LOCUS       NM_020414               5573 bp    mRNA    linear   PRI 23-APR-2024
DEFINITION  Homo sapiens DEAD-box helicase 24 (DDX24), mRNA.
ACCESSION   NM_020414
VERSION     NM_020414.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5573)
  AUTHORS   Axenhus,M., Doeswijk,T., Nilsson,P., Matton,A., Winblad,B.,
            Tjernberg,L. and Schedin-Weiss,S.
  TITLE     DEAD Box Helicase 24 Is Increased in the Brain in Alzheimer's
            Disease and AppN-LF Mice and Influences Presymptomatic Pathology
  JOURNAL   Int J Mol Sci 25 (7), 3622 (2024)
   PUBMED   38612434
  REMARK    GeneRIF: DEAD Box Helicase 24 Is Increased in the Brain in
            Alzheimer's Disease and App[N-LF] Mice and Influences
            Presymptomatic Pathology.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5573)
  AUTHORS   Ni,Y. and Zhuang,Z.
  TITLE     DDX24 promotes tumor progression by mediating hexokinase-1 induced
            glycolysis in gastric cancer
  JOURNAL   Cell Signal 114, 110995 (2024)
   PUBMED   38043669
  REMARK    GeneRIF: DDX24 promotes tumor progression by mediating hexokinase-1
            induced glycolysis in gastric cancer.
REFERENCE   3  (bases 1 to 5573)
  AUTHORS   Zhang,H., Chen,Q., Zhang,Q., Gan,H., Li,H., Chen,S., Shan,H.,
            Pang,P. and He,H.
  TITLE     DDX24 Mutation Alters NPM1 Phase Behavior and Disrupts Nucleolar
            Homeostasis in Vascular Malformations
  JOURNAL   Int J Biol Sci 19 (13), 4123-4138 (2023)
   PUBMED   37705750
  REMARK    GeneRIF: DDX24 Mutation Alters NPM1 Phase Behavior and Disrupts
            Nucleolar Homeostasis in Vascular Malformations.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5573)
  AUTHORS   Hu,X., Li,F., Zhou,Y., Gan,H., Wang,T., Li,L., Long,H., Li,B. and
            Pang,P.
  TITLE     DDX24 promotes metastasis by regulating RPL5 in non-small cell lung
            cancer
  JOURNAL   Cancer Med 11 (23), 4513-4525 (2022)
   PUBMED   35864588
  REMARK    GeneRIF: DDX24 promotes metastasis by regulating RPL5 in non-small
            cell lung cancer.
REFERENCE   5  (bases 1 to 5573)
  AUTHORS   Serfecz,J.C., Hong,Y., Gay,L.A., Shekhar,R., Turner,P.C. and
            Renne,R.
  TITLE     DExD/H Box Helicases DDX24 and DDX49 Inhibit Reactivation of
            Kaposi's Sarcoma Associated Herpesvirus by Interacting with Viral
            mRNAs
  JOURNAL   Viruses 14 (10), 2083 (2022)
   PUBMED   36298642
  REMARK    GeneRIF: DExD/H Box Helicases DDX24 and DDX49 Inhibit Reactivation
            of Kaposi's Sarcoma Associated Herpesvirus by Interacting with
            Viral mRNAs.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5573)
  AUTHORS   Andersen,J.S., Lam,Y.W., Leung,A.K., Ong,S.E., Lyon,C.E.,
            Lamond,A.I. and Mann,M.
  TITLE     Nucleolar proteome dynamics
  JOURNAL   Nature 433 (7021), 77-83 (2005)
   PUBMED   15635413
REFERENCE   7  (bases 1 to 5573)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
REFERENCE   8  (bases 1 to 5573)
  AUTHORS   Namciu,S.J., Friedman,R.D., Marsden,M.D., Sarausad,L.M.,
            Jasoni,C.L. and Fournier,R.E.
  TITLE     Sequence organization and matrix attachment regions of the human
            serine protease inhibitor gene cluster at 14q32.1
  JOURNAL   Mamm Genome 15 (3), 162-178 (2004)
   PUBMED   15014966
REFERENCE   9  (bases 1 to 5573)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
REFERENCE   10 (bases 1 to 5573)
  AUTHORS   Zhao,Y., Yu,L., Fu,Q., Chen,W., Jiang,J., Gao,J. and Zhao,S.
