LOCUS       NM_182699               3630 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens DEAD-box helicase 53 (DDX53), mRNA.
ACCESSION   NM_182699 XM_291343
VERSION     NM_182699.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3630)
  AUTHORS   Faheem,M., Deneault,E., Alexandrova,R., Rodrigues,D.C.,
            Pellecchia,G., Shum,C., Zarrei,M., Piekna,A., Wei,W., Howe,J.L.,
            Thiruvahindrapuram,B., Lamoureux,S., Ross,P.J., Bradley,C.A.,
            Ellis,J. and Scherer,S.W.
  TITLE     Disruption of DDX53 coding sequence has limited impact on
            iPSC-derived human NGN2 neurons
  JOURNAL   BMC Med Genomics 16 (1), 5 (2023)
   PUBMED   36635662
  REMARK    GeneRIF: Disruption of DDX53 coding sequence has limited impact on
            iPSC-derived human NGN2 neurons.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3630)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 3630)
  AUTHORS   Park,S.Y., Kim,W.J., Byun,J.H., Lee,J.J., Jeoung,D., Park,S.T. and
            Kim,Y.
  TITLE     Role of DDX53 in taxol-resistance of cervix cancer cells in vitro
  JOURNAL   Biochem Biophys Res Commun 506 (3), 641-647 (2018)
   PUBMED   30454700
  REMARK    GeneRIF: DDX53 plays a critical role in taxol-resistance by
            activating autophagy and a potential therapeutic target for the
            treatment of taxol-resistant cervix cancer.
REFERENCE   4  (bases 1 to 3630)
  AUTHORS   Kim,Y., Yeon,M. and Jeoung,D.
  TITLE     DDX53 Regulates Cancer Stem Cell-Like Properties by Binding to
            SOX-2
  JOURNAL   Mol Cells 40 (5), 322-330 (2017)
   PUBMED   28535666
  REMARK    GeneRIF: A novel role of DDX53 in regulating cancer stem cell-like
            properties by binding to SOX-2.DDX53 directly regulates the SOX-2
            expression in drug-resistant melanoma cells.
REFERENCE   5  (bases 1 to 3630)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   6  (bases 1 to 3630)
  AUTHORS   Kim,Y. and Jeoung,D.
  TITLE     Role of CAGE, a novel cancer/testis antigen, in various cellular
            processes, including tumorigenesis, cytolytic T lymphocyte
            induction, and cell motility
  JOURNAL   J Microbiol Biotechnol 18 (3), 600-610 (2008)
   PUBMED   18388483
  REMARK    GeneRIF: The CAGE gene is widely expressed in various cancer
            tissues and cancer cell lines.
REFERENCE   7  (bases 1 to 3630)
  AUTHORS   Lee,T.S., Kim,J.W., Kang,G.H., Park,N.H., Song,Y.S., Kang,S.B. and
            Lee,H.P.
  TITLE     DNA hypomethylation of CAGE promotors in squamous cell carcinoma of
            uterine cervix
  JOURNAL   Ann N Y Acad Sci 1091, 218-224 (2006)
   PUBMED   17341616
  REMARK    GeneRIF: Hypomethylated CAGE promoter CpG islands are frequently
            involved in uterine cervical carcinogenesis.
REFERENCE   8  (bases 1 to 3630)
  AUTHORS   Shim,H., Lee,H. and Jeoung,D.
  TITLE     Cancer/testis antigen cancer-associated gene (CAGE) promotes
            motility of cancer cells through activation of focal adhesion
            kinase (FAK)
  JOURNAL   Biotechnol Lett 28 (24), 2057-2063 (2006)
   PUBMED   17028776
  REMARK    GeneRIF: CAGE promotes motility of cancer cells through activation
            of focal adhesion kinase (FAK).
REFERENCE   9  (bases 1 to 3630)
  AUTHORS   Cho,B., Lee,H., Jeong,S., Bang,Y.J., Lee,H.J., Hwang,K.S.,
            Kim,H.Y., Lee,Y.S., Kang,G.H. and Jeoung,D.I.
