LOCUS       NM_007204               3600 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens DEAD-box helicase 20 (DDX20), mRNA.
ACCESSION   NM_007204
VERSION     NM_007204.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3600)
  AUTHORS   Yang,Y., Yang,M., Pang,H., Qiu,Y., Sun,T., Wang,T., Shen,S. and
            Wang,W.
  TITLE     A Macrophage Differentiation-Mediated Gene: DDX20 as a Molecular
            Biomarker Encompassing the Tumor Microenvironment, Disease Staging,
            and Prognoses in Hepatocellular Carcinoma
  JOURNAL   Oxid Med Cell Longev 2022, 9971776 (2022)
   PUBMED   36246406
  REMARK    GeneRIF: A Macrophage Differentiation-Mediated Gene: DDX20 as a
            Molecular Biomarker Encompassing the Tumor Microenvironment,
            Disease Staging, and Prognoses in Hepatocellular Carcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3600)
  AUTHORS   Chevalier,B., Baatallah,N., Najm,M., Castanier,S., Jung,V.,
            Pranke,I., Golec,A., Stoven,V., Marullo,S., Antigny,F.,
            Guerrera,I.C., Sermet-Gaudelus,I., Edelman,A. and Hinzpeter,A.
  TITLE     Differential CFTR-Interactome Proximity Labeling Procedures
            Identify Enrichment in Multiple SLC Transporters
  JOURNAL   Int J Mol Sci 23 (16), 8937 (2022)
   PUBMED   36012204
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3600)
  AUTHORS   Hobani,Y.H., Almars,A.I., Alelwani,W., Toraih,E.A., Nemr,N.A.,
            Shaalan,A.A.M., Fawzy,M.S. and Attallah,S.M.
  TITLE     Genetic Variation in DEAD-Box Helicase 20 as a Putative Marker of
            Recurrence in Propensity-Matched Colon Cancer Patients
  JOURNAL   Genes (Basel) 13 (8), 1404 (2022)
   PUBMED   36011315
  REMARK    GeneRIF: Genetic Variation in DEAD-Box Helicase 20 as a Putative
            Marker of Recurrence in Propensity-Matched Colon Cancer Patients.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3600)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   5  (bases 1 to 3600)
  AUTHORS   Lim,S.H., Snider,J., Birimberg-Schwartz,L., Ip,W., Serralha,J.C.,
            Botelho,H.M., Lopes-Pacheco,M., Pinto,M.C., Moutaoufik,M.T.,
            Zilocchi,M., Laselva,O., Esmaeili,M., Kotlyar,M., Lyakisheva,A.,
            Tang,P., Lopez Vazquez,L., Akula,I., Aboualizadeh,F., Wong,V.,
            Grozavu,I., Opacak-Bernardi,T., Yao,Z., Mendoza,M., Babu,M.,
            Jurisica,I., Gonska,T., Bear,C.E., Amaral,M.D. and Stagljar,I.
  TITLE     CFTR interactome mapping using the mammalian membrane two-hybrid
            high-throughput screening system
  JOURNAL   Mol Syst Biol 18 (2), e10629 (2022)
   PUBMED   35156780
REFERENCE   6  (bases 1 to 3600)
  AUTHORS   Meister,G., Buhler,D., Laggerbauer,B., Zobawa,M., Lottspeich,F. and
            Fischer,U.
  TITLE     Characterization of a nuclear 20S complex containing the survival
            of motor neurons (SMN) protein and a specific subset of
            spliceosomal Sm proteins
  JOURNAL   Hum Mol Genet 9 (13), 1977-1986 (2000)
   PUBMED   10942426
REFERENCE   7  (bases 1 to 3600)
  AUTHORS   Charroux,B., Pellizzoni,L., Perkinson,R.A., Yong,J., Shevchenko,A.,
            Mann,M. and Dreyfuss,G.
