LOCUS       NM_001359               2760 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens 2,4-dienoyl-CoA reductase 1 (DECR1), transcript
            variant 1, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001359
VERSION     NM_001359.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2760)
  AUTHORS   Guo,S., Jiang,H., Deng,Y., Dong,Y., Yin,A., Wang,Q., Lan,Q.,
            Zhang,Y. and Xu,C.
  TITLE     Reduced 2,4-dienoyl-CoA reductase 1 is served as an unfavorable
            biomarker and is related to immune infiltration in cervical cancer
  JOURNAL   J Obstet Gynaecol Res 49 (10), 2475-2486 (2023)
   PUBMED   37497824
  REMARK    GeneRIF: Reduced 2,4-dienoyl-CoA reductase 1 is served as an
            unfavorable biomarker and is related to immune infiltration in
            cervical cancer.
REFERENCE   2  (bases 1 to 2760)
  AUTHORS   Zhou,H., Zhang,J., Yan,Z., Qu,M., Zhang,G., Han,J., Wang,F.,
            Sun,K., Wang,L. and Yang,X.
  TITLE     DECR1 directly activates HSL to promote lipolysis in cervical
            cancer cells
  JOURNAL   Biochim Biophys Acta Mol Cell Biol Lipids 1867 (3), 159090 (2022)
   PUBMED   34896618
  REMARK    GeneRIF: DECR1 directly activates HSL to promote lipolysis in
            cervical cancer cells.
REFERENCE   3  (bases 1 to 2760)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   4  (bases 1 to 2760)
  AUTHORS   Fang,J., Sheng,R. and Qin,Z.H.
  TITLE     NADPH Oxidases in the Central Nervous System: Regional and Cellular
            Localization and the Possible Link to Brain Diseases
  JOURNAL   Antioxid Redox Signal 35 (12), 951-973 (2021)
   PUBMED   34293949
  REMARK    GeneRIF: NADPH Oxidases in the Central Nervous System: Regional and
            Cellular Localization and the Possible Link to Brain Diseases.
            Review article
REFERENCE   5  (bases 1 to 2760)
  AUTHORS   Santos,C.G.M., Rolim-Filho,N.G., Domingues,C.A.,
            Dornelas-Ribeiro,M., King,J.L., Budowle,B., Moura-Neto,R.S. and
            Silva,R.
  TITLE     Association of whole mtDNA, an NADPH G11914A variant, and
            haplogroups with high physical performance in an elite military
            troop
  JOURNAL   Braz J Med Biol Res 54 (6), e10317 (2021)
   PUBMED   33909855
  REMARK    GeneRIF: Association of whole mtDNA, an NADPH G11914A variant, and
            haplogroups with high physical performance in an elite military
            troop.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2760)
  AUTHORS   Koivuranta,K.T., Hakkola,E.H. and Hiltunen,J.K.
  TITLE     Isolation and characterization of cDNA for human 120 kDa
            mitochondrial 2,4-dienoyl-coenzyme A reductase
  JOURNAL   Biochem J 304 (Pt 3) (Pt 3), 787-792 (1994)
   PUBMED   7818482
REFERENCE   7  (bases 1 to 2760)
  AUTHORS   Luo,M.J., Smeland,T.E., Shoukry,K. and Schulz,H.
  TITLE     Delta 3,5, delta 2,4-dienoyl-CoA isomerase from rat liver
            mitochondria. Purification and characterization of a new enzyme
            involved in the beta-oxidation of unsaturated fatty acids
  JOURNAL   J Biol Chem 269 (4), 2384-2388 (1994)
   PUBMED   8300563
REFERENCE   8  (bases 1 to 2760)
  AUTHORS   Smeland,T.E., Nada,M., Cuebas,D. and Schulz,H.
  TITLE     NADPH-dependent beta-oxidation of unsaturated fatty acids with
            double bonds extending from odd-numbered carbon atoms
  JOURNAL   Proc Natl Acad Sci U S A 89 (15), 6673-6677 (1992)
   PUBMED   1495956
REFERENCE   9  (bases 1 to 2760)
  AUTHORS   Nishimaki-Mogami,T., Tanaka,A., Minegishi,K. and Takahashi,A.
  TITLE     Effect of sorbic acid feeding on peroxisomes and sorboyl-CoA
            metabolizing enzymes in mouse liver. Selective induction of
            2,4-dienoyl-CoA hydratase
  JOURNAL   Biochem Pharmacol 42 (2), 239-246 (1991)
   PUBMED   1859445
REFERENCE   10 (bases 1 to 2760)
  AUTHORS   Dommes,V., Baumgart,C. and Kunau,W.H.
