LOCUS       NM_004397               6128 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens DEAD-box helicase 6 (DDX6), transcript variant 1,
            mRNA.
ACCESSION   NM_004397
VERSION     NM_004397.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6128)
  AUTHORS   Khoroshkin,M., Buyan,A., Dodel,M., Navickas,A., Yu,J., Trejo,F.,
            Doty,A., Baratam,R., Zhou,S., Lee,S.B., Joshi,T., Garcia,K.,
            Choi,B., Miglani,S., Subramanyam,V., Modi,H., Carpenter,C.,
            Markett,D., Corces,M.R., Mardakheh,F.K., Kulakovskiy,I.V. and
            Goodarzi,H.
  TITLE     Systematic identification of post-transcriptional regulatory
            modules
  JOURNAL   Nat Commun 15 (1), 7872 (2024)
   PUBMED   39251607
  REMARK    Erratum:[Nat Commun. 2024 Oct 28;15(1):9277. doi:
            10.1038/s41467-024-52903-4.. PMID: 39468017]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6128)
  AUTHORS   Yao,G., Yu,S., Hou,F., Xiao,Z., Li,G., Ji,X. and Wang,J.
  TITLE     Rab3B enhances the stabilization of DDX6 to promote lung
            adenocarcinoma aggressiveness
  JOURNAL   Mol Med 30 (1), 75 (2024)
   PUBMED   38834947
  REMARK    GeneRIF: Rab3B enhances the stabilization of DDX6 to promote lung
            adenocarcinoma aggressiveness.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6128)
  AUTHORS   Ripin,N., Macedo de Vasconcelos,L., Ugay,D.A. and Parker,R.
  TITLE     DDX6 modulates P-body and stress granule assembly, composition, and
            docking
  JOURNAL   J Cell Biol 223 (6) (2024)
   PUBMED   38536035
  REMARK    GeneRIF: DDX6 modulates P-body and stress granule assembly,
            composition, and docking.
REFERENCE   4  (bases 1 to 6128)
  AUTHORS   Deng,X., Liu,Z., Wang,B., Ma,J. and Meng,X.
  TITLE     The DDX6/KIFC1 signaling axis, as regulated by YY1, contributes to
            the malignant behavior of pancreatic cancer
  JOURNAL   FASEB J 38 (7), e23581 (2024)
   PUBMED   38551642
  REMARK    GeneRIF: The DDX6/KIFC1 signaling axis, as regulated by YY1,
            contributes to the malignant behavior of pancreatic cancer.
REFERENCE   5  (bases 1 to 6128)
  AUTHORS   Naito,S., Tanaka,H., Jiang,J.J., Tarumi,M., Hashimoto,A.,
            Tanaka,Y., Murakami,K., Kubota,S.I., Hojyo,S., Hashimoto,S. and
            Murakami,M.
  TITLE     DDX6 is involved in the pathogenesis of inflammatory diseases via
            NF-kappaB activation
  JOURNAL   Biochem Biophys Res Commun 703, 149666 (2024)
   PUBMED   38377944
  REMARK    GeneRIF: DDX6 is involved in the pathogenesis of inflammatory
            diseases via NF-kappaB activation.
REFERENCE   6  (bases 1 to 6128)
  AUTHORS   Akiyama,K., Akao,Y., Yokoyama,M., Nakagawa,Y., Noguchi,T., Yagi,K.
            and Nishi,Y.
  TITLE     Expression of two dead box genes (DDX1 and DDX6) is independent of
            that of MYCN in human neuroblastoma cell lines
  JOURNAL   Biochem Mol Biol Int 47 (4), 563-568 (1999)
   PUBMED   10319407
REFERENCE   7  (bases 1 to 6128)
  AUTHORS   Zhang,W.J. and Wu,J.Y.
