LOCUS       NM_019070               1793 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens DEAD-box helicase 49 (DDX49), transcript variant 1,
            mRNA.
ACCESSION   NM_019070
VERSION     NM_019070.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1793)
  AUTHORS   Tao,J., Ge,Q., Meng,J., Liang,C., Hao,Z. and Zhou,J.
  TITLE     Overexpression of DDX49 in prostate cancer is associated with poor
            prognosis
  JOURNAL   BMC Urol 23 (1), 66 (2023)
   PUBMED   37106339
  REMARK    GeneRIF: Overexpression of DDX49 in prostate cancer is associated
            with poor prognosis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1793)
  AUTHORS   Chen,Y., Ma,Q. and Sun,N.
  TITLE     DDX49 Promotes Proliferation and Metastasis of Cervical Cancer by
            Regulation of AKT and Wnt/beta-Catenin Signalings
  JOURNAL   Ann Clin Lab Sci 53 (2), 271-277 (2023)
   PUBMED   37094865
  REMARK    GeneRIF: DDX49 Promotes Proliferation and Metastasis of Cervical
            Cancer by Regulation of AKT and Wnt/beta-Catenin Signalings.
REFERENCE   3  (bases 1 to 1793)
  AUTHORS   Serfecz,J.C., Hong,Y., Gay,L.A., Shekhar,R., Turner,P.C. and
            Renne,R.
  TITLE     DExD/H Box Helicases DDX24 and DDX49 Inhibit Reactivation of
            Kaposi's Sarcoma Associated Herpesvirus by Interacting with Viral
            mRNAs
  JOURNAL   Viruses 14 (10), 2083 (2022)
   PUBMED   36298642
  REMARK    GeneRIF: DExD/H Box Helicases DDX24 and DDX49 Inhibit Reactivation
            of Kaposi's Sarcoma Associated Herpesvirus by Interacting with
            Viral mRNAs.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1793)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 1793)
  AUTHORS   Dai,H., Feng,J., Nan,Z., Wei,L., Lin,F., Jin,R., Zhang,S., Wang,X.
            and Pan,L.
  TITLE     Morphine may act via DDX49 to inhibit hepatocellular carcinoma cell
            growth
  JOURNAL   Aging (Albany NY) 13 (9), 12766-12779 (2021)
   PUBMED   33952717
  REMARK    GeneRIF: Morphine may act via DDX49 to inhibit hepatocellular
            carcinoma cell growth.
REFERENCE   6  (bases 1 to 1793)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   7  (bases 1 to 1793)
  AUTHORS   Lian,X., Xiang,D., Peng,C., Chen,J., Liao,M., Sun,G. and Zhang,Z.
  TITLE     DDX49 is a novel biomarker and therapeutic target for lung cancer
            metastases
  JOURNAL   J Cell Mol Med 24 (1), 1141-1145 (2020)
   PUBMED   31749282
  REMARK    GeneRIF: DDX49 is a novel biomarker and therapeutic target for lung
            cancer metastases.
REFERENCE   8  (bases 1 to 1793)
  AUTHORS   Awasthi,S., Verma,M., Mahesh,A., K Khan,M.I., Govindaraju,G.,
            Rajavelu,A., Chavali,P.L., Chavali,S. and Dhayalan,A.
  TITLE     DDX49 is an RNA helicase that affects translation by regulating
            mRNA export and the levels of pre-ribosomal RNA
  JOURNAL   Nucleic Acids Res 46 (12), 6304-6317 (2018)
   PUBMED   29618122
  REMARK    GeneRIF: DDX49 displays a robust ATPase and RNA helicase activity
            and it is involved in the export of poly (A)+ mRNAs to cytoplasm.
            DDX49 is localized in the nucleolus and regulates the steady state
            levels of pre-ribosomal 47S RNA and global translation.
