LOCUS       NM_020664               1551 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens 2,4-dienoyl-CoA reductase 2 (DECR2), mRNA.
ACCESSION   NM_020664
VERSION     NM_020664.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1551)
  AUTHORS   Mah,C.Y., Nguyen,A.D.T., Niijima,T., Helm,M., Dehairs,J.,
            Ryan,F.J., Ryan,N., Quek,L.E., Hoy,A.J., Don,A.S., Mills,I.G.,
            Swinnen,J.V., Lynn,D.J., Nassar,Z.D. and Butler,L.M.
  TITLE     Peroxisomal beta-oxidation enzyme, DECR2, regulates lipid
            metabolism and promotes treatment resistance in advanced prostate
            cancer
  JOURNAL   Br J Cancer 130 (5), 741-754 (2024)
   PUBMED   38216720
  REMARK    GeneRIF: Peroxisomal beta-oxidation enzyme, DECR2, regulates lipid
            metabolism and promotes treatment resistance in advanced prostate
            cancer.
REFERENCE   2  (bases 1 to 1551)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 1551)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1551)
  AUTHORS   Ghosh,D. and Berg,J.M.
  TITLE     A proteome-wide perspective on peroxisome targeting signal
            1(PTS1)-Pex5p affinities
  JOURNAL   J Am Chem Soc 132 (11), 3973-3979 (2010)
   PUBMED   20178365
REFERENCE   5  (bases 1 to 1551)
  AUTHORS   Persson,B., Kallberg,Y., Bray,J.E., Bruford,E., Dellaporta,S.L.,
            Favia,A.D., Duarte,R.G., Jornvall,H., Kavanagh,K.L., Kedishvili,N.,
            Kisiela,M., Maser,E., Mindnich,R., Orchard,S., Penning,T.M.,
            Thornton,J.M., Adamski,J. and Oppermann,U.
  TITLE     The SDR (short-chain dehydrogenase/reductase and related enzymes)
            nomenclature initiative
  JOURNAL   Chem Biol Interact 178 (1-3), 94-98 (2009)
   PUBMED   19027726
REFERENCE   6  (bases 1 to 1551)
  AUTHORS   Martin,J., Han,C., Gordon,L.A., Terry,A., Prabhakar,S., She,X.,
            Xie,G., Hellsten,U., Chan,Y.M., Altherr,M., Couronne,O., Aerts,A.,
            Bajorek,E., Black,S., Blumer,H., Branscomb,E., Brown,N.C.,
            Bruno,W.J., Buckingham,J.M., Callen,D.F., Campbell,C.S.,
            Campbell,M.L., Campbell,E.W., Caoile,C., Challacombe,J.F.,
            Chasteen,L.A., Chertkov,O., Chi,H.C., Christensen,M., Clark,L.M.,
            Cohn,J.D., Denys,M., Detter,J.C., Dickson,M.,
            Dimitrijevic-Bussod,M., Escobar,J., Fawcett,J.J., Flowers,D.,
            Fotopulos,D., Glavina,T., Gomez,M., Gonzales,E., Goodstein,D.,
            Goodwin,L.A., Grady,D.L., Grigoriev,I., Groza,M., Hammon,N.,
            Hawkins,T., Haydu,L., Hildebrand,C.E., Huang,W., Israni,S.,
            Jett,J., Jewett,P.B., Kadner,K., Kimball,H., Kobayashi,A.,
            Krawczyk,M.C., Leyba,T., Longmire,J.L., Lopez,F., Lou,Y., Lowry,S.,
            Ludeman,T., Manohar,C.F., Mark,G.A., McMurray,K.L., Meincke,L.J.,
            Morgan,J., Moyzis,R.K., Mundt,M.O., Munk,A.C., Nandkeshwar,R.D.,
            Pitluck,S., Pollard,M., Predki,P., Parson-Quintana,B., Ramirez,L.,
            Rash,S., Retterer,J., Ricke,D.O., Robinson,D.L., Rodriguez,A.,
            Salamov,A., Saunders,E.H., Scott,D., Shough,T., Stallings,R.L.,
            Stalvey,M., Sutherland,R.D., Tapia,R., Tesmer,J.G., Thayer,N.,
            Thompson,L.S., Tice,H., Torney,D.C., Tran-Gyamfi,M., Tsai,M.,
            Ulanovsky,L.E., Ustaszewska,A., Vo,N., White,P.S., Williams,A.L.,
            Wills,P.L., Wu,J.R., Wu,K., Yang,J., Dejong,P., Bruce,D.,
            Doggett,N.A., Deaven,L., Schmutz,J., Grimwood,J., Richardson,P.,
            Rokhsar,D.S., Eichler,E.E., Gilna,P., Lucas,S.M., Myers,R.M.,
            Rubin,E.M. and Pennacchio,L.A.
