LOCUS       NM_022779               4159 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens DEAD-box helicase 31 (DDX31), transcript variant 1,
            mRNA.
ACCESSION   NM_022779
VERSION     NM_022779.9
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4159)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 4159)
  AUTHORS   Fasci,D., van Ingen,H., Scheltema,R.A. and Heck,A.J.R.
  TITLE     Histone Interaction Landscapes Visualized by Crosslinking Mass
            Spectrometry in Intact Cell Nuclei
  JOURNAL   Mol Cell Proteomics 17 (10), 2018-2033 (2018)
   PUBMED   30021884
REFERENCE   3  (bases 1 to 4159)
  AUTHORS   Daizumoto,K., Yoshimaru,T., Matsushita,Y., Fukawa,T., Uehara,H.,
            Ono,M., Komatsu,M., Kanayama,H.O. and Katagiri,T.
  TITLE     A DDX31/Mutant-p53/EGFR Axis Promotes Multistep Progression of
            Muscle-Invasive Bladder Cancer
  JOURNAL   Cancer Res 78 (9), 2233-2247 (2018)
   PUBMED   29440146
  REMARK    GeneRIF: DDX31 cooperates with mutp53 and EGFR to promote
            progression of muscle invasive bladder cancer.
REFERENCE   4  (bases 1 to 4159)
  AUTHORS   Fukawa,T., Ono,M., Matsuo,T., Uehara,H., Miki,T., Nakamura,Y.,
            Kanayama,H.O. and Katagiri,T.
  TITLE     DDX31 regulates the p53-HDM2 pathway and rRNA gene transcription
            through its interaction with NPM1 in renal cell carcinomas
  JOURNAL   Cancer Res 72 (22), 5867-5877 (2012)
   PUBMED   23019224
  REMARK    GeneRIF: Findings define a mechanism through which control of the
            DDX31-NPM1 complex is likely to play critical roles in renal
            carcinogenesis.
REFERENCE   5  (bases 1 to 4159)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   6  (bases 1 to 4159)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   7  (bases 1 to 4159)
  AUTHORS   Andersen,J.S., Lam,Y.W., Leung,A.K., Ong,S.E., Lyon,C.E.,
            Lamond,A.I. and Mann,M.
  TITLE     Nucleolar proteome dynamics
  JOURNAL   Nature 433 (7021), 77-83 (2005)
   PUBMED   15635413
REFERENCE   8  (bases 1 to 4159)
  AUTHORS   Humphray,S.J., Oliver,K., Hunt,A.R., Plumb,R.W., Loveland,J.E.,
            Howe,K.L., Andrews,T.D., Searle,S., Hunt,S.E., Scott,C.E.,
            Jones,M.C., Ainscough,R., Almeida,J.P., Ambrose,K.D., Ashwell,R.I.,
            Babbage,A.K., Babbage,S., Bagguley,C.L., Bailey,J., Banerjee,R.,
            Barker,D.J., Barlow,K.F., Bates,K., Beasley,H., Beasley,O.,
            Bird,C.P., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.,
            Burrill,W., Burton,J., Carder,C., Carter,N.P., Chapman,J.C.,
            Chen,Y., Clarke,G., Clark,S.Y., Clee,C.M., Clegg,S., Collier,R.E.,
            Corby,N., Crosier,M., Cummings,A.T., Davies,J., Dhami,P., Dunn,M.,