REFERENCE   9  (bases 1 to 1793)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   10 (bases 1 to 1793)
  AUTHORS   Grimwood,J., Gordon,L.A., Olsen,A., Terry,A., Schmutz,J.,
            Lamerdin,J., Hellsten,U., Goodstein,D., Couronne,O.,
            Tran-Gyamfi,M., Aerts,A., Altherr,M., Ashworth,L., Bajorek,E.,
            Black,S., Branscomb,E., Caenepeel,S., Carrano,A., Caoile,C.,
            Chan,Y.M., Christensen,M., Cleland,C.A., Copeland,A., Dalin,E.,
            Dehal,P., Denys,M., Detter,J.C., Escobar,J., Flowers,D.,
            Fotopulos,D., Garcia,C., Georgescu,A.M., Glavina,T., Gomez,M.,
            Gonzales,E., Groza,M., Hammon,N., Hawkins,T., Haydu,L., Ho,I.,
            Huang,W., Israni,S., Jett,J., Kadner,K., Kimball,H., Kobayashi,A.,
            Larionov,V., Leem,S.H., Lopez,F., Lou,Y., Lowry,S., Malfatti,S.,
            Martinez,D., McCready,P., Medina,C., Morgan,J., Nelson,K.,
            Nolan,M., Ovcharenko,I., Pitluck,S., Pollard,M., Popkie,A.P.,
            Predki,P., Quan,G., Ramirez,L., Rash,S., Retterer,J., Rodriguez,A.,
            Rogers,S., Salamov,A., Salazar,A., She,X., Smith,D., Slezak,T.,
            Solovyev,V., Thayer,N., Tice,H., Tsai,M., Ustaszewska,A., Vo,N.,
            Wagner,M., Wheeler,J., Wu,K., Xie,G., Yang,J., Dubchak,I.,
            Furey,T.S., DeJong,P., Dickson,M., Gordon,D., Eichler,E.E.,
            Pennacchio,L.A., Richardson,P., Stubbs,L., Rokhsar,D.S.,
            Myers,R.M., Rubin,E.M. and Lucas,S.M.
  TITLE     The DNA sequence and biology of human chromosome 19
  JOURNAL   Nature 428 (6982), 529-535 (2004)
   PUBMED   15057824
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC002674.2 and AU148229.1.
            
            On Nov 22, 2018 this sequence version replaced NM_019070.4.
            
            Transcript Variant: This variant (1) represents the longer
            transcript.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163658.537247.1, BC002674.2
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000247003.9/ ENSP00000247003.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1651              BC002674.2         31-1681
            1652-1793           AU148229.1         4-145               c
FEATURES             Location/Qualifiers
     source          1..1793
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.11"
     gene            1..1793
                     /gene="DDX49"
                     /gene_synonym="Dbp8; R27090_2"
                     /note="DEAD-box helicase 49"
                     /db_xref="GeneID:54555"
                     /db_xref="HGNC:HGNC:18684"
     exon            1..142
                     /gene="DDX49"
                     /gene_synonym="Dbp8; R27090_2"
                     /inference="alignment:Splign:2.1.0"
     CDS             28..1479
                     /gene="DDX49"
                     /gene_synonym="Dbp8; R27090_2"
                     /EC_number="3.6.4.13"
                     /note="DEAD box protein 49; DEAD (Asp-Glu-Ala-Asp) box
                     polypeptide 49"
                     /codon_start=1
                     /product="probable ATP-dependent RNA helicase DDX49"
                     /protein_id="NP_061943.2"
                     /db_xref="CCDS:CCDS12390.1"
                     /db_xref="GeneID:54555"
                     /db_xref="HGNC:HGNC:18684"
                     /translation="MAGFAELGLSSWLVEQCRQLGLKQPTPVQLGCIPAILEGRDCLG
                     CAKTGSGKTAAFVLPILQKLSEDPYGIFCLVLTPTRELAYQIAEQFRVLGKPLGLKDC
                     IIVGGMDMVAQALELSRKPHVVIATPGRLADHLRSSNTFSIKKIRFLVMDEADRLLEQ
                     GCTDFTVDLEAILAAVPARRQTLLFSATLTDTLRELQGLATNQPFFWEAQAPVSTVEQ
                     LDQRYLLVPEKVKDAYLVHLIQRFQDEHEDWSIIIFTNTCKTCQILCMMLRKFSFPTV
                     ALHSMMKQKERFAALAKFKSSIYRILIATDVASRGLDIPTVQVVINHNTPGLPKIYIH
                     RVGRTARAGRQGQAITLVTQYDIHLVHAIEEQIKKKLEEFSVEEAEVLQILTQVNVVR
                     RECEIKLEAAHFDEKKEINKRKQLILEGKDPDLEAKRKAELAKIKQKNRRFKEKVEET
                     LKRQKAGRAGHKGRPPRTPSGSHSGPVPSQGLV"
     exon            143..266
                     /gene="DDX49"
                     /gene_synonym="Dbp8; R27090_2"
                     /inference="alignment:Splign:2.1.0"
     exon            267..352
                     /gene="DDX49"
                     /gene_synonym="Dbp8; R27090_2"
                     /inference="alignment:Splign:2.1.0"
