LOCUS       NM_007010               6383 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens DExD-box helicase 52 (DDX52), transcript variant 1,
            mRNA.
ACCESSION   NM_007010
VERSION     NM_007010.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6383)
  AUTHORS   Xu,M. and Yang,M.
  TITLE     DDX52 gene expression in LUAD tissues indicates potential as a
            prognostic biomarker and therapeutic target
  JOURNAL   Sci Rep 13 (1), 17434 (2023)
   PUBMED   37833424
  REMARK    GeneRIF: DDX52 gene expression in LUAD tissues indicates potential
            as a prognostic biomarker and therapeutic target.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6383)
  AUTHORS   Wang,Q., Qian,L., Tao,M., Liu,J. and Qi,F.Z.
  TITLE     Knockdown of DEAD-box RNA helicase 52 (DDX52) suppresses the
            proliferation of melanoma cells in vitro and of nude mouse
            xenografts by targeting c-Myc
  JOURNAL   Bioengineered 12 (1), 3539-3549 (2021)
   PUBMED   34233596
  REMARK    GeneRIF: Knockdown of DEAD-box RNA helicase 52 (DDX52) suppresses
            the proliferation of melanoma cells in vitro and of nude mouse
            xenografts by targeting c-Myc.
REFERENCE   3  (bases 1 to 6383)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   4  (bases 1 to 6383)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   5  (bases 1 to 6383)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   6  (bases 1 to 6383)
  AUTHORS   Stanchi,F., Bertocco,E., Toppo,S., Dioguardi,R., Simionati,B.,
            Cannata,N., Zimbello,R., Lanfranchi,G. and Valle,G.
  TITLE     Characterization of 16 novel human genes showing high similarity to
            yeast sequences
  JOURNAL   Yeast 18 (1), 69-80 (2001)
   PUBMED   11124703
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC041785.1, AK001245.1, AC243585.2 and AK025721.1.
            
            On Nov 22, 2018 this sequence version replaced NM_007010.4.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC041785.1, SRR1803612.246260.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000617633.5/ ENSP00000479504.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-817               BC041785.1         1-817
            818-2371            AK001245.1         345-1898
            2372-5940           AC243585.2         141872-145440       c
            5941-6383           AK025721.1         2508-2950
FEATURES             Location/Qualifiers
     source          1..6383
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q12"
     gene            1..6383
                     /gene="DDX52"
                     /gene_synonym="HUSSY19; ROK1"
                     /note="DExD-box helicase 52"
                     /db_xref="GeneID:11056"
                     /db_xref="HGNC:HGNC:20038"
                     /db_xref="MIM:612500"
     exon            1..113
                     /gene="DDX52"
                     /gene_synonym="HUSSY19; ROK1"
                     /inference="alignment:Splign:2.1.0"
     CDS             27..1826
                     /gene="DDX52"
                     /gene_synonym="HUSSY19; ROK1"
                     /EC_number="3.6.4.13"
