LOCUS       NM_019082               1855 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens DEAD-box helicase 56 (DDX56), transcript variant 1,
            mRNA.
ACCESSION   NM_019082
VERSION     NM_019082.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1855)
  AUTHORS   Zhou,H., Du,Y., Wei,X., Song,C., Song,J., Xu,N., Huang,W., Chen,L.,
            Yao,F., Du,D., Qiu,C., Zhong,L., Liu,Y., Gu,D., Wang,J. and Xu,Y.
  TITLE     DDX56 transcriptionally activates MIST1 to facilitate tumorigenesis
            of HCC through PTEN-AKT signaling
  JOURNAL   Theranostics 12 (14), 6069-6087 (2022)
   PUBMED   36168636
  REMARK    GeneRIF: DDX56 transcriptionally activates MIST1 to facilitate
            tumorigenesis of HCC through PTEN-AKT signaling.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1855)
  AUTHORS   Wang,J., Wang,Y., Wang,J., Zhang,S., Yu,Z., Zheng,K., Fu,Z.,
            Wang,C., Huang,W. and Chen,J.
  TITLE     DEAD-box helicase 56 functions as an oncogene promote cell
            proliferation and invasion in gastric cancer via the FOXO1/p21
            Cip1/c-Myc signaling pathway
  JOURNAL   Bioengineered 13 (5), 13970-13985 (2022)
   PUBMED   35723050
  REMARK    GeneRIF: DEAD-box helicase 56 functions as an oncogene promote cell
            proliferation and invasion in gastric cancer via the FOXO1/p21
            Cip1/c-Myc signaling pathway.
REFERENCE   3  (bases 1 to 1855)
  AUTHORS   Wu,Q., Luo,X., Terp,M.G., Li,Q., Li,Y., Shen,L., Chen,Y.,
            Jacobsen,K., Bivona,T.G., Chen,H., Zeng,R. and Ditzel,H.J.
  TITLE     DDX56 modulates post-transcriptional Wnt signaling through miRNAs
            and is associated with early recurrence in squamous cell lung
            carcinoma
  JOURNAL   Mol Cancer 20 (1), 108 (2021)
   PUBMED   34446021
  REMARK    GeneRIF: DDX56 modulates post-transcriptional Wnt signaling through
            miRNAs and is associated with early recurrence in squamous cell
            lung carcinoma.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1855)
  AUTHORS   Pryszlak,M., Wiggans,M., Chen,X., Jaramillo,J.E., Burns,S.E.,
            Richards,L.M., Pugh,T.J., Kaplan,D.R., Huang,X., Dirks,P.B. and
            Pearson,B.J.
  TITLE     The DEAD-box helicase DDX56 is a conserved stemness regulator in
            normal and cancer stem cells
  JOURNAL   Cell Rep 34 (13), 108903 (2021)
   PUBMED   33789112
  REMARK    GeneRIF: The DEAD-box helicase DDX56 is a conserved stemness
            regulator in normal and cancer stem cells.
REFERENCE   5  (bases 1 to 1855)
  AUTHORS   Taschuk,F., Tapescu,I., Moy,R.H. and Cherry,S.
  TITLE     DDX56 Binds to Chikungunya Virus RNA To Control Infection
  JOURNAL   mBio 11 (5), e02623-20 (2020)
   PUBMED   33109765
  REMARK    GeneRIF: DDX56 Binds to Chikungunya Virus RNA To Control Infection.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1855)
  AUTHORS   Valdez,B.C., Yang,H., Hong,E. and Sequitin,A.M.
  TITLE     Genomic structure of newly identified paralogue of RNA helicase
            II/Gu: detection of pseudogenes and multiple alternatively spliced
            mRNAs
  JOURNAL   Gene 284 (1-2), 53-61 (2002)
   PUBMED   11891046
REFERENCE   7  (bases 1 to 1855)
  AUTHORS   Andersen,J.S., Lyon,C.E., Fox,A.H., Leung,A.K., Lam,Y.W., Steen,H.,
            Mann,M. and Lamond,A.I.
  TITLE     Directed proteomic analysis of the human nucleolus
  JOURNAL   Curr Biol 12 (1), 1-11 (2002)
   PUBMED   11790298
REFERENCE   8  (bases 1 to 1855)
  AUTHORS   Camargo,A.A., Nunes,D.N., Samaia,H.B., Liu,L., Collins,V.P.,
            Simpson,A.J. and Dias-Neto,E.
  TITLE     Molecular characterization of DDX26, a human DEAD-box RNA helicase,
            located on chromosome 7p12
  JOURNAL   Braz J Med Biol Res 34 (10), 1237-1245 (2001)
   PUBMED   11593297
  REMARK    GeneRIF: DDX26 maps to7p12, a region of frequent chromosome
            amplifications in glioblastoma involving the EGFR gene.
REFERENCE   9  (bases 1 to 1855)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
REFERENCE   10 (bases 1 to 1855)
  AUTHORS   Zirwes,R.F., Eilbracht,J., Kneissel,S. and Schmidt-Zachmann,M.S.
