LOCUS       NM_001037497             397 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens defensin beta 110 (DEFB110), transcript variant 1,
            mRNA.
ACCESSION   NM_001037497
VERSION     NM_001037497.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 397)
  AUTHORS   Rodriguez,A., Pedersen,M.O., Villegas,E., Rivas-Santiago,B.,
            Villegas-Moreno,J., Amero,C., Norton,R.S. and Corzo,G.
  TITLE     Antimicrobial activity and structure of a consensus human
            beta-defensin and its comparison to a novel putative hBD10
  JOURNAL   Proteins 88 (1), 175-186 (2020)
   PUBMED   31325337
  REMARK    GeneRIF: Antimicrobial activity and structure of a consensus human
            beta-defensin and its comparison to a novel putative hBD10.
REFERENCE   2  (bases 1 to 397)
  AUTHORS   Patil,A.A., Cai,Y., Sang,Y., Blecha,F. and Zhang,G.
  TITLE     Cross-species analysis of the mammalian beta-defensin gene family:
            presence of syntenic gene clusters and preferential expression in
            the male reproductive tract
  JOURNAL   Physiol Genomics 23 (1), 5-17 (2005)
   PUBMED   16033865
  REMARK    GeneRIF: The encoded protein is thought to have antimicrobial
            activity.
REFERENCE   3  (bases 1 to 397)
  AUTHORS   Schutte,B.C., Mitros,J.P., Bartlett,J.A., Walters,J.D., Jia,H.P.,
            Welsh,M.J., Casavant,T.L. and McCray,P.B. Jr.
  TITLE     Discovery of five conserved beta -defensin gene clusters using a
            computational search strategy
  JOURNAL   Proc Natl Acad Sci U S A 99 (4), 2129-2133 (2002)
   PUBMED   11854508
  REMARK    Erratum:[Proc Natl Acad Sci U S A 2002 Oct 29;99(22):14611]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL138879.10 and DQ012015.1.
            
            On May 17, 2019 this sequence version replaced NM_001037497.1.
            
            Summary: Defensins form a family of antimicrobial and cytotoxic
            peptides made by neutrophils. Defensins are short, processed
            peptide molecules that are classified by structure into three
            groups: alpha-defensins, beta-defensins and theta-defensins. All
            beta-defensin genes are densely clustered in four to five syntenic
            chromosomal regions. Two transcript variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, Oct
            2014].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a, also known as
            DEFB111).
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ012015.1, BX111343.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match                 :: ENST00000371148.3/
                                                  ENSP00000360190.2
            Protein has antimicrobial activity :: PMID: 16033865
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                AL138879.10        70961-70973         c
            14-397              DQ012015.1         1-384
FEATURES             Location/Qualifiers
     source          1..397
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p12.3"
     gene            1..397
                     /gene="DEFB110"
                     /gene_synonym="DEFB-10; DEFB-11; DEFB111"
                     /note="defensin beta 110"
                     /db_xref="GeneID:245913"
                     /db_xref="HGNC:HGNC:18091"
     exon            1..114
                     /gene="DEFB110"
                     /gene_synonym="DEFB-10; DEFB-11; DEFB111"
                     /inference="alignment:Splign:2.1.0"
     CDS             60..263
                     /gene="DEFB110"
                     /gene_synonym="DEFB-10; DEFB-11; DEFB111"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; defensin, beta 10; beta-defensin 110;
                     beta-defensin 10; beta-defensin 111; defensin, beta 110
                     locus"
                     /codon_start=1
                     /product="beta-defensin 110 isoform a precursor"
                     /protein_id="NP_001032586.1"
                     /db_xref="CCDS:CCDS34475.1"
                     /db_xref="GeneID:245913"
                     /db_xref="HGNC:HGNC:18091"
                     /translation="MKIQLFFFILHFWVTILPAKKKYPEYGSLDLRRECRIGNGQCKN
                     QCHENEIRIAYCIRPGTHCCLQQ"
     exon            115..397
                     /gene="DEFB110"
                     /gene_synonym="DEFB-10; DEFB-11; DEFB111"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaaacaactg acttgaaaaa ggaggtctgt tgcccccttt ttttaagaaa ctctctacca
       61 tgaagattca actttttttc tttattctgc acttttgggt cacaatttta ccagccaaaa
      121 agaaatatcc tgagtatggt agcttggact tgaggagaga gtgcagaata ggtaatggtc
      181 aatgtaaaaa tcagtgtcat gaaaatgaaa ttaggattgc ttactgcata agacctggaa
      241 ctcattgctg cttgcagcag taacgatgac agaagaaaag agtcacaagc tccaagaaga
      301 gagaccagcg ttattaagtt ttcccagcac atccttcaag gcgtgtgtgt ctctataata
      361 cacaagaact aaataaaaat taatgttgaa ccattca
//
