LOCUS       NM_001300860            5674 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens DEAD-box helicase 46 (DDX46), transcript variant 1,
            mRNA.
ACCESSION   NM_001300860 XM_005272142
VERSION     NM_001300860.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5674)
  AUTHORS   Yang,G., Wang,Y., Wang,K., Liu,X. and Yang,J.
  TITLE     Oncogenic DDX46 promotes pancreatic cancer development and
            gemcitabine resistance by facilitating the JMJD6/CDK4 signaling
            pathway
  JOURNAL   Neoplasma 71 (3), 231-242 (2024)
   PUBMED   38764294
  REMARK    GeneRIF: Oncogenic DDX46 promotes pancreatic cancer development and
            gemcitabine resistance by facilitating the JMJD6/CDK4 signaling
            pathway.
REFERENCE   2  (bases 1 to 5674)
  AUTHORS   Yang,F., Bian,T., Zhan,X., Chen,Z., Xing,Z., Larsen,N.A., Zhang,X.
            and Shi,Y.
  TITLE     Mechanisms of the RNA helicases DDX42 and DDX46 in human U2 snRNP
            assembly
  JOURNAL   Nat Commun 14 (1), 897 (2023)
   PUBMED   36797247
  REMARK    GeneRIF: Mechanisms of the RNA helicases DDX42 and DDX46 in human
            U2 snRNP assembly.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5674)
  AUTHORS   Ma,Z., Song,J., Hua,Y., Wang,Y., Cao,W., Wang,H. and Hou,L.
  TITLE     The role of DDX46 in breast cancer proliferation and invasiveness:
            A potential therapeutic target
  JOURNAL   Cell Biol Int 47 (1), 283-291 (2023)
   PUBMED   36200534
  REMARK    GeneRIF: The role of DDX46 in breast cancer proliferation and
            invasiveness: A potential therapeutic target.
REFERENCE   4  (bases 1 to 5674)
  AUTHORS   Tholen,J., Razew,M., Weis,F. and Galej,W.P.
  TITLE     Structural basis of branch site recognition by the human
            spliceosome
  JOURNAL   Science 375 (6576), 50-57 (2022)
   PUBMED   34822310
REFERENCE   5  (bases 1 to 5674)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 5674)
  AUTHORS   Gudbjartsson,D.F., Walters,G.B., Thorleifsson,G., Stefansson,H.,
            Halldorsson,B.V., Zusmanovich,P., Sulem,P., Thorlacius,S.,
            Gylfason,A., Steinberg,S., Helgadottir,A., Ingason,A.,
            Steinthorsdottir,V., Olafsdottir,E.J., Olafsdottir,G.H.,
            Jonsson,T., Borch-Johnsen,K., Hansen,T., Andersen,G., Jorgensen,T.,
            Pedersen,O., Aben,K.K., Witjes,J.A., Swinkels,D.W., den Heijer,M.,
            Franke,B., Verbeek,A.L., Becker,D.M., Yanek,L.R., Becker,L.C.,
            Tryggvadottir,L., Rafnar,T., Gulcher,J., Kiemeney,L.A., Kong,A.,
            Thorsteinsdottir,U. and Stefansson,K.
  TITLE     Many sequence variants affecting diversity of adult human height
  JOURNAL   Nat Genet 40 (5), 609-615 (2008)
   PUBMED   18391951
REFERENCE   7  (bases 1 to 5674)
  AUTHORS   Sigal,A., Milo,R., Cohen,A., Geva-Zatorsky,N., Klein,Y., Alaluf,I.,
            Swerdlin,N., Perzov,N., Danon,T., Liron,Y., Raveh,T.,
            Carpenter,A.E., Lahav,G. and Alon,U.
  TITLE     Dynamic proteomics in individual human cells uncovers widespread
            cell-cycle dependence of nuclear proteins
  JOURNAL   Nat Methods 3 (7), 525-531 (2006)
   PUBMED   16791210
REFERENCE   8  (bases 1 to 5674)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
REFERENCE   9  (bases 1 to 5674)
  AUTHORS   Xu,Y.Z., Newnham,C.M., Kameoka,S., Huang,T., Konarska,M.M. and
            Query,C.C.