     exon            353..474
                     /gene="DDX49"
                     /gene_synonym="Dbp8; R27090_2"
                     /inference="alignment:Splign:2.1.0"
     exon            475..662
                     /gene="DDX49"
                     /gene_synonym="Dbp8; R27090_2"
                     /inference="alignment:Splign:2.1.0"
     exon            663..803
                     /gene="DDX49"
                     /gene_synonym="Dbp8; R27090_2"
                     /inference="alignment:Splign:2.1.0"
     exon            804..879
                     /gene="DDX49"
                     /gene_synonym="Dbp8; R27090_2"
                     /inference="alignment:Splign:2.1.0"
     exon            880..956
                     /gene="DDX49"
                     /gene_synonym="Dbp8; R27090_2"
                     /inference="alignment:Splign:2.1.0"
     exon            957..1054
                     /gene="DDX49"
                     /gene_synonym="Dbp8; R27090_2"
                     /inference="alignment:Splign:2.1.0"
     exon            1055..1129
                     /gene="DDX49"
                     /gene_synonym="Dbp8; R27090_2"
                     /inference="alignment:Splign:2.1.0"
     exon            1130..1218
                     /gene="DDX49"
                     /gene_synonym="Dbp8; R27090_2"
                     /inference="alignment:Splign:2.1.0"
     exon            1219..1290
                     /gene="DDX49"
                     /gene_synonym="Dbp8; R27090_2"
                     /inference="alignment:Splign:2.1.0"
     exon            1291..1793
                     /gene="DDX49"
                     /gene_synonym="Dbp8; R27090_2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1768..1773
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DDX49"
                     /gene_synonym="Dbp8; R27090_2"
                     /note="hexamer: AATAAA"
     polyA_site      1793
                     /gene="DDX49"
                     /gene_synonym="Dbp8; R27090_2"
                     /note="major polyA site"
ORIGIN      
        1 aaggggcccc tacaagcggc cacaaggatg gcaggcttcg cggagctcgg gctgtcatcg
       61 tggctcgtgg aacaatgtcg gcagctgggt ttgaagcagc ccacgcccgt gcagctcggc
      121 tgcatccccg ccatcctgga gggtcgagac tgcttgggct gtgctaagac aggcagtggg
      181 aagacagcag cgtttgtcct tcccatcttg cagaagctgt ctgaggatcc ctatggcatc
      241 ttctgcctcg tcctgacacc caccagggag ctggcctacc agatcgcaga gcagttccgg
      301 gtcctgggga agcctctagg gctgaaagac tgcatcatcg tcggtggcat ggacatggtg
      361 gcccaggcgc tggagctctc tcggaaacca cacgtggtca tcgccacgcc ggggcgcctg
      421 gcagatcacc tgcgcagctc caacactttt agtataaaga agatccgctt cctggtgatg
      481 gatgaggcag accggctgct ggaacagggc tgcactgact tcaccgtgga cctggaggcc
      541 atcctggcgg ctgtgccggc ccgcaggcag acactgctgt tcagcgccac gctgaccgac
      601 acactccggg agctgcaggg tctggccacc aaccagccct tcttctggga agcacaggcc
      661 ccggtgagca ccgtggagca gctggaccag cgctacctgc tggtgcctga gaaggtcaag
      721 gacgcctacc tggtccacct gatccagcgc ttccaggatg agcacgagga ctggtccatt
      781 atcatcttca ccaacacgtg caagacctgc cagattctgt gcatgatgct gcgcaaattc
      841 agcttcccca ccgtggctct gcactccatg atgaagcaga aagaacgctt tgccgcccta
      901 gccaagttca agtccagcat ctaccggatc ctgatcgcaa cagacgtggc ctcccggggc
      961 ctggacatcc ctacggtaca ggtggtcatc aaccacaaca cccccgggct ccccaagatc
     1021 tacatccacc gagtcggccg gacggcccgt gcagggcggc agggtcaggc catcacgctg
     1081 gtgacacagt acgacatcca cctggtgcac gccatcgagg agcagatcaa gaagaagctg
     1141 gaggagttct ccgtggaaga ggccgaggtg ctacagatcc tcacacaggt caacgtggtg
     1201 cgaagagagt gtgagatcaa actggaggcg gcccactttg acgaaaagaa ggagatcaac
     1261 aaacggaagc agctgatcct ggaggggaag gaccctgacc tggaggccaa gcgcaaggct
     1321 gagctggcca agatcaagca gaagaaccgg cgcttcaagg agaaggtgga ggagacgctg
     1381 aagcgacaga aggctggcag ggctggccac aaggggcgtc cacccaggac accgtctggg
     1441 tcccactcag gcccagtccc ctcccagggc ctggtctgag ccccacacgg ccatctgccc
     1501 agtccttgac tcgtccatgg agctgagggt cggaggaacc ttccttgggg gcagcagccc
     1561 ttcccggggg cctacccagt gccccacagc agaacccgtg ggcgctcgtg ttgtgcgggc
     1621 cctgctcctc tgccccgaaa ccactggctg gtcccttccc tgagccctgg ccaagattca
     1681 ggctgcaggg gaagaaagaa catgaccggg aggttgtgac cccaacccaa ggtcaccccc
     1741 caggggtgcc gcatacagga ggtgcttaat aaacgggtct tttgacttcc tca
//