                     /note="isoform 1 is encoded by transcript variant 1;
                     probable ATP-dependent RNA helicase DDX52; DEAD box
                     protein 52; DEAD-box helicase 52; DEAD (Asp-Glu-Ala-Asp)
                     box polypeptide 52"
                     /codon_start=1
                     /product="probable ATP-dependent RNA helicase DDX52
                     isoform 1"
                     /protein_id="NP_008941.3"
                     /db_xref="CCDS:CCDS11323.1"
                     /db_xref="GeneID:11056"
                     /db_xref="HGNC:HGNC:20038"
                     /db_xref="MIM:612500"
                     /translation="MDVHDLFRRLGAGAKFDTRRFSADAARFQIGKRKYDFDSSEVLQ
                     GLDFFGNKKSVPGVCGASQTHQKPQNGEKKEESLTERKREQSKKKRKTMTSEIASQEE
                     GATIQWMSSVEAKIEDKKVQRESKLTSGKLENLRKEKINFLRNKHKIHVQGTDLPDPI
                     ATFQQLDQEYKINSRLLQNILDAGFQMPTPIQMQAIPVMLHGRELLASAPTGSGKTLA
                     FSIPILMQLKQPANKGFRALIISPTRELASQIHRELIKISEGTGFRIHMIHKAAVAAK
                     KFGPKSSKKFDILVTTPNRLIYLLKQDPPGIDLASVEWLVVDESDKLFEDGKTGFRDQ
                     LASIFLACTSHKVRRAMFSATFAYDVEQWCKLNLDNVISVSIGARNSAVETVEQELLF
                     VGSETGKLLAVRELVKKGFNPPVLVFVQSIERAKELFHELIYEGINVDVIHAERTQQQ
                     RDNTVHSFRAGKIWVLICTALLARGIDFKGVNLVINYDFPTSSVEYIHRIGRTGRAGN
                     KGKAITFFTEDDKPLLRSVANVIQQAGCPVPEYIKGFQKLLSKQKKKMIKKPLERESI
                     STTPKCFLEKAKDKQKKVTGQNSKKKVALEDKS"
     exon            114..312
                     /gene="DDX52"
                     /gene_synonym="HUSSY19; ROK1"
                     /inference="alignment:Splign:2.1.0"
     exon            313..443
                     /gene="DDX52"
                     /gene_synonym="HUSSY19; ROK1"
                     /inference="alignment:Splign:2.1.0"
     exon            444..629
                     /gene="DDX52"
                     /gene_synonym="HUSSY19; ROK1"
                     /inference="alignment:Splign:2.1.0"
     exon            630..773
                     /gene="DDX52"
                     /gene_synonym="HUSSY19; ROK1"
                     /inference="alignment:Splign:2.1.0"
     exon            774..885
                     /gene="DDX52"
                     /gene_synonym="HUSSY19; ROK1"
                     /inference="alignment:Splign:2.1.0"
     exon            886..958
                     /gene="DDX52"
                     /gene_synonym="HUSSY19; ROK1"
                     /inference="alignment:Splign:2.1.0"
     exon            959..1162
                     /gene="DDX52"
                     /gene_synonym="HUSSY19; ROK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1163..1253
                     /gene="DDX52"
                     /gene_synonym="HUSSY19; ROK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1254..1376
                     /gene="DDX52"
                     /gene_synonym="HUSSY19; ROK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1377..1527
                     /gene="DDX52"
                     /gene_synonym="HUSSY19; ROK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1528..1603
                     /gene="DDX52"