  TITLE     Gemin4. A novel component of the SMN complex that is found in both
            gems and nucleoli
  JOURNAL   J Cell Biol 148 (6), 1177-1186 (2000)
   PUBMED   10725331
REFERENCE   8  (bases 1 to 3600)
  AUTHORS   Charroux,B., Pellizzoni,L., Perkinson,R.A., Shevchenko,A., Mann,M.
            and Dreyfuss,G.
  TITLE     Gemin3: A novel DEAD box protein that interacts with SMN, the
            spinal muscular atrophy gene product, and is a component of gems
  JOURNAL   J Cell Biol 147 (6), 1181-1194 (1999)
   PUBMED   10601333
REFERENCE   9  (bases 1 to 3600)
  AUTHORS   Sleeman,J.E. and Lamond,A.I.
  TITLE     Newly assembled snRNPs associate with coiled bodies before
            speckles, suggesting a nuclear snRNP maturation pathway
  JOURNAL   Curr Biol 9 (19), 1065-1074 (1999)
   PUBMED   10531003
REFERENCE   10 (bases 1 to 3600)
  AUTHORS   Grundhoff,A.T., Kremmer,E., Tureci,O., Glieden,A., Gindorf,C.,
            Atz,J., Mueller-Lantzsch,N., Schubach,W.H. and Grasser,F.A.
  TITLE     Characterization of DP103, a novel DEAD box protein that binds to
            the Epstein-Barr virus nuclear proteins EBNA2 and EBNA3C
  JOURNAL   J Biol Chem 274 (27), 19136-19144 (1999)
   PUBMED   10383418
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF171063.1, AK001506.1,
            AY007146.1 and AL049557.19.
            
            On Nov 23, 2018 this sequence version replaced NM_007204.4.
            
            Summary: DEAD box proteins, characterized by the conserved motif
            Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are
            implicated in a number of cellular processes involving alteration
            of RNA secondary structure such as translation initiation, nuclear
            and mitochondrial splicing, and ribosome and spliceosome assembly.
            Based on their distribution patterns, some members of this family
            are believed to be involved in embryogenesis, spermatogenesis, and
            cellular growth and division. This gene encodes a DEAD box protein,
            which has an ATPase activity and is a component of the survival of
            motor neurons (SMN) complex. This protein interacts directly with
            SMN, the spinal muscular atrophy gene product, and may play a
            catalytic role in the function of the SMN complex on RNPs.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC034953.2, AF155803.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000369702.5/ ENSP00000358716.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1939              AF171063.1         270-2208
            1940-2529           AK001506.1         1935-2524
            2530-3073           AY007146.1         466-1009
            3074-3075           AL049557.19        118915-118916
            3076-3177           AY007146.1         1010-1111
            3178-3600           AL049557.19        119019-119441
FEATURES             Location/Qualifiers
     source          1..3600
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p13.2"
     gene            1..3600
                     /gene="DDX20"
                     /gene_synonym="DP103; GEMIN3"
                     /note="DEAD-box helicase 20"
                     /db_xref="GeneID:11218"
