LOCUS       NM_001356               4635 bp    mRNA    linear   PRI 17-NOV-2024
DEFINITION  Homo sapiens DEAD-box helicase 3 X-linked (DDX3X), transcript
            variant 1, mRNA.
ACCESSION   NM_001356 XM_001126185 XM_001129278
VERSION     NM_001356.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4635)
  AUTHORS   Secchi,M., Garbelli,A., Riva,V., Deidda,G., Santonicola,C.,
            Formica,T.M., Sabbioneda,S., Crespan,E. and Maga,G.
  TITLE     Synergistic action of human RNaseH2 and the RNA helicase-nuclease
            DDX3X in processing R-loops
  JOURNAL   Nucleic Acids Res 52 (19), 11641-11658 (2024)
   PUBMED   39189461
  REMARK    GeneRIF: Synergistic action of human RNaseH2 and the RNA
            helicase-nuclease DDX3X in processing R-loops.
REFERENCE   2  (bases 1 to 4635)
  AUTHORS   Hsu,W.J., Chiang,M.C., Chao,Y.C., Chang,Y.C., Hsu,M.C., Chung,C.H.,
            Tsai,I.L., Chu,C.Y., Wu,H.C., Yang,C.C., Lee,C.C. and Lin,C.W.
  TITLE     Arginine Methylation of DDX3 by PRMT1 Mediates Mitochondrial
            Homeostasis to Promote Breast Cancer Metastasis
  JOURNAL   Cancer Res 84 (18), 3023-3043 (2024)
   PUBMED   39042374
  REMARK    GeneRIF: Arginine Methylation of DDX3 by PRMT1 Mediates
            Mitochondrial Homeostasis to Promote Breast Cancer Metastasis.
REFERENCE   3  (bases 1 to 4635)
  AUTHORS   Swarup,A. and Bolger,T.A.
  TITLE     The Role of the RNA Helicase DDX3X in Medulloblastoma Progression
  JOURNAL   Biomolecules 14 (7), 803 (2024)
   PUBMED   39062517
  REMARK    GeneRIF: The Role of the RNA Helicase DDX3X in Medulloblastoma
            Progression.
            Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4635)
  AUTHORS   Rauschendorf,M.A., Zimmer,J., Ohnmacht,C. and Vogt,P.H.
  TITLE     DDX3X, the X homologue of AZFa gene DDX3Y, expresses a complex
            pattern of transcript variants only in the male germ line
  JOURNAL   Mol Hum Reprod 20 (12), 1208-1222 (2014)
   PUBMED   25208899
  REMARK    GeneRIF: Data suggest complex translational control mechanism(s)
            for the human DDX3X gene locus functioning only in the male germ
            line and resulting in expression of its protein only in the
            postmeiotic spermatids.
REFERENCE   5  (bases 1 to 4635)
  AUTHORS   Sharma,D. and Jankowsky,E.
  TITLE     The Ded1/DDX3 subfamily of DEAD-box RNA helicases
  JOURNAL   Crit Rev Biochem Mol Biol 49 (4), 343-360 (2014)
   PUBMED   25039764
  REMARK    GeneRIF: This review discusses the considerable body of work on the
            biochemistry and biology of DDX3, including the recently discovered
            link of human DDX3 to tumorigenesis.
            Review article
REFERENCE   6  (bases 1 to 4635)
  AUTHORS   Soto-Rifo,R. and Ohlmann,T.
  TITLE     The role of the DEAD-box RNA helicase DDX3 in mRNA metabolism
  JOURNAL   Wiley Interdiscip Rev RNA 4 (4), 369-385 (2013)
   PUBMED   23606618
  REMARK    Review article
REFERENCE   7  (bases 1 to 4635)
  AUTHORS   You,L.R., Chen,C.M., Yeh,T.S., Tsai,T.Y., Mai,R.T., Lin,C.H. and
            Lee,Y.H.