            Dutta,I., Dyer,L.W., Earthrowl,M.E., Faulkner,L., Fleming,C.J.,
            Frankish,A., Frankland,J.A., French,L., Fricker,D.G., Garner,P.,
            Garnett,J., Ghori,J., Gilbert,J.G., Glison,C., Grafham,D.V.,
            Gribble,S., Griffiths,C., Griffiths-Jones,S., Grocock,R., Guy,J.,
            Hall,R.E., Hammond,S., Harley,J.L., Harrison,E.S., Hart,E.A.,
            Heath,P.D., Henderson,C.D., Hopkins,B.L., Howard,P.J., Howden,P.J.,
            Huckle,E., Johnson,C., Johnson,D., Joy,A.A., Kay,M., Keenan,S.,
            Kershaw,J.K., Kimberley,A.M., King,A., Knights,A., Laird,G.K.,
            Langford,C., Lawlor,S., Leongamornlert,D.A., Leversha,M., Lloyd,C.,
            Lloyd,D.M., Lovell,J., Martin,S., Mashreghi-Mohammadi,M.,
            Matthews,L., McLaren,S., McLay,K.E., McMurray,A., Milne,S.,
            Nickerson,T., Nisbett,J., Nordsiek,G., Pearce,A.V., Peck,A.I.,
            Porter,K.M., Pandian,R., Pelan,S., Phillimore,B., Povey,S.,
            Ramsey,Y., Rand,V., Scharfe,M., Sehra,H.K., Shownkeen,R.,
            Sims,S.K., Skuce,C.D., Smith,M., Steward,C.A., Swarbreck,D.,
            Sycamore,N., Tester,J., Thorpe,A., Tracey,A., Tromans,A.,
            Thomas,D.W., Wall,M., Wallis,J.M., West,A.P., Whitehead,S.L.,
            Willey,D.L., Williams,S.A., Wilming,L., Wray,P.W., Young,L.,
            Ashurst,J.L., Coulson,A., Blocker,H., Durbin,R., Sulston,J.E.,
            Hubbard,T., Jackson,M.J., Bentley,D.R., Beck,S., Rogers,J. and
            Dunham,I.
  TITLE     DNA sequence and analysis of human chromosome 9
  JOURNAL   Nature 429 (6990), 369-374 (2004)
   PUBMED   15164053
REFERENCE   9  (bases 1 to 4159)
  AUTHORS   Abdelhaleem,M., Maltais,L. and Wain,H.
  TITLE     The human DDX and DHX gene families of putative RNA helicases
  JOURNAL   Genomics 81 (6), 618-622 (2003)
   PUBMED   12782131
REFERENCE   10 (bases 1 to 4159)
  AUTHORS   Scherl,A., Coute,Y., Deon,C., Calle,A., Kindbeiter,K.,
            Sanchez,J.C., Greco,A., Hochstrasser,D. and Diaz,J.J.
  TITLE     Functional proteomic analysis of human nucleolus
  JOURNAL   Mol Biol Cell 13 (11), 4100-4109 (2002)
   PUBMED   12429849
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL160165.17 and AL354735.14.
            
            On Feb 1, 2021 this sequence version replaced NM_022779.8.
            
            Summary: DEAD box proteins, characterized by the conserved motif
            Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are
            implicated in a number of cellular processes involving alteration
            of RNA secondary structure such as translation initiation, nuclear
            and mitochondrial splicing, and ribosome and spliceosome assembly.