  TITLE     Promoter hypomethylation of a novel cancer/testis antigen gene CAGE
            is correlated with its aberrant expression and is seen in
            premalignant stage of gastric carcinoma
  JOURNAL   Biochem Biophys Res Commun 307 (1), 52-63 (2003)
   PUBMED   12849980
  REMARK    GeneRIF: results suggest that the methylation status of the CpG
            sites of CAGE determines its expression, and that hypomethylation
            of CAGE precedes the development of gastric cancer and
            hepatocellular carcinoma
REFERENCE   10 (bases 1 to 3630)
  AUTHORS   Cho,B., Lim,Y., Lee,D.Y., Park,S.Y., Lee,H., Kim,W.H., Yang,H.,
            Bang,Y.J. and Jeoung,D.I.
  TITLE     Identification and characterization of a novel cancer/testis
            antigen gene CAGE
  JOURNAL   Biochem Biophys Res Commun 292 (3), 715-726 (2002)
   PUBMED   11922625
  REMARK    GeneRIF: CAGE is expressed in a variety of cancers but not in
            normal tissues except testis, and might play a role in cellular
            proliferation.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC117517.7, AY039237.1 and
            BC067878.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_182699.3.
            
            Summary: This intronless gene encodes a protein which contains
            several domains found in members of the DEAD-box helicase protein
            family. Other members of this protein family participate in
            ATP-dependent RNA unwinding. [provided by RefSeq, Sep 2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC067878.1, AY039237.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000327968.7/ ENSP00000368667.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 AC117517.7         83691-83691         c
            2-1767              AY039237.1         6-1771
            1768-1952           BC067878.1         1758-1942
            1953-2130           AY039237.1         1954-2131
            2131-3630           AC117517.7         80062-81561         c
FEATURES             Location/Qualifiers
     source          1..3630
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp22.11"
     gene            1..3630
                     /gene="DDX53"
                     /gene_synonym="CAGE; CT26"
                     /note="DEAD-box helicase 53"
                     /db_xref="GeneID:168400"
                     /db_xref="HGNC:HGNC:20083"
                     /db_xref="MIM:301079"
     exon            1..3630
                     /gene="DDX53"
                     /gene_synonym="CAGE; CT26"
                     /inference="alignment:Splign:2.1.0"
     CDS             99..1994
                     /gene="DDX53"
                     /gene_synonym="CAGE; CT26"
                     /EC_number="3.6.4.13"
                     /note="cancer/testis antigen 26; DEAD-box protein CAGE;
                     probable ATP-dependent RNA helicase DDX53;
                     cancer-associated gene protein; DEAD (Asp-Glu-Ala-Asp) box
                     polypeptide 53"
                     /codon_start=1
                     /product="DEAD box protein 53"
                     /protein_id="NP_874358.2"
