LOCUS       NM_175066               4702 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens DEAD-box helicase 51 (DDX51), mRNA.
ACCESSION   NM_175066
VERSION     NM_175066.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4702)
  AUTHORS   Wang,X., Liu,H., Zhao,C., Li,W., Xu,H. and Chen,Y.
  TITLE     The DEAD-box RNA helicase 51 controls non-small cell lung cancer
            proliferation by regulating cell cycle progression via multiple
            pathways
  JOURNAL   Sci Rep 6, 26108 (2016)
   PUBMED   27198888
  REMARK    GeneRIF: these data suggest that DDX51 aids cell cancer
            proliferation by regulating multiple signaling pathways
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4702)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   3  (bases 1 to 4702)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   4  (bases 1 to 4702)
  AUTHORS   Oshikawa,M., Tsutsui,C., Ikegami,T., Fuchida,Y., Matsubara,M.,
            Toyama,S., Usami,R., Ohtoko,K. and Kato,S.
  TITLE     Full-length transcriptome analysis of human retina-derived cell
            lines ARPE-19 and Y79 using the vector-capping method
  JOURNAL   Invest Ophthalmol Vis Sci 52 (9), 6662-6670 (2011)
   PUBMED   21697133
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4702)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   6  (bases 1 to 4702)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
REFERENCE   7  (bases 1 to 4702)
  AUTHORS   Andersen,J.S., Lyon,C.E., Fox,A.H., Leung,A.K., Lam,Y.W., Steen,H.,
            Mann,M. and Lamond,A.I.
  TITLE     Directed proteomic analysis of the human nucleolus
  JOURNAL   Curr Biol 12 (1), 1-11 (2002)
   PUBMED   11790298
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK097078.1, AC138466.12, BC029279.1, BC040185.2 and BC063603.1.
            
            On Nov 23, 2018 this sequence version replaced NM_175066.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC040185.2, AK097078.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000397333.4/ ENSP00000380495.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 AK097078.1         17-19
            4-4                 AC138466.12        53357-53357         c
            5-987               BC029279.1         1-983
            988-1238            BC040185.2         977-1227
            1239-2298           AK097078.1         1255-2314
            2299-3544           AC138466.12        46793-48038         c
            3545-4702           BC063603.1         685-1842
FEATURES             Location/Qualifiers
     source          1..4702
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.33"
     gene            1..4702
                     /gene="DDX51"
                     /note="DEAD-box helicase 51"
                     /db_xref="GeneID:317781"
                     /db_xref="HGNC:HGNC:20082"
     exon            1..327
                     /gene="DDX51"
                     /inference="alignment:Splign:2.1.0"
     CDS             24..2024
                     /gene="DDX51"
                     /EC_number="3.6.4.13"
                     /note="DEAD box protein 51; DEAD (Asp-Glu-Ala-Asp) box