  TITLE     Functional properties of p54, a novel SR protein active in
            constitutive and alternative splicing
  JOURNAL   Mol Cell Biol 16 (10), 5400-5408 (1996)
   PUBMED   8816452
REFERENCE   8  (bases 1 to 6128)
  AUTHORS   Akao,Y., Marukawa,O., Morikawa,H., Nakao,K., Kamei,M., Hachiya,T.
            and Tsujimoto,Y.
  TITLE     The rck/p54 candidate proto-oncogene product is a 54-kilodalton
            D-E-A-D box protein differentially expressed in human and mouse
            tissues
  JOURNAL   Cancer Res 55 (15), 3444-3449 (1995)
   PUBMED   7614484
REFERENCE   9  (bases 1 to 6128)
  AUTHORS   Akao,Y., Seto,M., Yamamoto,K., Iida,S., Nakazawa,S., Inazawa,J.,
            Abe,T., Takahashi,T. and Ueda,R.
  TITLE     The RCK gene associated with t(11;14) translocation is distinct
            from the MLL/ALL-1 gene with t(4;11) and t(11;19) translocations
  JOURNAL   Cancer Res 52 (21), 6083-6087 (1992)
   PUBMED   1394235
REFERENCE   10 (bases 1 to 6128)
  AUTHORS   Lu,D. and Yunis,J.J.
  TITLE     Cloning, expression and localization of an RNA helicase gene from a
            human lymphoid cell line with chromosomal breakpoint 11q23.3
  JOURNAL   Nucleic Acids Res 20 (8), 1967-1972 (1992)
   PUBMED   1579499
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA993470.1, D17532.1,
            AP002954.1, KF511134.1, KF510354.1 and AI265778.1.
            
            On Nov 22, 2018 this sequence version replaced NM_004397.5.
            
            Summary: This gene encodes a member of the DEAD box protein family.
            The protein is an RNA helicase found in P-bodies and stress
            granules, and functions in translation suppression and mRNA
            degradation. It is required for microRNA-induced gene silencing.
            Multiple alternatively spliced variants, encoding the same protein,
            have been identified. [provided by RefSeq, Mar 2012].
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D17532.1, SRR1660805.218867.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000534980.7/ ENSP00000442266.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                DA993470.1         100-127
            29-1855             D17532.1           1-1827
            1856-2709           AP002954.1         129596-130449       c
            2710-2712           KF511134.1         15-17               c
            2713-3882           AP002954.1         128424-129593       c
            3883-3884           KF510354.1         194-195
            3885-5763           AP002954.1         126542-128420       c
            5764-6128           AI265778.1         20-384              c
FEATURES             Location/Qualifiers
     source          1..6128
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q23.3"
     gene            1..6128
                     /gene="DDX6"
                     /gene_synonym="HLR2; IDDILF; P54; RCK; Rck/p54"
                     /note="DEAD-box helicase 6"
                     /db_xref="GeneID:1656"
                     /db_xref="HGNC:HGNC:2747"
                     /db_xref="MIM:600326"