                     /gene_synonym="HUSSY19; ROK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1604..1675
                     /gene="DDX52"
                     /gene_synonym="HUSSY19; ROK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1676..1768
                     /gene="DDX52"
                     /gene_synonym="HUSSY19; ROK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1769..6383
                     /gene="DDX52"
                     /gene_synonym="HUSSY19; ROK1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2351..2356
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DDX52"
                     /gene_synonym="HUSSY19; ROK1"
                     /note="hexamer: AATAAA"
     polyA_site      2370
                     /gene="DDX52"
                     /gene_synonym="HUSSY19; ROK1"
     regulatory      2987..2992
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DDX52"
                     /gene_synonym="HUSSY19; ROK1"
                     /note="hexamer: AATATA"
     polyA_site      3010
                     /gene="DDX52"
                     /gene_synonym="HUSSY19; ROK1"
                     /note="major polyA site"
     regulatory      6344..6349
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DDX52"
                     /gene_synonym="HUSSY19; ROK1"
                     /note="hexamer: AATAAA"
     polyA_site      6383
                     /gene="DDX52"
                     /gene_synonym="HUSSY19; ROK1"
ORIGIN      
        1 agaactgtgg cgctttctgg gtaaagatgg acgtccacga tctctttcgc cggctcggcg
       61 cgggggccaa attcgacacg agacgcttct cggcagacgc agctcgattc cagataggaa
      121 aaaggaaata tgactttgat tcttcggagg tgcttcaggg actggacttt tttggaaaca
      181 agaagtctgt cccaggtgtg tgtggagcat cacaaacaca tcagaagccc caaaatggag
      241 agaaaaaaga agagagccta actgaaagga agagggagca gagcaagaaa aaaaggaaga
      301 cgatgacttc agaaattgct tcccaagaag aaggtgctac tatacagtgg atgtcatctg
      361 tagaagcaaa gattgaagac aaaaaagttc agagagaaag taaactaact tccggaaagt
      421 tggagaatct cagaaaagaa aagataaact tcttgcggaa taaacacaaa attcacgtcc
      481 aaggaaccga tcttcctgac ccaattgcta catttcagca acttgaccag gaatataaaa
      541 tcaattctcg actacttcag aacattctag atgcaggttt ccaaatgcct acgccaatcc
      601 aaatgcaagc catcccagtt atgctgcatg gtcgggaact tctggcttct gctccaactg
      661 gatctggaaa aacattagct tttagcattc ctattttaat gcagctgaaa caacccgcaa
      721 ataaaggctt cagagccctg attatatcac caacacgaga acttgccagc cagattcaca
      781 gagagttaat aaaaatttct gagggaacag gattcagaat acacatgatc cacaaagcag
      841 cagtggcagc caagaaattt ggacctaaat catctaaaaa gtttgatatt cttgtgacta
      901 ctccaaatcg actaatctat ttattaaagc aagatccccc cggaatcgac ctagcaagtg
      961 ttgagtggct tgtagtagac gaatcagata aactgtttga agatggcaaa actgggttca
     1021 gagaccagct ggcttccatt ttcctggcct gcacatccca caaggtccga agagctatgt
     1081 tcagtgcaac ttttgcatat gatgttgaac agtggtgcaa actcaacctg gacaatgtca
     1141 tcagtgtgtc cattggagca aggaattctg cagtagaaac tgtagaacaa gagcttctct
     1201 ttgttggatc tgagaccgga aaacttctgg ccgtgagaga acttgttaaa aagggtttca
     1261 atccacctgt tcttgttttt gttcagtcca ttgaaagggc taaagaactt tttcatgagc
     1321 tcatatatga aggtattaat gtggatgtta ttcatgcaga gagaacacaa caacagagag
