LOCUS       NM_032998               2344 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens death effector domain containing (DEDD), transcript
            variant 1, mRNA.
ACCESSION   NM_032998
VERSION     NM_032998.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2344)
  AUTHORS   Hong,A.L., Guerriero,J.L., Doshi,M.B., Kynnap,B.D., Kim,W.J.,
            Schinzel,A.C., Modiste,R., Schlauch,A.J., Adam,R.M.,
            Kwiatkowski,D.J., Beroukhim,R., Letai,A., Rosenberg,J.E. and
            Hahn,W.C.
  TITLE     MCL1 and DEDD Promote Urothelial Carcinoma Progression
  JOURNAL   Mol Cancer Res 17 (6), 1294-1304 (2019)
   PUBMED   30777879
  REMARK    GeneRIF: Identify MCL1 and DEDD as genes that contribute to
            aggressive urothelial carcinomas.
REFERENCE   2  (bases 1 to 2344)
  AUTHORS   Wu,D.M., Hong,X.W., Wang,L.L., Cui,X.F., Lu,J., Chen,G.Q. and
            Zheng,Y.L.
  TITLE     MicroRNA-17 inhibition overcomes chemoresistance and suppresses
            epithelial-mesenchymal transition through a DEDD-dependent
            mechanism in gastric cancer
  JOURNAL   Int J Biochem Cell Biol 102, 59-70 (2018)
   PUBMED   29953965
  REMARK    GeneRIF: MicroRNA-17 inhibition overcomes chemoresistance and
            suppresses epithelial-mesenchymal transition through a
            DEDD-dependent mechanism in gastric cancer
REFERENCE   3  (bases 1 to 2344)
  AUTHORS   Yu,G., Jia,Z. and Dou,Z.
  TITLE     miR-24-3p regulates bladder cancer cell proliferation, migration,
            invasion and autophagy by targeting DEDD
  JOURNAL   Oncol Rep 37 (2), 1123-1131 (2017)
   PUBMED   28000900
  REMARK    GeneRIF: DEDD protein role in cell proliferation and migration of
            bladder cancer
REFERENCE   4  (bases 1 to 2344)
  AUTHORS   Lv,Q., Wang,W., Xue,J., Hua,F., Mu,R., Lin,H., Yan,J., Lv,X.,
            Chen,X. and Hu,Z.W.
  TITLE     DEDD interacts with PI3KC3 to activate autophagy and attenuate
            epithelial-mesenchymal transition in human breast cancer
  JOURNAL   Cancer Res 72 (13), 3238-3250 (2012)
   PUBMED   22719072
  REMARK    GeneRIF: Via direct interaction with the class III PI-3-kinase
            (PI3KC3)/Beclin1, DEDD activated autophagy and induced the
            degradation of Snail and Twist, two master regulators of EMT
REFERENCE   5  (bases 1 to 2344)
  AUTHORS   Miyamoto-Sato,E., Fujimori,S., Ishizaka,M., Hirai,N., Masuoka,K.,
            Saito,R., Ozawa,Y., Hino,K., Washio,T., Tomita,M., Yamashita,T.,
            Oshikubo,T., Akasaka,H., Sugiyama,J., Matsumoto,Y. and Yanagawa,H.
  TITLE     A comprehensive resource of interacting protein regions for
            refining human transcription factor networks
  JOURNAL   PLoS One 5 (2), e9289 (2010)
   PUBMED   20195357
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2344)
  AUTHORS   Zhan,Y., Hegde,R., Srinivasula,S.M., Fernandes-Alnemri,T. and
            Alnemri,E.S.
  TITLE     Death effector domain-containing proteins DEDD and FLAME-3 form
            nuclear complexes with the TFIIIC102 subunit of human transcription
            factor IIIC
  JOURNAL   Cell Death Differ 9 (4), 439-447 (2002)
   PUBMED   11965497
  REMARK    GeneRIF: DEDD forms nuclear complexes with the TFIIIC102 subunit of
            human transcription factor IIIC
REFERENCE   7  (bases 1 to 2344)
  AUTHORS   Roth,W., Stenner-Liewen,F., Pawlowski,K., Godzik,A. and Reed,J.C.
