LOCUS       NP_060101               1712 aa            linear   PRI 15-OCT-2024
DEFINITION  probable ATP-dependent RNA helicase DDX60 isoform 1 [Homo sapiens].
ACCESSION   NP_060101
VERSION     NP_060101.3
DBSOURCE    REFSEQ: accession NM_017631.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 1712)
  AUTHORS   Zhou,Y., Zhang,Y., Li,M., Ming,T., Zhang,C., Huang,C., Li,J.,
            Li,F., Li,H., Zhao,E., Shu,F., Liu,L., Pan,X., Gao,Y., Tian,L.,
            Song,L., Huang,H. and Liao,W.
  TITLE     Oncogenic KRAS drives immunosuppression of colorectal cancer by
            impairing DDX60-mediated dsRNA accumulation and viral mimicry
  JOURNAL   Sci Immunol 9 (100), eado8758 (2024)
   PUBMED   39365875
  REMARK    GeneRIF: Oncogenic KRAS drives immunosuppression of colorectal
            cancer by impairing DDX60-mediated dsRNA accumulation and viral
            mimicry.
REFERENCE   2  (residues 1 to 1712)
  AUTHORS   Nakamura,Y., Ishibashi,H.K., Saruga,T., Imaizumi,T., Kurose,A.,
            Tachizaki,M., Kawaguchi,S., Seya,K., Sasaki,E. and Ishibashi,Y.
  TITLE     Possible involvement of DExD/H box helicase 60 in synovial
            inflammation of rheumatoid arthritis: role of toll-like receptor 3
            signaling
  JOURNAL   Mol Biol Rep 51 (1), 131 (2024)
   PUBMED   38236450
  REMARK    GeneRIF: Possible involvement of DExD/H box helicase 60 in synovial
            inflammation of rheumatoid arthritis: role of toll-like receptor 3
            signaling.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 1712)
  AUTHORS   Han,Y., Gao,J. and Liu,L.
  TITLE     DDX60 Promotes Migration and Invasion of Head and Neck Squamous
            Cell Carcinoma Cell through the NF-kappaB/IFI27 Signaling Pathway
  JOURNAL   Front Biosci (Landmark Ed) 29 (1), 14 (2024)
   PUBMED   38287816
  REMARK    GeneRIF: DDX60 Promotes Migration and Invasion of Head and Neck
            Squamous Cell Carcinoma Cell through the NF-kappaB/IFI27 Signaling
            Pathway.
REFERENCE   4  (residues 1 to 1712)
  AUTHORS   Chen,W., Li,Z.Y., Huang,L., Zhou,D.H., Luo,W.Q., Zhang,X.F., Li,L.,
            Wen,C.P. and Wang,Q.
  TITLE     Integrative Bioinformatics Analysis Identifies DDX60 as a Potential
            Biomarker for Systemic Lupus Erythematosus
  JOURNAL   Dis Markers 2023, 8564650 (2023)
   PUBMED   36655136
  REMARK    GeneRIF: Integrative Bioinformatics Analysis Identifies DDX60 as a
            Potential Biomarker for Systemic Lupus Erythematosus.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 1712)
  AUTHORS   Karasawa,T., Sato,R., Imaizumi,T., Hashimoto,S., Fujita,M.,
            Aizawa,T., Tsugawa,K., Kawaguchi,S., Seya,K., Terui,K. and
            Tanaka,H.
  TITLE     Glomerular endothelial expression of type I IFN-stimulated gene,
            DExD/H-Box helicase 60 via toll-like receptor 3 signaling: possible
            involvement in the pathogenesis of lupus nephritis
  JOURNAL   Ren Fail 44 (1), 137-145 (2022)
   PUBMED   35392757
  REMARK    GeneRIF: Glomerular endothelial expression of type I IFN-stimulated
            gene, DExD/H-Box helicase 60 via toll-like receptor 3 signaling:
            possible involvement in the pathogenesis of lupus nephritis.
