LOCUS       NM_001040703             321 bp    mRNA    linear   PRI 10-SEP-2020
DEFINITION  Homo sapiens defensin beta 105B (DEFB105B), mRNA.
ACCESSION   NM_001040703
VERSION     NM_001040703.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 321)
  AUTHORS   Wanniarachchi YA, Kaczmarek P, Wan A and Nolan EM.
  TITLE     Human defensin 5 disulfide array mutants: disulfide bond deletion
            attenuates antibacterial activity against Staphylococcus aureus
  JOURNAL   Biochemistry 50 (37), 8005-8017 (2011)
   PUBMED   21861459
  REMARK    GeneRIF: Defensin-beta 105 displays antimicrobial activity against
            S. aureus and E. coli, among other bacteria.
REFERENCE   2  (bases 1 to 321)
  AUTHORS   Patil AA, Cai Y, Sang Y, Blecha F and Zhang G.
  TITLE     Cross-species analysis of the mammalian beta-defensin gene family:
            presence of syntenic gene clusters and preferential expression in
            the male reproductive tract
  JOURNAL   Physiol. Genomics 23 (1), 5-17 (2005)
   PUBMED   16033865
REFERENCE   3  (bases 1 to 321)
  AUTHORS   Taudien S, Galgoczy P, Huse K, Reichwald K, Schilhabel M,
            Szafranski K, Shimizu A, Asakawa S, Frankish A, Loncarevic IF,
            Shimizu N, Siddiqui R and Platzer M.
  TITLE     Polymorphic segmental duplications at 8p23.1 challenge the
            determination of individual defensin gene repertoires and the
            assembly of a contiguous human reference sequence
  JOURNAL   BMC Genomics 5 (1), 92 (2004)
   PUBMED   15588320
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 321)
  AUTHORS   Boniotto M, Ventura M, Eskdale J, Crovella S and Gallagher G.
  TITLE     Evidence for duplication of the human defensin gene DEFB4 in
            chromosomal region 8p22-23 and implications for the analysis of SNP
            allele distribution
  JOURNAL   Genet. Test. 8 (3), 325-327 (2004)
   PUBMED   15727258
REFERENCE   5  (bases 1 to 321)
  AUTHORS   Hollox EJ, Armour JA and Barber JC.
  TITLE     Extensive normal copy number variation of a beta-defensin
            antimicrobial-gene cluster
  JOURNAL   Am. J. Hum. Genet. 73 (3), 591-600 (2003)
   PUBMED   12916016
REFERENCE   6  (bases 1 to 321)
  AUTHORS   Semple CA, Rolfe M and Dorin JR.
  TITLE     Duplication and selection in the evolution of primate beta-defensin
            genes
  JOURNAL   Genome Biol. 4 (5), R31 (2003)
   PUBMED   12734011
REFERENCE   7  (bases 1 to 321)
  AUTHORS   Yamaguchi Y, Nagase T, Makita R, Fukuhara S, Tomita T, Tominaga T,
            Kurihara H and Ouchi Y.
  TITLE     Identification of multiple novel epididymis-specific beta-defensin
            isoforms in humans and mice
  JOURNAL   J. Immunol. 169 (5), 2516-2523 (2002)
   PUBMED   12193721
REFERENCE   8  (bases 1 to 321)
  AUTHORS   Schutte BC, Mitros JP, Bartlett JA, Walters JD, Jia HP, Welsh MJ,
            Casavant TL and McCray PB Jr.
  TITLE     Discovery of five conserved beta -defensin gene clusters using a
            computational search strategy
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 99 (4), 2129-2133 (2002)
   PUBMED   11854508
  REMARK    Erratum:[Proc Natl Acad Sci U S A 2002 Oct 29;99(22):14611]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC140937.1 and AC134684.5.
            
            On May 17, 2019 this sequence version replaced NM_001040703.2.
            
            Summary: Defensins form a family of antimicrobial and cytotoxic
            peptides made by neutrophils. Defensins are short, processed
            peptide molecules that are classified by structure into three
            groups: alpha-defensins, beta-defensins and theta-defensins. All
            beta-defensin genes are densely clustered in four to five syntenic
            chromosomal regions. Chromosome 8p23 contains at least two copies
            of the duplicated beta-defensin cluster. This duplication results
            in two identical copies of defensin, beta 105, DEFB105A and
            DEFB105B, in tail-to-tail orientation. This gene, DEFB105B,
            represents the more telomeric copy. [provided by RefSeq, Oct 2014].
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC140937.1, SRR5189667.97321.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match                 :: ENST00000335510.7/
                                                  ENSP00000335281.6
            Protein has antimicrobial activity :: PMID: 21861459
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-52                BC140937.1         11-62
            53-53               AC134684.5         45806-45806
            54-321              BC140937.1         64-331
FEATURES             Location/Qualifiers
     source          1..321
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p23.1"
     gene            1..321
                     /gene="DEFB105B"
                     /gene_synonym="BD-5; DEFB-5"
                     /note="defensin beta 105B"
                     /db_xref="GeneID:504180"
                     /db_xref="HGNC:HGNC:29930"
     exon            1..112
                     /gene="DEFB105B"
                     /gene_synonym="BD-5; DEFB-5"
                     /inference="alignment:Splign:2.1.0"
     CDS             43..279
                     /gene="DEFB105B"
                     /gene_synonym="BD-5; DEFB-5"
                     /note="beta-defensin 5; defensin, beta 105; beta-defensin
                     105"
                     /codon_start=1
                     /product="beta-defensin 105 precursor"
                     /protein_id="NP_001035793.1"
                     /db_xref="CCDS:CCDS34814.1"
                     /db_xref="GeneID:504180"
                     /db_xref="HGNC:HGNC:29930"
                     /translation="MALIRKTFYFLFAMFFILVQLPSGCQAGLDFSQPFPSGEFAVCE
                     SCKLGRGKCRKECLENEKPDGNCRLNFLCCRQRI"
     exon            113..154
                     /gene="DEFB105B"
                     /gene_synonym="BD-5; DEFB-5"
                     /inference="alignment:Splign:2.1.0"
     exon            155..321
                     /gene="DEFB105B"
                     /gene_synonym="BD-5; DEFB-5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaggaaatcc caatctctat tccgaagagt cttccctaaa agatggccct gatcaggaag
       61 acattttatt ttctatttgc tatgttcttc attttggttc aactgccatc agggtgccag
      121 gcaggacttg atttttccca accatttcca tcaggtgagt ttgctgtctg tgagtcgtgc
      181 aagcttggtc ggggaaaatg caggaaggag tgcttggaga atgagaagcc cgatggaaat
      241 tgcaggctga actttctctg ctgcagacag aggatctgac aaaccagacc agcacacttc
      301 tggccttaga agcagacctg g
//