  TITLE     The sequence and analysis of duplication-rich human chromosome 16
  JOURNAL   Nature 432 (7020), 988-994 (2004)
   PUBMED   15616553
REFERENCE   7  (bases 1 to 1551)
  AUTHORS   De Nys,K., Meyhi,E., Mannaerts,G.P., Fransen,M. and Van
            Veldhoven,P.P.
  TITLE     Characterisation of human peroxisomal 2,4-dienoyl-CoA reductase
  JOURNAL   Biochim Biophys Acta 1533 (1), 66-72 (2001)
   PUBMED   11514237
REFERENCE   8  (bases 1 to 1551)
  AUTHORS   Daniels,R.J., Peden,J.F., Lloyd,C., Horsley,S.W., Clark,K.,
            Tufarelli,C., Kearney,L., Buckle,V.J., Doggett,N.A., Flint,J. and
            Higgs,D.R.
  TITLE     Sequence, structure and pathology of the fully annotated terminal 2
            Mb of the short arm of human chromosome 16
  JOURNAL   Hum Mol Genet 10 (4), 339-352 (2001)
   PUBMED   11157797
REFERENCE   9  (bases 1 to 1551)
  AUTHORS   Das,A.K., Uhler,M.D. and Hajra,A.K.
  TITLE     Molecular cloning and expression of mammalian peroxisomal
            trans-2-enoyl-coenzyme A reductase cDNAs
  JOURNAL   J Biol Chem 275 (32), 24333-24340 (2000)
   PUBMED   10811639
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC010740.1 and BC030226.1.
            
            On Nov 22, 2018 this sequence version replaced NM_020664.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.814114.1, BC010740.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000219481.10/ ENSP00000219481.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-750               BC010740.1         14-763
            751-755             BC030226.1         933-937
            756-1551            BC010740.1         769-1564
FEATURES             Location/Qualifiers
     source          1..1551
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.3"
     gene            1..1551
                     /gene="DECR2"
                     /gene_synonym="PDCR; SDR17C1"
                     /note="2,4-dienoyl-CoA reductase 2"
                     /db_xref="GeneID:26063"
                     /db_xref="HGNC:HGNC:2754"
                     /db_xref="MIM:615839"
     exon            1..159
                     /gene="DECR2"
                     /gene_synonym="PDCR; SDR17C1"
                     /inference="alignment:Splign:2.1.0"
     CDS             80..958
                     /gene="DECR2"
                     /gene_synonym="PDCR; SDR17C1"
                     /EC_number="1.3.1.124"
                     /note="peroxisomal 2,4-dienoyl-CoA reductase; short chain
                     dehydrogenase/reductase family 17C member 1;
                     2,4-dienoyl-CoA reductase 2, peroxisomal"
                     /codon_start=1
                     /product="peroxisomal 2,4-dienoyl-CoA reductase
                     [(3E)-enoyl-CoA-producing]"
                     /protein_id="NP_065715.1"
                     /db_xref="CCDS:CCDS10409.1"
                     /db_xref="GeneID:26063"
                     /db_xref="HGNC:HGNC:2754"
                     /db_xref="MIM:615839"
                     /translation="MAQPPPDVEGDDCLPAYRHLFCPDLLRDKVAFITGGGSGIGFRI
                     AEIFMRHGCHTVIASRSLPRVLTAARKLAGATGRRCLPLSMDVRAPPAVMAAVDQALK
                     EFGRIDILINCAAGNFLCPAGALSFNAFKTVMDIDTSGTFNVSRVLYEKFFRDHGGVI
                     VNITATLGNRGQALQVHAGSAKAAVDAMTRHLAVEWGPQNIRVNSLAPGPISGTEGLR
                     RLGGPQASLSTKVTASPLQRLGNKTEIAHSVLYLASPLASYVTGAVLVADGGAWLTFP
                     NGVKGLPDFASFSAKL"
     exon            160..228
                     /gene="DECR2"
                     /gene_synonym="PDCR; SDR17C1"
                     /inference="alignment:Splign:2.1.0"
     exon            229..280
                     /gene="DECR2"
                     /gene_synonym="PDCR; SDR17C1"