  TITLE     Identification and characterization of DEDD2, a death effector
            domain-containing protein
  JOURNAL   J Biol Chem 277 (9), 7501-7508 (2002)
   PUBMED   11741985
REFERENCE   8  (bases 1 to 2344)
  AUTHORS   Schickling,O., Stegh,A.H., Byrd,J. and Peter,M.E.
  TITLE     Nuclear localization of DEDD leads to caspase-6 activation through
            its death effector domain and inhibition of RNA polymerase I
            dependent transcription
  JOURNAL   Cell Death Differ 8 (12), 1157-1168 (2001)
   PUBMED   11753564
REFERENCE   9  (bases 1 to 2344)
  AUTHORS   Leo,C.P., Hsu,S.Y., McGee,E.A., Salanova,M. and Hsueh,A.J.
  TITLE     DEFT, a novel death effector domain-containing molecule
            predominantly expressed in testicular germ cells
  JOURNAL   Endocrinology 139 (12), 4839-4848 (1998)
   PUBMED   9832420
REFERENCE   10 (bases 1 to 2344)
  AUTHORS   Stegh,A.H., Schickling,O., Ehret,A., Scaffidi,C., Peterhansel,C.,
            Hofmann,T.G., Grummt,I., Krammer,P.H. and Peter,M.E.
  TITLE     DEDD, a novel death effector domain-containing protein, targeted to
            the nucleolus
  JOURNAL   EMBO J 17 (20), 5974-5986 (1998)
   PUBMED   9774341
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL591806.16 and BC013910.2.
            
            On Nov 22, 2018 this sequence version replaced NM_032998.2.
            
            Summary: This gene encodes a protein that contains a death effector
            domain (DED). DED is a protein-protein interaction domain shared by
            adaptors, regulators and executors of the programmed cell death
            pathway. Overexpression of this gene was shown to induce weak
            apoptosis. Upon stimulation, this protein was found to translocate
            from cytoplasm to nucleus and colocalize with UBTF, a basal factor
            required for RNA polymerase I transcription, in the nucleolus. At
            least three transcript variants encoding the same protein have been
            found for this gene. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) uses an alternate in-frame
            splice junction compared to variant 5. The resulting isoform (b)
            has the same N- and C-termini but is shorter compared to isoform a.
            Variants 1, 3, and 4 all encode the same isoform (b).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.129837.1,
                                           SRR1660809.54455.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000368006.8/ ENSP00000356985.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-117               AL591806.16        186553-186669       c
            118-1987            BC013910.2         119-1988
            1988-2341           AL591806.16        174979-175332       c
            2342-2344           AL591806.16        174976-174978       c
FEATURES             Location/Qualifiers
     source          1..2344
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q23.3"
     gene            1..2344
                     /gene="DEDD"
                     /gene_synonym="CASP8IP1; DEDD1; DEDPro1; DEFT; FLDED-1;
                     FLDED1; KE05"
                     /note="death effector domain containing"
                     /db_xref="GeneID:9191"
                     /db_xref="HGNC:HGNC:2755"
                     /db_xref="MIM:606841"
     exon            1..117
                     /gene="DEDD"