  TITLE     Hepatitis C virus core protein interacts with cellular putative RNA
            helicase
  JOURNAL   J Virol 73 (4), 2841-2853 (1999)
   PUBMED   10074132
REFERENCE   8  (bases 1 to 4635)
  AUTHORS   Park,S.H., Lee,S.G., Kim,Y. and Song,K.
  TITLE     Assignment of a human putative RNA helicase gene, DDX3, to human X
            chromosome bands p11.3-->p11.23
  JOURNAL   Cytogenet Cell Genet 81 (3-4), 178-179 (1998)
   PUBMED   9730595
REFERENCE   9  (bases 1 to 4635)
  AUTHORS   Lahn,B.T. and Page,D.C.
  TITLE     Functional coherence of the human Y chromosome
  JOURNAL   Science 278 (5338), 675-680 (1997)
   PUBMED   9381176
REFERENCE   10 (bases 1 to 4635)
  AUTHORS   Johnson-Kerner,B., Snijders Blok,L., Suit,L., Thomas,J.,
            Kleefstra,T. and Sherr,E.H.
  TITLE     DDX3X-Related Neurodevelopmental Disorder
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   32852922
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK291153.1, BC007668.2,
            AU144400.1 and BM454841.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Dec 18, 2019 this sequence version replaced NM_001356.4.
            
            Summary: The protein encoded by this gene is a member of the large
            DEAD-box protein family, that is defined by the presence of the
            conserved Asp-Glu-Ala-Asp (DEAD) motif, and has ATP-dependent RNA
            helicase activity. This protein has been reported to display a high
            level of RNA-independent ATPase activity, and unlike most DEAD-box
            helicases, the ATPase activity is thought to be stimulated by both
            RNA and DNA. This protein has multiple conserved domains and is
            thought to play roles in both the nucleus and cytoplasm. Nuclear
            roles include transcriptional regulation, mRNP assembly, pre-mRNA
            splicing, and mRNA export. In the cytoplasm, this protein is
            thought to be involved in translation, cellular signaling, and
            viral replication. Misregulation of this gene has been implicated
            in tumorigenesis. This gene has a paralog located in the
            nonrecombining region of the Y chromosome. Pseudogenes sharing
            similarity to both this gene and the DDX3Y paralog are found on
            chromosome 4 and the X chromosome. Alternative splicing results in
            multiple transcript variants. [provided by RefSeq, Oct 2014].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK291153.1, AF000982.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000644876.2/ ENSP00000494040.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2465              AK291153.1         1-2465
            2466-4202           BC007668.2         2449-4185
            4203-4603           AU144400.1         28-428              c
            4604-4635           BM454841.1         191-222
FEATURES             Location/Qualifiers
     source          1..4635
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp11.4"
     gene            1..4635
                     /gene="DDX3X"
                     /gene_synonym="CAP-Rf; DBX; DDX14; DDX3; HLP2; MRX102;
                     MRXSSB"
                     /note="DEAD-box helicase 3 X-linked"