  TITLE     Prp5 bridges U1 and U2 snRNPs and enables stable U2 snRNP
            association with intron RNA
  JOURNAL   EMBO J 23 (2), 376-385 (2004)
   PUBMED   14713954
  REMARK    GeneRIF: Prp5 forms a bridge between U1 and U2 Small Nuclear
            Ribonucleoproteins at the time of pre-spliceosome formation
REFERENCE   10 (bases 1 to 5674)
  AUTHORS   Will,C.L., Urlaub,H., Achsel,T., Gentzel,M., Wilm,M. and
            Luhrmann,R.
  TITLE     Characterization of novel SF3b and 17S U2 snRNP proteins, including
            a human Prp5p homologue and an SF3b DEAD-box protein
  JOURNAL   EMBO J 21 (18), 4978-4988 (2002)
   PUBMED   12234937
  REMARK    GeneRIF: characterization of protein associated with the human 17S
            U2 snRNP and one of its stable subunits, SF3b; results indicate
            that Prp5 plays an important role in pre-mRNA splicing, acting
            during or prior to prespliceosome assembly
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BF244218.1, BK000565.1,
            AC010301.7 and BU608108.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001300860.1.
            
            Summary: This gene encodes a member of the DEAD box protein family.
            DEAD box proteins, characterized by the conserved motif
            Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are
            implicated in a number of cellular processes involving alteration
            of RNA secondary structure, such as translation initiation, nuclear
            and mitochondrial splicing, and ribosome and spliceosome assembly.
            Based on their distribution patterns, some members of this family
            are believed to be involved in embryogenesis, spermatogenesis, and
            cellular growth and division. The protein encoded by this gene is a
            component of the 17S U2 snRNP complex; it plays an important role
            in pre-mRNA splicing. Multiple alternatively spliced transcript
            variants have been found for this gene. [provided by RefSeq, Jul
            2014].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.182204.1,
                                           SRR1803614.104240.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000452510.7/ ENSP00000416534.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-160               BF244218.1         47-206
            161-3259            BK000565.1         1-3099
            3260-5032           AC010301.7         150401-152173
            5033-5674           BU608108.1         32-673              c
FEATURES             Location/Qualifiers
     source          1..5674
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q31.1"
     gene            1..5674
                     /gene="DDX46"
                     /gene_synonym="Prp5; PRPF5"
                     /note="DEAD-box helicase 46"
                     /db_xref="GeneID:9879"
                     /db_xref="HGNC:HGNC:18681"
                     /db_xref="MIM:617848"
     exon            1..177
                     /gene="DDX46"
                     /gene_synonym="Prp5; PRPF5"
                     /inference="alignment:Splign:2.1.0"
     CDS             161..3259
                     /gene="DDX46"
                     /gene_synonym="Prp5; PRPF5"
                     /EC_number="3.6.4.13"
                     /note="isoform 1 is encoded by transcript variant 1; RNA
                     helicase; Prp5-like DEAD-box protein; probable
