LOCUS       NM_007242               3275 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens DEAD-box helicase 19B (DDX19B), transcript variant 1,
            mRNA.
ACCESSION   NM_007242
VERSION     NM_007242.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3275)
  AUTHORS   Banerjee,P., Markande,S., Kalarikkal,M. and Joseph,J.
  TITLE     SUMOylation modulates the function of DDX19 in mRNA export
  JOURNAL   J Cell Sci 135 (4) (2022)
   PUBMED   35080244
  REMARK    GeneRIF: SUMOylation modulates the function of DDX19 in mRNA
            export.
REFERENCE   2  (bases 1 to 3275)
  AUTHORS   Park,Y., Park,J., Hwang,H.J., Kim,L., Jeong,K., Song,H.K.,
            Rufener,S.C., Muhlemann,O. and Kim,Y.K.
  TITLE     Translation mediated by the nuclear cap-binding complex is confined
            to the perinuclear region via a CTIF-DDX19B interaction
  JOURNAL   Nucleic Acids Res 49 (14), 8261-8276 (2021)
   PUBMED   34232997
  REMARK    GeneRIF: Translation mediated by the nuclear cap-binding complex is
            confined to the perinuclear region via a CTIF-DDX19B interaction.
REFERENCE   3  (bases 1 to 3275)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 3275)
  AUTHORS   Arul Nambi Rajan,A. and Montpetit,B.
  TITLE     Emerging molecular functions and novel roles for the DEAD-box
            protein Dbp5/DDX19 in gene expression
  JOURNAL   Cell Mol Life Sci 78 (5), 2019-2030 (2021)
   PUBMED   33205304
  REMARK    GeneRIF: Emerging molecular functions and novel roles for the
            DEAD-box protein Dbp5/DDX19 in gene expression.
            Review article
REFERENCE   5  (bases 1 to 3275)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 3275)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   7  (bases 1 to 3275)
  AUTHORS   Yin,L., Li,J., Zhu,H., Lin,M., Cheng,L., Wang,Y., Zhou,Z. and
            Sha,J.
  TITLE     Identification and characterization of a gene coding a novel
            isoform of DEAD-box protein
  JOURNAL   Reprod Fertil Dev 14 (3-4), 185-189 (2002)
   PUBMED   12219940
  REMARK    GeneRIF: identification and characterization of a gene coding a
            novel isoform
REFERENCE   8  (bases 1 to 3275)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
REFERENCE   9  (bases 1 to 3275)
  AUTHORS   Schmitt,C., von Kobbe,C., Bachi,A., Pante,N., Rodrigues,J.P.,
            Boscheron,C., Rigaut,G., Wilm,M., Seraphin,B., Carmo-Fonseca,M. and
            Izaurralde,E.
  TITLE     Dbp5, a DEAD-box protein required for mRNA export, is recruited to
            the cytoplasmic fibrils of nuclear pore complex via a conserved
            interaction with CAN/Nup159p
  JOURNAL   EMBO J 18 (15), 4332-4347 (1999)
   PUBMED   10428971
REFERENCE   10 (bases 1 to 3275)
  AUTHORS   Mattioni,T., Hume,C.R., Konigorski,S., Hayes,P., Osterweil,Z. and
            Lee,J.S.
  TITLE     A cDNA clone for a novel nuclear protein with DNA binding activity
  JOURNAL   Chromosoma 101 (10), 618-624 (1992)
   PUBMED   1424986
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC012184.7.
            
            On Aug 28, 2019 this sequence version replaced NM_007242.6.
            
            Summary: DEAD box proteins, characterized by the conserved motif
            Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are
            implicated in a number of cellular processes involving alteration
            of RNA secondary structure such as translation initiation, nuclear
            and mitochondrial splicing, and ribosome and spliceosome assembly.
            Based on their distribution patterns, some members of this family
            are believed to be involved in embryogenesis, spermatogenesis, and
            cellular growth and division. This gene encodes a DEAD box protein,
            which exhibits RNA-dependent ATPase and ATP-dependent RNA-unwinding
            activities. This protein is recruited to the cytoplasmic fibrils of
            the nuclear pore complex, where it participates in the export of
            mRNA from the nucleus. Multiple alternatively spliced transcript
            variants encoding different isoforms have been found for this gene.