  TITLE     Cloning and characterization of human DDX24 and mouse Ddx24, two
            novel putative DEAD-Box proteins, and mapping DDX24 to human
            chromosome 14q32
  JOURNAL   Genomics 67 (3), 351-355 (2000)
   PUBMED   10936056
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL079302.7.
            
            On Nov 26, 2018 this sequence version replaced NM_020414.3.
            
            Summary: DEAD box proteins, characterized by the conserved motif
            Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are
            implicated in a number of cellular processes involving alteration
            of RNA secondary structure such as translation initiation, nuclear
            and mitochondrial splicing, and ribosome and spliceosome assembly.
            Based on their distribution patterns, some members of this family
            are believed to be involved in embryogenesis, spermatogenesis, and
            cellular growth and division. This gene encodes a DEAD box protein,
            which shows little similarity to any of the other known human DEAD
            box proteins, but shows a high similarity to mouse Ddx24 at the
            amino acid level. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.211782.1,
                                           SRR1803614.143602.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2154665 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000621632.5/ ENSP00000481495.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-84                AL079302.7         166456-166539       c
            85-807              AL079302.7         164362-165084       c
            808-1332            AL079302.7         147434-147958       c
            1333-1486           AL079302.7         146250-146403       c
            1487-2002           AL079302.7         145435-145950       c
            2003-2078           AL079302.7         143159-143234       c
            2079-2267           AL079302.7         140333-140521       c
            2268-2397           AL079302.7         138335-138464       c
            2398-5573           AL079302.7         133624-136799       c
FEATURES             Location/Qualifiers
     source          1..5573
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q32.12"
     gene            1..5573
                     /gene="DDX24"
                     /note="DEAD-box helicase 24"
                     /db_xref="GeneID:57062"
                     /db_xref="HGNC:HGNC:13266"
                     /db_xref="MIM:606181"
     exon            1..84
                     /gene="DDX24"
                     /inference="alignment:Splign:2.1.0"
     exon            85..807
                     /gene="DDX24"
                     /inference="alignment:Splign:2.1.0"
     CDS             90..2669
                     /gene="DDX24"
                     /EC_number="3.6.4.13"
                     /note="DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 24; S.
                     cerevisiae CHL1-like helicase; DEAD box protein 24; DEAD
                     (Asp-Glu-Ala-Asp) box polypeptide 24; DEAD
                     (Asp-Glu-Ala-Asp) box helicase 24"
                     /codon_start=1
                     /product="ATP-dependent RNA helicase DDX24"
