LOCUS       NM_020936               2656 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens DEAD-box helicase 55 (DDX55), transcript variant 1,
            mRNA.
ACCESSION   NM_020936 XM_045520
VERSION     NM_020936.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2656)
  AUTHORS   Choudhury,P., Kretschmer,J., Hackert,P., Bohnsack,K.E. and
            Bohnsack,M.T.
  TITLE     The DExD box ATPase DDX55 is recruited to domain IV of the 28S
            ribosomal RNA by its C-terminal region
  JOURNAL   RNA Biol 18 (8), 1124-1135 (2021)
   PUBMED   33048000
  REMARK    GeneRIF: The DExD box ATPase DDX55 is recruited to domain IV of the
            28S ribosomal RNA by its C-terminal region.
REFERENCE   2  (bases 1 to 2656)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2656)
  AUTHORS   Schmid,S.R. and Linder,P.
  TITLE     D-E-A-D protein family of putative RNA helicases
  JOURNAL   Mol Microbiol 6 (3), 283-291 (1992)
   PUBMED   1552844
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC055713.29, BC030020.2,
            AB046815.1, BU619784.1 and AA403154.1.
            
            On Nov 23, 2018 this sequence version replaced NM_020936.2.
            
            Summary: This gene encodes a member of protein family containing a
            characteristic Asp-Glu-Ala-Asp (DEAD) motif. These proteins are
            putative RNA helicases, and may be involved in a range of nuclear
            processes including translational initiation, nuclear and
            mitochondrial splicing, and ribosome and spliceosome assembly.
            Multiple alternatively spliced transcript variants have been found
            for this gene. Pseudogenes have been identified on chromosomes 1
            and 12. [provided by RefSeq, Feb 2016].
            