            Based on their distribution patterns, some members of this DEAD box
            protein family are believed to be involved in embryogenesis,
            spermatogenesis, and cellular growth and division. This gene
            encodes a member of this family. The function of this member has
            not been determined. Alternative splicing of this gene generates
            multiple transcript variants encoding different isoforms. [provided
            by RefSeq, Apr 2016].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853566.28772.1, AF427339.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000372159.8/ ENSP00000361232.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-124               AL160165.17        53385-53508         c
            125-381             AL160165.17        45964-46220         c
            382-457             AL160165.17        45786-45861         c
            458-501             AL160165.17        44733-44776         c
            502-572             AL160165.17        43235-43305         c
            573-637             AL160165.17        42196-42260         c
            638-682             AL160165.17        35973-36017         c
            683-724             AL160165.17        34600-34641         c
            725-789             AL160165.17        33759-33823         c
            790-909             AL160165.17        31957-32076         c
            910-1016            AL160165.17        31714-31820         c
            1017-1252           AL160165.17        30348-30583         c
            1253-1429           AL160165.17        29420-29596         c
            1430-1489           AL160165.17        25529-25588         c
            1490-1540           AL160165.17        15566-15616         c
            1541-1680           AL160165.17        13789-13928         c
            1681-1762           AL160165.17        9189-9270           c
            1763-1874           AL160165.17        1855-1966           c
            1875-2043           AL354735.14        185333-185501       c
            2044-4159           AL354735.14        166243-168358       c
FEATURES             Location/Qualifiers
     source          1..4159
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q34.13"
     gene            1..4159
                     /gene="DDX31"
                     /gene_synonym="PPP1R25"
                     /note="DEAD-box helicase 31"
                     /db_xref="GeneID:64794"
                     /db_xref="HGNC:HGNC:16715"
                     /db_xref="MIM:616533"
     exon            1..124
                     /gene="DDX31"
                     /gene_synonym="PPP1R25"
                     /inference="alignment:Splign:2.1.0"
     CDS             50..2290
                     /gene="DDX31"
                     /gene_synonym="PPP1R25"
                     /EC_number="3.6.4.13"
                     /note="isoform 1 is encoded by transcript variant 1;
                     DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 31;
                     ATP-dependent DNA helicase DDX31; DEAD/DEXH helicase
                     DDX31; helicain; probable ATP-dependent RNA helicase
                     DDX31; G2 helicase; DEAD box protein 31; protein
                     phosphatase 1, regulatory subunit 25; DEAD
                     (Asp-Glu-Ala-Asp) box polypeptide 31"
                     /codon_start=1
                     /product="ATP-dependent DNA helicase DDX31 isoform 1"
                     /protein_id="NP_073616.7"