                     /db_xref="CCDS:CCDS35214.1"
                     /db_xref="GeneID:168400"
                     /db_xref="HGNC:HGNC:20083"
                     /db_xref="MIM:301079"
                     /translation="MSHWAPEWKRAEANPRDLGASWDVRGSRGSGWSGPFGHQGPRAA
                     GSREPPLCFKIKNNMVGVVIGYSGSKIKDLQHSTNTKIQIINGESEAKVRIFGNREMK
                     AKAKAAIETLIRKQESYNSESSVDNAASQTPIGRNLGRNDIVGEAEPLSNWDRIRAAV
                     VECEKRKWADLPPVKKNFYIESKATSCMSEMQVINWRKENFNITCDDLKSGEKRLIPK
                     PTCRFKDAFQQYPDLLKSIIRVGIVKPTPIQSQAWPIILQGIDLIVVAQTGTGKTLSY
                     LMPGFIHLDSQPISREQRNGPGMLVLTPTRELALHVEAECSKYSYKGLKSICIYGGRN
                     RNGQIEDISKGVDIIIATPGRLNDLQMNNSVNLRSITYLVIDEADKMLDMEFEPQIRK
                     ILLDVRPDRQTVMTSATWPDTVRQLALSYLKDPMIVYVGNLNLVAVNTVKQNIIVTTE
                     KEKRALTQEFVENMSPNDKVIMFVSQKHIADDLSSDFNIQGISAESLHGNSEQSDQER
                     AVEDFKSGNIKILITTDIVSRGLDLNDVTHVYNYDFPRNIDVYVHRVGYIGRTGKTGT
                     SVTLITQRDSKMAGELIKILDRANQSVPEDLVVMAEQYKLNQQKRHRETRSRKPGQRR
                     KEFYFLS"
     regulatory      2109..2114
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DDX53"
                     /gene_synonym="CAGE; CT26"
                     /note="hexamer: AATAAT"
     polyA_site      2130
                     /gene="DDX53"
                     /gene_synonym="CAGE; CT26"
     regulatory      3605..3610
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DDX53"
                     /gene_synonym="CAGE; CT26"
                     /note="hexamer: AATAAA"
     polyA_site      3630
                     /gene="DDX53"
                     /gene_synonym="CAGE; CT26"
                     /note="major polyA site"
ORIGIN      
        1 atcttttggt gcagaaggtg acgggaaaca ggccgcagac ctgaacttcc aaccgtatgt
       61 aggcgagaag ccggtgccga tactcccact atcccacaat gtcccactgg gccccagagt
      121 ggaagagggc ggaggctaat ccaagagacc ttggggccag ctgggatgtc aggggcagca
      181 gaggcagtgg ctggagtggc cccttcggcc atcagggacc gagagcagca ggctcccgtg
      241 aaccaccact ctgctttaaa ataaagaaca atatggttgg tgtggtcatt ggttacagtg
      301 gatcaaaaat aaaagatcta caacattcga caaacactaa aatacagatc ataaacgggg
      361 aatctgaagc aaaagtcaga atttttggca atagggaaat gaaagcaaag gccaaagcgg
      421 ctatagaaac acttattaga aaacaagaaa gctacaactc agaatccagt gtggataatg
      481 ctgcatccca aacccctatt ggaagaaatc taggcagaaa tgacattgtt ggagaagctg
      541 agccattgtc aaattgggat cgcattaggg cagcagtcgt ggagtgcgaa aagagaaaat
      601 gggcagatct accaccagtt aagaaaaact tttacataga atccaaagca acaagctgca
      661 tgtctgaaat gcaggtgatt aactggagaa aggaaaattt caacataacg tgtgatgact
      721 tgaaaagtgg tgaaaagcgt ctcattccaa aaccaacttg caggtttaaa gacgcttttc
      781 agcaataccc tgatcttctg aaaagcataa taagggtagg gattgtaaag ccaacgccaa
      841 ttcagtcaca ggcatggcca attattctac aaggaataga tcttatagta gttgcacaaa
      901 ccggaacagg gaaaacattg tcctatctaa tgcctgggtt tattcatctt gattctcaac
      961 caatatctag agagcaaagg aatgggcctg ggatgctagt ccttacaccc actagagagt
     1021 tggctcttca cgtggaagct gaatgttcaa agtattcata taaaggtctc aaaagcattt
     1081 gcatatatgg tggtagaaac agaaatggac aaatagaaga cattagcaaa ggtgtagata