                     /protein_id="NP_065147.1"
                     /db_xref="CCDS:CCDS9918.1"
                     /db_xref="GeneID:57062"
                     /db_xref="HGNC:HGNC:13266"
                     /db_xref="MIM:606181"
                     /translation="MKLKDTKSRPKQSSCGKFQTKGIKVVGKWKEVKIDPNMFADGQM
                     DDLVCFEELTDYQLVSPAKNPSSLFSKEAPKRKAQAVSEEEEEEEGKSSSPKKKIKLK
                     KSKNVATEGTSTQKEFEVKDPELEAQGDDMVCDDPEAGEMTSENLVQTAPKKKKNKGK
                     KGLEPSQSTAAKVPKKAKTWIPEVHDQKADVSAWKDLFVPRPVLRALSFLGFSAPTPI
                     QALTLAPAIRDKLDILGAAETGSGKTLAFAIPMIHAVLQWQKRNAAPPPSNTEAPPGE
                     TRTEAGAETRSPGKAEAESDALPDDTVIESEALPSDIAAEARAKTGGTVSDQALLFGD
                     DDAGEGPSSLIREKPVPKQNENEEENLDKEQTGNLKQELDDKSATCKAYPKRPLLGLV
                     LTPTRELAVQVKQHIDAVARFTGIKTAILVGGMSTQKQQRMLNRRPEIVVATPGRLWE
                     LIKEKHYHLRNLRQLRCLVVDEADRMVEKGHFAELSQLLEMLNDSQYNPKRQTLVFSA
                     TLTLVHQAPARILHKKHTKKMDKTAKLDLLMQKIGMRGKPKVIDLTRNEATVETLTET
                     KIHCETDEKDFYLYYFLMQYPGRSLVFANSISCIKRLSGLLKVLDIMPLTLHACMHQK
                     QRLRNLEQFARLEDCVLLATDVAARGLDIPKVQHVIHYQVPRTSEIYVHRSGRTARAT
                     NEGLSLMLIGPEDVINFKKIYKTLKKDEDIPLFPVQTKYMDVVKERIRLARQIEKSEY
                     RNFQACLHNSWIEQAAAALEIELEEDMYKGGKADQQEERRRQKQMKVLKKELRHLLSQ
                     PLFTESQKTKYPTQSGKPPLLVSAPSKSESALSCLSKQKKKKTKKPKEPQPEQPQPST
                     SAN"
     exon            808..1332
                     /gene="DDX24"
                     /inference="alignment:Splign:2.1.0"
     exon            1333..1486
                     /gene="DDX24"
                     /inference="alignment:Splign:2.1.0"
     exon            1487..2002
                     /gene="DDX24"
                     /inference="alignment:Splign:2.1.0"
     exon            2003..2078
                     /gene="DDX24"
                     /inference="alignment:Splign:2.1.0"
     exon            2079..2267
                     /gene="DDX24"
                     /inference="alignment:Splign:2.1.0"
     exon            2268..2397
                     /gene="DDX24"
                     /inference="alignment:Splign:2.1.0"
     exon            2398..5573
                     /gene="DDX24"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2920..2925
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DDX24"
                     /note="hexamer: ATTAAA"
     polyA_site      2938
                     /gene="DDX24"
                     /note="major polyA site"
     regulatory      5549..5554
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DDX24"
                     /note="hexamer: AATAAA"
     polyA_site      5573
                     /gene="DDX24"
ORIGIN      
        1 agttgctgct gcagctgagg tacagcggcg gtttctgagg ttcttcactc gcgactgacg
       61 gagctgcggt ggcgtctcca cacgcaacca tgaagttgaa ggacacaaaa tcaaggccaa
      121 agcagtcaag ctgtggcaaa tttcagacaa agggaatcaa agttgtggga aaatggaagg
      181 aagtgaagat tgacccaaat atgtttgcag atggacagat ggatgacttg gtgtgctttg
      241 aggaattgac agattaccag ttggtctccc ctgccaagaa tccctccagt ctcttctcaa
      301 aggaagcacc caagagaaag gcacaagctg tttcagaaga agaggaggag gaggagggaa
      361 agtctagctc accaaagaaa aagatcaagt tgaagaaaag taaaaatgta gcaactgaag
