LOCUS       NM_001002035             370 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens defensin beta 108B (DEFB108B), mRNA.
ACCESSION   NM_001002035
VERSION     NM_001002035.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 370)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 370)
  AUTHORS   Milanese,M., Segat,L., Arraes,L.C., Garzino-Demo,A. and Crovella,S.
  TITLE     Copy number variation of defensin genes and HIV infection in
            Brazilian children
  JOURNAL   J Acquir Immune Defic Syndr 50 (3), 331-333 (2009)
   PUBMED   19194307
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   3  (bases 1 to 370)
  AUTHORS   Kao,C.Y., Chen,Y., Zhao,Y.H. and Wu,R.
  TITLE     ORFeome-based search of airway epithelial cell-specific novel human
            [beta]-defensin genes
  JOURNAL   Am J Respir Cell Mol Biol 29 (1), 71-80 (2003)
   PUBMED   12600824
  REMARK    GeneRIF: The encoded protein is thought to have antimicrobial
            activity.
REFERENCE   4  (bases 1 to 370)
  AUTHORS   Semple,C.A., Rolfe,M. and Dorin,J.R.
  TITLE     Duplication and selection in the evolution of primate beta-defensin
            genes
  JOURNAL   Genome Biol 4 (5), R31 (2003)
   PUBMED   12734011
REFERENCE   5  (bases 1 to 370)
  AUTHORS   Schutte,B.C., Mitros,J.P., Bartlett,J.A., Walters,J.D., Jia,H.P.,
            Welsh,M.J., Casavant,T.L. and McCray,P.B. Jr.
  TITLE     Discovery of five conserved beta -defensin gene clusters using a
            computational search strategy
  JOURNAL   Proc Natl Acad Sci U S A 99 (4), 2129-2133 (2002)
   PUBMED   11854508
  REMARK    Erratum:[Proc Natl Acad Sci U S A 2002 Oct 29;99(22):14611]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP002495.3.
            
            On Sep 2, 2019 this sequence version replaced NM_001002035.1.
            
            Summary: Defensins form a family of antimicrobial and cytotoxic
            peptides made by neutrophils. Defensins are short, processed
            peptide molecules that are classified by structure into three
            groups: alpha-defensins, beta-defensins and theta-defensins. All
            beta-defensin genes are densely clustered in four to five syntenic
            chromosomal regions. A pseudogene of this gene has been found on
            chromosome 8. [provided by RefSeq, Oct 2014].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF529416.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match                 :: ENST00000328698.2/
                                                  ENSP00000333234.1
            Protein has antimicrobial activity :: PMID: 12600824
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-58                AP002495.3         63459-63516
            59-370              AP002495.3         67658-67969
FEATURES             Location/Qualifiers
     source          1..370
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.4"
     gene            1..370
                     /gene="DEFB108B"
                     /gene_synonym="DEFB-8; hBD-8"
                     /note="defensin beta 108B"
                     /db_xref="GeneID:245911"
                     /db_xref="HGNC:HGNC:29966"
     CDS             1..222
                     /gene="DEFB108B"
                     /gene_synonym="DEFB-8; hBD-8"
                     /note="defensin, beta 8; beta-defensin 8; beta-defensin
                     108B"
                     /codon_start=1
                     /product="beta-defensin 108B precursor"
                     /protein_id="NP_001002035.1"
                     /db_xref="CCDS:CCDS31631.1"
                     /db_xref="GeneID:245911"
                     /db_xref="HGNC:HGNC:29966"
                     /translation="MRIAVLLFAIFFFMSQVLPARGKFKEICERPNGSCRDFCLETEI
                     HVGRCLNSQPCCLPLGHQPRIESTTPKKD"
     exon            1..58
                     /gene="DEFB108B"
                     /gene_synonym="DEFB-8; hBD-8"
                     /inference="alignment:Splign:2.1.0"
     exon            59..370
                     /gene="DEFB108B"
                     /gene_synonym="DEFB-8; hBD-8"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgaggattg ctgtcctcct cttcgccatt ttcttcttta tgagccaagt tctaccagcc
       61 aggggcaaat tcaaggagat ctgtgaacgt ccaaatggct cctgtcggga cttttgcctt
      121 gaaacagaaa tccatgttgg gagatgttta aatagccaac cctgctgcct gcctctgggg
      181 catcaaccaa gaattgagag cactacaccc aaaaaggact gaagcctgtt gttttctgga
      241 ggttttatgt tctctttttt ctctctccct ctctctgtct ccctgtctcc ctttccctct
      301 ctccattttt ctcacaggga tttttattga atcctcaaaa aagaataaac caaaaccaac
      361 cagcacaaaa
//