  TITLE     Degradation of unsaturated fatty acids in peroxisomes. Existence of
            a 2,4-dienoyl-CoA reductase pathway
  JOURNAL   J Biol Chem 256 (16), 8259-8262 (1981)
   PUBMED   7263650
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC105080.1, H98841.1,
            CR737790.1, CB104585.1, AC004612.1 and AA725334.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 28, 2018 this sequence version replaced NM_001359.1.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.270996.1,
                                           SRR1660809.40469.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000220764.7/
                                                  ENSP00000220764.2
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1047              BC105080.1         73-1119
            1048-1219           H98841.1           1-172               c
            1220-1673           CR737790.1         11-464
            1674-1931           CB104585.1         206-463
            1932-2327           AC004612.1         78882-79277
            2328-2760           AA725334.1         6-438               c
FEATURES             Location/Qualifiers
     source          1..2760
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q21.3"
     gene            1..2760
                     /gene="DECR1"
                     /gene_synonym="DECR; NADPH; SDR18C1"
                     /note="2,4-dienoyl-CoA reductase 1"
                     /db_xref="GeneID:1666"
                     /db_xref="HGNC:HGNC:2753"
                     /db_xref="MIM:222745"
     exon            1..85
                     /gene="DECR1"
                     /gene_synonym="DECR; NADPH; SDR18C1"
                     /inference="alignment:Splign:2.1.0"
     CDS             17..1024
                     /gene="DECR1"
                     /gene_synonym="DECR; NADPH; SDR18C1"
                     /EC_number="1.3.1.124"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; 4-enoyl-CoA reductase; 2,4-dienoyl-CoA
                     reductase, mitochondrial; short chain
                     dehydrogenase/reductase family 18C member 1;
                     2,4-dienoyl-CoA reductase 1, mitochondrial;
                     2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing],
                     mitochondrial"
                     /codon_start=1
                     /product="2,4-dienoyl-CoA reductase
                     [(3E)-enoyl-CoA-producing], mitochondrial isoform 1
                     precursor"
                     /protein_id="NP_001350.1"
                     /db_xref="CCDS:CCDS6250.1"
                     /db_xref="GeneID:1666"
                     /db_xref="HGNC:HGNC:2753"
                     /db_xref="MIM:222745"
                     /translation="MKLPARVFFTLGSRLPCGLAPRRFFSYGTKILYQNTEALQSKFF
                     SPLQKAMLPPNSFQGKVAFITGGGTGLGKGMTTLLSSLGAQCVIASRKMDVLKATAEQ
                     ISSQTGNKVHAIQCDVRDPDMVQNTVSELIKVAGHPNIVINNAAGNFISPTERLSPNA
                     WKTITDIVLNGTAFVTLEIGKQLIKAQKGAAFLSITTIYAETGSGFVVPSASAKAGVE
                     AMSKSLAAEWGKYGMRFNVIQPGPIKTKGAFSRLDPTGTFEKEMIGRIPCGRLGTVEE
                     LANLAAFLCSDYASWINGAVIKFDGGEEVLISGEFNDLRKVTKEQWDTIEELIRKTKG
                     S"
     exon            86..288
                     /gene="DECR1"
                     /gene_synonym="DECR; NADPH; SDR18C1"
                     /inference="alignment:Splign:2.1.0"
     exon            289..346
                     /gene="DECR1"
                     /gene_synonym="DECR; NADPH; SDR18C1"
                     /inference="alignment:Splign:2.1.0"
     exon            347..433
                     /gene="DECR1"
                     /gene_synonym="DECR; NADPH; SDR18C1"
                     /inference="alignment:Splign:2.1.0"
     exon            434..581
                     /gene="DECR1"
                     /gene_synonym="DECR; NADPH; SDR18C1"
                     /inference="alignment:Splign:2.1.0"
     exon            582..681
                     /gene="DECR1"
                     /gene_synonym="DECR; NADPH; SDR18C1"
                     /inference="alignment:Splign:2.1.0"
     exon            682..754
                     /gene="DECR1"
                     /gene_synonym="DECR; NADPH; SDR18C1"
                     /inference="alignment:Splign:2.1.0"
     exon            755..901
                     /gene="DECR1"
                     /gene_synonym="DECR; NADPH; SDR18C1"
                     /inference="alignment:Splign:2.1.0"
     exon            902..964
                     /gene="DECR1"
                     /gene_synonym="DECR; NADPH; SDR18C1"
                     /inference="alignment:Splign:2.1.0"