                     /db_xref="HGNC:HGNC:2743"
                     /db_xref="MIM:606168"
     exon            1..325
                     /gene="DDX20"
                     /gene_synonym="DP103; GEMIN3"
                     /inference="alignment:Splign:2.1.0"
     CDS             25..2499
                     /gene="DDX20"
                     /gene_synonym="DP103; GEMIN3"
                     /EC_number="3.6.1.15"
                     /EC_number="3.6.4.13"
                     /note="DEAD-box protein DP103; SMN-interacting protein;
                     DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 20, 103kD;
                     gemin-3; DEAD box protein 20; component of gems 3; DEAD
                     (Asp-Glu-Ala-Asp) box polypeptide 20; DEAD box protein DP
                     103"
                     /codon_start=1
                     /product="probable ATP-dependent RNA helicase DDX20"
                     /protein_id="NP_009135.4"
                     /db_xref="CCDS:CCDS842.1"
                     /db_xref="GeneID:11218"
                     /db_xref="HGNC:HGNC:2743"
                     /db_xref="MIM:606168"
                     /translation="MAAAFEASGALAAVATAMPAEHVAVQVPAPEPTPGPVRILRTAQ
                     DLSSPRTRTGDVLLAEPADFESLLLSRPVLEGLRAAGFERPSPVQLKAIPLGRCGLDL
                     IVQAKSGTGKTCVFSTIALDSLVLENLSTQILILAPTREIAVQIHSVITAIGIKMEGL
                     ECHVFIGGTPLSQDKTRLKKCHIAVGSPGRIKQLIELDYLNPGSIRLFILDEADKLLE
                     EGSFQEQINWIYSSLPASKQMLAVSATYPEFLANALTKYMRDPTFVRLNSSDPSLIGL
                     KQYYKVVNSYPLAHKVFEEKTQHLQELFSRIPFNQALVFSNLHSRAQHLADILSSKGF
                     PAECISGNMNQNQRLDAMAKLKHFHCRVLISTDLTSRGIDAEKVNLVVNLDVPLDWET
                     YMHRIGRAGRFGTLGLTVTYCCRGEEENMMMRIAQKCNINLLPLPDPIPSGLMEECVD
                     WDVEVKAAVHTYGIASVPNQPLKKQIQKIERTLQIQKAHGDHMASSRNNSVSGLSVKS
                     KNNTKQKLPVKSHSECGIIEKATSPKELGCDRQSEEQMKNSVQTPVENSTNSQHQVKE
                     ALPVSLPQIPCLSSFKIHQPYTLTFAELVEDYEHYIKEGLEKPVEIIRHYTGPGDQTV
                     NPQNGFVRNKVIEQRVPVLASSSQSGDSESDSDSYSSRTSSQSKGNKSYLEGSSDNQL
                     KDSESTPVDDRISLEQPPNGSDTPNPEKYQESPGIQMKTRLKEGASQRAKQSRRNLPR
                     RSSFRLQTEAQEDDWYDCHREIRLSFSDTYQDYEEYWRAYYRAWQEYYAAASHSYYWN
                     AQRHPSWMAAYHMNTIYLQEMMHSNQ"
     exon            326..420
                     /gene="DDX20"
                     /gene_synonym="DP103; GEMIN3"
                     /inference="alignment:Splign:2.1.0"
     exon            421..589
                     /gene="DDX20"
                     /gene_synonym="DP103; GEMIN3"
                     /inference="alignment:Splign:2.1.0"
     exon            590..704
                     /gene="DDX20"
                     /gene_synonym="DP103; GEMIN3"
                     /inference="alignment:Splign:2.1.0"
     exon            705..847
                     /gene="DDX20"
                     /gene_synonym="DP103; GEMIN3"
                     /inference="alignment:Splign:2.1.0"
     exon            848..986
                     /gene="DDX20"
                     /gene_synonym="DP103; GEMIN3"
                     /inference="alignment:Splign:2.1.0"
     exon            987..1045
                     /gene="DDX20"
                     /gene_synonym="DP103; GEMIN3"
