LOCUS       NM_018661                518 bp    mRNA    linear   PRI 03-SEP-2024
DEFINITION  Homo sapiens defensin beta 103B (DEFB103B), mRNA.
ACCESSION   NM_018661
VERSION     NM_018661.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 518)
  AUTHORS   Chen,G., Zheng,Y., Wu,N., Yang,X. and Qu,S.
  TITLE     Human beta defensin 3 knockdown inhibits the proliferation and
            migration of airway smooth muscle cells through regulating the
            PI3K/AKT signaling pathway
  JOURNAL   Mol Immunol 168, 38-46 (2024)
   PUBMED   38422885
  REMARK    GeneRIF: Human beta defensin 3 knockdown inhibits the proliferation
            and migration of airway smooth muscle cells through regulating the
            PI3K/AKT signaling pathway.
REFERENCE   2  (bases 1 to 518)
  AUTHORS   Gursoy,U.K., Gursoy,M., Loimaranta,V. and Rautava,J.
  TITLE     Salivary Th17 cytokine, human beta-defensin 1-3, and salivary
            scavenger and agglutinin levels in Crohn's disease
  JOURNAL   Clin Oral Investig 28 (1), 108 (2024)
   PUBMED   38246944
  REMARK    GeneRIF: Salivary Th17 cytokine, human beta-defensin 1-3, and
            salivary scavenger and agglutinin levels in Crohn's disease.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 518)
  AUTHORS   Noda-Nicolau,N.M., Silva,M.C., Bento,G.F.C., Ferreira,J.S.B.,
            Novak,J., Morales,J.A.P., Tronco,J.A., Bolpetti,A.N., Pinto,G.V.S.,
            Polettini,J., Marconi,C. and Silva,M.G.D.
  TITLE     Cervicovaginal levels of human beta defensins during bacterial
            vaginosis
  JOURNAL   PLoS One 16 (12), e0260753 (2021)
   PUBMED   34855866
  REMARK    GeneRIF: Cervicovaginal levels of human beta defensins during
            bacterial vaginosis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 518)
  AUTHORS   Brewer,A. and Zhang,L.
  TITLE     Binding free energy calculation of human beta defensin 3 with
            negatively charged lipid bilayer using free energy perturbation
            method
  JOURNAL   Biophys Chem 277, 106662 (2021)
   PUBMED   34399250
  REMARK    GeneRIF: Binding free energy calculation of human beta defensin 3
            with negatively charged lipid bilayer using free energy
            perturbation method.
REFERENCE   5  (bases 1 to 518)
  AUTHORS   Zhang,L.
  TITLE     Interaction of Human beta Defensin Type 3 (hBD-3) with Different
            PIP2-Containing Membranes, a Molecular Dynamics Simulation Study
  JOURNAL   J Chem Inf Model 61 (9), 4670-4686 (2021)
   PUBMED   34473496
  REMARK    GeneRIF: Interaction of Human beta Defensin Type 3 (hBD-3) with
            Different PIP2-Containing Membranes, a Molecular Dynamics
            Simulation Study.
REFERENCE   6  (bases 1 to 518)
  AUTHORS   Schibli,D.J., Hunter,H.N., Aseyev,V., Starner,T.D., Wiencek,J.M.,
            McCray,P.B. Jr., Tack,B.F. and Vogel,H.J.
  TITLE     The solution structures of the human beta-defensins lead to a
            better understanding of the potent bactericidal activity of HBD3
            against Staphylococcus aureus
  JOURNAL   J Biol Chem 277 (10), 8279-8289 (2002)
   PUBMED   11741980
  REMARK    GeneRIF: HBD-3 is a dimer, while HBD-1 and HBD-2 are monomeric.
            Subsequently, the NMR solution structures of HBD1 and HBD3 were
            determined using standard homonuclear techniques and compared with
            the previously determined solution structure of HBD2
REFERENCE   7  (bases 1 to 518)
  AUTHORS   Biragyn,A., Surenhu,M., Yang,D., Ruffini,P.A., Haines,B.A.,
            Klyushnenkova,E., Oppenheim,J.J. and Kwak,L.W.
  TITLE     Mediators of innate immunity that target immature, but not mature,
            dendritic cells induce antitumor immunity when genetically fused
            with nonimmunogenic tumor antigens
  JOURNAL   J Immunol 167 (11), 6644-6653 (2001)
   PUBMED   11714836
REFERENCE   8  (bases 1 to 518)
  AUTHORS   Garcia,J.R., Jaumann,F., Schulz,S., Krause,A.,
            Rodriguez-Jimenez,J., Forssmann,U., Adermann,K., Kluver,E.,
            Vogelmeier,C., Becker,D., Hedrich,R., Forssmann,W.G. and Bals,R.