      421 gaaccagtac ccagaaagaa tttgaagtga aagatcctga gctggaggcc cagggagatg
      481 acatggtttg tgatgatccg gaggctgggg agatgacatc agaaaacctg gtccaaactg
      541 ctccaaaaaa gaagaaaaat aaagggaaaa aagggttgga gccttctcag agcactgctg
      601 ccaaggtgcc caaaaaagcg aagacatgga ttcctgaagt tcatgatcag aaagcagatg
      661 tgtcagcttg gaaggacctg tttgttccca ggccggttct ccgagcactc agctttctag
      721 gcttctctgc acccacacca atccaagccc tgaccttggc acctgccatc cgtgacaaac
      781 tggacatcct tggggctgct gagacaggaa gtgggaaaac tcttgccttt gccatcccaa
      841 tgattcatgc ggtgttgcag tggcagaaga ggaatgctgc ccctcctcca agtaacaccg
      901 aagcaccacc tggagagacc agaactgagg ccggagctga gactagatca ccaggcaagg
      961 ctgaagctga gtctgatgca ttgcctgacg atactgtaat tgagagtgaa gcactgccca
     1021 gtgatattgc agccgaggcc agagccaaga ctggaggcac tgtctcagac caggcgttgc
     1081 tctttggtga cgatgatgct ggtgaagggc cttcttccct gatcagggag aaacctgttc
     1141 ccaaacagaa tgagaatgag gaggaaaatc ttgataaaga gcagactgga aatctaaaac
     1201 aggagttgga tgacaaaagc gccacctgta aggcatatcc aaagcgtcct ctgcttggac
     1261 tggttctgac tcccactcga gagctggccg tccaggtcaa acagcacatt gatgctgtgg
     1321 ccaggtttac aggaattaaa actgctattt tggttggtgg aatgtccacg cagaaacagc
     1381 agaggatgct gaaccgtcgt cctgagattg tggttgctac tccaggccgg ctgtgggaat
     1441 taattaaaga aaagcattat catttgagga accttcggca gctcaggtgc ctggtagtgg
     1501 atgaggctga ccggatggtt gagaaaggcc attttgctga gctctcacag ctgctagaga
     1561 tgctcaatga ctcccaatac aacccaaaga gacaaacgct tgttttttct gccacactca
     1621 ccctggtgca tcaggctcct gctcgaatcc ttcataagaa gcacaccaag aaaatggata
     1681 aaacagccaa acttgacctc cttatgcaga aaattggcat gaggggcaag cccaaggtca
     1741 ttgacctcac aaggaatgag gccacggtgg agacgctaac agagaccaag atccattgtg
     1801 agactgatga gaaagacttc tacttgtact acttcctgat gcagtatcca ggccgcagct
     1861 tagtgtttgc caacagtatc tcctgcatca aacgcctctc tgggctcctc aaagtccttg
     1921 atatcatgcc cttgaccctg catgcctgta tgcaccagaa gcagaggctc agaaacctgg
     1981 agcagtttgc ccgtctggaa gactgtgttc tcttggcaac agatgtggca gctcggggtc
     2041 tggatattcc taaagtccag catgtcatcc attaccaggt cccacgtacc tcggagattt
     2101 atgtccaccg aagtggtcga actgctcgag ctaccaatga aggcctcagt ctgatgctca
     2161 ttgggcctga ggatgtgatc aactttaaga agatttacaa aacgctcaag aaagatgagg
     2221 atatcccact gttccccgtg cagacaaaat acatggatgt ggtcaaggag cgaatccgtt
     2281 tagctcgaca gattgagaaa tctgagtatc ggaacttcca ggcttgcctg cacaactctt
     2341 ggattgagca ggcagcagct gccctggaga ttgagctgga agaagacatg tataagggag
     2401 gaaaagctga ccagcaagaa gaacgtcgga gacaaaagca gatgaaggtt ctgaagaagg
     2461 agctgcgcca cctgctgtcc cagccactgt ttacggagag ccagaaaacc aagtatccca
     2521 ctcagtctgg caagccgccc ctgcttgtgt ctgccccaag taagagcgag tctgctttga
     2581 gctgtctctc caagcagaag aagaagaaga caaagaagcc gaaggagcca cagccggaac
     2641 agccacagcc aagtacaagt gcaaattaac tggtcaagtg tgtcagtgac tgcacattgg
     2701 tttctgttct ctggctattt gcaaaacctc tcccaccctt gtgtttcact ccaccaccaa
     2761 ccccaggtaa aaaagtctcc ctctcttcca ctcacaccca tagcgggaga gacctcatgc
     2821 agatttgcat tgttttggag taagaattca atgcagcagc ttaatttttc tgtattgcag
     2881 tgtttatagg cttcttgtgt gttaaacttg atttcataaa ttaaaaacaa tggtcagagc
     2941 cattgtgtca tcctgatttt tttttttttt ttttagatag aagatggggg tggtggtgta