                     ATP-dependent RNA helicase DDX46; PRP5 homolog; DEAD
                     (Asp-Glu-Ala-Asp) box polypeptide 46; DEAD box protein 46"
                     /codon_start=1
                     /product="probable ATP-dependent RNA helicase DDX46
                     isoform 1"
                     /protein_id="NP_001287789.1"
                     /db_xref="CCDS:CCDS75306.1"
                     /db_xref="GeneID:9879"
                     /db_xref="HGNC:HGNC:18681"
                     /db_xref="MIM:617848"
                     /translation="MGRESRHYRKRSASRGRSGSRSRSRSPSDKRSKRGDDRRSRSRD
                     RDRRRERSRSRDKRRSRSRDRKRLRRSRSRERDRSRERRRSRSRDRRRSRSRSRGRRS
                     RSSSPGNKSKKTENRSRSKEKTDGGESSKEKKKDKDDKEDEKEKDAGNFDQNKLEEEM
                     RKRKERVEKWREEQRKKAMENIGELKKEIEEMKQGKKWSLEDDDDDEDDPAEAEKEGN
                     EMEGEELDPLDAYMEEVKEEVKKFNMRSVKGGGGNEKKSGPTVTKVVTVVTTKKAVVD
                     SDKKKGELMENDQDAMEYSSEEEEVDLQTALTGYQTKQRKLLEPVDHGKIEYEPFRKN
                     FYVEVPELAKMSQEEVNVFRLEMEGITVKGKGCPKPIKSWVQCGISMKILNSLKKHGY
                     EKPTPIQTQAIPAIMSGRDLIGIAKTGSGKTIAFLLPMFRHIMDQRSLEEGEGPIAVI
                     MTPTRELALQITKECKKFSKTLGLRVVCVYGGTGISEQIAELKRGAEIIVCTPGRMID
                     MLAANSGRVTNLRRVTYVVLDEADRMFDMGFEPQVMRIVDNVRPDRQTVMFSATFPRA
                     MEALARRILSKPIEVQVGGRSVVCSDVEQQVIVIEEEKKFLKLLELLGHYQESGSVII
                     FVDKQEHADGLLKDLMRASYPCMSLHGGIDQYDRDSIINDFKNGTCKLLVATSVAARG
                     LDVKHLILVVNYSCPNHYEDYVHRAGRTGRAGNKGYAYTFITEDQARYAGDIIKALEL
                     SGTAVPPDLEKLWSDFKDQQKAEGKIIKKSSGFSGKGFKFDETEQALANERKKLQKAA
                     LGLQDSDDEDAAVDIDEQIESMFNSKKRVKDMAAPGTSSVPAPTAGNAEKLEIAKRLA
                     LRINAQKNLGIESQVDVMQQATNAILRGGTILAPTVSAKTIAEQLAEKINAKLNYVPL
                     EKQEEERQDGGQNESFKRYEEELEINDFPQTARWKVTSKEALQRISEYSEAAITIRGT
                     YFPPGKEPKEGERKIYLAIESANELAVQKAKAEITRLIKEELIRLQNSYQPTNKGRYK
                     VL"
     exon            178..366
                     /gene="DDX46"
                     /gene_synonym="Prp5; PRPF5"
                     /inference="alignment:Splign:2.1.0"
     exon            367..510
                     /gene="DDX46"
                     /gene_synonym="Prp5; PRPF5"
                     /inference="alignment:Splign:2.1.0"
     exon            511..607
                     /gene="DDX46"
                     /gene_synonym="Prp5; PRPF5"
                     /inference="alignment:Splign:2.1.0"
     exon            608..773
                     /gene="DDX46"
                     /gene_synonym="Prp5; PRPF5"
                     /inference="alignment:Splign:2.1.0"
     exon            774..925
                     /gene="DDX46"
                     /gene_synonym="Prp5; PRPF5"
                     /inference="alignment:Splign:2.1.0"
     exon            926..1039
                     /gene="DDX46"
                     /gene_synonym="Prp5; PRPF5"
                     /inference="alignment:Splign:2.1.0"
     exon            1040..1205
                     /gene="DDX46"
                     /gene_synonym="Prp5; PRPF5"
                     /inference="alignment:Splign:2.1.0"
     exon            1206..1326
                     /gene="DDX46"
                     /gene_synonym="Prp5; PRPF5"
                     /inference="alignment:Splign:2.1.0"
     exon            1327..1502
                     /gene="DDX46"
                     /gene_synonym="Prp5; PRPF5"
                     /inference="alignment:Splign:2.1.0"