     1381 ataacacagt ccacagtttc agagcaggaa aaatctgggt tctgatttgt acagccttgc
     1441 tagcaagagg gattgatttt aaaggtgtga acttggtgat caactatgac tttccaacta
     1501 gctcagtgga atatatccac aggataggtc gaactggaag agcagggaat aagggaaaag
     1561 caattacatt tttcactgag gatgataagc cattattaag aagcgttgct aatgttatac
     1621 agcaggctgg gtgtcctgta ccagaataca taaaaggttt tcagaaacta ctaagcaaac
     1681 aaaagaaaaa gatgattaag aaaccattgg aaagggagag cattagtaca actccaaaat
     1741 gtttcttaga aaaagctaag gataaacaga aaaaggtcac tggtcagaac agcaagaaga
     1801 aagtagctct tgaagacaaa agttaaaaac agactttaaa aatactgtcc cagaaatgta
     1861 attttatgat cccagcatga atgttatttt catggaatac ttgaagtctt acagtcacct
     1921 gtaccaaaca tttgaaatca actacaagta catgggactg gtgataaatg atcctaaact
     1981 atcaagtcag tttcaatttg taggtgcctt ttttttttcc tgtagagatg agggtcttgc
     2041 catgttgtcc aggctggtct tgaactcctg acctcacaca atcctcctgc cttagcctcc
     2101 tgagtaactg agattacagg cacaagctgc tgcacccagc tctgtaggtg acttttaaat
     2161 gattatacaa tggaaataac attcattgac atttctgtgg tttgaatcca gagagatact
     2221 tcttatagaa aaacaaatgt ttatgctaaa aataacacca aaatgtggtg aactcttaag
     2281 gacttttccc ttcaagtgtg aaggaaggtg tgatgaatgc tgtggagagg catctggaac
     2341 agaaattcaa aataaagcct tgacattaaa taccccttcc actgctcact ttgtggatgg
     2401 tagcatgagc tgtctaccaa gaagaaacct gctgctctct taattttaat atttcctaat
     2461 ttgttgatgg ccttttgtgt tgtgaaccac aacaaagaga ggcctctttt gtggctggtt
     2521 attccagttc cctgggattt taaattcttt ggtctattaa gtatccttgt attggatacg
     2581 taatacctta gtgctgtcat aatgttgtac aagatcatga tcagcttctc cctttcttca
     2641 ttttctgtga tttaaccatg ttctttcctg tctctttcca tttaagatat tttatttgaa
     2701 tactgataaa cattttatcc tgataaggaa gaatgttctt gttacttgat atacctctgt
     2761 cttcattctc ttacagctta tctttcctta ggttgatggt gcctcattta ataagtagat
     2821 ctctacttaa gctaaaggat tatgatcata tggtgttgga gactattagc tattagattt
     2881 ttctcaaaat atgagttttg tacaatggaa tgaaaaagtg acttcatata cgtaagactg
     2941 gtgcctaaga atgacttgaa tgttatcagt actaccacag aactataata tacattgcct
     3001 tttctcagca gcatttgaat tcaacttatt tatttcctct atttgtagct ttttgttcta
     3061 gagtcagaac aggtggactt tgctttgaat attttagatg ggacaaaaat tgttcatctt
     3121 cggaatttat ttaaagaaag atctactggt acagggtgta aaaatactta caagaatatg
     3181 atttttttgt ttgttcatgc aaacagatcc tttacccaat atatattctg gaggtaggta
     3241 tactggtgca acccatttgc cagctgtgtg actttgagta agttcttaat ttctcagagt
     3301 ttcagtgttc tcatctataa aattatgtct ccaattgtga gtacctagca ctgtacctga
     3361 tacatagtaa actcacaata aatatttctt aaacatagat tttgttagga atacaggctt
     3421 gataacacag tccttaccct tacaatgtaa tgttagagat aaaggagcaa atagagtcac
     3481 gcatcactta atgacagaga tatgttctga gaaatgcatc gttaggtgat attgtcattg
     3541 tgtaaacatc atgttgttta cttccacaaa cctagatggt atagcctacc agtacaccta
     3601 ggctatatgg tatagtctgt tgctcctagg ctacaaaccc gtatagcatg ttactgtcct
     3661 gcatgctata gacagttgga acatgtagac ttgtataaac actgcacact taacctatac
     3721 taaatttatt gaaaatattt ttcttggcca ggcgtagtgg ctcatgcctg taatcctaac
     3781 acttcgggag gcctaggcgg gcaggttgtc tgagctcagg agtttagaga ccagcccggg
     3841 caacatggca aaaccccatc tctactaaaa aaaataccaa aaaaagttag ccgggtgtgg