     1141 tcattattgc aactcctggg aggctgaatg acctacaaat gaataactct gtcaacctaa
     1201 gaagcataac ctacttggtt atagatgagg cagataaaat gctggatatg gaatttgaac
     1261 cccagataag gaagatttta ttagatgtgc gcccagaccg acagactgtt atgacaagtg
     1321 caacttggcc agatactgta cgtcaactag cactttctta tttgaaagat cctatgattg
     1381 tttatgttgg taatctgaat ctagtggctg taaatacagt gaagcaaaat ataattgtta
     1441 ccacagaaaa agaaaaacga gctctcaccc aagaattcgt agagaacatg tcacccaacg
     1501 acaaagtcat catgtttgtc agccaaaaac atattgctga tgacttgtca agcgacttca
     1561 atatccaagg catatctgca gaatcattac atggcaacag tgaacagagt gatcaagagc
     1621 gagcagtaga ggactttaaa agcggaaaca taaagatact gattacaact gatatagtat
     1681 cccgaggtct tgatcttaat gatgtcacac atgtatataa ttatgatttc ccaaggaata
     1741 ttgacgtata tgtacacaga gtagggtaca ttggacggac aggaaagact ggcacatcag
     1801 ttaccctcat cactcagaga gattcgaaaa tggccggtga attgattaaa attctggaca
     1861 gagcaaatca gagtgttccg gaagatcttg tagtaatggc tgagcaatac aagttaaatc
     1921 aacaaaagag gcacagagaa acacgatcaa gaaaacctgg acaaagacgc aaggagtttt
     1981 attttttaag ttgaaaagtt gtaccaggct actggaagat tccaggcatg ttaaagatat
     2041 gcagtattga atatatgtaa ggaagtattg gaaacatact agccatttga agacataact
     2101 aattcttaaa taatactgct aaactttcaa tattgtgtat gctccttaat tttaaaaaag
     2161 tctcaaaaat gagagagtga gagactgtgt gaagagaaag tgaatgttac gtgttggtta
     2221 aagtttaatt tctcttaaaa atacttttat tttaggtttg ggggtatatg tgaaggtttg
     2281 ttaaagaaac acgtgccatg ggggtttatc aactttcaat attgtgtatg ttccttaatt
     2341 ttagaaaaag tctcaaaaat gagagagaga ctatgtgaag agaaggtaaa tgttatgtgt
     2401 tggttaaagt ttaatttctc ctaaaaatac ttttatttta ggtttggggg tatttgtgaa
     2461 ggtttgttaa agaaacacgt gtcatggggg tttatcaact ttcaatattg tgtatgctcc
     2521 ttaattttaa aaaagtctca aaaatgagag agtgagagac tatgtgaaga gaaagtaaat
     2581 gttacgtgtt ggttaaagtt taatttctct taaaaatact tttattttag gtttgggggt
     2641 atatgtgaag gtttgttaaa gaaacacgtg tcatgggggt ttatcaactt tcaatattgt
     2701 gtatgttcct taattttaaa aaagtctcaa aaatgagaga gtgagagact atgtgaagag
     2761 aaagtaaatg ttatgtgttg gttaaagttt aatttctctt aaaaatactt ttattttagg
     2821 tttgggggta tatgtgaagg tttgttaaag aaacacgtgt catgggggtt tactgtacat
     2881 attatttcgt cacccaggta ttaagaccag tgcccaataa ttatcttttc tgctcttctg
     2941 cctccttcca ccctccccca tcagctagac cccagtgtct gctgtttcct tctttgcgtt
     3001 cataagttct catcgtttgc ttcccactta taagtgagaa catgtggtat ttgagtttct
     3061 gttcttgtgt taattttata gtctaccatg tccatttgtc ttctctaaaa cacttggtag
     3121 aagacaacaa tggtgctttt ctggctttaa aatagttgta ctaaattgaa gcatagcttc
     3181 aagcttatcc agtcaaagta ttctcttttc ccccgagcag ttggtgccac aacagttctt
     3241 aaagttattt ccactatcat tctctacttg ttttagttca ttagaaaata agtgctaaat
     3301 tttttagaag attccacaat tctattttta tcagaatgat gtcaccagca gagcaggatg
     3361 tctgactcac tgggattcag gtccttgtat gcattttgtc actaaccctt ggttaaaact
     3421 ctgaggaaat cacttgcctt ctctaggcct caatttctct actcataaaa tgggacagtt
     3481 ttattaattt agaggtctct tttacctcta aaattcggtg acattataac taaaactgta
     3541 taccccagcc ttgtattaac acttttttgt ctaatctagg ggaaattgca tccttgtata
     3601 attgaataaa acaatccttt tcaatgacaa
//
