LOCUS       NP_008941                599 aa            linear   PRI 27-APR-2025
DEFINITION  probable ATP-dependent RNA helicase DDX52 isoform 1 [Homo sapiens].
ACCESSION   NP_008941
VERSION     NP_008941.3
DBSOURCE    REFSEQ: accession NM_007010.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 599)
  AUTHORS   Xu,M. and Yang,M.
  TITLE     DDX52 gene expression in LUAD tissues indicates potential as a
            prognostic biomarker and therapeutic target
  JOURNAL   Sci Rep 13 (1), 17434 (2023)
   PUBMED   37833424
  REMARK    GeneRIF: DDX52 gene expression in LUAD tissues indicates potential
            as a prognostic biomarker and therapeutic target.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 599)
  AUTHORS   Wang,Q., Qian,L., Tao,M., Liu,J. and Qi,F.Z.
  TITLE     Knockdown of DEAD-box RNA helicase 52 (DDX52) suppresses the
            proliferation of melanoma cells in vitro and of nude mouse
            xenografts by targeting c-Myc
  JOURNAL   Bioengineered 12 (1), 3539-3549 (2021)
   PUBMED   34233596
  REMARK    GeneRIF: Knockdown of DEAD-box RNA helicase 52 (DDX52) suppresses
            the proliferation of melanoma cells in vitro and of nude mouse
            xenografts by targeting c-Myc.
REFERENCE   3  (residues 1 to 599)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   4  (residues 1 to 599)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   5  (residues 1 to 599)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   6  (residues 1 to 599)
  AUTHORS   Stanchi,F., Bertocco,E., Toppo,S., Dioguardi,R., Simionati,B.,
            Cannata,N., Zimbello,R., Lanfranchi,G. and Valle,G.
  TITLE     Characterization of 16 novel human genes showing high similarity to
            yeast sequences
  JOURNAL   Yeast 18 (1), 69-80 (2001)
   PUBMED   11124703
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC041785.1, AK001245.1, AC243585.2 and AK025721.1.
            
            On Apr 17, 2014 this sequence version replaced NP_008941.2.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC041785.1, SRR1803612.246260.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000617633.5/ ENSP00000479504.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..599
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q12"
     Protein         1..599
                     /product="probable ATP-dependent RNA helicase DDX52
                     isoform 1"
                     /EC_number="3.6.4.13"
                     /note="probable ATP-dependent RNA helicase DDX52; DEAD box
                     protein 52; DEAD-box helicase 52; DEAD (Asp-Glu-Ala-Asp)
                     box polypeptide 52"
                     /calculated_mol_wt=67335
     Site            15
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:19608861; propagated from
                     UniProtKB/Swiss-Prot (Q9Y2R4.4)"
     Site            39
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:18669648; propagated from
                     UniProtKB/Swiss-Prot (Q9Y2R4.4)"
     Region          59..100
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Y2R4.4)"
     Region          162..533
                     /region_name="SrmB"
                     /note="Superfamily II DNA and RNA helicase [Replication,
                     recombination and repair]; COG0513"
                     /db_xref="CDD:440279"
     Region          165..193
                     /region_name="Q motif"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Y2R4.4)"
     Region          318..321
                     /region_name="DEAD box"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Y2R4.4)"
     Region          577..599
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Y2R4.4)"
     CDS             1..599
                     /gene="DDX52"
                     /gene_synonym="HUSSY19; ROK1"
                     /coded_by="NM_007010.5:27..1826"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS11323.1"
                     /db_xref="GeneID:11056"
                     /db_xref="HGNC:HGNC:20038"
                     /db_xref="MIM:612500"
ORIGIN      
        1 mdvhdlfrrl gagakfdtrr fsadaarfqi gkrkydfdss evlqgldffg nkksvpgvcg
       61 asqthqkpqn gekkeeslte rkreqskkkr ktmtseiasq eegatiqwms sveakiedkk
      121 vqreskltsg klenlrkeki nflrnkhkih vqgtdlpdpi atfqqldqey kinsrllqni
      181 ldagfqmptp iqmqaipvml hgrellasap tgsgktlafs ipilmqlkqp ankgfralii
      241 sptrelasqi hrelikiseg tgfrihmihk aavaakkfgp ksskkfdilv ttpnrliyll
      301 kqdppgidla svewlvvdes dklfedgktg frdqlasifl actshkvrra mfsatfaydv
      361 eqwcklnldn visvsigarn savetveqel lfvgsetgkl lavrelvkkg fnppvlvfvq
      421 sierakelfh eliyeginvd vihaertqqq rdntvhsfra gkiwvlicta llargidfkg
      481 vnlvinydfp tssveyihri grtgragnkg kaitfftedd kpllrsvanv iqqagcpvpe
      541 yikgfqklls kqkkkmikkp leresisttp kcflekakdk qkkvtgqnsk kkvaledks
//