     exon            1503..1624
                     /gene="DDX46"
                     /gene_synonym="Prp5; PRPF5"
                     /inference="alignment:Splign:2.1.0"
     exon            1625..1703
                     /gene="DDX46"
                     /gene_synonym="Prp5; PRPF5"
                     /inference="alignment:Splign:2.1.0"
     exon            1704..1786
                     /gene="DDX46"
                     /gene_synonym="Prp5; PRPF5"
                     /inference="alignment:Splign:2.1.0"
     exon            1787..1951
                     /gene="DDX46"
                     /gene_synonym="Prp5; PRPF5"
                     /inference="alignment:Splign:2.1.0"
     exon            1952..2114
                     /gene="DDX46"
                     /gene_synonym="Prp5; PRPF5"
                     /inference="alignment:Splign:2.1.0"
     exon            2115..2308
                     /gene="DDX46"
                     /gene_synonym="Prp5; PRPF5"
                     /inference="alignment:Splign:2.1.0"
     exon            2309..2446
                     /gene="DDX46"
                     /gene_synonym="Prp5; PRPF5"
                     /inference="alignment:Splign:2.1.0"
     exon            2447..2596
                     /gene="DDX46"
                     /gene_synonym="Prp5; PRPF5"
                     /inference="alignment:Splign:2.1.0"
     exon            2597..2773
                     /gene="DDX46"
                     /gene_synonym="Prp5; PRPF5"
                     /inference="alignment:Splign:2.1.0"
     exon            2774..2992
                     /gene="DDX46"
                     /gene_synonym="Prp5; PRPF5"
                     /inference="alignment:Splign:2.1.0"
     exon            2993..3137
                     /gene="DDX46"
                     /gene_synonym="Prp5; PRPF5"
                     /inference="alignment:Splign:2.1.0"
     exon            3138..3211
                     /gene="DDX46"
                     /gene_synonym="Prp5; PRPF5"
                     /inference="alignment:Splign:2.1.0"
     exon            3212..5674
                     /gene="DDX46"
                     /gene_synonym="Prp5; PRPF5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3573..3578
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DDX46"
                     /gene_synonym="Prp5; PRPF5"
                     /note="hexamer: AATAAA"
     polyA_site      3610
                     /gene="DDX46"
                     /gene_synonym="Prp5; PRPF5"
                     /note="major polyA site"
     regulatory      3736..3741
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DDX46"
                     /gene_synonym="Prp5; PRPF5"
                     /note="hexamer: AATAGA"
     polyA_site      3756
                     /gene="DDX46"
                     /gene_synonym="Prp5; PRPF5"
                     /note="major polyA site"
     regulatory      5653..5658
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DDX46"
                     /gene_synonym="Prp5; PRPF5"
                     /note="hexamer: AATAAA"
     polyA_site      5674
                     /gene="DDX46"
                     /gene_synonym="Prp5; PRPF5"
                     /note="major polyA site"
ORIGIN      
        1 ctgttttcgt tggccgcgct gggatggccg ccacagctgt aggtgctgct agtgtttagc
       61 gctggtcttt gccgggcgtt gagggcagct cagcctcctt gtttgtccgg ttcgcctgtg
      121 cgtggtactc aagggcacca gtattcccgc ggtcggcagc atgggtcggg agtcacgcca