     exon            965..2760
                     /gene="DECR1"
                     /gene_synonym="DECR; NADPH; SDR18C1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1109..1114
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DECR1"
                     /gene_synonym="DECR; NADPH; SDR18C1"
                     /note="hexamer: AATAAA"
     polyA_site      1131
                     /gene="DECR1"
                     /gene_synonym="DECR; NADPH; SDR18C1"
                     /note="major polyA site"
     regulatory      2340..2345
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DECR1"
                     /gene_synonym="DECR; NADPH; SDR18C1"
                     /note="hexamer: AATAAA"
     polyA_site      2379
                     /gene="DECR1"
                     /gene_synonym="DECR; NADPH; SDR18C1"
     regulatory      2740..2745
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DECR1"
                     /gene_synonym="DECR; NADPH; SDR18C1"
                     /note="hexamer: AATAAA"
     polyA_site      2760
                     /gene="DECR1"
                     /gene_synonym="DECR; NADPH; SDR18C1"
ORIGIN      
        1 gttctggaga ctcaacatga agctaccggc cagggttttc tttactctgg ggtcccggct
       61 gccctgtggc ctcgctcctc ggaggttttt cagttatggg acaaaaatat tatatcaaaa
      121 cactgaagct ttgcaatcta aattcttttc acctcttcaa aaagcgatgc taccacctaa
      181 tagttttcaa ggaaaagtgg cattcattac tgggggaggt actggccttg gtaaaggaat
      241 gacaactctt ctgtccagcc taggtgctca gtgcgtgata gccagccgga agatggatgt
      301 tttgaaagct accgcagaac aaatttcttc tcaaactgga aataaggttc atgcaattca
      361 gtgtgatgtg agggatcctg atatggttca aaacactgtg tcagaactga tcaaagttgc
      421 aggacatcct aatattgtga taaacaatgc agcagggaat tttatttctc ctactgaaag
      481 actttctcct aatgcttgga aaaccataac tgacatagtt ctaaatggca cagccttcgt
      541 gacactagaa attggaaaac aactaattaa agcacagaaa ggagcagcat ttctttctat
      601 tactactatc tatgctgaga ctggttcagg ttttgtagta ccaagtgctt ctgccaaagc
      661 aggtgtggaa gccatgagca agtctcttgc agctgaatgg ggtaaatatg gaatgcgatt
      721 caatgtgatt caaccagggc ctataaaaac caaaggtgcc tttagccgtc tggacccaac
      781 tggaacattt gagaaagaaa tgattggcag aattccctgt ggtcgcctgg ggactgtaga
      841 agaactcgca aatcttgctg ctttcctttg tagtgattat gcttcttgga ttaatggagc
      901 agtcattaaa tttgacggtg gagaggaagt acttatttca ggggaattca acgacctgag
      961 aaaggtcacc aaggagcagt gggacaccat agaagaactc atcaggaaga caaaaggttc
     1021 ctaagaccac tttggccttc atcttggtta cagaaaaggg aatagaaatg aaacaaatta
     1081 tctctcatct tttgactatt tcaagtctaa taaattctta attaacaaac attcattgaa
     1141 tatgtattat gtgccaggcc agtgatagcc attgtatatt caaagataaa taaaatgaaa
     1201 tatagtcctt caaaacatta aaaaaaaaaa aaggaggcat ggggagagta ggtaaaggct
     1261 cctctttacc tattgataga ggtaaaaagt acttagaagt gcagagagaa cagatctttg
     1321 tgacttggaa aatcaggaga aactcaatgg tggcggtagc atttgagtta cataatatac
     1381 tatacctata ttaatagggc ctaaaagaaa gaaattagag gatacacact aaatataata
     1441 gactttgcct ttccagtata ctttcttttc actggacttg tgaattatct tctttgggta
     1501 actcagtatt aactcaaacc tttaattttt actaggacct atttgtagcc aggcatttta
     1561 tttagtactg aataagctat agccgttgcc ctttttaaat tcattatcta gcaagatagt
     1621 caaacttata aataattatt tatgatacat tgtgataagt attattccag cagtatttaa
     1681 gtgtagagga ggaagtaatt cattctgtct ccagagtttg gagaatgtga tgcctaagag
     1741 atagcatgcc atcccagctg taaaagaaga atagatttct ctgggtaaaa gaggtaaaga
     1801 aagcctataa aatatttttg tatatcattt gattaaattt catctttggt ttgactaatt
     1861 tgtcatcctg aaaatcaaat aataatgaat ccaaagtctc aagtctacag agctatactt
     1921 ttgagcctat atttttaaaa tgtccatttt gctttcccag gagtcagtta caacatgttc
     1981 actagactga ctatccccat tgcccaagtt gacacaagag gaaaccagct tccatcttac
     2041 ctcatctgaa taaatctgcc acaagcccat ggaaacccca attaacattg acagttaatt
     2101 gtgtacataa attacattta ttacatttaa ttgtgtatat ataggggatg ttataggttt
     2161 ggaataagtg gcccaacatt tccaattata ctgactttca ctgggctttt ttttaggctg
     2221 ttgcactttt tctccacatg cttgcaatac aatactctca aaataaaacg cagacaggta
     2281 cctagtctcc attttacctt tagtactaat cctgtgtatt agtctgttct catgctgcta
     2341 ataaagacat aacccaaact gggtaattta taaaagaaag aggtttcatt gactcatagt
     2401 tcagcatggc tagggaggcc tcacaatcat ggcagaaggt gagtgaggag caaagtcatg
     2461 tcttacgtgg tggcacccaa gagagcttgt gcaggggaac tcccatttat aaaaccatca
     2521 gatctcgtga gacttattca ctatcacact attgtgttga tattgtgttc acacaccaat
     2581 aatgatggtt tatcactcac tccatttcca aacccacctt cccacccacc tctcaccaaa
     2641 cacacaaaga cacactcttt ccctccactg attccaccag tatagccata tttctctttc
     2701 tggttaaatt tatactaaat gtttacattt atataactta ataaatatta tttttttcca
//