     exon            1..67
                     /gene="DDX6"
                     /gene_synonym="HLR2; IDDILF; P54; RCK; Rck/p54"
                     /inference="alignment:Splign:2.1.0"
     exon            68..534
                     /gene="DDX6"
                     /gene_synonym="HLR2; IDDILF; P54; RCK; Rck/p54"
                     /inference="alignment:Splign:2.1.0"
     CDS             335..1786
                     /gene="DDX6"
                     /gene_synonym="HLR2; IDDILF; P54; RCK; Rck/p54"
                     /EC_number="3.6.4.13"
                     /note="isoform 1 is encoded by transcript variant 1;
                     DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 6 (RNA
                     helicase, 54kD); DEAD box-6; probable ATP-dependent RNA
                     helicase DDX6; oncogene RCK; DEAD box protein 6;
                     ATP-dependent RNA helicase p54; DEAD (Asp-Glu-Ala-Asp) box
                     polypeptide 6; DEAD (Asp-Glu-Ala-Asp) box helicase 6"
                     /codon_start=1
                     /product="probable ATP-dependent RNA helicase DDX6 isoform
                     1"
                     /protein_id="NP_004388.2"
                     /db_xref="CCDS:CCDS44751.1"
                     /db_xref="GeneID:1656"
                     /db_xref="HGNC:HGNC:2747"
                     /db_xref="MIM:600326"
                     /translation="MSTARTENPVIMGLSSQNGQLRGPVKPTGGPGGGGTQTQQQMNQ
                     LKNTNTINNGTQQQAQSMTTTIKPGDDWKKTLKLPPKDLRIKTSDVTSTKGNEFEDYC
                     LKRELLMGIFEMGWEKPSPIQEESIPIALSGRDILARAKNGTGKSGAYLIPLLERLDL
                     KKDNIQAMVIVPTRELALQVSQICIQVSKHMGGAKVMATTGGTNLRDDIMRLDDTVHV
                     VIATPGRILDLIKKGVAKVDHVQMIVLDEADKLLSQDFVQIMEDIILTLPKNRQILLY
                     SATFPLSVQKFMNSHLQKPYEINLMEELTLKGVTQYYAYVTERQKVHCLNTLFSRLQI
                     NQSIIFCNSSQRVELLAKKISQLGYSCFYIHAKMRQEHRNRVFHDFRNGLCRNLVCTD
                     LFTRGIDIQAVNVVINFDFPKLAETYLHRIGRSGRFGHLGLAINLITYDDRFNLKSIE
                     EQLGTEIKPIPSNIDKSLYVAEYHSEPVEDEKP"
     exon            535..598
                     /gene="DDX6"
                     /gene_synonym="HLR2; IDDILF; P54; RCK; Rck/p54"
                     /inference="alignment:Splign:2.1.0"
     exon            599..703
                     /gene="DDX6"
                     /gene_synonym="HLR2; IDDILF; P54; RCK; Rck/p54"
                     /inference="alignment:Splign:2.1.0"
     exon            704..833
                     /gene="DDX6"
                     /gene_synonym="HLR2; IDDILF; P54; RCK; Rck/p54"
                     /inference="alignment:Splign:2.1.0"
     exon            834..980
                     /gene="DDX6"
                     /gene_synonym="HLR2; IDDILF; P54; RCK; Rck/p54"
                     /inference="alignment:Splign:2.1.0"
     exon            981..1075
                     /gene="DDX6"
                     /gene_synonym="HLR2; IDDILF; P54; RCK; Rck/p54"
                     /inference="alignment:Splign:2.1.0"
     exon            1076..1198
                     /gene="DDX6"
                     /gene_synonym="HLR2; IDDILF; P54; RCK; Rck/p54"