     3901 tggcatagtc ccggctactc aggagtctga ggcaggagaa tagcttgaac ctgtgaggcg
     3961 gaggttgcag taagccgaga tcgcgctact gcactccagc ctgggcgaca gggcaagact
     4021 gtcttgaaaa taaacacaca cacacacatt atatatatta tgtattatat atattagata
     4081 tatatttttt cttcaataaa ttaaccttag cttactgtaa cttttacttt atgagttttt
     4141 ttgttttgtt tttttttttt tttttgagaa acagggtctg ttacctaatt tggagtttag
     4201 tggcacaatc atggcccact gcagccttga cctcttagac tcaagtgatc ctcaaacctc
     4261 agcctcccga gtagctggta ctataggtgc gggccaccaa cactcagcta atttttaaat
     4321 tttgtagaga cgaggtcttg cttgttgtcc agttgggttt tttagatttt tttttttttt
     4381 tttttttgga gatggagtct tgctctgttg cccaggctgg agtgcagtgg catgatctcg
     4441 gctcactgca acctctgact cctgggttca agtgattctc ctgcctcagc ctcccgagtt
     4501 gctgggacta caggcatgcg ccaccacacc cagctaattt ttgtattttt agtgacaggg
     4561 tttcaccatg ttggccaggc tggtctcaaa ctcctgacct ggagtgagcc actatatccg
     4621 gcctttataa acttttttga ttcttgtcat aacacttagc ctaaaatgca aatgtacagc
     4681 tgtagaaaaa tactttattt ctttatatcc ttattctaga agcttttttt ctattaattt
     4741 ttgtttgttt gttttgtttt actatttact tctaaaactt ttttgttaaa aaccatggca
     4801 caaacacaca cattatgcta ggcatacaaa aggtcaggat catcagtctc actgtcttcc
     4861 acccccactt ctcatcccac cattgtatct gctgtctgtg gctgaccaaa acatcatcat
     4921 gtagcacatg actagtgtgg caagtgctct gttagatgta aggccatgat gctaaagcat
     4981 cacaagaggg catctaaccc agattgggga tgtcatggaa ggccgacatc ctgagttgaa
     5041 tcctgcaaat gtaaaaacca ataggcaaag aagaggaaca aaaaggattc caggacaaac
     5101 tgaggtcaca tctatgatcc ttgactttat tgtgtctgtt taaagtatct acagtaacct
     5161 gtatcaactt agtcagtgta ttaatactaa atttagctcc ttcaaagcag ttggaactat
     5221 gtgctacata aatttcagct tcacacaagg aagggaagga gtgaaattag tgaacaggca
     5281 gttacagcaa aagaaaaaac ataaaaattg aatagctggc tctggtgaaa tgagcaagga
     5341 ctttagagtc aaactggcct ggatttgaat cctgatcctc attgcttgta gctgtatgat
     5401 ctggacaaat gacagtaact gtttctaacc ttgattttct catctgtaag atgccaattg
     5461 taactcctaa ggatactgag gattttttaa aatgcgtgta cagttcctga ccagtggttt
     5521 gtgcctaata acttattaca aattattacc cagtaaaaac cttgagacaa gagtgaaaac
     5581 gtaaagctaa ttaatccatt acttgttagc aagcaaacta cgtgcttgag aaaattactc
     5641 aactttcatg ttttacttcc agacagtagt ttgattaaaa gaaaaaaaaa aatcacagcc
     5701 caggcatgtg gctcacaccc tggcacttgg aggccgaggt gggagcatag cttgagccta
     5761 gcagtttgaa actagcctgg gcaacataga tcctatctct acaaaaaaaa aaaaaaaaaa
     5821 aaaaaaaaaa attggcccgg tgtggtggtg catgcctgtg gtcccagcta ctcaggaggc
     5881 tgaggcgaga ggatcgcttg agccagggag gctgaggctg ctgtgagcca tgatcatgcc
     5941 actgcactcc agcctggaca acagagcaag accctgtctc aaaaaaaaaa aaaatcagta
     6001 aaaaatatgc cgaaatagct tcagagtaat tatgaattgc cttccaaaaa ccactgtttt
     6061 gcacttgcct gcaagaatag gaaaaacaaa aggactgtaa ggtggcagga tggcagaacc
     6121 aaacaagagt agtacacctt ggagtttttt cgaaatatgg gttgggtttt tgggctcttg
     6181 gttgatttaa aataaaattt aaatgccttc agcgtctgtg ataggtgcca acatgaagct
     6241 accgagttcc agagaaagag gggagagctg atcactcatc agtgctgcga gactatcaaa
     6301 gggcccttca ggacctatct gttctttgtg tgtaaagagt aacaataaaa gaacaccagt
     6361 gtacccaccg tatagtttaa aaa
//
