LOCUS       NM_001040705             324 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens defensin beta 107B (DEFB107B), mRNA.
ACCESSION   NM_001040705
VERSION     NM_001040705.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 324)
  AUTHORS   Jones,E.A., Kananurak,A., Bevins,C.L., Hollox,E.J. and
            Bakaletz,L.O.
  TITLE     Copy number variation of the beta defensin gene cluster on
            chromosome 8p influences the bacterial microbiota within the
            nasopharynx of otitis-prone children
  JOURNAL   PLoS One 9 (5), e98269 (2014)
   PUBMED   24867293
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 324)
  AUTHORS   Milanese,M., Segat,L., Arraes,L.C., Garzino-Demo,A. and Crovella,S.
  TITLE     Copy number variation of defensin genes and HIV infection in
            Brazilian children
  JOURNAL   J Acquir Immune Defic Syndr 50 (3), 331-333 (2009)
   PUBMED   19194307
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   3  (bases 1 to 324)
  AUTHORS   Patil,A.A., Cai,Y., Sang,Y., Blecha,F. and Zhang,G.
  TITLE     Cross-species analysis of the mammalian beta-defensin gene family:
            presence of syntenic gene clusters and preferential expression in
            the male reproductive tract
  JOURNAL   Physiol Genomics 23 (1), 5-17 (2005)
   PUBMED   16033865
  REMARK    GeneRIF: This protein is thought to have antimicrobial activity.
REFERENCE   4  (bases 1 to 324)
  AUTHORS   Taudien,S., Galgoczy,P., Huse,K., Reichwald,K., Schilhabel,M.,
            Szafranski,K., Shimizu,A., Asakawa,S., Frankish,A.,
            Loncarevic,I.F., Shimizu,N., Siddiqui,R. and Platzer,M.
  TITLE     Polymorphic segmental duplications at 8p23.1 challenge the
            determination of individual defensin gene repertoires and the
            assembly of a contiguous human reference sequence
  JOURNAL   BMC Genomics 5 (1), 92 (2004)
   PUBMED   15588320
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 324)
  AUTHORS   Boniotto,M., Ventura,M., Eskdale,J., Crovella,S. and Gallagher,G.
  TITLE     Evidence for duplication of the human defensin gene DEFB4 in
            chromosomal region 8p22-23 and implications for the analysis of SNP
            allele distribution
  JOURNAL   Genet Test 8 (3), 325-327 (2004)
   PUBMED   15727258
REFERENCE   6  (bases 1 to 324)
  AUTHORS   Hollox,E.J., Armour,J.A. and Barber,J.C.
  TITLE     Extensive normal copy number variation of a beta-defensin
            antimicrobial-gene cluster
  JOURNAL   Am J Hum Genet 73 (3), 591-600 (2003)
   PUBMED   12916016
REFERENCE   7  (bases 1 to 324)
  AUTHORS   Semple,C.A., Rolfe,M. and Dorin,J.R.
  TITLE     Duplication and selection in the evolution of primate beta-defensin
            genes
  JOURNAL   Genome Biol 4 (5), R31 (2003)
   PUBMED   12734011
REFERENCE   8  (bases 1 to 324)
  AUTHORS   Yamaguchi,Y., Nagase,T., Makita,R., Fukuhara,S., Tomita,T.,
            Tominaga,T., Kurihara,H. and Ouchi,Y.
  TITLE     Identification of multiple novel epididymis-specific beta-defensin
            isoforms in humans and mice
  JOURNAL   J Immunol 169 (5), 2516-2523 (2002)
   PUBMED   12193721
REFERENCE   9  (bases 1 to 324)
  AUTHORS   Schutte,B.C., Mitros,J.P., Bartlett,J.A., Walters,J.D., Jia,H.P.,
            Welsh,M.J., Casavant,T.L. and McCray,P.B. Jr.
  TITLE     Discovery of five conserved beta -defensin gene clusters using a
            computational search strategy
  JOURNAL   Proc Natl Acad Sci U S A 99 (4), 2129-2133 (2002)
   PUBMED   11854508
  REMARK    Erratum:[Proc Natl Acad Sci U S A 2002 Oct 29;99(22):14611]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC134684.5.
            
            On May 17, 2019 this sequence version replaced NM_001040705.1.
            
            Summary: Defensins form a family of antimicrobial and cytotoxic
            peptides made by neutrophils. Defensins are short, processed
            peptide molecules that are classified by structure into three
            groups: alpha-defensins, beta-defensins and theta-defensins. All
            beta-defensin genes are densely clustered in four to five syntenic
            chromosomal regions. Chromosome 8p23 contains at least two copies
            of the duplicated beta-defensin cluster. This duplication results
            in two identical copies of defensin, beta 107, DEFB107A and
            DEFB107B, in tail-to-tail orientation. This gene, DEFB107B,
            represents the more telomeric copy. [provided by RefSeq, Oct 2014].
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match                 :: ENST00000355602.3/
                                                  ENSP00000347810.2
            Protein has antimicrobial activity :: PMID: 16033865
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-93                AC134684.5         53986-54078
            94-324              AC134684.5         67156-67386
FEATURES             Location/Qualifiers
     source          1..324
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p23.1"
     gene            1..324
                     /gene="DEFB107B"
                     /gene_synonym="HsT21816"
                     /note="defensin beta 107B"
                     /db_xref="GeneID:503614"
                     /db_xref="HGNC:HGNC:31918"
     exon            1..93
                     /gene="DEFB107B"
                     /gene_synonym="HsT21816"
                     /inference="alignment:Splign:2.1.0"
     CDS             24..236
                     /gene="DEFB107B"
                     /gene_synonym="HsT21816"
                     /note="beta-defensin 107; beta-defensin 7; defensin, beta
                     107"
                     /codon_start=1
                     /product="beta-defensin 107 precursor"
                     /protein_id="NP_001035795.1"
                     /db_xref="CCDS:CCDS43696.1"
                     /db_xref="GeneID:503614"
                     /db_xref="HGNC:HGNC:31918"
                     /translation="MPGAMKIFVFILAALILLAQIFQARTAIHRALISKRMEGHCEAE
                     CLTFEVKIGGCRAELAPFCCKNRKKH"
     exon            94..324
                     /gene="DEFB107B"
                     /gene_synonym="HsT21816"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cttccttcat cagctctcca ctgatgcctg gagccatgaa aatatttgtc tttattttgg
       61 ctgctctcat tcttcttgct caaattttcc aagccaggac agcaattcat agagcactaa
      121 ttagtaagag aatggaaggt cactgtgaag ccgaatgtct tacctttgaa gtaaagattg
      181 ggggctgtag agctgaatta gcaccatttt gctgcaaaaa cagaaagaaa cattaaaaac
      241 taagcaccag ctgcaagaaa caaagaggtg aagattctct ggctgcgata tcagtgggat
      301 aaatctctct ggaccatctc tctt
//