     3001 gtttgtttca ttattaactt agtgattctc ctgggccagc acagtgctaa gcccttgaaa
     3061 ggacaggaat agtgtcaggc ctctggctgc aggccaagat tggacagtgt gaatggagca
     3121 agaggctgga atgttcaaga ggtgcatgtt cctgctttac ccagagcagc accctaatag
     3181 ctccttagct ctctccactc tcctgggtat tgtctgagcc accgtgggag gtgggcaggg
     3241 atgaggttgc tgtcttcagg cttccctcac atcacagagc caacagtaac agtcgctagg
     3301 tctggcgtgt gaagccctca ggatctagcc ccagccttgt ctccactccc tcctgtttga
     3361 cagagcaggc tcctgcccac ggttccatgc accccttctc ttgtcctgag cctttgtgca
     3421 gaataggctt ttccctcggt ctggattgcc ttttggcctt ctccatcctg gagcactgcc
     3481 atgggtcctc tagtcctgag cctctaaggg gaagcagtgc ttctcctggg gctcccttag
     3541 tgtcccgtgc ttaccctctt catagcactt gccatgctgt gttcccttag ctgagctcct
     3601 tgggagaaga ggaactcaag gcttggtcag cctggtataa atatgtgctc agggaactag
     3661 ggacttcctg atgctgcccc agctttgtct ggatcagtgt aggtgagtat ccacaactcc
     3721 cacaaccatg ggagaagcat agatgatttc tgcacagctg tctggcttcc aaacaggtat
     3781 tcgtcggggc acaatacaat acagctgttt agttcaaggg gtgctaggga attgaagagg
     3841 atacacaaag ggaccaagat accccaagat ctaagtagct agcctctctc agcctcatgg
     3901 ttggcacttt tatctaatta gcatttagtc ttgaaggtcc tgagaaataa ttttcttttt
     3961 tttttgagac agggtcttgc tccattgccc aggttggagt gcaatggcac aatcacagct
     4021 cactgcaacc tcacactcct gggcccaggc agtcctcccg cctcagcctc ccaagtagct
     4081 gggactacag gcacacacca ccacacctgg ctgaattttt tttttttagt agagatgggg
     4141 tctcactatg ttggcgtagg ctggtctcaa aactcctgcc ctcaagtgat cctcttgcct
     4201 cagcctccca aagtactgag attacaggtg tgagccactg tgcccatcta taagtcttta
     4261 ttagtgtttt ttgtacttga gcatatagac acccagtgat tgagacttgc ccagggccac
     4321 acagcagcca agtagcagag gtgggattag tatcttcctt ctgggcccag gacaagttca
     4381 gaaaactact tcagtctcag aagtgttgcc aaggaatggc ctcccatccc ccagtgtcac
     4441 cagtgaccgg aataggaggg gaaattgccc gtctgtgagg tcagctcctg actgacagct
     4501 atcagagaat ggcagggaga ctctccattt tccaaatgat gcagtggtgg tcagtggggt
     4561 tagtaagcgg gcttaatatc ccctaatggc acctgagccg tgggagtgaa gccacttgcc
     4621 ataagccaaa catagatccc ctgatgactg tccgtgtcct gccctagcca tctaacagca
     4681 aattcttttc cttggtggag gagctaatac gtagacaggc tttaaaaggc aggagcagcc
     4741 ttccaagcag tgctactctc gcctggtaag gtgaagttgg tgggcagagc ttccggagtg
     4801 tcctggatct gccattaaac aaggaatatc cctccccagc taatctactt aatacataag
     4861 caccacggaa aagcagagtt cttggctgca tgccaggtac ccagtattaa gaagccagga
     4921 caaaagtagt tatggaaacc attttaatgc taggagaatg tttttactta ctgcctaggg
     4981 aagctgtagg gcttggccca catccagcag ggcctggggc ccctggaagc cactcactga
     5041 gttacagccc cctccccact cctgtatctg ctcagggtgg tgatgtgttt gctcctagac
     5101 tctctctcat ggttcccctg acactcctgc ttgggaagcc accgagtcac tgccaaggtg
     5161 acatgcttcc ccatctgcag tgccctatgc ttcctgtcag gaaggacagg ttggggaata
     5221 tccctttgca gagcccatac gatgagtgtg tcaggtataa tagctatttt cacacaagga
     5281 atctcattct gttttaacca ataatccagt gacacatagg tattgttgcc atttcacaaa
     5341 cttgggaatt ggggctcagg gaggtgaagt gacttggcca agatcataca gctagtaagt
     5401 gaatgctgaa gttagaaccc tggcattctg gctccagagc tctcatttgt gcttaaaata
     5461 ggaacccagt caaaagcagg gactgtgctc tttctgttgc taattgttcc cattgattta
     5521 aaagtttcct ttggagagaa agtatcataa taaacatgca gttgtaaaaa caa
//
