LOCUS       NP_057439                455 aa            linear   PRI 27-APR-2025
DEFINITION  probable ATP-dependent RNA helicase DDX47 isoform 1 [Homo sapiens].
ACCESSION   NP_057439
VERSION     NP_057439.2
DBSOURCE    REFSEQ: accession NM_016355.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 455)
  AUTHORS   Zhu,Y., Cai,W., Zheng,Y., Zhang,W., Wang,B. and Kang,Y.
  TITLE     BIOINFORMATICS APPLICATIONS UNDER CONDITION CONTROL: HIGH
            DIAGNOSTIC VALUE OF DDX47 IN REAL MEDICAL SETTINGS
  JOURNAL   Shock 61 (1), 97-104 (2024)
   PUBMED   37553903
  REMARK    GeneRIF: BIOINFORMATICS APPLICATIONS UNDER CONDITION CONTROL: HIGH
            DIAGNOSTIC VALUE OF DDX47 IN REAL MEDICAL SETTINGS.
REFERENCE   2  (residues 1 to 455)
  AUTHORS   Marchena-Cruz,E., Camino,L.P., Bhandari,J., Silva,S.,
            Marqueta-Gracia,J.J., Amdeen,S.A., Guillen-Mendoza,C.,
            Garcia-Rubio,M.L., Calderon-Montano,J.M., Xue,X., Luna,R. and
            Aguilera,A.
  TITLE     DDX47, MeCP2, and other functionally heterogeneous factors protect
            cells from harmful R loops
  JOURNAL   Cell Rep 42 (3), 112148 (2023)
   PUBMED   36827184
  REMARK    GeneRIF: DDX47, MeCP2, and other functionally heterogeneous factors
            protect cells from harmful R loops.
REFERENCE   3  (residues 1 to 455)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   4  (residues 1 to 455)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   5  (residues 1 to 455)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   6  (residues 1 to 455)
  AUTHORS   Andersen,J.S., Lam,Y.W., Leung,A.K., Ong,S.E., Lyon,C.E.,
            Lamond,A.I. and Mann,M.
  TITLE     Nucleolar proteome dynamics
  JOURNAL   Nature 433 (7021), 77-83 (2005)
   PUBMED   15635413
REFERENCE   7  (residues 1 to 455)
  AUTHORS   Regard,J.B., Scheek,S., Borbiev,T., Lanahan,A.A., Schneider,A.,
            Demetriades,A.M., Hiemisch,H., Barnes,C.A., Verin,A.D. and
            Worley,P.F.
  TITLE     Verge: a novel vascular early response gene
  JOURNAL   J Neurosci 24 (16), 4092-4103 (2004)
   PUBMED   15102925
REFERENCE   8  (residues 1 to 455)
  AUTHORS   Scherl,A., Coute,Y., Deon,C., Calle,A., Kindbeiter,K.,
            Sanchez,J.C., Greco,A., Hochstrasser,D. and Diaz,J.J.
  TITLE     Functional proteomic analysis of human nucleolus
  JOURNAL   Mol Biol Cell 13 (11), 4100-4109 (2002)
   PUBMED   12429849
REFERENCE   9  (residues 1 to 455)
  AUTHORS   Doorbar,J., Elston,R.C., Napthine,S., Raj,K., Medcalf,E.,
            Jackson,D., Coleman,N., Griffin,H.M., Masterson,P., Stacey,S.,
            Mengistu,Y. and Dunlop,J.
  TITLE     The E1E4 protein of human papillomavirus type 16 associates with a
            putative RNA helicase through sequences in its C terminus
  JOURNAL   J Virol 74 (21), 10081-10095 (2000)
   PUBMED   11024137
REFERENCE   10 (residues 1 to 455)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL136666.1 and BC009379.2.
            
            On Apr 15, 2002 this sequence version replaced NP_057439.1.
            
            Summary: This gene encodes a member of the DEAD box protein family.
            DEAD box proteins, characterized by the conserved motif
            Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are
            implicated in a number of cellular processes involving alteration
            of RNA secondary structure, such as translation initiation, nuclear
            and mitochondrial splicing, and ribosome and spliceosome assembly.
            Based on their distribution patterns, some members of this family
            are believed to be involved in embryogenesis, spermatogenesis, and
            cellular growth and division. The protein encoded by this gene can
            shuttle between the nucleus and the cytoplasm, and has an
            RNA-independent ATPase activity. Two alternatively spliced
            transcript variants encoding distinct isoforms have been found for
            this gene. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL136666.1, SRR5189661.115172.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000358007.7/ ENSP00000350698.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..455
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.1"
     Protein         1..455
                     /product="probable ATP-dependent RNA helicase DDX47
                     isoform 1"
                     /EC_number="3.6.4.13"
                     /note="E4-DEAD box protein; probable ATP-dependent RNA
                     helicase DDX47; DEAD box polypeptide 47; DEAD box protein
                     47; DEAD (Asp-Glu-Ala-Asp) box polypeptide 47"
                     /calculated_mol_wt=50516
     Region          1..20
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9H0S4.1)"
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylalanine. /evidence=ECO:0000269|Ref.6,
                     ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:20068231,
                     ECO:0007744|PubMed:21406692; propagated from
                     UniProtKB/Swiss-Prot (Q9H0S4.1)"
     Site            9
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21406692,
                     ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (Q9H0S4.1)"
     Region          23..453
                     /region_name="SrmB"
                     /note="Superfamily II DNA and RNA helicase [Replication,
                     recombination and repair]; COG0513"
                     /db_xref="CDD:440279"
     Region          24..52
                     /region_name="Q motif"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9H0S4.1)"
     Site            149
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (Q9H0S4.1)"
     Region          174..177
                     /region_name="DEAD box"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9H0S4.1)"
     Region          413..455
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9H0S4.1)"
     Site            424
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:18669648; propagated from
                     UniProtKB/Swiss-Prot (Q9H0S4.1)"
     CDS             1..455
                     /gene="DDX47"
                     /gene_synonym="E4-DBP; HQ0256; MSTP162; RRP3"
                     /coded_by="NM_016355.4:23..1390"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS8655.1"
                     /db_xref="GeneID:51202"
                     /db_xref="HGNC:HGNC:18682"
                     /db_xref="MIM:615428"
ORIGIN      
        1 maapeehdsp teasqpivee eetktfkdlg vtdvlceacd qlgwtkptki qieaiplalq
       61 grdiiglaet gsgktgafal pilnalletp qrlfalvltp trelafqise qfealgssig
      121 vqsavivggi dsmsqslala kkphiiiatp grlidhlent kgfnlralky lvmdeadril
      181 nmdfetevdk ilkviprdrk tflfsatmtk kvqklqraal knpvkcavss kyqtveklqq
      241 yyifipskfk dtylvyilne lagnsfmifc stcnntqrta lllrnlgfta iplhgqmsqs
      301 krlgslnkfk akarsillat dvasrgldip hvdvvvnfdi pthskdyihr vgrtaragrs
      361 gkaitfvtqy dvelfqrieh ligkklpgfp tqddevmmlt ervaeaqrfa rmelrehgek
      421 kkrsredagd nddtegaigv rnkvaggkmk krkgr
//