                     /db_xref="CCDS:CCDS6951.2"
                     /db_xref="GeneID:64794"
                     /db_xref="HGNC:HGNC:16715"
                     /db_xref="MIM:616533"
                     /translation="MAAADGSLFDNPRTFSRRPPAQASRQAKATKRKYQASSEAPPAK
                     RRNETSFLPAKKTSVKETQRTFKGNAQKMFSPKKHSVSTSDRNQEERQCIKTSSLFKN
                     NPDIPELHRPVVKQVQEKVFTSAAFHELGLHPHLISTINTVLKMSSMTSVQKQSIPVL
                     LEGRDALVRSQTGSGKTLAYCIPVVQSLQAMESKIQRSDGPYALVLVPTRELALQSFD
                     TVQKLLKPFTWIVPGVLMGGEKRKSEKARLRKGINILISTPGRLVDHIKSTKNIHFSR
                     LRWLVFDEADRILDLGFEKDITVILNAVNAECQKRQNVLLSATLTEGVTRLADISLHD
                     PVSISVLDKSHDQLNPKDKAVQEVCPPPAGDKLDSFAIPESLKQHVTVVPSKLRLVCL
                     AAFILQKCKFEEDQKMVVFFSSCELVEFHYSLFLQTLLSSSGAPASGQLPSASMRLKF
                     LRLHGGMEQEERTAVFQEFSHSRRGVLLCTDVAARGLDLPQVTWIVQYNAPSSPAEYI
                     HRIGRTARIGCHGSSLLILAPSEAEYVNSLASHKINVSEIKMEDILCVLTRDDCFKGK
                     RWGAQKSHAVGPQEIRERATVLQTVFEDYVHSSERRVSWAKKALQSFIQAYATYPREL
                     KHIFHVRSLHLGHVAKSFGLRDAPRNLSALTRKKRKAHVKRPDLHKKTQSKHSLAEIL
                     RSEYSSGMEADIAKVKKQNAPGEPGGRPLQHSLQPTPCFGRGKTLKWRKTQKGVQRDS
                     KTSQKV"
     exon            125..381
                     /gene="DDX31"
                     /gene_synonym="PPP1R25"
                     /inference="alignment:Splign:2.1.0"
     exon            382..457
                     /gene="DDX31"
                     /gene_synonym="PPP1R25"
                     /inference="alignment:Splign:2.1.0"
     exon            458..501
                     /gene="DDX31"
                     /gene_synonym="PPP1R25"
                     /inference="alignment:Splign:2.1.0"
     exon            502..572
                     /gene="DDX31"
                     /gene_synonym="PPP1R25"
                     /inference="alignment:Splign:2.1.0"
     exon            573..637
                     /gene="DDX31"
                     /gene_synonym="PPP1R25"
                     /inference="alignment:Splign:2.1.0"
     exon            638..682
                     /gene="DDX31"
                     /gene_synonym="PPP1R25"
                     /inference="alignment:Splign:2.1.0"
     exon            683..724
                     /gene="DDX31"
                     /gene_synonym="PPP1R25"
                     /inference="alignment:Splign:2.1.0"
     exon            725..789
                     /gene="DDX31"
                     /gene_synonym="PPP1R25"
                     /inference="alignment:Splign:2.1.0"
     exon            790..909
                     /gene="DDX31"
                     /gene_synonym="PPP1R25"
                     /inference="alignment:Splign:2.1.0"
     exon            910..1016
                     /gene="DDX31"
                     /gene_synonym="PPP1R25"
                     /inference="alignment:Splign:2.1.0"
     exon            1017..1252
                     /gene="DDX31"
                     /gene_synonym="PPP1R25"
                     /inference="alignment:Splign:2.1.0"
     exon            1253..1429
                     /gene="DDX31"
                     /gene_synonym="PPP1R25"
                     /inference="alignment:Splign:2.1.0"
     exon            1430..1489
                     /gene="DDX31"
                     /gene_synonym="PPP1R25"
                     /inference="alignment:Splign:2.1.0"
     exon            1490..1540
                     /gene="DDX31"
                     /gene_synonym="PPP1R25"
                     /inference="alignment:Splign:2.1.0"
