LOCUS       NM_001369057            1821 bp    mRNA    linear   PRI 05-OCT-2024
DEFINITION  Homo sapiens defensin beta 112 (DEFB112), mRNA.
ACCESSION   NM_001369057
VERSION     NM_001369057.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1821)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1821)
  AUTHORS   Scannell Bryan,M., Argos,M., Pierce,B., Tong,L., Rakibuz-Zaman,M.,
            Ahmed,A., Rahman,M., Islam,T., Yunus,M., Parvez,F., Roy,S.,
            Jasmine,F., Baron,J.A., Kibriya,M.G. and Ahsan,H.
  TITLE     Genome-wide association studies and heritability estimates of body
            mass index related phenotypes in Bangladeshi adults
  JOURNAL   PLoS One 9 (8), e105062 (2014)
   PUBMED   25133637
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1821)
  AUTHORS   Patil,A.A., Cai,Y., Sang,Y., Blecha,F. and Zhang,G.
  TITLE     Cross-species analysis of the mammalian beta-defensin gene family:
            presence of syntenic gene clusters and preferential expression in
            the male reproductive tract
  JOURNAL   Physiol Genomics 23 (1), 5-17 (2005)
   PUBMED   16033865
  REMARK    GeneRIF: The encoded protein is thought to display antimicrobial
            activity.
REFERENCE   4  (bases 1 to 1821)
  AUTHORS   Schutte,B.C., Mitros,J.P., Bartlett,J.A., Walters,J.D., Jia,H.P.,
            Welsh,M.J., Casavant,T.L. and McCray,P.B. Jr.
  TITLE     Discovery of five conserved beta -defensin gene clusters using a
            computational search strategy
  JOURNAL   Proc Natl Acad Sci U S A 99 (4), 2129-2133 (2002)
   PUBMED   11854508
  REMARK    Erratum:[Proc Natl Acad Sci U S A 2002 Oct 29;99(22):14611]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL138879.10.
            
            On Aug 27, 2019 this sequence version replaced NM_001369057.1.
            
            Summary: Defensins form a family of antimicrobial and cytotoxic
            peptides made by neutrophils. Defensins are short, processed
            peptide molecules that are classified by structure into three
            groups: alpha-defensins, beta-defensins and theta-defensins. All
            beta-defensin genes are densely clustered in four to five syntenic
            chromosomal regions. [provided by RefSeq, Oct 2014].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.31757.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG   :: upstream AUG and CDS
                                                  extension is not conserved
            MANE Ensembl match                 :: ENST00000651554.2/
                                                  ENSP00000499066.1
            Protein has antimicrobial activity :: PMID: 16033865
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-118               AL138879.10        98791-98908         c
            119-1821            AL138879.10        91078-92780         c
FEATURES             Location/Qualifiers
     source          1..1821
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p12.3"
     gene            1..1821
                     /gene="DEFB112"
                     /gene_synonym="DEFB-12"
                     /note="defensin beta 112"
                     /db_xref="GeneID:245915"
                     /db_xref="HGNC:HGNC:18093"
     exon            1..118
                     /gene="DEFB112"
                     /gene_synonym="DEFB-12"
                     /inference="alignment:Splign:2.1.0"
     CDS             61..345
                     /gene="DEFB112"
                     /gene_synonym="DEFB-12"
                     /note="defensin, beta 12; beta-defensin 12; beta-defensin
                     112"
                     /codon_start=1
                     /product="beta-defensin 112 precursor"
                     /protein_id="NP_001355986.1"
                     /db_xref="CCDS:CCDS34476.2"
                     /db_xref="GeneID:245915"
                     /db_xref="HGNC:HGNC:18093"
                     /translation="MKILLFFCILLFFGVLIPPARSEGHHITFSRWKSCTAIGGRCKN
                     QCDDSEFRISYCARPTTHCCVTECDPTDPNNWIPKDSVGTQEWYPKDSRH"
     exon            119..1821
                     /gene="DEFB112"
                     /gene_synonym="DEFB-12"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1801..1806
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DEFB112"
                     /gene_synonym="DEFB-12"
                     /note="hexamer: AATAAA"
     polyA_site      1821
                     /gene="DEFB112"
                     /gene_synonym="DEFB-12"
                     /note="major polyA site"
ORIGIN      
        1 aacaacagct gagtcagaca gatgatctgt acactgtttt ataccaagaa atcatttaca
       61 atgaagatcc ttctcttttt ctgtattttg cttttctttg gagtccttat tccaccagcc
      121 agaagtgaag ggcaccatat cacctttagt aggtggaagt catgtacagc gattggaggt
      181 cgatgtaaaa atcaatgtga tgatagtgaa tttaggattt catactgtgc aagacctaca
      241 actcattgct gcgtgacaga atgtgaccct acggacccaa ataattggat cccaaaggac
      301 tcagtaggga ctcaagaatg gtaccctaaa gactcacgtc attgaagaaa tccatgcaca
      361 agaagatgat acatctgaat gaagtcctct cattatttca tcacttcatt aatgacctat
      421 aatttccatg catgcatacc tataatgaat aaataattaa ataaaatata tttcagctgg
      481 acatttttat aaacattgtg cttgcttaga agaaagaatc agaatacaaa gcagggattt
      541 gaactctgga atagaagcag cgtggagaag aaaatccatg atgggaccgc taagtttagt
      601 gagattctgg ggccaattcc ttatttagtg tgaaaagcat attatgagtc attagtgagg
      661 tattatcaag aattctttga ggagactcag gagtggggac agagttgata agagatgtga
      721 cccctgaact agtaaaaatc gttgcaagaa atttgaagga ttatgaaatc ctcataactt
      781 tctcatattg cttatacttc ctggttatac tttttctctc ttttttgaaa gaattatgaa
      841 aataaaaata actgattttt tttccaagaa taatctcaaa aggtagaata gagggagact
      901 aggttgagga aggaaaagaa gaatggtaaa tccctgtagc ttgtggcaat aacgataatg
      961 tgaaattatg attaactttt ttgttttgtt ttgctttgtt tcatgttttt aatgtttcca
     1021 catattatca gatgattctt atcatgctac ttattggtgt cttagtaaat tttaagtttt
     1081 taaaaaataa tgtaacagaa ttatatatgt gtgtatgcat gctcacacat ataatttcta
     1141 ttatagaaat ttttgtcata cccaggattt atgtggcaag gatgtgttaa caaaggctaa
     1201 attgtggcct tgagggaaag ggtcagcagt tggtcttaat acctcaccta gattaaagat
     1261 tttcccctta ttcaaacatt ttgaaatatc aactctaaaa ataggtgatg gttttgcagg
     1321 gcttggtatg tgctaagtat tacttaaaga atgtcctcta ggctttgtcc ttggctggca
     1381 gccttggtta ttatgtgact tacaacctgt ggactaaggc cacatgaaga aaagggagct
     1441 agtcacttaa aattatgtgg taacaaggta tttaagttga ggctacttgt acctggtagg
     1501 tttcttatgc tgctgtgaca tatacacatt tcagctttgg gttaatctta taaccaaaac
     1561 atatcctgta cacagtacct gggcacatag ggaaaagcat ctgggtgtcc aaattatata
     1621 tgatattcct gatatgtata atactatgct ctctgaccag tgtcaatttg gagctaaata
     1681 accctatttg catcttgtga ttttggttta tgatccaaac tctgaacccc acttcagggg
     1741 tctcacagta tacctatact ataatttaat gtatctgtgg taggatagat gaaaattatg
     1801 aataaagctg ctataattgt a
//
