LOCUS       NM_001037668             389 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens defensin beta 107A (DEFB107A), mRNA.
ACCESSION   NM_001037668
VERSION     NM_001037668.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 389)
  AUTHORS   Jones,E.A., Kananurak,A., Bevins,C.L., Hollox,E.J. and
            Bakaletz,L.O.
  TITLE     Copy number variation of the beta defensin gene cluster on
            chromosome 8p influences the bacterial microbiota within the
            nasopharynx of otitis-prone children
  JOURNAL   PLoS One 9 (5), e98269 (2014)
   PUBMED   24867293
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 389)
  AUTHORS   Taudien,S., Huse,K., Groth,M. and Platzer,M.
  TITLE     Narrowing down the distal border of the copy number variable
            beta-defensin gene cluster on human 8p23
  JOURNAL   BMC Res Notes 7, 93 (2014)
   PUBMED   24552181
  REMARK    GeneRIF: Data indicate the copy number variation (CNV) of
            beta-defensin gene cluster for six indels between ~1 kb distal of
            DEFB108P and 10 kb proximal of DEFB107.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 389)
  AUTHORS   Patil,A.A., Cai,Y., Sang,Y., Blecha,F. and Zhang,G.
  TITLE     Cross-species analysis of the mammalian beta-defensin gene family:
            presence of syntenic gene clusters and preferential expression in
            the male reproductive tract
  JOURNAL   Physiol Genomics 23 (1), 5-17 (2005)
   PUBMED   16033865
  REMARK    GeneRIF: This protein is thought to have antimicrobial activity.
REFERENCE   4  (bases 1 to 389)
  AUTHORS   Taudien,S., Galgoczy,P., Huse,K., Reichwald,K., Schilhabel,M.,
            Szafranski,K., Shimizu,A., Asakawa,S., Frankish,A.,
            Loncarevic,I.F., Shimizu,N., Siddiqui,R. and Platzer,M.
  TITLE     Polymorphic segmental duplications at 8p23.1 challenge the
            determination of individual defensin gene repertoires and the
            assembly of a contiguous human reference sequence
  JOURNAL   BMC Genomics 5 (1), 92 (2004)
   PUBMED   15588320
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 389)
  AUTHORS   Boniotto,M., Ventura,M., Eskdale,J., Crovella,S. and Gallagher,G.
  TITLE     Evidence for duplication of the human defensin gene DEFB4 in
            chromosomal region 8p22-23 and implications for the analysis of SNP
            allele distribution
  JOURNAL   Genet Test 8 (3), 325-327 (2004)
   PUBMED   15727258
REFERENCE   6  (bases 1 to 389)
  AUTHORS   Hollox,E.J., Armour,J.A. and Barber,J.C.
  TITLE     Extensive normal copy number variation of a beta-defensin
            antimicrobial-gene cluster
  JOURNAL   Am J Hum Genet 73 (3), 591-600 (2003)
   PUBMED   12916016
REFERENCE   7  (bases 1 to 389)
  AUTHORS   Semple,C.A., Rolfe,M. and Dorin,J.R.
  TITLE     Duplication and selection in the evolution of primate beta-defensin
            genes
  JOURNAL   Genome Biol 4 (5), R31 (2003)
   PUBMED   12734011
REFERENCE   8  (bases 1 to 389)
  AUTHORS   Yamaguchi,Y., Nagase,T., Makita,R., Fukuhara,S., Tomita,T.,
            Tominaga,T., Kurihara,H. and Ouchi,Y.
  TITLE     Identification of multiple novel epididymis-specific beta-defensin
            isoforms in humans and mice
  JOURNAL   J Immunol 169 (5), 2516-2523 (2002)
   PUBMED   12193721
REFERENCE   9  (bases 1 to 389)
  AUTHORS   Schutte,B.C., Mitros,J.P., Bartlett,J.A., Walters,J.D., Jia,H.P.,
            Welsh,M.J., Casavant,T.L. and McCray,P.B. Jr.
  TITLE     Discovery of five conserved beta -defensin gene clusters using a
            computational search strategy
  JOURNAL   Proc Natl Acad Sci U S A 99 (4), 2129-2133 (2002)
   PUBMED   11854508
  REMARK    Erratum:[Proc Natl Acad Sci U S A 2002 Oct 29;99(22):14611]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DQ119826.1.
            
            Summary: Defensins form a family of antimicrobial and cytotoxic
            peptides made by neutrophils. Defensins are short, processed
            peptide molecules that are classified by structure into three
            groups: alpha-defensins, beta-defensins and theta-defensins. All
            beta-defensin genes are densely clustered in four to five syntenic
            chromosomal regions. Chromosome 8p23 contains at least two copies
            of the duplicated beta-defensin cluster. This duplication results
            in two identical copies of defensin, beta 107, DEFB107A and
            DEFB107B, in tail-to-tail orientation. This gene, DEFB107A,
            represents the more centromeric copy. [provided by RefSeq, Oct
            2014].
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ119826.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match                 :: ENST00000335021.2/
                                                  ENSP00000334681.2
            Protein has antimicrobial activity :: PMID: 16033865
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-389               DQ119826.1         1-389
FEATURES             Location/Qualifiers
     source          1..389
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p23.1"
     gene            1..389
                     /gene="DEFB107A"
                     /gene_synonym="BD-7; DEFB-7; DEFB107"
                     /note="defensin beta 107A"
                     /db_xref="GeneID:245910"
                     /db_xref="HGNC:HGNC:18086"
     exon            1..158
                     /gene="DEFB107A"
                     /gene_synonym="BD-7; DEFB-7; DEFB107"
                     /inference="alignment:Splign:2.1.0"
     CDS             89..301
                     /gene="DEFB107A"
                     /gene_synonym="BD-7; DEFB-7; DEFB107"
                     /note="defensin, beta 7; beta-defensin 107; beta-defensin
                     7"
                     /codon_start=1
                     /product="beta-defensin 107 precursor"
                     /protein_id="NP_001032757.2"
                     /db_xref="CCDS:CCDS43699.1"
                     /db_xref="GeneID:245910"
                     /db_xref="HGNC:HGNC:18086"
                     /translation="MPGAMKIFVFILAALILLAQIFQARTAIHRALISKRMEGHCEAE
                     CLTFEVKIGGCRAELAPFCCKNRKKH"
     exon            159..389
                     /gene="DEFB107A"
                     /gene_synonym="BD-7; DEFB-7; DEFB107"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tcagggcagt agaacatatt ttaatcaatg ccccttgata aaagagcttg attccagcta
       61 ctgcacttcc ttcatcagct ctccactgat gcctggagcc atgaaaatat ttgtctttat
      121 tttggctgct ctcattcttc ttgctcaaat tttccaagcc aggacagcaa ttcatagagc
      181 actaattagt aagagaatgg aaggtcactg tgaagccgaa tgtcttacct ttgaagtaaa
      241 gattgggggc tgtagagctg aattagcacc attttgctgc aaaaacagaa agaaacatta
      301 aaaactaagc accagctgca agaaacaaag aggtgaagat tctctggctg cgatatcagt
      361 gggataaatc tctctggacc atctctctt
//