                     polypeptide 51"
                     /codon_start=1
                     /product="ATP-dependent RNA helicase DDX51"
                     /protein_id="NP_778236.2"
                     /db_xref="CCDS:CCDS41865.1"
                     /db_xref="GeneID:317781"
                     /db_xref="HGNC:HGNC:20082"
                     /translation="MALFYVARYPGPDAAAAAGPEGAEAGAHGRARALLERLQSRARE
                     RQQQREPAQTEAAASTEPATRRRRRPRRRRRVNDAEPGSPEAPQGKRRKADGEDAGAE
                     SNEEAPGEPSAGSSEEAPGEPSAGSSEEAPGERSTSASAEAAPDGPALEEAAGPLVPG
                     LVLGGFGKRKAPKVQPFLPRWLAEPNCVRRNVTEDLVPIEDIPDVHPDLQKQLRAHGI
                     SSYFPVQAAVIPALLESAACGFLVGRGGYRPSDLCVSAPTGSGKTLAFVIPVVQALLS
                     RVVCHIRALVVLPTKELAQQVSKVFNIYTDATPLRVSLVTGQKSLAKEQESLVQKTAD
                     GYRCLADIVVATPGRLVDHIDQTPGFSLQQLRFLIIDEADRMIDSMHQSWLPRVVAAA
                     FQSEDPADPCALLQRRQAQAVTAASTCCPQMPLQKLLFSATLTQNPEKLQQLGLHQPR
                     LFSTGLAHRGLEDTDGDGDSGKYAFPVGLTHHYVPCSLSSKPLVVLHLVLEMGFSRVL
                     CFTNSRENSHRLFLLVQAFGGVDVAEFSSRYGPGQRRMILKQFEQGKIQLLISTDATA
                     RGIDVQGVELVVNYDAPQYLRTYVHRVGRTARAGKTGQAFTLLLKVQERRFLRMLTEA
                     GAPELQRHELSSKLLQPLVPRYEEALSQLEESVKEERKQRAA"
     exon            328..542
                     /gene="DDX51"
                     /inference="alignment:Splign:2.1.0"
     exon            543..693
                     /gene="DDX51"
                     /inference="alignment:Splign:2.1.0"
     exon            694..839
                     /gene="DDX51"
                     /inference="alignment:Splign:2.1.0"
     exon            840..911
                     /gene="DDX51"
                     /inference="alignment:Splign:2.1.0"
     exon            912..1018
                     /gene="DDX51"
                     /inference="alignment:Splign:2.1.0"
     exon            1019..1127
                     /gene="DDX51"
                     /inference="alignment:Splign:2.1.0"
     exon            1128..1273
                     /gene="DDX51"
                     /inference="alignment:Splign:2.1.0"
     exon            1274..1463
                     /gene="DDX51"
                     /inference="alignment:Splign:2.1.0"
     exon            1464..1579
                     /gene="DDX51"
                     /inference="alignment:Splign:2.1.0"
     exon            1580..1696
                     /gene="DDX51"
                     /inference="alignment:Splign:2.1.0"
     exon            1697..1798
                     /gene="DDX51"
                     /inference="alignment:Splign:2.1.0"
     exon            1799..1862
                     /gene="DDX51"
                     /inference="alignment:Splign:2.1.0"
     exon            1863..1997
                     /gene="DDX51"
                     /inference="alignment:Splign:2.1.0"
     exon            1998..4702
                     /gene="DDX51"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3505..3510
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DDX51"
                     /note="hexamer: TATAAA"
     polyA_site      3527