                     /inference="alignment:Splign:2.1.0"
     exon            281..416
                     /gene="DECR2"
                     /gene_synonym="PDCR; SDR17C1"
                     /inference="alignment:Splign:2.1.0"
     exon            417..541
                     /gene="DECR2"
                     /gene_synonym="PDCR; SDR17C1"
                     /inference="alignment:Splign:2.1.0"
     exon            542..635
                     /gene="DECR2"
                     /gene_synonym="PDCR; SDR17C1"
                     /inference="alignment:Splign:2.1.0"
     exon            636..740
                     /gene="DECR2"
                     /gene_synonym="PDCR; SDR17C1"
                     /inference="alignment:Splign:2.1.0"
     exon            741..958
                     /gene="DECR2"
                     /gene_synonym="PDCR; SDR17C1"
                     /inference="alignment:Splign:2.1.0"
     exon            959..1551
                     /gene="DECR2"
                     /gene_synonym="PDCR; SDR17C1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1486..1491
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DECR2"
                     /gene_synonym="PDCR; SDR17C1"
                     /note="hexamer: AATAAA"
     polyA_site      1522
                     /gene="DECR2"
                     /gene_synonym="PDCR; SDR17C1"
     regulatory      1531..1536
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DECR2"
                     /gene_synonym="PDCR; SDR17C1"
                     /note="hexamer: ATTAAA"
     polyA_site      1551
                     /gene="DECR2"
                     /gene_synonym="PDCR; SDR17C1"
                     /note="major polyA site"
ORIGIN      
        1 gagttcgcag ctgcgcgccg ggtcctggag gccgaggccg ctcccgcccg ttgtccccgc
       61 agtccccgac gggagcgcca tggcccagcc gccgcccgac gtggaggggg acgactgtct
      121 ccccgcgtac cgccacctct tctgcccgga cctgctgcgg gacaaagtgg ccttcatcac
      181 aggaggcggc tctgggattg ggttccggat tgctgagatt ttcatgcggc acggctgcca
      241 tacggtgatt gccagtagga gcctgccgcg agtgctgacg gccgccagga agctggctgg
      301 ggccaccggc cggcgctgcc tccctctctc tatggacgtc cgagcgcccc cagctgtcat
      361 ggccgccgtg gaccaggctc tgaaggagtt tggcagaatc gacattctca ttaactgtgc
      421 ggccgggaac ttcctgtgcc ccgctggcgc cttgtccttc aacgccttca agaccgtgat
      481 ggacatcgat accagcggca ccttcaatgt gtctcgtgtg ctctatgaga agttcttccg
      541 ggaccacgga ggggtgatcg tgaacatcac tgccaccctg gggaaccggg ggcaggcgct
      601 ccaggtgcat gcaggctccg ccaaggccgc tgtggacgcg atgacgcggc acttggctgt
      661 ggagtggggt ccccaaaaca tccgcgtcaa cagcctcgcc cctggcccca tcagtggcac
      721 agaggggctc cggcgactgg gtggccctca ggccagcctg agcaccaagg tcactgccag
      781 cccgctgcag aggctgggga acaagaccga gatcgcccac agcgtgctct acctggccag
      841 ccctctggct tcctacgtga cgggggccgt gctggtggcc gatggcgggg catggttgac
      901 gttcccaaac ggtgtcaaag ggctgccgga tttcgcatcc ttctctgcta agctctagga
      961 atcttccggc cgctgcttcc tgccgcctca ctcagccagg tggagagcac caatctgaac
     1021 cagcaatgcc tgcagcccag cccctcctct gaacactcag ctattactgc gctttccctc
     1081 cccacggccc caactccagg gcaggagcaa ctggacagtg ggcctggccc gtggagctgc
     1141 cacgcaggtg cctgagggcc aggtgccacg caggtgtctg aggaccaggt gccacgcagg
     1201 tggtgggggt acagacaaga tgctgggatg tcccctgccc catggtcaag ggtgtcctgc
     1261 ctgcctgggt ccagggcctg agggagccac atggatcccg agacttgtgt tctcttggct
     1321 gaaaacactg aggtgctccc atctgtgcgt ggcccatgag ctgggatggt cctccagctg
     1381 cccacaaggt ccgcccctct gtctctgcac cacctgtttg cataaacaca ctttgctaca
     1441 atcttgctag tgcgttttct taaaagataa tctatttact gtaaaaataa attggacttt
     1501 gcaaaagctt ttagaaggaa aagaaagagg attaaagaga attgctggtg a
//