                     /inference="alignment:Splign:2.1.0"
     exon            1199..1327
                     /gene="DDX6"
                     /gene_synonym="HLR2; IDDILF; P54; RCK; Rck/p54"
                     /inference="alignment:Splign:2.1.0"
     exon            1328..1444
                     /gene="DDX6"
                     /gene_synonym="HLR2; IDDILF; P54; RCK; Rck/p54"
                     /inference="alignment:Splign:2.1.0"
     exon            1445..1508
                     /gene="DDX6"
                     /gene_synonym="HLR2; IDDILF; P54; RCK; Rck/p54"
                     /inference="alignment:Splign:2.1.0"
     exon            1509..1610
                     /gene="DDX6"
                     /gene_synonym="HLR2; IDDILF; P54; RCK; Rck/p54"
                     /inference="alignment:Splign:2.1.0"
     exon            1611..1793
                     /gene="DDX6"
                     /gene_synonym="HLR2; IDDILF; P54; RCK; Rck/p54"
                     /inference="alignment:Splign:2.1.0"
     exon            1794..6128
                     /gene="DDX6"
                     /gene_synonym="HLR2; IDDILF; P54; RCK; Rck/p54"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6104..6109
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DDX6"
                     /gene_synonym="HLR2; IDDILF; P54; RCK; Rck/p54"
                     /note="hexamer: AATAAA"
     polyA_site      6128
                     /gene="DDX6"
                     /gene_synonym="HLR2; IDDILF; P54; RCK; Rck/p54"
                     /note="major polyA site"
ORIGIN      
        1 agaggagccg agttagctca gccaggcggc gacttcggcg gcgccacgag agcgggcagc
       61 ggaggagatt gacgtgagtg aattcagata taactcaagc ttgttagagg gctttttaaa
      121 aataaaaagt tgattccgtg caagagagca agttactgct gcttaccgtt cagagactta
      181 caggtgcttg cctgcattgc aataaaggac tcatttattg agcaagactt atatttatct
      241 cttcattttg gagagcctaa taaactgtta ttacagtttc tctactgact ttcaaaagtt
      301 ttgaagtttg aaagaccttt gcaattaaaa cagcatgagc acggccagaa cagagaaccc
      361 tgttataatg ggtctgtcca gtcaaaatgg tcagctgaga ggccctgtga aacccactgg
      421 tggccctgga ggagggggca cacagacaca gcaacagatg aaccagctga aaaacaccaa
      481 cacaatcaat aatggcactc agcagcaagc acagagtatg accaccacta ttaaacctgg
      541 tgatgactgg aaaaagactt taaaactccc tccaaaggat ctaagaatca aaacttcgga
      601 tgtgacctcc acaaaaggaa atgagtttga agattactgt ttgaaacggg agttactgat
      661 gggaattttt gaaatgggct gggaaaagcc atctcctatt caggaggaga gcattcccat
      721 tgctttatct ggtagggata tcttagctag agcaaaaaat ggaacaggca agagcggtgc
      781 ctacctcatt cccttacttg aacggctaga cctgaagaag gacaatatac aagcaatggt
      841 gattgttccc actagagaac ttgctctaca ggtcagtcaa atttgcatcc aggtcagcaa
      901 acacatggga ggggccaaag tgatggcaac cacaggagga accaatttac gagatgacat
      961 aatgaggctt gatgatacag tgcacgtggt gattgctacc cctgggagaa tcctggatct
     1021 tattaagaaa ggagtagcaa aggttgatca tgtccagatg atagtattgg atgaggcaga
     1081 taagttgctg tcacaggatt ttgtgcagat aatggaggat attattctca cgctacctaa
     1141 aaacaggcag attttactat attccgctac tttccctctt agtgtacaga agttcatgaa