                     /db_xref="GeneID:1654"
                     /db_xref="HGNC:HGNC:2745"
                     /db_xref="MIM:300160"
     exon            1..136
                     /gene="DDX3X"
                     /gene_synonym="CAP-Rf; DBX; DDX14; DDX3; HLP2; MRX102;
                     MRXSSB"
                     /inference="alignment:Splign:2.1.0"
     CDS             92..2080
                     /gene="DDX3X"
                     /gene_synonym="CAP-Rf; DBX; DDX14; DDX3; HLP2; MRX102;
                     MRXSSB"
                     /EC_number="3.6.4.13"
                     /note="isoform 1 is encoded by transcript variant 1;
                     DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3; DEAD/H
                     box-3; ATP-dependent RNA helicase DDX3X; helicase-like
                     protein 2; DEAD box protein 3, X-chromosomal; DEAD
                     (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked; DEAD
                     (Asp-Glu-Ala-Asp) box helicase 3, X-linked"
                     /codon_start=1
                     /product="ATP-dependent RNA helicase DDX3X isoform 1"
                     /protein_id="NP_001347.3"
                     /db_xref="CCDS:CCDS43931.1"
                     /db_xref="GeneID:1654"
                     /db_xref="HGNC:HGNC:2745"
                     /db_xref="MIM:300160"
                     /translation="MSHVAVENALGLDQQFAGLDLNSSDNQSGGSTASKGRYIPPHLR
                     NREATKGFYDKDSSGWSSSKDKDAYSSFGSRSDSRGKSSFFSDRGSGSRGRFDDRGRS
                     DYDGIGSRGDRSGFGKFERGGNSRWCDKSDEDDWSKPLPPSERLEQELFSGGNTGINF
                     EKYDDIPVEATGNNCPPHIESFSDVEMGEIIMGNIELTRYTRPTPVQKHAIPIIKEKR
                     DLMACAQTGSGKTAAFLLPILSQIYSDGPGEALRAMKENGRYGRRKQYPISLVLAPTR
                     ELAVQIYEEARKFSYRSRVRPCVVYGGADIGQQIRDLERGCHLLVATPGRLVDMMERG
                     KIGLDFCKYLVLDEADRMLDMGFEPQIRRIVEQDTMPPKGVRHTMMFSATFPKEIQML
                     ARDFLDEYIFLAVGRVGSTSENITQKVVWVEESDKRSFLLDLLNATGKDSLTLVFVET
                     KKGADSLEDFLYHEGYACTSIHGDRSQRDREEALHQFRSGKSPILVATAVAARGLDIS
                     NVKHVINFDLPSDIEEYVHRIGRTGRVGNLGLATSFFNERNINITKDLLDLLVEAKQE
                     VPSWLENMAYEHHYKGSSRGRSKSSRFSGGFGARDYRQSSGASSSSFSSSRASSSRSG
                     GGGHGSSRGFGGGGYGGFYNSDGYGGNYNSQGVDWWGN"
     exon            137..194
                     /gene="DDX3X"
                     /gene_synonym="CAP-Rf; DBX; DDX14; DDX3; HLP2; MRX102;
                     MRXSSB"
                     /inference="alignment:Splign:2.1.0"
     exon            195..242
                     /gene="DDX3X"
                     /gene_synonym="CAP-Rf; DBX; DDX14; DDX3; HLP2; MRX102;
                     MRXSSB"
                     /inference="alignment:Splign:2.1.0"
     exon            243..375
                     /gene="DDX3X"
                     /gene_synonym="CAP-Rf; DBX; DDX14; DDX3; HLP2; MRX102;
                     MRXSSB"
                     /inference="alignment:Splign:2.1.0"
     exon            376..534
                     /gene="DDX3X"
                     /gene_synonym="CAP-Rf; DBX; DDX14; DDX3; HLP2; MRX102;
                     MRXSSB"
                     /inference="alignment:Splign:2.1.0"
     exon            535..634
                     /gene="DDX3X"