REFERENCE   6  (residues 1 to 1712)
  AUTHORS   Hubel,P., Urban,C., Bergant,V., Schneider,W.M., Knauer,B.,
            Stukalov,A., Scaturro,P., Mann,A., Brunotte,L., Hoffmann,H.H.,
            Schoggins,J.W., Schwemmle,M., Mann,M., Rice,C.M. and Pichlmair,A.
  TITLE     A protein-interaction network of interferon-stimulated genes
            extends the innate immune system landscape
  JOURNAL   Nat Immunol 20 (4), 493-502 (2019)
   PUBMED   30833792
REFERENCE   7  (residues 1 to 1712)
  AUTHORS   Fu,T.Y., Wu,C.N., Sie,H.C., Cheng,J.T., Lin,Y.S., Liou,H.H.,
            Tseng,Y.K., Shu,C.W., Tsai,K.W., Yen,L.M., Tseng,H.W., Tseng,C.J.,
            Ger,L.P. and Liu,P.F.
  TITLE     Subsite-specific association of DEAD box RNA helicase DDX60 with
            the development and prognosis of oral squamous cell carcinoma
  JOURNAL   Oncotarget 7 (51), 85097-85108 (2016)
   PUBMED   27835882
  REMARK    GeneRIF: DDX60 is a novel and unfavorable biomarker for
            tumorigenesis and prognosis of oral squamous cell carcinoma in a
            subsite-specific manner
REFERENCE   8  (residues 1 to 1712)
  AUTHORS   Oshiumi,H., Miyashita,M., Okamoto,M., Morioka,Y., Okabe,M.,
            Matsumoto,M. and Seya,T.
  TITLE     DDX60 Is Involved in RIG-I-Dependent and Independent Antiviral
            Responses, and Its Function Is Attenuated by Virus-Induced EGFR
            Activation
  JOURNAL   Cell Rep 11 (8), 1193-1207 (2015)
   PUBMED   25981042
  REMARK    GeneRIF: Results define DDX60 as a sentinel for cytoplasmic
            antiviral response, which is counteracted by virus-mediated EGF
            receptor activation.
REFERENCE   9  (residues 1 to 1712)
  AUTHORS   Miyashita,M., Oshiumi,H., Matsumoto,M. and Seya,T.
  TITLE     DDX60, a DEXD/H box helicase, is a novel antiviral factor promoting
            RIG-I-like receptor-mediated signaling
  JOURNAL   Mol Cell Biol 31 (18), 3802-3819 (2011)
   PUBMED   21791617
  REMARK    GeneRIF: DDX60 is a novel antiviral helicase promoting RIG-I-like
            receptor-mediated signaling.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK307404.1, AK001649.1,
            BC038115.2, BC074781.2 and BC020601.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Feb 6, 2009 this sequence version replaced NP_060101.2.
            
            Summary: DEAD box proteins, characterized by the conserved motif
            Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases which are
            implicated in a number of cellular procsses involving RNA binding
            and alteration of RNA secondary structure. This gene encodes a
            DEXD/H box RNA helicase that functions as an antiviral factor and
            promotes RIG-I-like receptor-mediated signaling. [provided by
            RefSeq, Apr 2017].
