LOCUS       NM_001040704             316 bp    mRNA    linear   PRI 01-FEB-2021
DEFINITION  Homo sapiens defensin beta 106B (DEFB106B), mRNA.
ACCESSION   NM_001040704
VERSION     NM_001040704.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 316)
  AUTHORS   Xin A, Zhao Y, Yu H, Shi H, Liu H, Diao H and Zhang Y.
  TITLE     Soluble fusion expression, characterization and localization of
            human beta-defensin 6
  JOURNAL   Mol Med Rep 9 (1), 149-155 (2014)
   PUBMED   24189797
  REMARK    GeneRIF: DEFB106 (also known as DEFB6) displays antimicrobial
            activity against E. coli, C. albicans and S. aureus.
REFERENCE   2  (bases 1 to 316)
  AUTHORS   De Paula VS, Gomes NS, Lima LG, Miyamoto CA, Monteiro RQ, Almeida
            FC and Valente AP.
  TITLE     Structural basis for the interaction of human beta-defensin 6 and
            its putative chemokine receptor CCR2 and breast cancer
            microvesicles
  JOURNAL   J Mol Biol 425 (22), 4479-4495 (2013)
   PUBMED   23938203
REFERENCE   3  (bases 1 to 316)
  AUTHORS   Patil AA, Cai Y, Sang Y, Blecha F and Zhang G.
  TITLE     Cross-species analysis of the mammalian beta-defensin gene family:
            presence of syntenic gene clusters and preferential expression in
            the male reproductive tract
  JOURNAL   Physiol Genomics 23 (1), 5-17 (2005)
   PUBMED   16033865
REFERENCE   4  (bases 1 to 316)
  AUTHORS   Taudien S, Galgoczy P, Huse K, Reichwald K, Schilhabel M,
            Szafranski K, Shimizu A, Asakawa S, Frankish A, Loncarevic IF,
            Shimizu N, Siddiqui R and Platzer M.
  TITLE     Polymorphic segmental duplications at 8p23.1 challenge the
            determination of individual defensin gene repertoires and the
            assembly of a contiguous human reference sequence
  JOURNAL   BMC Genomics 5 (1), 92 (2004)
   PUBMED   15588320
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 316)
  AUTHORS   Boniotto M, Ventura M, Eskdale J, Crovella S and Gallagher G.
  TITLE     Evidence for duplication of the human defensin gene DEFB4 in
            chromosomal region 8p22-23 and implications for the analysis of SNP
            allele distribution
  JOURNAL   Genet Test 8 (3), 325-327 (2004)
   PUBMED   15727258
REFERENCE   6  (bases 1 to 316)
  AUTHORS   Hollox EJ, Armour JA and Barber JC.
  TITLE     Extensive normal copy number variation of a beta-defensin
            antimicrobial-gene cluster
  JOURNAL   Am J Hum Genet 73 (3), 591-600 (2003)
   PUBMED   12916016
REFERENCE   7  (bases 1 to 316)
  AUTHORS   Semple CA, Rolfe M and Dorin JR.
  TITLE     Duplication and selection in the evolution of primate beta-defensin
            genes
  JOURNAL   Genome Biol 4 (5), R31 (2003)
   PUBMED   12734011
REFERENCE   8  (bases 1 to 316)
  AUTHORS   Yamaguchi Y, Nagase T, Makita R, Fukuhara S, Tomita T, Tominaga T,
            Kurihara H and Ouchi Y.
  TITLE     Identification of multiple novel epididymis-specific beta-defensin
            isoforms in humans and mice
  JOURNAL   J Immunol 169 (5), 2516-2523 (2002)
   PUBMED   12193721
REFERENCE   9  (bases 1 to 316)
  AUTHORS   Schutte BC, Mitros JP, Bartlett JA, Walters JD, Jia HP, Welsh MJ,
            Casavant TL and McCray PB Jr.
  TITLE     Discovery of five conserved beta -defensin gene clusters using a
            computational search strategy
  JOURNAL   Proc Natl Acad Sci U S A 99 (4), 2129-2133 (2002)
   PUBMED   11854508
  REMARK    Erratum:[Proc Natl Acad Sci U S A 2002 Oct 29;99(22):14611]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC134684.5 and AC130360.4.
            
            On Aug 14, 2020 this sequence version replaced NM_001040704.1.
            
            Summary: Defensins form a family of antimicrobial and cytotoxic
            peptides made by neutrophils. Defensins are short, processed
            peptide molecules that are classified by structure into three
            groups: alpha-defensins, beta-defensins and theta-defensins. All
            beta-defensin genes are densely clustered in four to five syntenic
            chromosomal regions. Chromosome 8p23 contains at least two copies
            of the duplicated beta-defensin cluster. This duplication results
            in two identical copies of defensin, beta 106, DEFB106A and
            DEFB106B, in head-to-head orientation. This gene, DEFB106B,
            represents the more telomeric copy. [provided by RefSeq, Oct 2014].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AW103145.1, BX104316.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match                 :: ENST00000335479.2/
                                                  ENSP00000334364.2
            Protein has antimicrobial activity :: PMID: 24189797
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-67                AC134684.5         44409-44475         c
            68-316              AC130360.4         170611-170859       c
FEATURES             Location/Qualifiers
     source          1..316
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p23.1"
     gene            1..316
                     /gene="DEFB106B"
                     /gene_synonym="BD-6; DEFB-6"
                     /note="defensin beta 106B"
                     /db_xref="GeneID:503841"
                     /db_xref="HGNC:HGNC:28879"
     exon            1..67
                     /gene="DEFB106B"
                     /gene_synonym="BD-6; DEFB-6"
                     /inference="alignment:Splign:2.1.0"
     CDS             19..216
                     /gene="DEFB106B"
                     /gene_synonym="BD-6; DEFB-6"
                     /note="beta-defensin 106; beta-defensin 6; defensin, beta
                     106"
                     /codon_start=1
                     /product="beta-defensin 106 precursor"
                     /protein_id="NP_001035794.1"
                     /db_xref="CCDS:CCDS34813.1"
                     /db_xref="GeneID:503841"
                     /db_xref="HGNC:HGNC:28879"
                     /translation="MRTFLFLFAVLFFLTPAKNAFFDEKCNKLKGTCKNNCGKNEELI
                     ALCQKSLKCCRTIQPCGSIID"
     exon            68..316
                     /gene="DEFB106B"
                     /gene_synonym="BD-6; DEFB-6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcaagaccc acccagtcat gaggactttc ctctttctct ttgccgtgct cttctttctg
       61 accccagcca agaatgcatt ttttgatgag aaatgcaaca aacttaaagg gacatgcaag
      121 aacaattgcg ggaaaaatga agaacttatt gctctctgcc agaagtctct gaaatgctgt
      181 cggaccatcc agccatgtgg gagcattata gattaatgca gaagatttag gtttccagag
      241 aagcatacat aacctagctt ctttttactc ttgcctctgc tgtaggcaga cactttaata
      301 aaaataaatg actgtc
//