                     /gene_synonym="CAP-Rf; DBX; DDX14; DDX3; HLP2; MRX102;
                     MRXSSB"
                     /inference="alignment:Splign:2.1.0"
     exon            635..770
                     /gene="DDX3X"
                     /gene_synonym="CAP-Rf; DBX; DDX14; DDX3; HLP2; MRX102;
                     MRXSSB"
                     /inference="alignment:Splign:2.1.0"
     exon            771..856
                     /gene="DDX3X"
                     /gene_synonym="CAP-Rf; DBX; DDX14; DDX3; HLP2; MRX102;
                     MRXSSB"
                     /inference="alignment:Splign:2.1.0"
     exon            857..955
                     /gene="DDX3X"
                     /gene_synonym="CAP-Rf; DBX; DDX14; DDX3; HLP2; MRX102;
                     MRXSSB"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1116
                     /gene="DDX3X"
                     /gene_synonym="CAP-Rf; DBX; DDX14; DDX3; HLP2; MRX102;
                     MRXSSB"
                     /inference="alignment:Splign:2.1.0"
     exon            1117..1261
                     /gene="DDX3X"
                     /gene_synonym="CAP-Rf; DBX; DDX14; DDX3; HLP2; MRX102;
                     MRXSSB"
                     /inference="alignment:Splign:2.1.0"
     exon            1262..1406
                     /gene="DDX3X"
                     /gene_synonym="CAP-Rf; DBX; DDX14; DDX3; HLP2; MRX102;
                     MRXSSB"
                     /inference="alignment:Splign:2.1.0"
     exon            1407..1588
                     /gene="DDX3X"
                     /gene_synonym="CAP-Rf; DBX; DDX14; DDX3; HLP2; MRX102;
                     MRXSSB"
                     /inference="alignment:Splign:2.1.0"
     exon            1589..1706
                     /gene="DDX3X"
                     /gene_synonym="CAP-Rf; DBX; DDX14; DDX3; HLP2; MRX102;
                     MRXSSB"
                     /inference="alignment:Splign:2.1.0"
     exon            1707..1860
                     /gene="DDX3X"
                     /gene_synonym="CAP-Rf; DBX; DDX14; DDX3; HLP2; MRX102;
                     MRXSSB"
                     /inference="alignment:Splign:2.1.0"
     exon            1861..2000
                     /gene="DDX3X"
                     /gene_synonym="CAP-Rf; DBX; DDX14; DDX3; HLP2; MRX102;
                     MRXSSB"
                     /inference="alignment:Splign:2.1.0"
     exon            2001..4635
                     /gene="DDX3X"
                     /gene_synonym="CAP-Rf; DBX; DDX14; DDX3; HLP2; MRX102;
                     MRXSSB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2468..2473
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DDX3X"
                     /gene_synonym="CAP-Rf; DBX; DDX14; DDX3; HLP2; MRX102;
                     MRXSSB"
                     /note="hexamer: AATAAA"
     polyA_site      2499
                     /gene="DDX3X"
                     /gene_synonym="CAP-Rf; DBX; DDX14; DDX3; HLP2; MRX102;
                     MRXSSB"
     regulatory      4547..4552
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DDX3X"
                     /gene_synonym="CAP-Rf; DBX; DDX14; DDX3; HLP2; MRX102;
                     MRXSSB"
                     /note="hexamer: AATAAA"