                     /gene="DDX51"
                     /note="major polyA site"
     regulatory      4684..4689
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DDX51"
                     /note="hexamer: ATTAAA"
     polyA_site      4702
                     /gene="DDX51"
                     /note="major polyA site"
ORIGIN      
        1 gagtcccagg cgtgcggctg gccatggcgc tgttctacgt cgcgcggtac ccgggccccg
       61 atgcggcagc tgcggcgggg ccggagggcg cggaggccgg ggcgcacggc agggcccgcg
      121 cgctgctcga gcggctgcag agccgggccc gcgaacggca gcagcagcgg gagcccgcgc
      181 agaccgaggc ggctgcatcg accgagccgg cgaccaggag gcgacggcgg ccccggcggc
      241 ggcggcgggt gaacgacgcg gagccgggga gcccggaggc gccgcaggga aagcgacgga
      301 aggcggacgg cgaggacgcg ggcgcagaaa gcaacgagga ggcgccaggg gagcccagcg
      361 cagggagcag cgaggaggcg ccaggggagc ccagcgcagg gagcagcgag gaggcgccgg
      421 gggagcgcag caccagcgcc agcgccgagg cggccccaga tggaccggcc ctggaggagg
      481 cggccggacc cctggtcccc ggcctggtgc tgggggggtt cgggaagagg aaggcgccga
      541 aggtccagcc tttcctgcca aggtggctgg ctgagcctaa ctgtgtcaga aggaatgtca
      601 ccgaagacct ggttcctatc gaggacatcc ctgacgtcca tcctgacctg cagaagcagc
      661 tgcgggcaca cggcatctcg tcctactttc cagtccaggc agctgtgatt cctgccctcc
      721 tggagagcgc agcctgtggg tttctggtgg gcagaggtgg ctaccggcct agcgacctct
      781 gtgtttctgc cccaacaggc agtgggaaga cactggcctt cgtcatccct gtggtgcagg
      841 ccctgctttc gagagtggtc tgccacatcc gtgccctggt tgtgctgccc accaaggagc
      901 tggcccagca ggtgagcaaa gttttcaaca tctacacaga tgccacacct ctgagagtct
      961 ccctggttac gggacagaag tctctggcca aggagcagga gagcctcgtc cagaaaacag
     1021 ctgatgggta ccgctgcttg gctgacatcg tggtagccac ccccggccgc ctggtggacc
     1081 acatcgacca gaccccagga ttcagcctcc agcagctccg cttcctgatt atcgacgagg
     1141 ctgaccggat gattgacagc atgcatcagt cctggctgcc gcgggtggtg gcggccgcct
     1201 tccagagcga ggaccccgcg gacccctgtg ccctgctcca gcgaaggcag gcccaggctg
     1261 tgacagccgc cagcacctgc tgtccccaga tgcccctgca gaagctgctc ttctcagcta
     1321 ctctgaccca gaaccctgaa aagctgcagc agctgggcct ccaccagccc cggcttttct
     1381 ccacagggct agcacacagg ggcctggaag atacagatgg ggacggggat tcggggaagt
     1441 atgcctttcc tgttgggctc acgcaccact acgtgccctg cagcctcagc tctaagccgc
     1501 tggtcgtcct gcacctggtc ctggagatgg gcttctcgag ggttctctgc ttcactaact
     1561 cccgagagaa ctcccacagg ctcttcctgc tggtgcaagc ttttgggggt gtggacgtgg
     1621 ctgagttctc ctcgcgctac gggcctggcc agaggaggat gatcctgaag cagtttgaac
     1681 aggggaagat ccagctgctc atcagcacgg acgccaccgc gcgaggcatc gacgtgcagg
     1741 gtgtggagct ggtggtgaac tacgacgccc cccagtacct gagaacctac gtgcaccggg
     1801 ttgggaggac agctcgcgct gggaaaactg gacaggcctt cacactgctc ctgaaagtgc
     1861 aggagaggag attcctccga atgctaactg aagctggggc acctgagttg cagcggcacg
     1921 agctctccag caagctgctg cagccgctgg ttcctcggta cgaggaggcc ctgtcccagc
     1981 tggaggagtc tgtcaaggaa gagcgcaagc agagggcggc ctaggctggg gctcagaggg
     2041 ccggagggac tgaacgctca ccaccctgac cctccttcca gagcagtgct gatcactgga
     2101 tcctgtatgt gaggaaagga atcccccagt ggacacagcc ttcctcccca agcacgtggt
     2161 ctctgcgcca ggcagcccgg gcgtcagagc tcaagcacct gccccgactg gagacttcag