                     /inference="alignment:Splign:2.1.0"
     exon            1046..1128
                     /gene="DDX20"
                     /gene_synonym="DP103; GEMIN3"
                     /inference="alignment:Splign:2.1.0"
     exon            1129..1234
                     /gene="DDX20"
                     /gene_synonym="DP103; GEMIN3"
                     /inference="alignment:Splign:2.1.0"
     exon            1235..1336
                     /gene="DDX20"
                     /gene_synonym="DP103; GEMIN3"
                     /inference="alignment:Splign:2.1.0"
     exon            1337..3600
                     /gene="DDX20"
                     /gene_synonym="DP103; GEMIN3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2846..2851
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DDX20"
                     /gene_synonym="DP103; GEMIN3"
                     /note="hexamer: AATAGA"
     polyA_site      2863
                     /gene="DDX20"
                     /gene_synonym="DP103; GEMIN3"
                     /note="major polyA site"
     regulatory      3064..3069
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DDX20"
                     /gene_synonym="DP103; GEMIN3"
                     /note="hexamer: AGTAAA"
     polyA_site      3085
                     /gene="DDX20"
                     /gene_synonym="DP103; GEMIN3"
     regulatory      3156..3161
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DDX20"
                     /gene_synonym="DP103; GEMIN3"
                     /note="hexamer: ATTAAA"
     polyA_site      3177
                     /gene="DDX20"
                     /gene_synonym="DP103; GEMIN3"
     regulatory      3582..3587
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DDX20"
                     /gene_synonym="DP103; GEMIN3"
                     /note="hexamer: AATATA"
     polyA_site      3600
                     /gene="DDX20"
                     /gene_synonym="DP103; GEMIN3"
ORIGIN      
        1 gcgagatctg acggcgcggc taccatggcg gcggcatttg aagcctcggg agccttagca
       61 gcagtggcga ctgctatgcc ggctgagcat gtggccgtgc aggtcccggc cccagagcca
      121 acacccgggc ctgtgaggat cctgcggacc gctcaggatc tcagcagccc gcggacccgc
      181 acgggggatg tgctgttggc ggagccggcc gacttcgagt cactgctgct ttcgcggccg
      241 gtgctggagg ggctgcgggc ggccggcttc gagaggccct cgccggtgca gctcaaggcc
      301 atcccgttgg ggcgctgcgg gctcgattta attgttcaag ctaaatctgg caccgggaaa
      361 acctgtgtgt tctccaccat agctttggac tctcttgttc ttgaaaactt aagtacccag
      421 attttgatct tggctcctac aagagaaatt gctgtacaga tacattctgt tattacagcc
      481 attggaataa aaatggaagg cttagagtgt catgtcttta ttggagggac cccattatca
      541 caagacaaaa ccagacttaa aaagtgtcat attgctgttg gatctcctgg cagaattaag
      601 caactcatag aacttgacta cttgaaccca ggcagtatac gcctctttat tcttgatgaa
      661 gcagataagc ttttagaaga aggcagcttc caggagcaaa taaattggat ttattcttcc
      721 ttgcctgcca gtaaacagat gctggcagta tcagctactt atcccgaatt tttggctaat
      781 gctttgacaa agtacatgag agatcccact tttgtaagac tgaattccag tgatccaagt
      841 ctcataggtt tgaagcagta ttacaaagtt gtcaattcat accctttggc acataaggtt
      901 tttgaggaaa agactcagca tttacaggaa ctgttcagca gaattccatt taatcaagct
      961 ttagtctttt ctaatttgca cagcagagca caacatttgg ctgatatcct ttcttctaaa