     polyA_site      4570
                     /gene="DDX3X"
                     /gene_synonym="CAP-Rf; DBX; DDX14; DDX3; HLP2; MRX102;
                     MRXSSB"
     regulatory      4612..4617
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DDX3X"
                     /gene_synonym="CAP-Rf; DBX; DDX14; DDX3; HLP2; MRX102;
                     MRXSSB"
                     /note="hexamer: AATAAA"
     polyA_site      4635
                     /gene="DDX3X"
                     /gene_synonym="CAP-Rf; DBX; DDX14; DDX3; HLP2; MRX102;
                     MRXSSB"
                     /note="major polyA site"
ORIGIN      
        1 agagccgcag ttctcccgtg agagggcctt cgcggtggaa caaacactcg cttagcagcg
       61 gaagactccg agttctcggt actcttcagg gatgagtcat gtggcagtgg aaaatgcgct
      121 cgggctggac cagcagtttg ctggcctaga cctgaactct tcagataatc agagtggagg
      181 aagtacagcc agcaaagggc gctatattcc tcctcattta aggaaccgag aagctactaa
      241 aggtttctac gataaagaca gttcagggtg gagttctagc aaagataagg atgcgtatag
      301 cagttttgga tctcgtagtg attcaagagg gaagtctagc ttcttcagtg atcgtggaag
      361 tggatcaagg ggaaggtttg atgatcgtgg acggagtgat tacgatggca ttggcagccg
      421 tggtgacaga agtggctttg gcaaatttga acgtggtgga aacagtcgct ggtgtgacaa
      481 atcagatgaa gatgattggt caaaaccact cccaccaagt gaacgcttgg aacaggaact
      541 cttttctgga ggcaacactg ggattaattt tgagaaatac gatgacattc cagttgaggc
      601 aacaggcaac aactgtcctc cacatattga aagtttcagt gatgttgaga tgggagaaat
      661 tatcatggga aacattgagc ttactcgtta tactcgccca actccagtgc aaaagcatgc
      721 tattcctatt atcaaagaga aaagagactt gatggcttgt gcccaaacag ggtctggaaa
      781 aactgcagca tttctgttgc ccatcttgag tcagatttat tcagatggtc caggcgaggc
      841 tttgagggcc atgaaggaaa atggaaggta tgggcgccgc aaacaatacc caatctcctt
      901 ggtattagca ccaacgagag agttggcagt acagatctac gaggaagcca gaaaattttc
      961 ataccgatct agagttcgtc cttgcgtggt ttatggtggt gccgatattg gtcagcagat
     1021 tcgagacttg gaacgtggat gccatttgtt agtagccact ccaggacgtc tagtggatat
     1081 gatggaaaga ggaaagattg gattagactt ttgcaaatac ttggtgttag atgaagctga
     1141 tcggatgttg gatatggggt ttgagcctca gattcgtaga atagtcgaac aagatactat
     1201 gcctccaaag ggtgtccgcc acactatgat gtttagtgct acttttccta aggaaataca
     1261 gatgctggct cgtgatttct tagatgaata tatcttcttg gctgtaggaa gagttggctc
     1321 tacctctgaa aacatcacac agaaagtagt ttgggtggaa gaatcagaca aacggtcatt
     1381 tctgcttgac ctcctaaatg caacaggcaa ggattcactg accttagtgt ttgtggagac
     1441 caaaaagggt gcagattctc tggaggattt cttataccat gaaggatacg catgtaccag
     1501 catccatgga gaccgttctc agagggatag agaagaggcc cttcaccagt tccgctcagg
     1561 aaaaagccca attttagtgg ctacagcagt agcagcaaga ggactggaca tttcaaatgt
     1621 gaaacatgtt atcaattttg acttgccaag tgatattgaa gaatatgtac atcgtattgg
     1681 tcgtacggga cgtgtaggaa accttggcct ggcaacctca ttctttaacg agaggaacat
     1741 aaatattact aaggatttgt tggatcttct tgttgaagct aaacaagaag tgccgtcttg
     1801 gttagaaaac atggcttatg aacaccacta caagggtagc agtcgtggac gttctaagag
     1861 tagcagattt agtggagggt ttggtgccag agactaccga caaagtagcg gtgccagcag
     1921 ttccagcttc agcagcagcc gcgcaagcag cagccgcagt ggcggaggtg gccacggtag
     1981 cagcagagga tttggtggag gtggctatgg aggcttttac aacagtgatg gatatggagg