     exon            1541..1680
                     /gene="DDX31"
                     /gene_synonym="PPP1R25"
                     /inference="alignment:Splign:2.1.0"
     exon            1681..1762
                     /gene="DDX31"
                     /gene_synonym="PPP1R25"
                     /inference="alignment:Splign:2.1.0"
     exon            1763..1874
                     /gene="DDX31"
                     /gene_synonym="PPP1R25"
                     /inference="alignment:Splign:2.1.0"
     exon            1875..2043
                     /gene="DDX31"
                     /gene_synonym="PPP1R25"
                     /inference="alignment:Splign:2.1.0"
     exon            2044..4159
                     /gene="DDX31"
                     /gene_synonym="PPP1R25"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2867
                     /gene="DDX31"
                     /gene_synonym="PPP1R25"
                     /note="major polyA site"
     regulatory      3666..3671
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DDX31"
                     /gene_synonym="PPP1R25"
                     /note="hexamer: ATTAAA"
     polyA_site      3697
                     /gene="DDX31"
                     /gene_synonym="PPP1R25"
     regulatory      4081..4086
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DDX31"
                     /gene_synonym="PPP1R25"
                     /note="hexamer: AAGAAA"
     polyA_site      4101
                     /gene="DDX31"
                     /gene_synonym="PPP1R25"
     regulatory      4139..4144
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DDX31"
                     /gene_synonym="PPP1R25"
                     /note="hexamer: AATAAA"
     polyA_site      4159
                     /gene="DDX31"
                     /gene_synonym="PPP1R25"
ORIGIN      
        1 agtctgcgca ccgggctcgc tgctgcacca cgcgtcaccc acgcagacca tggcagccgc
       61 cgacggttcg ctcttcgaca accccaggac gttctccaga cgtcccccag cccaggcgag
      121 tcggcaagca aaggctacga aaagaaaata ccaagcgtcc agtgaggctc ccccagcgaa
      181 acggaggaac gaaacttcat ttctcccagc caagaaaact agtgttaaag aaactcagag
      241 gacttttaag gggaacgcac aaaaaatgtt ttctccaaag aagcattcgg ttagcacaag
      301 tgatagaaac caggaggaga gacagtgcat taagacttca tcactgttta aaaacaaccc
      361 tgacattcca gaactccaca gacctgtggt aaagcaggtg caagaaaaag tgtttacttc
      421 agctgctttt catgagctgg gcctccaccc acatttaatt tccacaataa atacggtctt
      481 aaaaatgtct agtatgacca gtgttcagaa gcaaagtatt cctgtgttgc tggaaggcag
      541 agatgctctc gtgagatccc agacgggctc aggtaaaact cttgcctatt gcatccctgt
      601 ggtccagtcc cttcaagcaa tggagtcaaa aatacagcgc agtgatggcc cctatgccct
      661 ggtgctcgtg ccaacgagag agctagctct acaaagcttt gacactgtcc agaaactgct
      721 taagcctttc acctggattg tgcctggagt gttaatggga ggagagaaga gaaaatcaga
      781 aaaggccaga ctccgcaaag gaataaatat ccttatctca actcctggac gcctggtgga
      841 tcatataaaa tccacaaaga acattcattt tagtcggctg cggtggttgg tgtttgatga
      901 agcagacaga atcttggatt tgggttttga aaaggacatc acagtgatac ttaatgctgt
      961 aaatgctgaa tgccaaaaac gacagaatgt cttgctatca gcgacactca cagaaggtgt
     1021 aacgcggcta gctgatatca gtttgcatga tccagtcagt atttctgtcc tggacaagag
     1081 ccatgaccag ttgaacccaa aggacaaagc ggtccaggag gtctgtcctc caccagctgg
     1141 cgacaagctg gacagctttg caataccaga gagtctcaag cagcatgtga ctgtggttcc
     1201 cagcaaactg aggcttgtct gcctagcggc cttcatcctt cagaaatgca agtttgagga
     1261 agaccagaag atggttgtct ttttctcaag ttgcgagctg gtggagttcc actacagcct
