LOCUS       NM_152251                336 bp    mRNA    linear   PRI 08-FEB-2022
DEFINITION  Homo sapiens defensin beta 106A (DEFB106A), mRNA.
ACCESSION   NM_152251 XM_928779
VERSION     NM_152251.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 336)
  AUTHORS   De Paula VS, Pomin VH and Valente AP.
  TITLE     Unique properties of human beta-defensin 6 (hBD6) and
            glycosaminoglycan complex: sandwich-like dimerization and
            competition with the chemokine receptor 2 (CCR2) binding site
  JOURNAL   J. Biol. Chem. 289 (33), 22969-22979 (2014)
   PUBMED   24970887
  REMARK    GeneRIF: Unique properties of human beta-defensin 6 (hBD6) and
            glycosaminoglycan complex: sandwich-like dimerization and
            competition with the chemokine receptor 2 (CCR2) binding site.
REFERENCE   2  (bases 1 to 336)
  AUTHORS   Xin A, Zhao Y, Yu H, Shi H, Liu H, Diao H and Zhang Y.
  TITLE     Soluble fusion expression, characterization and localization of
            human beta-defensin 6
  JOURNAL   Mol Med Rep 9 (1), 149-155 (2014)
   PUBMED   24189797
  REMARK    GeneRIF: DEFB106 (also known as DEFB6) displays antimicrobial
            activity against E. coli, C. albicans and S. aureus.
REFERENCE   3  (bases 1 to 336)
  AUTHORS   De Paula VS, Gomes NS, Lima LG, Miyamoto CA, Monteiro RQ, Almeida
            FC and Valente AP.
  TITLE     Structural basis for the interaction of human beta-defensin 6 and
            its putative chemokine receptor CCR2 and breast cancer
            microvesicles
  JOURNAL   J. Mol. Biol. 425 (22), 4479-4495 (2013)
   PUBMED   23938203
REFERENCE   4  (bases 1 to 336)
  AUTHORS   Milanese M, Segat L, Arraes LC, Garzino-Demo A and Crovella S.
  TITLE     Copy number variation of defensin genes and HIV infection in
            Brazilian children
  JOURNAL   J. Acquir. Immune Defic. Syndr. 50 (3), 331-333 (2009)
   PUBMED   19194307
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   5  (bases 1 to 336)
  AUTHORS   Patil AA, Cai Y, Sang Y, Blecha F and Zhang G.
  TITLE     Cross-species analysis of the mammalian beta-defensin gene family:
            presence of syntenic gene clusters and preferential expression in
            the male reproductive tract
  JOURNAL   Physiol. Genomics 23 (1), 5-17 (2005)
   PUBMED   16033865
REFERENCE   6  (bases 1 to 336)
  AUTHORS   Boniotto M, Ventura M, Eskdale J, Crovella S and Gallagher G.
  TITLE     Evidence for duplication of the human defensin gene DEFB4 in
            chromosomal region 8p22-23 and implications for the analysis of SNP
            allele distribution
  JOURNAL   Genet. Test. 8 (3), 325-327 (2004)
   PUBMED   15727258
REFERENCE   7  (bases 1 to 336)
  AUTHORS   Kao CY, Chen Y, Zhao YH and Wu R.
  TITLE     ORFeome-based search of airway epithelial cell-specific novel human
            [beta]-defensin genes
  JOURNAL   Am. J. Respir. Cell Mol. Biol. 29 (1), 71-80 (2003)
   PUBMED   12600824
  REMARK    GeneRIF: A pilot study with cRNA probes for in situ hybridization
            and a synthetic propeptide for the functional characterization
            demonstrated the tissue-/cell-specific expression and the strong
            antimicrobial activity of DEFB106
REFERENCE   8  (bases 1 to 336)
  AUTHORS   Semple CA, Rolfe M and Dorin JR.
  TITLE     Duplication and selection in the evolution of primate beta-defensin
            genes
  JOURNAL   Genome Biol. 4 (5), R31 (2003)
   PUBMED   12734011
REFERENCE   9  (bases 1 to 336)
  AUTHORS   Yamaguchi Y, Nagase T, Makita R, Fukuhara S, Tomita T, Tominaga T,
            Kurihara H and Ouchi Y.