     1201 ttcccatttg cagaaaccct atgagattaa cctgatggag gaactaactc tgaagggagt
     1261 aacccagtac tacgcatatg taactgagcg ccaaaaagta cactgcctca acacactttt
     1321 ctccaggctt cagataaacc agtcgatcat tttctgtaac tcctctcagc gagttgaatt
     1381 gctagccaag aagatttctc aactgggtta ttcttgcttc tatattcatg ctaaaatgag
     1441 gcaggaacat cgaaatcgtg tatttcatga tttccgaaat ggcttatgcc gcaatcttgt
     1501 ttgcactgat ctgtttaccc gaggtattga tatacaagct gtgaatgtgg taataaactt
     1561 tgatttccca aagctggcag agacctatct ccatcgtatt ggaagatcag gtcgctttgg
     1621 tcatcttggc ttagccatca acttgatcac atatgatgat cgcttcaacc tgaaaagtat
     1681 tgaggagcag ctgggaacag aaattaaacc tattccgagc aacattgata agagcctgta
     1741 tgtggcagaa taccacagcg agcctgtaga agatgagaaa ccttaacaag catgctttga
     1801 caaattacaa aaggctcgtt tggatctgtg acacatcgtt ttggggggaa tgctcctctc
     1861 tttgtgggtt tttcatcttt tattttggaa ctatgaagac ttaaaagagc tcagacattt
     1921 tcttttttta actggtgaag agaaaaaggc tgaaaagaag gaatatacct tttttgttcc
     1981 acttgtttgc actgtgtgct gactgaacat tagttgcact aactgctggt ttttaaaaaa
     2041 tgttttctgg ggaaagggga caaggaagga aaagaaagaa gagaagggga gaaaccctaa
     2101 aaagagaaga atcttaatga acacacaagc ttgtcaatga tttcaaaatt ctccaacagc
     2161 tgactctcgt gcatttcaac ttctccctga ttcctcatcc gttttttaag cctgaagagc
     2221 ttattactta tttgtgcgaa gtgccttatg ctatgagacc attcagaata tcatctttta
     2281 gacacagccc gaggaatcaa caatagtaac tctttctttc cgtttttttt tctttttctt
     2341 ttaaaaaatg tcttcttatt ttggtttcag gttgaagtct cttccctttc tacccagtac
     2401 tcgagcccag ggctagaagt tgaaactcac tagtaatgtt aaacaccatt ttttttttct
     2461 ttttggggag gagttgatat gcaactgcag ttcatccgca ctgtaaatac atgtatttaa
     2521 aaaaacaatc ccaagtaaaa atttcttctg ggctgagtag ataaaaaaca tcatcgctcc
     2581 caaaggaaag agcagtctat cattgcagga gccatatgac aagcctttgt gctctatagc
     2641 agacactaaa gactgggtta catatgcctc cagtagtagt atggcacttg atgtgtagac
     2701 atgtcagagc cttggccctc tttcctctgt ggcaaagcgt gtcccataga aaattgggtg
     2761 tgtatacttg tataactttg taaataagtt ttttttctgg gttcatatat atatatatat
     2821 atacatatat atatattttt ttttggatga aggttgctgg gattaagggg attagagtga
     2881 ttatgggagc agctaaagat gagaggggct cagttttacg caacactaaa ttctagaaag
     2941 tactttggcc tcgtgctgta gagagcagat ttctatggta ccctgtgtta gtaaaggggc
     3001 ccagaaatct gggatgtact gtttgctgcc acactgtctc atctagtacc tttggagtag
     3061 gtttaccaga gagagcaagg aagcttcaaa acattgataa ttcaacattt attttgagaa
     3121 gctctgattt tgcttcttcc ccctttctaa aagtttgagg aatatttcaa gctctgcaac
     3181 agggggcaaa gattaatcta ccttgcagtg taggaattct attgagtggc agtgtcattg
     3241 agcagtatat atataaagca cagatttgca tttcagaata ttagccagta ccagctttgg
     3301 taatgttagc agttctggag cttaattttc tgtggatcat ttcctgtagt gtgtaaatgt
     3361 gttgccctct gcccgctttg atacataaac ttttgcagga atgggcaacc tgagagctgt
     3421 taactttcat gctacagaaa gctgcttgcc attctcttgc attgtgacaa gaattgttac
     3481 ctgtcatttt gcactgtaaa ttgctggcag atgctttaca gtcaatagtg ttgctttaaa
     3541 ttgtgcccct cccaacatgc ttgatgtttg gcctgatctc caggcaaaag gagtgagatg
     3601 aatcaaaacc agtgaacttt tttttttaat gtttttaatt cccttttaac ccagtgtact