     1321 cttcctacag accctgctga gcagctcagg ggcgccggca tcagggcagt tgccatctgc
     1381 ctccatgcga ttaaaattcc tacggctgca tggcggcatg gagcaggagg aaagaacagc
     1441 agtgtttcag gaattttcac attccagaag aggcgtcctt ctttgcacgg atgttgcagc
     1501 tcggggctta gatctccctc aagtcacgtg gattgttcag tacaacgctc catcttcacc
     1561 tgcagaatac atccaccgga ttggaagaac cgcccggatt ggctgccatg ggagcagcct
     1621 gctcattttg gctccttcgg aggcagaata tgtcaactcg ttggcttctc acaaaatcaa
     1681 cgtttctgag attaagatgg aagatatttt gtgtgttctg acaagagatg attgttttaa
     1741 agggaaacga tggggagccc agaaatccca tgctgttggc ccccaggaaa tccgagagcg
     1801 agccacagtc ttgcagacgg tatttgaaga ttacgtgcac tccagtgaga ggagggtctc
     1861 ctgggcaaag aaagctctgc agtccttcat ccaagcctac gccacctacc ccagggagct
     1921 gaagcacatc ttccacgtcc gatccctcca ccttgggcat gtggcgaaga gcttcggact
     1981 aagagatgcc cccaggaatc ttagtgcctt gactagaaag aagaggaaag cacacgtgaa
     2041 aaggcctgac cttcataaga agacccagag taaacacagc ctcgctgaaa tcctacgttc
     2101 ggaatactca agcggcatgg aggccgacat cgccaaggtc aaaaagcaaa acgcacctgg
     2161 agagcctggt ggccggcccc tgcagcacag tctgcagccg acaccctgct ttggccgtgg
     2221 gaaaacatta aaatggagaa aaacccaaaa aggtgtacag cgggacagca agacttccca
     2281 gaaagtttaa aatctctctg ggtcttcgag tggaacctgg aagccccggg tggcagtgga
     2341 ttgatgtcca gttcttgtca gaggaggctt gtgaaaaata actgcgcctt tgcctgaata
     2401 ccacgtcccc aagaatcaga ggggccacag cccttctcct ccatgggagg ccctggagcc
     2461 tgatagaaat cagtggtgtg gggcactgta gagactagcc agctcccgac ggaaggggtc
     2521 tgtgtcttgt attgatccca tcagtgcccg gcactccctt cacccaggtg ctgacgtgcc
     2581 ggggttgagc tggcaccccg ggatgtgatg taagaacgcc ctgcgcgtca gcctggaacg
     2641 ggcttgattg ctgcccttaa ctgtgttctg aagtttcaca gcttggcttc agcctatcag
     2701 cgcatacatt ggcatgaatt ttgtgaatta gggtgttaaa aactggaatt gaatttgtac
     2761 aaaaagagaa tatatttatc actaattatt ttcttaatgt aggaatgtac cgttaaaaag
     2821 gaccaaaagt ttttggtctg ggtcaaaaaa tacgaatgtg ttctcaggct cgtggtccct
     2881 cttattttct tctggaaaca cgaggttgca tttacatgca ttgctccctc tttcatgtcc
     2941 actgaaaact cactctctca gggctaattg atttactgtt ggctttttat tatttgcctt
     3001 tgaagtcaaa aggcaccagt atcccaagct ttttttccct atcgaatcct gtcttgtctt
     3061 caagaaaggt ctgggggtct ttgtattgtg acccaggcca cagctgcccg ccccccgccc
     3121 ccgacccacc ccgccctgcc cctgcattgt gttttctggg aggtttgaaa gaggccccct
     3181 ggagcatatt gatttcccaa taaatgtaag atttgggcac ttgcagaggg gtccagaaga
     3241 gaaagggttg gaggcctcca cacctgtggg caccgctcct gtcctctcca ctgtgtcttg
     3301 ccttctcagt ttccttctcc tctgcagtga ctgtgccgcc ctctgtggtc tccccaggac
     3361 cagtgttgag gcaccacttc agtagatccc cccagatcct tggaaggtct gagtggccac
     3421 gagagggtgg tgagagttgg caaggtgggc cttcctgcag ggaccacggg gggtcagcat
     3481 ccttgcctcc gttctagaca caggtgaatg tcagtgggca cccacactgg cggagactcc
     3541 agtgtgaggg caaggaggag cctagtgaga ctggatcctc tgcaggtgga aaaataggac
     3601 cttctcagag ttggctgtca catacaaatt aacagggact gtgggtgacg tttctaacaa
     3661 taataattaa aaaacaacaa ccctgcagca catgtcagcc tggcgttggg caagtctgcc
     3721 acctttcttt tatttcgatg tgtaatggtt cacatgattt ggatgagaaa aggagggatc
     3781 aaactttata gacaaaaccc agctgtgtga aaaacaggat taatgccagt gattggggat
     3841 gatcaaagag aaaccttact ttttctcccc cagtactcat tccactaaag ggcgaattgg
     3901 cagagttcgg catccctggg gggaaagaga agtgctagaa tcatgcaacg tgtgagtgac
     3961 gataattcca agatcaaaac ttacacactt aatctgctaa ctcttatggt gagggtttct
     4021 tgccatagat gctatgtggg tctgtttcta agtagaatca ctatattacc ccagttaata
     4081 aagaaacatg gatttagcag atttaaggtt aatattgttt aaatttaaat aaccttaaaa
     4141 taaatctctt tctcttcta
//