  TITLE     A novel helicase-type protein in the nucleolus: protein NOH61
  JOURNAL   Mol Biol Cell 11 (4), 1153-1167 (2000)
   PUBMED   10749921
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC001235.1 and AK125595.1.
            
            On Aug 11, 2020 this sequence version replaced NM_019082.3.
            
            Summary: This gene encodes a member of the DEAD box protein family.
            DEAD box proteins, characterized by the conserved motif
            Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are
            implicated in a number of cellular processes involving alteration
            of RNA secondary structure such as translation initiation, nuclear
            and mitochondrial splicing, and ribosome and spliceosome assembly.
            Based on their distribution patterns, some members of this family
            are believed to be involved in embryogenesis, spermatogenesis, and
            cellular growth and division. The protein encoded by this gene
            shows ATPase activity in the presence of polynucleotides and
            associates with nucleoplasmic 65S preribosomal particles. This gene
            may be involved in ribosome synthesis, most likely during assembly
            of the large 60S ribosomal subunit. Multiple transcript variants
            encoding different isoforms have been found for this gene.
            [provided by RefSeq, Mar 2012].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer protein (isoform 1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC001235.1, AF247666.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000258772.10/ ENSP00000258772.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1527              BC001235.1         18-1544
            1528-1854           AK125595.1         2704-3030
            1855-1855           BC001235.1         1872-1872
FEATURES             Location/Qualifiers
     source          1..1855
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p13"
     gene            1..1855
                     /gene="DDX56"
                     /gene_synonym="DDX21; DDX26; NOH61"
                     /note="DEAD-box helicase 56"
                     /db_xref="GeneID:54606"
                     /db_xref="HGNC:HGNC:18193"
                     /db_xref="MIM:608023"
     exon            1..73
                     /gene="DDX56"
                     /gene_synonym="DDX21; DDX26; NOH61"
                     /inference="alignment:Splign:2.1.0"
     CDS             14..1657
                     /gene="DDX56"
                     /gene_synonym="DDX21; DDX26; NOH61"
                     /EC_number="3.6.4.13"
                     /note="isoform 1 is encoded by transcript variant 1;
                     putative nucleolar RNA helicase; 61-kd nucleolar helicase;
                     DEAD-box RNA helicase; probable ATP-dependent RNA helicase
                     DDX56; DEAD (Asp-Glu-Ala-Asp) box helicase 56; DEAD
                     (Asp-Glu-Ala-Asp) box polypeptide 56; nucleolar helicase
                     of 61 kDa; DEAD box protein 21; DEAD box protein 56;
                     ATP-dependent 61 kDa nucleolar RNA helicase"
                     /codon_start=1
                     /product="probable ATP-dependent RNA helicase DDX56
                     isoform 1"
                     /protein_id="NP_061955.1"
                     /db_xref="CCDS:CCDS5492.1"
                     /db_xref="GeneID:54606"
                     /db_xref="HGNC:HGNC:18193"
                     /db_xref="MIM:608023"
                     /translation="MEDSEALGFEHMGLDPRLLQAVTDLGWSRPTLIQEKAIPLALEG
                     KDLLARARTGSGKTAAYAIPMLQLLLHRKATGPVVEQAVRGLVLVPTKELARQAQSMI
                     QQLATYCARDVRVANVSAAEDSVSQRAVLMEKPDVVVGTPSRILSHLQQDSLKLRDSL
                     ELLVVDEADLLFSFGFEEELKSLLCHLPRIYQAFLMSATFNEDVQALKELILHNPVTL
                     KLQESQLPGPDQLQQFQVVCETEEDKFLLLYALLKLSLIRGKSLLFVNTLERSYRLRL
                     FLEQFSIPTCVLNGELPLRSRCHIISQFNQGFYDCVIATDAEVLGAPVKGKRRGRGPK
                     GDKASDPEAGVARGIDFHHVSAVLNFDLPPTPEAYIHRAGRTARANNPGIVLTFVLPT
                     EQFHLGKIEELLSGENRGPILLPYQFRMEEIEGFRYRCRDAMRSVTKQAIREARLKEI
                     KEELLHSEKLKTYFEDNPRDLQLLRHDLPLHPAVVKPHLGHVPDYLVPPALRGLVRPH
                     KKRKKLSSSCRKAKRAKSQNPLRSFKHKGKKFRPTAKPS"
     exon            74..235
                     /gene="DDX56"
                     /gene_synonym="DDX21; DDX26; NOH61"
                     /inference="alignment:Splign:2.1.0"
     exon            236..396
                     /gene="DDX56"
                     /gene_synonym="DDX21; DDX26; NOH61"
                     /inference="alignment:Splign:2.1.0"