      181 ctatcgaaaa cgatcggcat cccggggtcg ctctggaagt cggtctagaa gtcgctcacc
      241 ctcagacaaa agaagtaaac gtggagatga cagacggtct agaagtagag atagagatag
      301 gaggagagag aggtctcgta gcagggataa aagaagatct cggtcaaggg acaggaagcg
      361 tctgagacgt tccagaagta gagagagaga cagaagccga gagcgaagaa gatctcgaag
      421 tagagacagg agacgctcaa ggagtagaag ccggggccgg cgatcccgat cctccagtcc
      481 tggaaataaa agcaagaaaa ctgagaatag atctaggtcc aaagagaaaa ctgatggtgg
      541 ggaaagttct aaagagaaga aaaaagacaa agatgacaag gaggatgaaa aagaaaaaga
      601 tgctggcaac tttgaccaga ataagctgga agaagaaatg agaaagcgaa aagaaagagt
      661 agaaaaatgg cgagaagagc aacgtaaaaa ggctatggaa aacataggag aactgaaaaa
      721 ggaaatcgaa gagatgaaac aagggaaaaa gtggagttta gaggacgatg atgatgacga
      781 agatgatcct gcagaagctg aaaaggaggg aaatgaaatg gagggtgagg agttagatcc
      841 attagatgct tacatggaag aagtgaaaga ggaagtaaaa aaatttaaca tgagaagtgt
      901 aaaaggtggt gggggaaatg aaaagaagtc tgggccaacg gtcacaaaag ttgtcactgt
      961 tgtgacaacc aaaaaagcag ttgtggattc tgataagaag aaaggtgagc tgatggagaa
     1021 tgaccaggat gccatggagt attcttcaga ggaggaagaa gttgatcttc agacagccct
     1081 tacagggtat caaacaaaac agcgaaagct tctagaacca gttgatcatg gaaaaattga
     1141 gtatgagcca tttaggaaaa acttctatgt tgaagttcca gaactagcaa aaatgtctca
     1201 agaagaggta aatgtgtttc gattggaaat ggagggcatt acagttaaag gaaaaggttg
     1261 ccccaaacca attaaatcct gggtccagtg tggaatttcc atgaagatct taaattccct
     1321 caagaagcat ggctatgaaa agcccacgcc catccaaacc caagctattc ctgctataat
     1381 gtctggacga gatttgattg gcattgccaa aacaggaagt ggaaagacca ttgcttttct
     1441 gttgcccatg tttagacaca tcatggatca gaggtcatta gaggaaggag aggggccaat
     1501 agctgtcatc atgactccaa ctcgagaact ggctttacag attactaaag agtgtaagaa
     1561 gttttccaag actttgggac ttagagtggt ctgtgtttac ggaggaacag gaatcagtga
     1621 gcagattgct gagctgaaaa gaggtgctga aattattgtt tgcacacctg gtcgaatgat
     1681 tgacatgtta gccgctaaca gtggtcgggt cacaaatctt cgaagagtga catatgttgt
     1741 tttagatgaa gcagacagaa tgtttgacat gggttttgaa ccccaggtca tgcgcatcgt
     1801 ggataatgtt cgtcctgatc gacagacggt tatgttttca gctactttcc ccagagctat
     1861 ggaggctttg gctcgcagga tcctcagtaa acctattgaa gtacaagttg gaggcaggag
     1921 tgtggtttgc tcagatgtgg agcaacaagt gattgtgatt gaagaagaaa agaaattctt
     1981 gaagttactt gagcttctag gccattatca agagtcagga tctgtcatta tatttgtgga
     2041 taagcaggaa catgctgatg gtcttcttaa ggatttaatg agagcatctt atccttgcat
     2101 gtctcttcat ggaggcattg atcaatatga cagagatagc atcataaatg actttaagaa
     2161 tgggacctgc aaacttcttg tggctacctc tgttgctgcc cgaggtctag atgtgaaaca
     2221 tctgattctt gtagtaaatt atagctgccc caaccattat gaggattatg tacacagagc
     2281 agggcggact ggaagagcag gaaacaaggg ttatgcttat acttttatca cagaggatca
     2341 agctcgctat gctggtgaca taattaaagc tcttgaattg tcagggactg cagtacctcc
     2401 tgatttagag aaactgtgga gtgatttcaa agatcagcag aaagctgagg ggaaaataat
     2461 taaaaagagt agtgggttct ctggtaaggg attcaagttt gatgaaacag aacaagcttt
     2521 ggctaatgag aggaagaagt tacaaaaagc agctcttggt ctacaagatt cagatgatga
     2581 ggatgctgca gttgatattg atgagcaaat tgaaagcatg tttaattcaa agaagagagt
     2641 aaaggatatg gctgctcctg gaacatcaag tgttcctgct ccaactgcag gaaatgctga
     2701 gaaattagaa attgctaaga gattggctct tagaatcaat gcccagaaga atttgggcat
     2761 cgagtctcag gtagatgtga tgcagcaggc caccaatgca attcttaggg gtggcaccat
     2821 tctggctccc actgtttctg caaaaaccat tgcagaacaa cttgctgaaa agatcaatgc
     2881 caagctcaat tatgtgccgt tagagaaaca agaagaagag agacaggatg gtggacagaa
