYQKPIINKITSKLHQK"
     exon            1..58
                     /gene="DEFB113"
                     /gene_synonym="DEFB-13"
                     /inference="alignment:Splign:2.1.0"
     exon            59..249
                     /gene="DEFB113"
                     /gene_synonym="DEFB-13"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgaagatac tttgtatttt tctgaccttt gtcttcactg tgtcttgtgg tccatcagtt
       61 ccacagaaaa aaacaagaga agttgcagag agaaaaagag aatgtcagct tgttcgtggt
      121 gcttgcaagc cggaatgcaa cagctgggaa tatgtatatt attactgcaa tgttaacccc
      181 tgctgtgcgg tatgggaata ccaaaagcca atcattaaca aaatcactag taaactccat
      241 caaaaataa
//
