LOCUS       NM_133328               1905 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens death effector domain containing 2 (DEDD2), transcript
            variant 1, mRNA.
ACCESSION   NM_133328
VERSION     NM_133328.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1905)
  AUTHORS   Valmiki,M.G. and Ramos,J.W.
  TITLE     Death effector domain-containing proteins
  JOURNAL   Cell Mol Life Sci 66 (5), 814-830 (2009)
   PUBMED   18989622
  REMARK    Review article
REFERENCE   2  (bases 1 to 1905)
  AUTHORS   Barnhart,B.C., Lee,J.C., Alappat,E.C. and Peter,M.E.
  TITLE     The death effector domain protein family
  JOURNAL   Oncogene 22 (53), 8634-8644 (2003)
   PUBMED   14634625
REFERENCE   3  (bases 1 to 1905)
  AUTHORS   Alcivar,A., Hu,S., Tang,J. and Yang,X.
  TITLE     DEDD and DEDD2 associate with caspase-8/10 and signal cell death
  JOURNAL   Oncogene 22 (2), 291-297 (2003)
   PUBMED   12527898
  REMARK    GeneRIF: DEDD and DEDD2 may be important mediators for death
            receptors and that they may target caspases to the nucleus.
REFERENCE   4  (bases 1 to 1905)
  AUTHORS   Lee,J.C., Schickling,O., Stegh,A.H., Oshima,R.G., Dinsdale,D.,
            Cohen,G.M. and Peter,M.E.
  TITLE     DEDD regulates degradation of intermediate filaments during
            apoptosis
  JOURNAL   J Cell Biol 158 (6), 1051-1066 (2002)
   PUBMED   12235123
REFERENCE   5  (bases 1 to 1905)
  AUTHORS   Zhan,Y., Hegde,R., Srinivasula,S.M., Fernandes-Alnemri,T. and
            Alnemri,E.S.
  TITLE     Death effector domain-containing proteins DEDD and FLAME-3 form
            nuclear complexes with the TFIIIC102 subunit of human transcription
            factor IIIC
  JOURNAL   Cell Death Differ 9 (4), 439-447 (2002)
   PUBMED   11965497
  REMARK    GeneRIF: FLAME-3 forms nuclear complexes with the TFIIIC102 subunit
            of human transcription factor IIIC
REFERENCE   6  (bases 1 to 1905)
  AUTHORS   Roth,W., Stenner-Liewen,F., Pawlowski,K., Godzik,A. and Reed,J.C.
  TITLE     Identification and characterization of DEDD2, a death effector
            domain-containing protein
  JOURNAL   J Biol Chem 277 (9), 7501-7508 (2002)
   PUBMED   11741985
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC337066.1, BC027930.1,
            AF443591.1 and AA635978.1.
            
            On Nov 22, 2018 this sequence version replaced NM_133328.3.
            
            Summary: This gene encodes a nuclear-localized protein containing a
            death effector domain (DED). The encoded protein may regulate the
            trafficking of caspases and other proteins into the nucleus during
            death receptor-induced apoptosis. Alternative splicing results in
            multiple transcript variants. [provided by RefSeq, Jul 2012].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1). Both variants 1 and
            2 encode the same isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.444887.1,
                                           SRR3476690.665194.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2153031, SAMEA2153733
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000596251.6/ ENSP00000471512.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                DC337066.1         116-131
            17-821              BC027930.1         1-805
            822-891             AF443591.1         738-807
            892-1883            BC027930.1         876-1867
            1884-1905           AA635978.1         6-27                c
FEATURES             Location/Qualifiers
     source          1..1905
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.2"
     gene            1..1905
                     /gene="DEDD2"
                     /gene_synonym="FLAME-3; FLAME3"
                     /note="death effector domain containing 2"
                     /db_xref="GeneID:162989"
                     /db_xref="HGNC:HGNC:24450"
                     /db_xref="MIM:617078"
     exon            1..46
                     /gene="DEDD2"
                     /gene_synonym="FLAME-3; FLAME3"
                     /inference="alignment:Splign:2.1.0"
     exon            47..412
                     /gene="DEDD2"
                     /gene_synonym="FLAME-3; FLAME3"
                     /inference="alignment:Splign:2.1.0"
     CDS             85..1065
                     /gene="DEDD2"
                     /gene_synonym="FLAME-3; FLAME3"