     3661 aggtcaatca ggaggcatct ggaaaggggg ggaaaaaagc aaaaaacaaa attaaaaaaa
     3721 attgatttcc atattttatt tttcaaaacc ctaaaatatt acaaaataag tcccgcatat
     3781 actttaatgt tttaactctt ttggacaaag gaatcaatta cttgaagttg cttttttgac
     3841 tctgcctact tctgagcaaa ctatttgcga ctcacccaca attccttgga gatcaaaatc
     3901 ctacagatgc ctcctgatgg gacatagccc taactcctta acaactgtag caagaactgc
     3961 acggtacaaa cccaaaaaag aacaagctca tctatttgga acccaagcct catattttct
     4021 gtccagtcaa tgttggttac taaatagaaa acctaattaa ggaagtaact tttttccagg
     4081 gaggggtggg agagggaatt taaaaggtgt caacttttga ccaaaaaaat tgtgcccttg
     4141 taccgatgca gctctctttc tcccccacct cttgcgagat aagagggatc attcatgtag
     4201 aagaaaagag tataaatgca attctgtatc tcgctagaga acgtgtgggt gactaaacaa
     4261 aaagtgcagt ctccttcacc aactttagac tgcgtggtgc cacatgcctg tgggtccctc
     4321 ttaaagcaca gacttaaaat ggaaagtatt actgaagtat agcctctaat gaggagtggc
     4381 acttaaacta tctgggacac cactactgga cacggtcttg tagaggcagc tgtccagttt
     4441 tggtgcttga ctcttgaata ggaattgtta aatggaaaga tgctctgagg actaggtcaa
     4501 agcctggtct tttttttttt tttttttttt ttctttcttt tttgggccct cataataagc
     4561 attgttacta ttggaagttg ttttcacatt ctttccaata ttaaatatgt atttttttaa
     4621 gtaatgataa tattttccag tggctcattt ggatgagaac taccctctat ttttaatatt
     4681 aaaactacat ccaactcatc atttagcctt tggttgtaca gttgtgtaat gggctatgga
     4741 ctgttacaca ccttaccacc tctaggccta tgttttttct ttccccatat attctgatgg
     4801 ggataaatac tgttttgcct ctcccatagg aatggaatac atttattcta aaatgatctt
     4861 tcacagaagt aagagagagg gaaacctaaa tatacctcta aattgtttga agttggtccc
     4921 agcagcataa aatgggttgg ccccaaaggg ttggagggtg ggcttggtta tcagtatttg
     4981 ttttcagaat gagatgggag catctttcct ttgccacgtg ctttgtgctt gataacatca
     5041 tgcttggttc aaacgacaac tcagcacaaa gccttgagta taaattgttg gaatcaaaac
     5101 atctcattct gatgacgtgg tttaattttt taattttttt ttttaatagg ggtgggaggg
     5161 agggtacttt gccccagaag ggagggtgtc tgcactaagg atttagaaac actttggaag
     5221 ctcataacct catcagaaac tgcctttagc cacactcctg accttctaga tgagtaacaa
     5281 aaaaatgaaa taagttcttg gaaattaagc catttatttt aatttgctat ttttttcaat
     5341 gttctaggta tctttaaatt tgttattgtg gaatcatttt cctgccagat acctttatca
     5401 aaattattgg cctcatgaga gctgaagtaa gtcagctttt tggtgaactt tagtggactt
     5461 ctgtgagatt gtagttgtac tttgtatctc taaatctaaa gatagttttt taaaactccc
     5521 aaagaaaatc tgctctcctt tctgatctaa aaactcatct ttggggtaaa gagttaagtg
     5581 tccaaaggtt gtcacagttc atgaggtcag agggagctag cctggcacct ggactctgcc
     5641 catccacagc tgacagattc caacagaagt gtatttaaat tctccagtag acaatgctgg
     5701 gtaagggagg gggtagggct gggttattaa gatacaggct gctgtatttt acattggttg
     5761 tgtgggaagg ggagcctgga gaaaacaaag tcactattcc cttttttgaa acaggaaaaa
     5821 aaattatttt ttgttcagta aaaatggtag agaattccaa tgtccctagc cacaagggac
     5881 cagttccact gagaagtgaa cagtgggaac tcaaaatttc agaaacattg ggggaaggga
     5941 aaattggctt tctcttaatt ggcagatgtt ccagtggggg gggggggggc tctgtttttg
     6001 ttgggatgtg ttatgttgta tgtacgcata tatggaccgg agtctgctga gtttataagg
     6061 ttccaaaaat atggtaaaat cttggttttt gttaatttat ctcaataaaa gcccactgga
     6121 actccaaa
//