                     /gene_synonym="CASP8IP1; DEDD1; DEDPro1; DEFT; FLDED-1;
                     FLDED1; KE05"
                     /inference="alignment:Splign:2.1.0"
     exon            118..150
                     /gene="DEDD"
                     /gene_synonym="CASP8IP1; DEDD1; DEDPro1; DEFT; FLDED-1;
                     FLDED1; KE05"
                     /inference="alignment:Splign:2.1.0"
     exon            151..539
                     /gene="DEDD"
                     /gene_synonym="CASP8IP1; DEDD1; DEDPro1; DEFT; FLDED-1;
                     FLDED1; KE05"
                     /inference="alignment:Splign:2.1.0"
     CDS             215..1171
                     /gene="DEDD"
                     /gene_synonym="CASP8IP1; DEDD1; DEDPro1; DEFT; FLDED-1;
                     FLDED1; KE05"
                     /note="isoform b is encoded by transcript variant 1; death
                     effector domain-containing protein; death effector
                     domain-containing testicular molecule"
                     /codon_start=1
                     /product="death effector domain-containing protein isoform
                     b"
                     /protein_id="NP_127491.1"
                     /db_xref="CCDS:CCDS1219.1"
                     /db_xref="GeneID:9191"
                     /db_xref="HGNC:HGNC:2755"
                     /db_xref="MIM:606841"
                     /translation="MAGLKRRASQVWPEEHGEQEHGLYSLHRMFDIVGTHLTHRDVRV
                     LSFLFVDVIDDHERGLIRNGRDFLLALERQGRCDESNFRQVLQLLRIITRHDLLPYVT
                     LKRRRAVCPDLVDKYLEETSIRYVTPRALSDPEPRPPQPSKTVPPHYPVVCCPTSGPQ
                     MCSKRPARGRATLGSQRKRRKSVTPDPKEKQTCDIRLRVRAEYCQHETALQGNVFSNK
                     QDPLERQFERFNQANTILKSRDLGSIICDIKFSELTYLDAFWRDYINGSLLEALKGVF
                     ITDSLKQAVGHEAIKLLVNVDEEDYELGRQKLLRNLMLQALP"
     exon            540..647
                     /gene="DEDD"
                     /gene_synonym="CASP8IP1; DEDD1; DEDPro1; DEFT; FLDED-1;
                     FLDED1; KE05"
                     /inference="alignment:Splign:2.1.0"
     exon            648..794
                     /gene="DEDD"
                     /gene_synonym="CASP8IP1; DEDD1; DEDPro1; DEFT; FLDED-1;
                     FLDED1; KE05"
                     /inference="alignment:Splign:2.1.0"
     exon            795..2344
                     /gene="DEDD"
                     /gene_synonym="CASP8IP1; DEDD1; DEDPro1; DEFT; FLDED-1;
                     FLDED1; KE05"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1649..1654
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DEDD"
                     /gene_synonym="CASP8IP1; DEDD1; DEDPro1; DEFT; FLDED-1;
                     FLDED1; KE05"
                     /note="hexamer: ATTATA"
     polyA_site      1671
                     /gene="DEDD"
                     /gene_synonym="CASP8IP1; DEDD1; DEDPro1; DEFT; FLDED-1;
                     FLDED1; KE05"
                     /note="major polyA site"
     regulatory      1968..1973
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DEDD"
                     /gene_synonym="CASP8IP1; DEDD1; DEDPro1; DEFT; FLDED-1;
                     FLDED1; KE05"
                     /note="hexamer: AATAAA"
     polyA_site      1987
                     /gene="DEDD"
                     /gene_synonym="CASP8IP1; DEDD1; DEDPro1; DEFT; FLDED-1;
                     FLDED1; KE05"
                     /note="major polyA site"