  TITLE     Identification of a novel, multifunctional beta-defensin (human
            beta-defensin 3) with specific antimicrobial activity. Its
            interaction with plasma membranes of Xenopus oocytes and the
            induction of macrophage chemoattraction
  JOURNAL   Cell Tissue Res 306 (2), 257-264 (2001)
   PUBMED   11702237
REFERENCE   9  (bases 1 to 518)
  AUTHORS   Harder,J., Bartels,J., Christophers,E. and Schroder,J.M.
  TITLE     Isolation and characterization of human beta -defensin-3, a novel
            human inducible peptide antibiotic
  JOURNAL   J Biol Chem 276 (8), 5707-5713 (2001)
   PUBMED   11085990
REFERENCE   10 (bases 1 to 518)
  AUTHORS   Jia,H.P., Schutte,B.C., Schudy,A., Linzmeier,R., Guthmiller,J.M.,
            Johnson,G.K., Tack,B.F., Mitros,J.P., Rosenthal,A., Ganz,T. and
            McCray,P.B. Jr.
  TITLE     Discovery of new human beta-defensins using a genomics-based
            approach
  JOURNAL   Gene 263 (1-2), 211-218 (2001)
   PUBMED   11223260
  REMARK    GeneRIF: HBD-3 is a broad-spectrum, inducible cationic
            antimicrobial peptide expressed at mucosal surfaces including
            pulmonary epithelia, esophagus, skin, placenta and gingiva.  May
            also act as a chemokine for adaptive immune cells.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC130360.4 and AB037972.1.
            
            On Apr 11, 2014 this sequence version replaced NM_018661.3.
            
            Summary: Defensins form a family of microbicidal and cytotoxic
            peptides made by neutrophils. Members of the defensin family are
            highly similar in protein sequence. This gene encodes defensin,
            beta 103, which has broad spectrum antimicrobial activity and may
            play an important role in innate epithelial defense. [provided by
            RefSeq, Oct 2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ237673.1, AF295370.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142670, SAMEA2142680
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match                 :: ENST00000318124.3/
                                                  ENSP00000324633.3
            Protein has antimicrobial activity :: PMID: 11085990
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-195               AC130360.4         118261-118455       c
            196-518             AB037972.1         1-323
FEATURES             Location/Qualifiers
     source          1..518
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p23.1"
     gene            1..518
                     /gene="DEFB103B"
                     /gene_synonym="BD-3; DEFB-3; DEFB103; DEFB3; HBD-3; HBD3;
                     HBP-3; HBP3"
                     /note="defensin beta 103B"
                     /db_xref="GeneID:55894"
                     /db_xref="HGNC:HGNC:31702"
                     /db_xref="MIM:606611"
     exon            1..276
                     /gene="DEFB103B"
                     /gene_synonym="BD-3; DEFB-3; DEFB103; DEFB3; HBD-3; HBD3;
                     HBP-3; HBP3"
                     /inference="alignment:Splign:2.1.0"
     CDS             219..422
                     /gene="DEFB103B"
                     /gene_synonym="BD-3; DEFB-3; DEFB103; DEFB3; HBD-3; HBD3;
                     HBP-3; HBP3"
                     /note="beta-defensin 103; beta-defensin 3; defensin-like
                     protein"
                     /codon_start=1
                     /product="beta-defensin 103 precursor"
                     /protein_id="NP_061131.1"
                     /db_xref="CCDS:CCDS34810.1"
                     /db_xref="GeneID:55894"
                     /db_xref="HGNC:HGNC:31702"
                     /db_xref="MIM:606611"
                     /translation="MRIHYLLFALLFLFLVPVPGHGGIINTLQKYYCRVRGGRCAVLS
                     CLPKEEQIGKCSTRGRKCCRRKK"
     exon            277..518
                     /gene="DEFB103B"
                     /gene_synonym="BD-3; DEFB-3; DEFB103; DEFB3; HBD-3; HBD3;
                     HBP-3; HBP3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caaatccata gggagctctg ccttaccatt gggttcctaa ttaactgagt gagtgggtgt
       61 gttctgcatg gtgagaggca ttggaatgat gcatcagaaa acatgtcata atgtcatcac
      121 tgtaatatga caagaattgc agctgtggct ggaaccttta taaagtgacc aagcacacct
      181 tttcatccag tctcagcgtg gggtgaagcc tagcagctat gaggatccat tatcttctgt
      241 ttgctttgct cttcctgttt ttggtgcctg ttccaggtca tggaggaatc ataaacacat
      301 tacagaaata ttattgcaga gtcagaggcg gccggtgtgc tgtgctcagc tgccttccaa
      361 aggaggaaca gatcggcaag tgctcgacgc gtggccgaaa atgctgccga agaaagaaat
      421 aaaaaccctg aaacatgacg agagtgttgt aaagtgtgga aatgccttct taaagtttat
      481 aaaagtaaaa tcaaattaca tttttttttc aaaaaaaa
//