            Transcript Variant: This variant (1) encodes the protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.78589.1,
                                           SRR1803615.3510.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000238146.9/ ENSP00000238146.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-39                AC055713.29        5900-5938           c
            40-491              BC030020.2         6-457
            492-2184            AB046815.1         2341-4033
            2185-2648           BU619784.1         17-480              c
            2649-2656           AA403154.1         5-12                c
FEATURES             Location/Qualifiers
     source          1..2656
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.31"
     gene            1..2656
                     /gene="DDX55"
                     /note="DEAD-box helicase 55"
                     /db_xref="GeneID:57696"
                     /db_xref="HGNC:HGNC:20085"
                     /db_xref="MIM:620176"
     exon            1..158
                     /gene="DDX55"
                     /inference="alignment:Splign:2.1.0"
     CDS             51..1853
                     /gene="DDX55"
                     /EC_number="3.6.4.13"
                     /note="DEAD box protein 55; DEAD (Asp-Glu-Ala-Asp) box
                     polypeptide 55; epididymis secretory sperm binding
                     protein"
                     /codon_start=1
                     /product="ATP-dependent RNA helicase DDX55"
                     /protein_id="NP_065987.1"
                     /db_xref="CCDS:CCDS9251.1"
                     /db_xref="GeneID:57696"
                     /db_xref="HGNC:HGNC:20085"
                     /db_xref="MIM:620176"
                     /translation="MEHVTEGSWESLPVPLHPQVLGALRELGFPYMTPVQSATIPLFM
                     RNKDVAAEAVTGSGKTLAFVIPILEILLRREEKLKKSQVGAIIITPTRELAIQIDEVL
                     SHFTKHFPEFSQILWIGGRNPGEDVERFKQQGGNIIVATPGRLEDMFRRKAEGLDLAS
                     CVRSLDVLVLDEADRLLDMGFEASINTILEFLPKQRRTGLFSATQTQEVENLVRAGLR
                     NPVRVSVKEKGVAASSAQKTPSRLENYYMVCKADEKFNQLVHFLRNHKQEKHLVFFST
                     CACVEYYGKALEVLVKGVKIMCIHGKMKYKRNKIFMEFRKLQSGILVCTDVMARGIDI
                     PEVNWVLQYDPPSNASAFVHRCGRTARIGHGGSALVFLLPMEESYINFLAINQKCPLQ
                     EMKPQRNTADLLPKLKSMALADRAVFEKGMKAFVSYVQAYAKHECNLIFRLKDLDFAS
                     LARGFALLRMPKMPELRGKQFPDFVPVDVNTDTIPFKDKIREKQRQKLLEQQRREKTE
                     NEGRRKFIKNKAWSKQKAKKEKKKKMNEKRKREEGSDIEDEDMEELLNDTRLLKKLKK
                     GKITEEEFEKGLLTTGKRTIKTVDLGISDLEDDC"
     exon            159..209
                     /gene="DDX55"
                     /inference="alignment:Splign:2.1.0"
     exon            210..296
                     /gene="DDX55"
                     /inference="alignment:Splign:2.1.0"
     exon            297..388
                     /gene="DDX55"
                     /inference="alignment:Splign:2.1.0"
     exon            389..451
                     /gene="DDX55"
                     /inference="alignment:Splign:2.1.0"
     exon            452..601
                     /gene="DDX55"
                     /inference="alignment:Splign:2.1.0"
     exon            602..791
                     /gene="DDX55"
                     /inference="alignment:Splign:2.1.0"
     exon            792..874
                     /gene="DDX55"
                     /inference="alignment:Splign:2.1.0"
     exon            875..1006
                     /gene="DDX55"
                     /inference="alignment:Splign:2.1.0"
     exon            1007..1099
                     /gene="DDX55"
                     /inference="alignment:Splign:2.1.0"
     exon            1100..1214
                     /gene="DDX55"
                     /inference="alignment:Splign:2.1.0"
     exon            1215..1383
                     /gene="DDX55"
                     /inference="alignment:Splign:2.1.0"
     exon            1384..1676
                     /gene="DDX55"
                     /inference="alignment:Splign:2.1.0"
     exon            1677..2656
                     /gene="DDX55"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2163..2168
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DDX55"
                     /note="hexamer: ATTAAA"
     polyA_site      2186
                     /gene="DDX55"
                     /note="major polyA site"
     regulatory      2631..2636
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DDX55"
                     /note="hexamer: AATAAA"
     polyA_site      2656
                     /gene="DDX55"
                     /note="major polyA site"
ORIGIN      
        1 gcacaaggcg cgttcgagca gcggcgaccg acgcggcgaa ggagcgcgcc atggagcatg
       61 tgacagaggg ctcctgggag tcgctgcctg tgccgctgca cccgcaggtg ctgggcgcgc
      121 tgcgggagct gggcttcccg tacatgacgc cggtgcagtc cgcaaccatc cctctgttca
      181 tgcgaaacaa agatgtcgct gcagaagcgg tcacaggtag tggcaaaaca ctcgcttttg
      241 tcatccccat cctggaaatt cttctgagaa gagaagagaa gttaaaaaag agtcaggttg
      301 gagccataat catcaccccc actcgagagc tggccattca aatagacgag gtcctgtcgc
      361 atttcacgaa gcacttcccc gagttcagcc agattctttg gatcggaggc aggaatcctg
      421 gagaagatgt tgagaggttt aagcaacaag gtgggaacat cattgtggcc actccaggcc
      481 gcttggagga catgttccgg aggaaggccg aaggcttgga tctggccagc tgtgtgcgat
      541 ccctggatgt cctggtgttg gatgaggcag acagacttct ggacatgggg tttgaggcaa
      601 gcatcaacac cattctggag tttttgccaa agcagaggag aacaggcctt ttctctgcca
      661 ctcagacgca ggaagtggag aacctggtga gagcgggcct ccggaaccct gtccgggtct
      721 cagtgaagga gaagggcgtg gcagccagca gtgcccagaa gaccccctcc cgcctggaaa
      781 actactacat ggtatgcaag gcagatgaga aatttaatca gctggtccat tttcttcgca
      841 atcataagca ggagaaacac ctggtcttct tcagcacctg tgcctgtgtg gaatactatg
      901 ggaaggctct ggaagtgctg gtgaagggcg tgaagattat gtgcattcac ggaaagatga
      961 aatataaacg caataagatc ttcatggagt tccgcaaatt gcaaagtggg attttagtgt
     1021 gcactgatgt gatggcccgg ggaattgata ttcctgaagt caactgggtt ttgcagtatg
     1081 accctcccag caatgcaagt gccttcgtgc atcgctgcgg tcgcacagct cgcattggcc
     1141 acgggggcag cgctctggtg ttcctcctgc ccatggaaga gtcatacatc aatttccttg
     1201 caattaacca aaaatgcccc ctgcaggaga tgaagcccca gagaaacaca gcggaccttc
     1261 tgccaaaact caagtccatg gccctggctg acagagctgt gtttgaaaag ggcatgaaag
     1321 cttttgtgtc atatgtccaa gcttatgcaa agcatgaatg caacctgatt ttcagattaa
     1381 aggatcttga ttttgccagc cttgctcgag gttttgccct gctgaggatg cccaagatgc
     1441 cagaattgag aggaaagcag tttccagatt ttgtgcccgt ggacgttaat accgacacga
     1501 ttccatttaa agataaaatc agagaaaagc agaggcagaa actcctggag caacaaagaa
     1561 gagagaaaac agaaaatgaa gggagaagaa aattcataaa aaataaagct tggtcaaagc
     1621 agaaggccaa aaaagaaaag aagaaaaaaa tgaatgagaa aaggaaaagg gaagagggtt
     1681 ctgatattga agatgaggac atggaagaac ttcttaatga cacaagactc ttgaaaaaac
     1741 ttaagaaagg caaaataact gaagaagaat ttgagaaggg cttgttgaca actggcaaaa
     1801 gaacaatcaa gacagtggat ttagggatct cagatttgga agatgactgc tgattccagt
     1861 gccacagatg aacccacaag gacatagctg ttccctaact tggtggatgg ctccagtttg
     1921 cttttaacga aaatcacaac ttcaggagac atctgaaaag aatgatgtct ctgaaagctg
     1981 tcctttcaga tgagggagaa atgaaggatt tcacacttca gaatatttta ctaaaaacat
     2041 tccagtcttg gccgggtgcg gtggctcctg cctataatcc cagcactttg ggaggctgag
     2101 gcaggaggat cacttgagcc caggagttca agaccagcct gggaacacag cgagaccctc
     2161 tcattaaaaa caacaaaaca aaacaattcc agtcttggag tagtctaaca gaagaaaatg
     2221 taaaattatt tgagtgtaaa taatagatgt cagtatttat catgatgggt cacatataga
     2281 catatgtaca tattatatat atatatatat atatatatat atatatatat atatatatat
     2341 aagctctttt ttctgaggct attttatagt tatttttaaa cataaagata cagaagtctt
     2401 cttgacttct gattttcaaa accattcctc agtatcttca ggcatttgac ctcctgaatg
     2461 tgcttggccc tgggcttcag ttatcctttg atgtcctgca ggggtggcta atgtgctggg
     2521 gtttttctgt gttaatagtc acagtattgt tttattggtg aatagctgaa aaacagaggg
     2581 attaagtcat attccgggaa agagaattat agtttttatg cctcctgttg aataaatggt
     2641 gtcctgattg cctggg
//
