LOCUS       NM_001037380             533 bp    mRNA    linear   PRI 05-OCT-2024
DEFINITION  Homo sapiens defensin beta 109B (DEFB109B), transcript variant 1,
            mRNA.
ACCESSION   NM_001037380 XR_001756298
VERSION     NM_001037380.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 533)
  AUTHORS   Dua,H.S., Otri,A.M., Hopkinson,A. and Mohammed,I.
  TITLE     In vitro studies on the antimicrobial peptide human beta-defensin 9
            (HBD9): signalling pathways and pathogen-related response (an
            American Ophthalmological Society thesis)
  JOURNAL   Trans Am Ophthalmol Soc 112, 50-73 (2014)
   PUBMED   25646028
REFERENCE   2  (bases 1 to 533)
  AUTHORS   Pierson,T., Learmonth-Pierson,S., Pinto,D. and van Hoek,M.L.
  TITLE     Cigarette smoke extract induces differential expression levels of
            beta-defensin peptides in human alveolar epithelial cells
  JOURNAL   Tob Induc Dis 11 (1), 10 (2013)
   PUBMED   23627872
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 533)
  AUTHORS   Otri,A.M., Mohammed,I., Al-Aqaba,M.A., Fares,U., Peng,C.,
            Hopkinson,A. and Dua,H.S.
  TITLE     Variable expression of human Beta defensins 3 and 9 at the human
            ocular surface in infectious keratitis
  JOURNAL   Invest Ophthalmol Vis Sci 53 (2), 757-761 (2012)
   PUBMED   22232436
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 533)
  AUTHORS   Mohammed,I., Suleman,H., Otri,A.M., Kulkarni,B.B., Chen,P.,
            Hopkinson,A. and Dua,H.S.
  TITLE     Localization and gene expression of human beta-defensin 9 at the
            human ocular surface epithelium
  JOURNAL   Invest Ophthalmol Vis Sci 51 (9), 4677-4682 (2010)
   PUBMED   20375350
REFERENCE   5  (bases 1 to 533)
  AUTHORS   Alekseeva,L., Huet,D., Femenia,F., Mouyna,I., Abdelouahab,M.,
            Cagna,A., Guerrier,D., Tichanne-Seltzer,V., Baeza-Squiban,A.,
            Chermette,R., Latge,J.P. and Berkova,N.
  TITLE     Inducible expression of beta defensins by human respiratory
            epithelial cells exposed to Aspergillus fumigatus organisms
  JOURNAL   BMC Microbiol 9, 33 (2009)
   PUBMED   19208266
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 533)
  AUTHORS   Abedin,A., Mohammed,I., Hopkinson,A. and Dua,H.S.
  TITLE     A novel antimicrobial peptide on the ocular surface shows decreased
            expression in inflammation and infection
  JOURNAL   Invest Ophthalmol Vis Sci 49 (1), 28-33 (2008)
   PUBMED   18172071
REFERENCE   7  (bases 1 to 533)
  AUTHORS   Patil,A.A., Cai,Y., Sang,Y., Blecha,F. and Zhang,G.
  TITLE     Cross-species analysis of the mammalian beta-defensin gene family:
            presence of syntenic gene clusters and preferential expression in
            the male reproductive tract
  JOURNAL   Physiol Genomics 23 (1), 5-17 (2005)
   PUBMED   16033865
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF228730.8.
            
            On Aug 12, 2021 this sequence version replaced NM_001037380.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ012013.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000382656.2/ ENSP00000516541.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-182               AF228730.8         272471-272652
            183-533             AF228730.8         279495-279845
FEATURES             Location/Qualifiers
     source          1..533
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p23.1"
     gene            1..533
                     /gene="DEFB109B"
                     /gene_synonym="DEF109P1B; DEFB109; DEFB109P1B; HBD9"
                     /note="defensin beta 109B"
                     /db_xref="GeneID:641517"
                     /db_xref="HGNC:HGNC:33469"
     exon            1..182
                     /gene="DEFB109B"
                     /gene_synonym="DEF109P1B; DEFB109; DEFB109P1B; HBD9"
                     /inference="alignment:Splign:2.1.0"
     CDS             125..388
                     /gene="DEFB109B"
                     /gene_synonym="DEF109P1B; DEFB109; DEFB109P1B; HBD9"
                     /note="defensin, beta 9 pseudogene; defensin beta 109
                     pseudogene 1B; putative beta-defensin 109B"
                     /codon_start=1
                     /product="putative beta-defensin 109B precursor"
                     /protein_id="NP_001032457.1"
                     /db_xref="GeneID:641517"
                     /db_xref="HGNC:HGNC:33469"
                     /translation="MRLHLLLLILLLFSILLSPVRGGLGPAEGHCLNLFGVCRTDVCN
                     IVEDQIGACRRRMKCCRAWWILMPIPTPLIMSDYQEPLKPNLK"
     exon            183..533
                     /gene="DEFB109B"
                     /gene_synonym="DEF109P1B; DEFB109; DEFB109P1B; HBD9"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcttttcgt taggctctac tgaccaagaa caaatcacag actcagagag catcataaaa
       61 aggcctagac ccacgatgcc cagagactcc aggctcaacc cacattgatg ctggcccttc
      121 agccatgaga ctccatttgc ttctccttat tctccttctt ttttcaattc tcttatcccc
      181 agtaagaggt ggtttgggtc ctgcggaagg tcattgtctc aatttgtttg gtgtttgcag
      241 aacagatgtc tgcaacatag tagaagatca aattggtgcc tgccgaagaa ggatgaagtg
      301 ctgtagagca tggtggattt taatgccaat tccaacacca cttatcatgt cagattatca
      361 agaacccctt aaacctaact tgaaatgaaa ctgaaacaaa ataaaaatac atcaaaagtg
      421 aagttatttg catctaagaa tattaaaata tacatattaa gtacttccat cttgataacc
      481 gtcttgcatt ttcacttatc aacataaatg aataaatact aatttcaaat aca
//