     1021 ggctttcctg ctgagtgcat ttcaggcaat atgaatcaga atcagcgtct tgatgctatg
     1081 gctaaactga agcactttca ttgcagagtc ctcatttcca cagatttgac ttctcgtggg
     1141 attgatgctg agaaggtgaa tctggttgta aatctggatg taccattgga ttgggagaca
     1201 tacatgcatc ggattgggag agctggccgt tttggtacat tggggctgac agtgacctac
     1261 tgttgccggg gagaggaaga aaatatgatg atgagaattg cccagaaatg taatatcaac
     1321 cttctccctt taccagatcc cattccttct ggtctgatgg aagaatgtgt ggattgggat
     1381 gtggaagtta aagctgctgt gcatacatat ggtatagcaa gtgtacctaa ccaaccctta
     1441 aaaaagcaaa ttcagaaaat agagagaacc cttcaaattc agaaagctca tggtgaccac
     1501 atggcttcct ctagaaataa ttctgtatct ggactatcag tcaaatcaaa aaataatacc
     1561 aaacaaaagc ttcctgtgaa aagccactca gaatgtggaa tcatagaaaa agcaacgtca
     1621 ccaaaagaac tgggctgtga caggcaatcc gaagagcaaa tgaagaattc tgttcagact
     1681 cccgttgaaa actccaccaa cagtcagcac caggtcaaag aagctttacc tgtgtcactc
     1741 ccccagattc cttgtctgtc ttcctttaaa atccatcagc catacacgtt gacttttgct
     1801 gaattggtag aggattatga acattatatt aaagaggggt tagagaaacc tgtggaaatc
     1861 atcaggcact acacaggccc tggggatcag actgtgaatc ctcaaaatgg ttttgtgaga
     1921 aataaagtta ttgaacagag agtccctgtg ttggcaagta gtagccaatc tggagactct
     1981 gagagtgaca gtgattctta cagctcaaga acctcttccc agagcaaagg aaataagtca
     2041 tacttggaag gctcttctga taatcagctg aaagactctg aatctacgcc tgtggatgat
     2101 cgtatttctt tggaacaacc accaaatgga agtgacaccc ccaatccaga gaaatatcaa
     2161 gaatcacctg gaatccagat gaagacaaga cttaaagagg gggctagcca gagagctaag
     2221 cagagccgga gaaacctacc caggcggtct tccttcagat tgcagactga agcccaggaa
     2281 gatgattggt atgactgtca tagggaaata cgtctgagtt tttctgatac ctatcaggat
     2341 tatgaggagt actggagagc ttactacagg gcatggcaag aatattatgc tgccgcttct
     2401 cattcatatt attggaatgc tcagagacat ccaagttgga tggcagctta tcacatgaat
     2461 accatttatc tacaagaaat gatgcatagt aaccagtgat tataggatat acctgagacc
     2521 atcaggaact gtcaacaaat gatacctttg gatatccatc ctcctcgact tatagtacag
     2581 tggtgtatag tggcatttct gataaacttg aaaagacttg agtctttcca ctgggacaca
     2641 tccatttttc agattgtttt gatttaggcc aggtatatta tcttcatttt taagagtttc
     2701 tttaagaaac ttcatcagat tgttgaaaga taatttttgg gacatagagc tgaaagtttc
     2761 agggtgccat tttctataag atcttcccaa aagaaacatt taaaaagatg acatatacca
     2821 ccacttactt aaaaacaata aaagcaatag atttgattag taatattatt gctgtggagt
     2881 tctttacaaa gggcttaggc tgcatttcct tctatagagg tgcattcttg tagaaatttg
     2941 tagcatggta gatcagaaaa tcctcttagg ttttaggcag gaaggaatat ttaaacattg
     3001 ctttagattt tcctaaaggt atttgatttg atctgttagc ttccagtaaa aatatttgtt
     3061 tttagtaaaa acaaatttaa atatatttac atgtttgttg tttatctttt gaatgtcttt
     3121 tgaggctgtg aaagctgtcc acatttttgc tgtgtattaa atagctgtgg gtcatcagtt
     3181 gctgtcttac ttgtgttgct cagatagagg agcagctctt aatctttttt ggttcttgga
     3241 tccttttatg aatcagctga tagctataga ttgacttcag gaaatttctc attccataag
     3301 cacagaattg tgagtgtaat ttcaaggggt tcatagaccc tctgaagttc atctatacag
     3361 tccagattaa caagtgacct gctctgctgg taggctaggg gaagttctag ctcttagttt
     3421 taagtatttt gtggaagctg gaattgattc tcttcagaca cttcttagta catcctaatt
     3481 ttgtgtcttc tagaaaattt tccccagttt ttacctctaa tgttaggatc caagaggagc
     3541 ttggatctga gctgatgcat ctgtaaatta cgatttagaa aaatataatt ggaaattaca
//