     exon            397..567
                     /gene="DDX56"
                     /gene_synonym="DDX21; DDX26; NOH61"
                     /inference="alignment:Splign:2.1.0"
     exon            568..658
                     /gene="DDX56"
                     /gene_synonym="DDX21; DDX26; NOH61"
                     /inference="alignment:Splign:2.1.0"
     exon            659..903
                     /gene="DDX56"
                     /gene_synonym="DDX21; DDX26; NOH61"
                     /inference="alignment:Splign:2.1.0"
     exon            904..1023
                     /gene="DDX56"
                     /gene_synonym="DDX21; DDX26; NOH61"
                     /inference="alignment:Splign:2.1.0"
     exon            1024..1137
                     /gene="DDX56"
                     /gene_synonym="DDX21; DDX26; NOH61"
                     /inference="alignment:Splign:2.1.0"
     exon            1138..1232
                     /gene="DDX56"
                     /gene_synonym="DDX21; DDX26; NOH61"
                     /inference="alignment:Splign:2.1.0"
     exon            1233..1306
                     /gene="DDX56"
                     /gene_synonym="DDX21; DDX26; NOH61"
                     /inference="alignment:Splign:2.1.0"
     exon            1307..1396
                     /gene="DDX56"
                     /gene_synonym="DDX21; DDX26; NOH61"
                     /inference="alignment:Splign:2.1.0"
     exon            1397..1502
                     /gene="DDX56"
                     /gene_synonym="DDX21; DDX26; NOH61"
                     /inference="alignment:Splign:2.1.0"
     exon            1503..1579
                     /gene="DDX56"
                     /gene_synonym="DDX21; DDX26; NOH61"
                     /inference="alignment:Splign:2.1.0"
     exon            1580..1855
                     /gene="DDX56"
                     /gene_synonym="DDX21; DDX26; NOH61"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1834..1839
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DDX56"
                     /gene_synonym="DDX21; DDX26; NOH61"
                     /note="hexamer: AATAAA"
     polyA_site      1855
                     /gene="DDX56"
                     /gene_synonym="DDX21; DDX26; NOH61"
                     /note="major polyA site"
ORIGIN      
        1 actgagcagc gccatggagg actctgaagc actgggcttc gaacacatgg gcctcgatcc
       61 ccggctcctt caggctgtca ccgatctggg ctggtcgcga cctacgctga tccaggagaa
      121 ggccatccca ctggccctag aagggaagga cctcctggct cgggcccgca cgggctccgg
      181 gaagacggcc gcttatgcta ttccgatgct gcagctgttg ctccatagga aggcgacagg
      241 tccggtggta gaacaggcag tgagaggcct tgttcttgtt cctaccaagg agctggcacg
      301 gcaagcacag tccatgattc agcagctggc tacctactgt gctcgggatg tccgagtggc
      361 caatgtctca gctgctgaag actcagtctc tcagagagct gtgctgatgg agaagccaga
      421 tgtggtagta gggaccccat ctcgcatatt aagccacttg cagcaagaca gcctgaaact
      481 tcgtgactcc ctggagcttt tggtggtgga cgaagctgac cttctttttt cctttggctt
      541 tgaagaagag ctcaagagtc tcctctgtca cttgccccgg atttaccagg cttttctcat
      601 gtcagctact tttaacgagg acgtacaagc actcaaggag ctgatattac ataacccggt
      661 tacccttaag ttacaggagt cccagctgcc tgggccagac cagttacagc agtttcaggt
      721 ggtctgtgag actgaggaag acaaattcct cctgctgtat gccctgctca agctgtcatt
      781 gattcggggc aagtctctgc tctttgtcaa cactctagaa cggagttacc ggctacgcct
      841 gttcttggaa cagttcagca tccccacctg tgtgctcaat ggagagcttc cactgcgctc
      901 caggtgccac atcatctcac agttcaacca aggcttctac gactgtgtca tagcaactga
      961 tgctgaagtc ctgggggccc cagtcaaggg caagcgtcgg ggccgagggc ccaaagggga
     1021 caaggcctct gatccggaag caggtgtggc ccggggcata gacttccacc atgtgtctgc
     1081 tgtgctcaac tttgatcttc ccccaacccc tgaggcctac atccatcgag ctggcaggac
     1141 agcacgcgct aacaacccag gcatagtctt aacctttgtg cttcccacgg agcagttcca
     1201 cttaggcaag attgaggagc ttctcagtgg agagaacagg ggccccattc tgctccccta
     1261 ccagttccgg atggaggaga tcgagggctt ccgctatcgc tgcagggatg ccatgcgctc
     1321 agtgactaag caggccattc gggaggcaag attgaaggag atcaaggaag agcttctgca
     1381 ttctgagaag cttaagacat actttgaaga caaccctagg gacctccagc tgctgcggca
     1441 tgacctacct ttgcaccccg cagtggtgaa gccccacctg ggccatgttc ctgactacct
     1501 ggttcctcct gctctccgtg gcctggtgcg ccctcacaag aagcggaaga agctgtcttc
     1561 ctcttgtagg aaggccaaga gagcaaagtc ccagaaccca ctgcgcagct tcaagcacaa
     1621 aggaaagaaa ttcagaccca cagccaagcc ctcctgaggt tgttgggcct ctctggagct
     1681 gagcacattg tggagcacag gcttacaccc ttcgtggaca ggcgaggctc tggtgcttac
     1741 tgcacagcct gaacagacag ttctggggcc ggcagtgctg ggccctttag ctccttggca
     1801 cttccaagct ggcatcttgc cccttgacaa cagaataaaa attttagctg cccca
//