     2041 aaattataac tcccaggggg ttgactggtg gggtaactga gcctgctttg cagtaggtca
     2101 ccctgccaaa caagctaata tggaaaccac atgtaactta gccagactat accttgtgta
     2161 gcttcaagaa ctcgcagtac attaccagct gtgattctcc actgaaattt tttttttaag
     2221 ggagctcaag gtcacaagaa gaaatgaaag gaacaatcag cagccctgtt cagaaggtgg
     2281 tttgaagact tcattgctgt agtttggatt aactcccctc ccgcctaccc ccatcccaaa
     2341 ctgcatttat aattttgtga ctgaggatca tttgtttgtt aatgtactgt gcctttaact
     2401 ttagacaact ttttattttg atgtcctgtt ggctcagtaa tgctcaagat atcaattgtt
     2461 ttgacaaaat aaatttactg aacttgggct aaaatcaaac cttggcacac aggtgtgata
     2521 caacttaaca ggaatcatcg attcatccat aaataatata aggaaaaact tatgcggtag
     2581 cctgcattag ggctttttga tacttgcaga ttgggggaaa acaacaaatg tcttgaagca
     2641 tattaatgga attagtttct aatgtggcaa actgtattaa gttaaagttc tgatttgctc
     2701 actctatcct ggataggtat ttagaacctg atagtcttta agccattcca gtcatgatga
     2761 ggtgatgtat gaatacatgc atacattcaa agcactgttt tcaaagttaa tgcaagtaaa
     2821 tacagcaatt cctctttcaa cgtttaggca gatcattaat tatgagctag ccaaatgtgg
     2881 gcatactatt acagggaaag tttaaaggtc tgataacttg aaataggttt ttaggagaat
     2941 tcatctactt agacttttta aatgcctgcc ataaatgaaa ttgaaatggt agaatggctg
     3001 accacagcaa tgaccagccc tcattagggc cctggatgat ttttggtcta ataacgcatg
     3061 ctagtgttga tgttttttgg tcaagagggt atgaacagga agaattaaat gcagcaggct
     3121 ttattttaaa tgccgattca cattactctg ttcaagctgc gttgagatgt taaactggct
     3181 tactatagac ttcgtaaaaa tggctccaga agagtaacaa actgaaatct ttgagatcac
     3241 acaggttgga aatatgtaca taactgcaca aggtgtcaat tctgctctac agtgcagttt
     3301 tagtcagttt tagttgcata ggtttccatt gtatttatag tctgtttatg ctaaatctgg
     3361 ccaaagatga gcattgtcca ccactaaaat gcctctgcca ctttgaattc tgtgctaatt
     3421 ttgtggccag aatgcggtga tcaaaacgct ccatcttttt acagtggcat aggaagacgg
     3481 caaaaatttc ctaaagtgca atagattttc aagtgtattg tgccttgttc taaaactttt
     3541 attaagtagg tgcacttgac agtattgagg tcatttgtta tggtgctatt tcaattagtc
     3601 taggtttagg cccttgtaca ttttgcccat aactttttac aaagtacttc ttttattgca
     3661 cattcagaga attttatata tatgtcttgt gtgcgtgtcc ttaaacttcc aatcttactt
     3721 tgtctcttgg agattgttga acgcagcttg tctaggaagg ggatgggact agattctaaa
     3781 atttatttgg gaccatggga atgatagttg ggaagaaaac tatttgcaca cgacagattt
     3841 ctagatactt tttgctgcta gttttatgta atatttattg aacattttga caaatattta
     3901 tttttgtaag cctaaaagtg attctttgaa agtttaaaga aacttgacca aaagacagta
     3961 caaaaacact ggcacttgaa tgttgaatgt caccgtatgc gtgaaattat atatttcggg
     4021 gtagtgtgag cttttaatgt ttaagtcata ttaaactctt aagtcaaatt aagcagaccc
     4081 ggcgttggca gtgtagccat aactttctga tgttagtaaa aacaaaattg gcgacttgaa
     4141 attaaatcat gccaaggttt tgatacactt gtcttaagat attaatgaaa cacttcaaaa
     4201 cactgatgtg aagtgtccag attctcagat gtttgttgtg tggattttgt ttagttgtgt
     4261 gttttttttt ttttttcagt gaatgtctgg cacattgcaa tcctcaaaca tgtggttatc
     4321 tttgttgtat tggcataatc agtgacttgt acattcagca atagcatttg agcaagtttt
     4381 atcagcaagc aatattttca gttaataagg tttcaaaaat catgtaagga tttaaacttg
     4441 ctgaatgtaa agattgaacc tcaagtcact gtagctttag taattgctta ttgtattagt
     4501 ttagatgcta gcactgcatg tgctgtgcat attctgattt tattaaaata aaaagttgaa
     4561 ctgcacagtc tcctttgttg ttgtcaattg tggtttattt tcagaggtgt aaataaagtg
     4621 ctcttgcctg aaaaa
//