     2221 ggcttgtcac tttcagagtg tggaggtcag gatggctgcg ggcaatgaag ccttagtaaa
     2281 acggtgaaaa gtactcccag acggacgcgg gcacccgtca tgcttttgct gagagttggg
     2341 ggcattaacc ttgagctaat gttaaaaatc aagctcttgg ccaggcatgg tggctcatgc
     2401 ctgtaattcc agcactttgg gaggccaagg cgggtggatc acctgaggtc acgagttcga
     2461 gaccagcctg accaacatgg agaaaccctg tctctactaa aaatacaaaa ttagccaggc
     2521 gtggtggtgc atgcctgtaa tccagctact tgggaggctg aggcaggaaa atggcttgaa
     2581 cccgggaggt ggaggttgca gtgagctgag attgcgccac tgcactccag cctgggcaac
     2641 aagagcaaaa ctccgtctca aaaaaaaaaa ttgccgggcg cggtggcaaa tgcctgtaat
     2701 cccagcactt tgggaggccg aggcaggtgg atcacaaggt caggagatag agaccatcat
     2761 tgctaacatg gtgaaacccc gtctctacta aaaatacaaa aaaaaaaaaa aaacaactag
     2821 ccgggcgtgg tggcgggcac ctatagtccc agctactcgg gaggctgagg caggagaatg
     2881 gcgtgaaccc gggaggcgga gcttgcagtg agcggagact gcgccactgc actccagcct
     2941 gggcaacaga gtgagactcc gtcaaaaaaa aagctctcct ccccagattt gtgaaccttg
     3001 tgactgttca gtggacacct cacatattgc tggtgggaag gtcacgtgga gacagctggg
     3061 caaagccttg gggcgttaaa cacagagtca ctcatgaccc agcacttcct ctcctatgca
     3121 ccttgtacac cccagatcaa tgaaacctac atccacacag aaacgtacac aaatctctca
     3181 gcagcactgt tcacagtagc caaaaactag aaaccacatg tccgtcagct gatgaatgga
     3241 gaataaaacg tgggaaatcc acaccaggag agaaaaagga gtgaggcacc agcataggca
     3301 ccccgtggat gaacccggaa cctgacgcta actgaaggaa ggctccggct atagggagtg
     3361 tcccaggcac agccagagat tgaagggtgc cggggccggg agttggtggg ggttggggct
     3421 ggggacacag tggccagtgt gtgggtttgt tttggggatg atgaaaatgt tcttaggttg
     3481 tgtgtggtga tggctgctca cctctataaa ccttttacta aaaaccatgg actgggtgga
     3541 tacagtgtgt gaattctctc agtccagtgc tttgtttgaa aaaggtggat gatgccaaca
     3601 tcactaaccg ccagggagac gcaggccacg gccacacccg gctcactgga gttgtgagga
     3661 tggaaacacc agcccacccc actcagttca gacctcagct tagatgcaaa gaatgtctgg
     3721 gatggggact ggcagctgat tagagatgca accactgaac ctgtggactg tgttcaaaca
     3781 aatgccagca gaacacaaaa ggcgactgtt acaggaggca gaaagaaatg atttaggtag
     3841 acggggtaaa gccagtcccc agcagaaaat ttgcctttta acaaaaagca gctcaaaaat
     3901 agctcccttt ctaacctcgg ggttcaaaat cacttctcac gacaagcagc cagaaagagc
     3961 agactgtgaa tcacagatga gacagctcgg gcacaggagt gcggggggtg tctcctgggt
     4021 gatcaccaaa cttcacactt ccacaatggg ccccagtaaa acagtggacc ctaataagca
     4081 cattcccgtc cccttaggtg cactaaggga agctaaaagc agactgaggg gtgcctgtaa
     4141 ccccaagaag atgtctggga gcagacccag agaccctcgc agaaaagtgt cacagagcag
     4201 cacagactga gtctgacaga aactctctat acaaatagca caccttgtcc cagctaaaac
     4261 cctgggccct gggaggacaa gacatccctc ctctaacccc tcgtcactag cccatttgta
     4321 aaaaccttga caggccgggc acggtggctc acacctgtaa tcccagcact ttgggaggct
     4381 gaggcaggcg catcacctga ggtcaggaga tcgagaccat cctggccaac atggtgaaac
     4441 cccatctcta ctaaaaatac aaaacttagc tgagcgtggt ggcgtgtgcc tggagtccca
     4501 actactcaag aggctgaggc aggagaatca cttgcccggg aggtggaggt tgcagtgggc
     4561 caagatcagc ccactgcact gcagcctggc gacagaaaaa aaagaaacct tgacatcttt
     4621 actacaactt agcaacccgc tcaggccccc tctgcaacgg agagctcttc ttcctttttg
     4681 cttattaaac ttctgctcca aa
//