  TITLE     Identification of multiple novel epididymis-specific beta-defensin
            isoforms in humans and mice
  JOURNAL   J. Immunol. 169 (5), 2516-2523 (2002)
   PUBMED   12193721
  REMARK    GeneRIF: The epididymis-specific expression pattern of the
            beta-defensin isoform BD-6 has been characterized.
REFERENCE   10 (bases 1 to 336)
  AUTHORS   Schutte BC, Mitros JP, Bartlett JA, Walters JD, Jia HP, Welsh MJ,
            Casavant TL and McCray PB Jr.
  TITLE     Discovery of five conserved beta -defensin gene clusters using a
            computational search strategy
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 99 (4), 2129-2133 (2002)
   PUBMED   11854508
  REMARK    Erratum:[Proc Natl Acad Sci U S A 2002 Oct 29;99(22):14611]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC084121.13, AY122466.1 and
            BC111688.1.
            
            On May 17, 2019 this sequence version replaced NM_152251.3.
            
            Summary: Defensins form a family of antimicrobial and cytotoxic
            peptides made by neutrophils. Defensins are short, processed
            peptide molecules that are classified by structure into three
            groups: alpha-defensins, beta-defensins and theta-defensins. All
            beta-defensin genes are densely clustered in four to five syntenic
            chromosomal regions. Chromosome 8p23 contains at least two copies
            of the duplicated beta-defensin cluster. This duplication results
            in two identical copies of defensin, beta 106, DEFB106A and
            DEFB106B, in head-to-head orientation. This gene, DEFB106A,
            represents the more centromeric copy. [provided by RefSeq, Oct
            2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AI910580.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match                 :: ENST00000335186.3/
                                                  ENSP00000335307.2
            Protein has antimicrobial activity :: PMID: 24189797
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-33                AC084121.13        12975-13007         c
            34-157              AY122466.1         28-151
            158-286             BC111688.1         125-253
            287-336             AY122466.1         281-330
FEATURES             Location/Qualifiers
     source          1..336
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p23.1"
     gene            1..336
                     /gene="DEFB106A"
                     /gene_synonym="BD-6; DEFB-6; DEFB106"
                     /note="defensin beta 106A"
                     /db_xref="GeneID:245909"
                     /db_xref="HGNC:HGNC:18088"
     exon            1..87
                     /gene="DEFB106A"
                     /gene_synonym="BD-6; DEFB-6; DEFB106"
                     /inference="alignment:Splign:2.1.0"
     CDS             39..236
                     /gene="DEFB106A"
                     /gene_synonym="BD-6; DEFB-6; DEFB106"
                     /note="defensin, beta 6; beta-defensin 6; beta-defensin
                     106"
                     /codon_start=1
                     /product="beta-defensin 106 precursor"
                     /protein_id="NP_689464.1"
                     /db_xref="CCDS:CCDS34833.1"
                     /db_xref="GeneID:245909"
                     /db_xref="HGNC:HGNC:18088"
                     /translation="MRTFLFLFAVLFFLTPAKNAFFDEKCNKLKGTCKNNCGKNEELI
                     ALCQKSLKCCRTIQPCGSIID"
     exon            88..336
                     /gene="DEFB106A"
                     /gene_synonym="BD-6; DEFB-6; DEFB106"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 catggacacg gtgctgatct ctcaagaccc acccagtcat gaggactttc ctctttctct
       61 ttgccgtgct cttctttctg accccagcca agaatgcatt ttttgatgag aaatgcaaca
      121 aacttaaagg gacatgcaag aacaattgcg ggaaaaatga agaacttatt gctctctgcc
      181 agaagtctct gaaatgctgt cggaccatcc agccatgtgg gagcattata gattaatgca
      241 gaagatttag gtttccagag aagcatacat aacctagctt ctttttactc ttgcctctgc
      301 tgtaggcaga cactttaata aaaataaatg actgtc
//