     2941 tgaatctttt aagagatatg aagaagaatt agagatcaat gacttcccac agactgctag
     3001 gtggaaagtt acctctaagg aagctctgca gagaatcagt gaatactctg aagccgcaat
     3061 tacaatcaga ggaacctact tccctcctgg caaagaaccc aaggaaggcg agcggaagat
     3121 ttacttggca attgaaagtg ccaatgaact ggctgtgcag aaagcaaagg cagaaatcac
     3181 caggctcata aaagaagagc tgatccggct gcaaaattca taccaaccaa caaataaagg
     3241 aagatacaaa gtcttataga catccggaaa aaagattttt acctgtgctg gtctatgatg
     3301 tatgtggcag ttgctgtctg cagtttacaa tgtattgtaa atgaagattt tttaaattct
     3361 atcttgctga ttttttttaa atataagaaa ctggtacttg gtaaagaaat ctgtccgtaa
     3421 gtacccccac aatcagtcaa actatattta aagccagcct gttttcagag tatgatgtcc
     3481 tttaatgtaa actcaaatat caatatttta aatgtccgga taatattcta gaggtttaaa
     3541 aaatggaaat atttgaactt tctattgaag acaataaagt acacaagtcg ttaaggggct
     3601 attcacttta tcctgtactt tcaatgaaat tgtgatcatt tcctaagaaa aggtaaaatt
     3661 cactatcata ttttgtgtcc ccaccttgat gttacatgac tctggaacaa tatgaactgg
     3721 atttaagaat gttataatag aagtcttaca aaatgggttg agagtttttg tttcaatttt
     3781 tatcatcata aatgggcaaa aagtagttgg actaatttcg gtttttatac aagtaaagat
     3841 ttaatagtat aaggattttt ttgcatttct ttacactgag tgtaaaactc tacaaagagt
     3901 tatagtattt actactttga ggtttccctc acaacttctg gctccatacc tagcccctct
     3961 tttataatct tccttaaaag aaagagtgta gcctataaat actaaatatg ataccttttc
     4021 cttctagaaa gtgtttattt atatatctat acatgttgta tgtacaaata tcctactact
     4081 tttaatctga tttttcttca ggattattga gtaggttgtg aattttcttt cttaaaaatt
     4141 gtaaaacata atggtaccca agttttaaac ttagatgtgc ttcatcttag tgaaatttaa
     4201 ttcacaagga atcataaatt gtgtttttga ggctgggcgc agtgactcac acctgtatcc
     4261 cagcaatttg ggaggccgag gtgggcagat cacttgaggt caggagttca agactagcct
     4321 ggtcaacatg gtgaaaccct gtctctacta aaaatacaaa aattagtcgg catggtggtg
     4381 ggtggctgta atcccagcta ctcaggaggc tgaggcagaa gaatctgagc caagataaca
     4441 ccattgcact ccagcctggg cgacagagtg agactatctc aaaaataaat aaataaataa
     4501 ataaatagta tttttgagcc ttcaagatac agttcctgaa tattctaatt taaattgtta
     4561 taattggatt acctaatatt cttttcaaga ctcctgatgt attaacttca tgttattgtc
     4621 acttttcaaa aaaggaattt ttttcaggag ttaaataaag tcagtctttt atatccaagg
     4681 gtttcaaacc cacagattaa accaaccaca gatcaaaaat agaaaaaaaa aaaaaaagaa
     4741 aaaaagaatg taaaatttta aaaatacagt ttaacagctg taaaagtttt actataacat
     4801 ttacattgtg ttaggtattt taagtaattt aaaggttaca gtatacaggc ggttaaagta
     4861 tacaggagga tgtgcatcgg ttatatgcat atagcaagcc atttcatata agaggcttga
     4921 acatccatgg attttggtat agaggagggg tttaaggggt gtcctgcaat cagtccccct
     4981 ctcataccaa aggatgactg tatatttctt aaatgaagag actttcattc tttaaatatt
     5041 attgacttac agtttaaaaa taaataaata aaagcatact atagttgtaa aaacaaataa
     5101 ttttaatagt atattcagtg gctgaagtga tagggagtat taatcattat ttcttcagta
     5161 taaagttatt cttcctgaaa aagtaagata tacctgggaa atattcttgg atccttcaca
     5221 catccactta atttcttgaa ggaagaaaac agacaaaaga catgtaacaa cagaaacaaa
     5281 taaaccactt actgtaaaat ttcagaaatt gtgggctcat tccctccctc tagtttattt
     5341 atttgctcat ctttatcacc taatggtagt ttgttttctt tggtagagta tatggcagtc
     5401 ccacatcgat gataattggt gctcccttca tccaactgga tcactttgag attcagtttt
     5461 acatcatttt agcattttgt ttgtatatca gttgtgatga gccactgata aaattttgtt
     5521 ctaaaatgaa acatattact ttgttagtac attttttagt gtcacactga cttttaaaat
     5581 ttgaatgata tatagacttt gtttttttaa tgcaatatga atatttgctc atgttttcta
     5641 aattccttat aaaataaaat taattcgaat tcaa
//