                     /note="isoform 1 is encoded by transcript variant 1;
                     DNA-binding death effector domain-containing protein 2;
                     FADD-like anti-apoptotic molecule 3; DED-containing
                     protein FLAME-3"
                     /codon_start=1
                     /product="DNA-binding death effector domain-containing
                     protein 2 isoform 1"
                     /protein_id="NP_579874.1"
                     /db_xref="CCDS:CCDS12597.1"
                     /db_xref="GeneID:162989"
                     /db_xref="HGNC:HGNC:24450"
                     /db_xref="MIM:617078"
                     /translation="MALSGSTPAPCWEEDECLDYYGMLSLHRMFEVVGGQLTECELEL
                     LAFLLDEAPGAAGGLARARSGLELLLELERRGQCDESNLRLLGQLLRVLARHDLLPHL
                     ARKRRRPVSPERYSYGTSSSSKRTEGSCRRRRQSSSSANSQQGQWETGSPPTKRQRRS
                     RGRPSGGARRRRRGAPAAPQQQSEPARPSSEGKVTCDIRLRVRAEYCEHGPALEQGVA
                     SRRPQALARQLDVFGQATAVLRSRDLGSVVCDIKFSELSYLDAFWGDYLSGALLQALR
                     GVFLTEALREAVGREAVRLLVSVDEADYEAGRRRLLLMEEEGGRRPTEAS"
     exon            413..532
                     /gene="DEDD2"
                     /gene_synonym="FLAME-3; FLAME3"
                     /inference="alignment:Splign:2.1.0"
     exon            533..673
                     /gene="DEDD2"
                     /gene_synonym="FLAME-3; FLAME3"
                     /inference="alignment:Splign:2.1.0"
     exon            674..1905
                     /gene="DEDD2"
                     /gene_synonym="FLAME-3; FLAME3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1873..1878
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DEDD2"
                     /gene_synonym="FLAME-3; FLAME3"
                     /note="hexamer: ATTAAA"
     polyA_site      1905
                     /gene="DEDD2"
                     /gene_synonym="FLAME-3; FLAME3"
                     /note="major polyA site"
ORIGIN      
        1 aagtggctgc ggccgtcgcc caggagtcat cggacgccag aatctggccg ggttctgagc
       61 ttgttccgcc tccctccccc gggaatggcg ctatccgggt cgaccccggc cccgtgctgg
      121 gaggaggatg agtgcctgga ctactacggg atgctgtcgc ttcaccgtat gttcgaggtg
      181 gtgggcgggc aactgaccga gtgcgagctg gagctcctgg cctttctgct ggatgaggct
      241 cctggcgccg ccggaggctt agcccgggcc cgcagcggcc tagagctcct gctggagctg
      301 gagcgccgcg ggcagtgcga cgagagcaac ctgcggctgc tggggcaact cctgcgcgtg
      361 ctggcccgcc acgacctgct gccgcacctg gcgcgcaagc ggcgccggcc agtgtctcca
      421 gaacgctata gctatggcac ctccagctct tcaaagagga cagagggtag ctgccgtcgc
      481 cgtcggcagt caagcagttc tgcaaattct cagcagggtc agtgggagac aggctccccc
      541 ccaaccaagc ggcagcggcg gagtcggggc cggcccagtg gtggtgccag acggcggcgg
      601 agaggggccc cagccgcacc ccagcagcag tcagagcccg ccagaccttc ctctgaaggc
      661 aaagtgacct gtgacatccg gctccgggtt cgagcagagt actgcgagca tgggccagcc
      721 ttggagcagg gcgtggcatc ccggcggccc caggcgctgg cgcggcagct ggacgtgttt
      781 gggcaggcca ccgcagtgct gcgctcaagg gacctgggct ctgtggtttg tgacatcaag
      841 ttctcagagc tctcctatct ggacgccttc tggggcgact acctgagtgg cgccctgctg
      901 caggccctgc ggggcgtgtt cctgactgag gccctgcgag aggctgtggg ccgggaggct
      961 gttcgcctgc tggtcagtgt ggatgaggct gactatgagg ctggccggcg ccgcctgttg
     1021 ctgatggagg aggaaggggg gcggcgcccg acagaggcct cctgatccag gactggcagg
     1081 attgatccca cctccaagtc tccgggccac cttctcctgg gaggacgacc atctctaccc
     1141 ctagaggact gtcactctag catctttgag gactgcgaca ggaccgggac agcaggcccc
     1201 ttgacagccc ctcccacagg atgtgggctc tgaggcctaa accatttcca gctgagtttc
     1261 cttcccagac tcctcctacc cccaggtgtg cccccttagc ctccggaggc gggggctggg
     1321 cctgtatctc agaagggagg ggcacagcta cacactcacc aaaggccccc ctgcacattg
     1381 tatctctgat cttgggctgt ctgcactgtc acaggtgcac acactcgctc atgctcacac
     1441 tgcccctgct gagatcttcc ctgggcctct gccctggcct gcttcccagc acacacttct
     1501 ttggcctaag ggcttctctc tcaggacctc taatttgacc acaaccaacc tgggcttcag
     1561 ccacatcagt gggcactgga gctggggtgc acatggggcc tgctcacctt gcccacacat
     1621 ctccagccag ccagggccct gcccagcttc aatttacaga cctgactctc ctcaccttcc
     1681 cccctgctgt ccagagctga acatagactt gcacttggat gtcacctgga gtgtcacatg
     1741 ggagtgttat ggcagcatca taccaaggcc tactgttgca catggggcca aaaccagtaa
     1801 acagccacct tcttggaaag ggaatgcaaa ggctttgggg gtgatggaaa agacctttta
     1861 caaatgatac caattaaact gccctggaaa gggcataggt gggca
//