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC038115.2, SRR1660807.174261.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000393743.8/ ENSP00000377344.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1712
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q32.3"
     Protein         1..1712
                     /product="probable ATP-dependent RNA helicase DDX60
                     isoform 1"
                     /EC_number="3.6.4.13"
                     /note="probable ATP-dependent RNA helicase DDX60; DEAD box
                     protein 60; DEAD (Asp-Glu-Ala-Asp) box polypeptide 60;
                     DEAD-box helicase 60"
                     /calculated_mol_wt=197723
     Region          763..952
                     /region_name="DEXHc_DDX60"
                     /note="DEXH-box helicase domain of DEAD box protein 60;
                     cd18025"
                     /db_xref="CDD:350783"
     Site            order(763..765,768,787..793)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:350783"
     Region          768..1442
                     /region_name="BRR2"
                     /note="Replicative superfamily II helicase [Replication,
                     recombination and repair]; COG1204"
                     /db_xref="CDD:440817"
     Site            order(817..818,849,863,865..866,869,899)
                     /site_type="other"
                     /note="nucleic acid binding site [nucleotide binding]"
                     /db_xref="CDD:350783"
     Region          889..892
                     /region_name="DEVH box"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8IY21.3)"
     CDS             1..1712
                     /gene="DDX60"
                     /coded_by="NM_017631.6:238..5376"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS34097.1"
                     /db_xref="GeneID:55601"
                     /db_xref="HGNC:HGNC:25942"
                     /db_xref="MIM:613974"
ORIGIN      
        1 mernvlttfs qemsqlilne mpkaeysslf ndfveseffl idgdsllitc iceisfkpgq
       61 nlhffylver ylvdliskgg qftivffkda eyayfnfpel lslrtalilh lqknttidvr
      121 ttfsrclske wgsfleesyp yflivadegl ndlqtqlfnf liihswarkv nvvlssgqes
      181 dvlclyayll psmyrhqifs wknkqnikda yttllnqler fklsalaplf gslkwnnite
      241 eahktvsllt qvwpegsdir rvfcvtscsl slrmyhrflg nrepssgqet eiqqvnsncl
      301 tlqemedlck lhcltvvfll hlplsqraca rvitshwaed mkpllqmkkw ceyfilrnih
      361 tfefwnlnli hlsdlndell lkniafyyen envkglhlnl gdtimkdyey lwntvsklvr
      421 dfevgqpfpl rttkvcflek kpspikdssn emvpnlgfip tssfvvdkfa gdilkdlpfl
      481 ksddpivtsl vkqkefdelv hwhshkplsd dydrsrcqfd eksrdprvlr svqkyhvfqr
      541 fygnsletvs skiivtqtik skkdfsgpks kkahetkaei iarenkkrlf areeqkeeqk
      601 wnalsfsiee qlkenlhsgi ksledflksc ksscvklqve mvgltaclka wkehcrseeg
      661 kttkdlsiav qvmkrihslm ekysellqed drqliarclk ylgfdelass lhpaqdaend
      721 vkvkkrnkys vgigparfql qymghylird erkdpdprvq dfipdtwqre lldvvdknes
      781 avivaptssg ktyasyycme kvlkesddgv vvyvaptkal vnqvaatvqn rftknlpsge
      841 vlcgvftrey rhdalncqvl itvpacfeil llaphrqnwv kkiryvifde vhclggeiga
      901 eiwehllvmi rcpflalsat isnpehltew lqsvkwywkq edkiiennta skrhvgrqag
      961 fpkdylqvkq sykvrlvlyg eryndlekhv csikhgdihf dhfhpcaalt tdhierygfp
     1021 pdltlspres iqlydamfqi wkswpraqel cpenfihfnn klvikkmdar kyeeslkael
     1081 tswikngnve qarmvlqnls peadlspenm itmfpllvek lrkmeklpal fflfklgave
     1141 naaesvstfl kkkqetkrpp kadkeahvma nklrkvkksi ekqkiideks qkktrnvdqs
     1201 liheaehdnl vkcleknlei pqdctyadqk avdtetlqkv fgrvkferkg eelkalaerg
     1261 igyhhsamsf kekqlveilf rkgylrvvta tgtlalgvnm pcksvvfaqn svyldalnyr
     1321 qmsgragrrg qdlmgdvyff dipfpkigkl iksnvpelrg hfplsitlvl rlmllaskgd
     1381 dpedakakvl svlkhsllsf kqprvmdmlk lyflfslqfl vkegyldqeg npmgfaglvs
     1441 hlhyhepsnl vfvsflvngl fhdlcqptrk gskhfsqdvm eklvlvlahl fgrryfppkf
     1501 qdahfefyqs kvflddlped fsdaldeynm kimedfttfl rivskladmn qeyqlplski
     1561 kftgkeceds qlvshlmsck egrvaispfv clsgnfdddl lrletpnhvt lgtigvnrsq
     1621 apvllsqkfd nrgrkmslna yaldfykhgs liglvqdnrm negdayyllk dfaltiksis
     1681 vslrelcene ddnvvlafeq lsttfwekln kv
//