     regulatory      2320..2325
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DEDD"
                     /gene_synonym="CASP8IP1; DEDD1; DEDPro1; DEFT; FLDED-1;
                     FLDED1; KE05"
                     /note="hexamer: AATAAA"
     polyA_site      2344
                     /gene="DEDD"
                     /gene_synonym="CASP8IP1; DEDD1; DEDPro1; DEFT; FLDED-1;
                     FLDED1; KE05"
ORIGIN      
        1 acggccgcgg cggcggcggc ggcggcggct gctggagccc ggatgcggcg ccgtgaggca
       61 ggcccgggag agcggcgcgg atggatccaa catggcggcg ccgagcctga gccgagagaa
      121 gagacctggg aaattaagtt tcttgcggag tacggtgggg attgcagctg ctgagcaggg
      181 attctggaaa gcattgcgta cctgagcccc cagcatggcg ggcctaaagc ggcgggcaag
      241 ccaggtgtgg ccagaagagc atggtgagca ggaacatggg ctgtacagcc tgcaccgcat
      301 gtttgacatc gtgggcactc atctgacaca cagagatgtg cgcgtgcttt ctttcctctt
      361 tgttgatgtc attgatgacc acgagcgtgg actcatccga aatggacgtg acttcttatt
      421 ggcactggag cgccagggcc gctgtgatga aagtaacttt cgccaggtgc tgcagctgct
      481 gcgcatcatc actcgccacg acctgctgcc ctacgtcacc ctcaagagga gacgggctgt
      541 gtgccctgat cttgtagaca agtatctgga ggagacatca attcgctatg tgacccccag
      601 agccctcagt gatccagaac caaggcctcc ccagccctct aaaacagtgc ctccccacta
      661 tcctgtggtg tgttgcccca cttcgggtcc tcagatgtgt agcaagcggc cagcccgagg
      721 gagagccaca cttgggagcc agcgaaaacg ccggaagtca gtgacaccag atcccaagga
      781 gaagcagaca tgtgacatca gactgcgggt tcgggctgaa tactgccagc atgagactgc
      841 tctgcagggc aatgtcttct ctaacaagca ggacccactt gagcgccagt ttgagcgctt
      901 taaccaggcc aacaccatcc tcaagtcccg ggacctgggc tccatcatct gtgacatcaa
      961 gttctctgag ctcacctacc tcgatgcatt ctggcgtgac tacatcaatg gctctttatt
     1021 agaggcactt aaaggtgtct tcatcacaga ctccctcaag caagctgtgg gccatgaagc
     1081 catcaagctg ctggtaaatg tagacgagga ggactatgag ctgggccgac agaaactcct
     1141 gaggaacttg atgctgcaag cattgccctg acctattccc tcttctcact ttggggactg
     1201 ttcccatcac ccacctctgg agcttacact gttctggggt ttgttctcta cccttccaac
     1261 caatcacacc cctgcctttt tttttttttt tttaaagaaa aagacaaaag aaagtggaag
     1321 tggtattccc cacccctccc tgcacccatg tgcctgggct tcccctttat ttcccttttc
     1381 catttacccc gtaatgtgtc tctacagcta ccttaccact gagccgtaag acaaatgtat
     1441 aggaagaagc aaagtctaca gcacatagtc tttgtaaggg attgatgtga acactttttt
     1501 ttggatgcac taaggagtta tcaatacttc tggctttatg agagctctta aattttgtct
     1561 aaaaaaccaa agggctgtga gtaagggagc tatgtggaaa gtgggactct gaagtgtatt
     1621 ttgaaaatta atcgccaccc tcttccaaat tatagaattt tttaaaaaca agctgtggcc
     1681 ctttccactc tctcctggcc tctggtgctg ctcctctctg ccgcctttcc tccattccat
     1741 ggcttgaaac ctctgcctga tgtggctcct tcctttttcc catttgtcaa accctcttca
     1801 aaggaggaac agataagact gggtcagcct agtcatgcct cccaactgtg gtggtatatg
     1861 tgtacacaca tacacagggt ggatggagaa gaggttgctg attaaaatac actcccccta
     1921 taaaggggaa gggggagtgt gacactttct ttccatgttc aagtgaaaat aaataatgta
     1981 ccctgcagcc cttttcccct ttgctttctt ctggcttggg caaagggcat cataggtgta
     2041 agtgaagtaa ttcctttttc cttccccctc ctccactcct acgcccactc ccatgcttgg
     2101 gagaatgggg ctgggacatg cactgagtgt tgcactttta tttaggtagg gaggcatgtt
     2161 gaatgagcca ggaggtctag aactggagct tagtccagct ggtacaatac caactcccct
     2221 tctagttccc aaaggcgatg tccagacaca gactttatga ttattatatt tttcaatgcc
     2281 agtgctgctc agccctcagc agaacttcag tttccatgaa ataaacaatg actatataaa
     2341 attc
//