            [provided by RefSeq, Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074968.348309.1,
                                           SRR11853561.11560.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000288071.11/ ENSP00000288071.7
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-169               AC012184.7         19872-20040
            170-218             AC012184.7         33295-33343
            219-272             AC012184.7         35588-35641
            273-408             AC012184.7         36655-36790
            409-501             AC012184.7         38182-38274
            502-604             AC012184.7         45271-45373
            605-719             AC012184.7         46260-46374
            720-897             AC012184.7         49978-50155
            898-1135            AC012184.7         50517-50754
            1136-1298           AC012184.7         52408-52570
            1299-1490           AC012184.7         53654-53845
            1491-3275           AC012184.7         54207-55991
FEATURES             Location/Qualifiers
     source          1..3275
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q22.1"
     gene            1..3275
                     /gene="DDX19B"
                     /gene_synonym="DBP5; DDX19; RNAh"
                     /note="DEAD-box helicase 19B"
                     /db_xref="GeneID:11269"
                     /db_xref="HGNC:HGNC:2742"
                     /db_xref="MIM:605812"
     exon            1..169
                     /gene="DDX19B"
                     /gene_synonym="DBP5; DDX19; RNAh"
                     /inference="alignment:Splign:2.1.0"
     CDS             113..1552
                     /gene="DDX19B"
                     /gene_synonym="DBP5; DDX19; RNAh"
                     /EC_number="3.6.4.13"
                     /note="isoform 1 is encoded by transcript variant 1;
                     DEAD-box protein 5; yeast Dbp5 homolog; DEAD/H
                     (Asp-Glu-Ala-Asp/His) box polypeptide 19 (Dbp5, yeast,
                     homolog); ATP-dependent RNA helicase DDX19; DEAD
                     (Asp-Glu-Ala-Asp) box polypeptide 19B; ATP-dependent RNA
                     helicase DDX19B; DEAD-box RNA helicase DEAD5; DEAD box
                     protein 19B; DEAD (Asp-Glu-Ala-As) box polypeptide 19B;
                     dead box protein 5 homolog"
                     /codon_start=1
                     /product="ATP-dependent RNA helicase DDX19B isoform 1"
                     /protein_id="NP_009173.1"
                     /db_xref="CCDS:CCDS10888.1"
                     /db_xref="GeneID:11269"
                     /db_xref="HGNC:HGNC:2742"
                     /db_xref="MIM:605812"
                     /translation="MATDSWALAVDEQEAAAESLSNLHLKEEKIKPDTNGAVVKTNAN
                     AEKTDEEEKEDRAAQSLLNKLIRSNLVDNTNQVEVLQRDPNSPLYSVKSFEELRLKPQ
                     LLQGVYAMGFNRPSKIQENALPLMLAEPPQNLIAQSQSGTGKTAAFVLAMLSQVEPAN
                     KYPQCLCLSPTYELALQTGKVIEQMGKFYPELKLAYAVRGNKLERGQKISEQIVIGTP
                     GTVLDWCSKLKFIDPKKIKVFVLDEADVMIATQGHQDQSIRIQRMLPRNCQMLLFSAT
                     FEDSVWKFAQKVVPDPNVIKLKREEETLDTIKQYYVLCSSRDEKFQALCNLYGAITIA
                     QAMIFCHTRKTASWLAAELSKEGHQVALLSGEMMVEQRAAVIERFREGKEKVLVTTNV
                     CARGIDVEQVSVVINFDLPVDKDGNPDNETYLHRIGRTGRFGKRGLAVNMVDSKHSMN
                     ILNRIQEHFNKKIERLDTDDLDEIEKIAN"
     exon            170..218
                     /gene="DDX19B"
                     /gene_synonym="DBP5; DDX19; RNAh"
                     /inference="alignment:Splign:2.1.0"
     exon            219..272
                     /gene="DDX19B"
                     /gene_synonym="DBP5; DDX19; RNAh"
                     /inference="alignment:Splign:2.1.0"
     exon            273..408
                     /gene="DDX19B"
                     /gene_synonym="DBP5; DDX19; RNAh"
                     /inference="alignment:Splign:2.1.0"
     exon            409..501
                     /gene="DDX19B"
                     /gene_synonym="DBP5; DDX19; RNAh"
                     /inference="alignment:Splign:2.1.0"
     exon            502..604
                     /gene="DDX19B"
                     /gene_synonym="DBP5; DDX19; RNAh"
                     /inference="alignment:Splign:2.1.0"
     exon            605..719
                     /gene="DDX19B"
                     /gene_synonym="DBP5; DDX19; RNAh"
                     /inference="alignment:Splign:2.1.0"
     exon            720..897
                     /gene="DDX19B"
                     /gene_synonym="DBP5; DDX19; RNAh"
                     /inference="alignment:Splign:2.1.0"
     exon            898..1135
                     /gene="DDX19B"
                     /gene_synonym="DBP5; DDX19; RNAh"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..1298
                     /gene="DDX19B"
                     /gene_synonym="DBP5; DDX19; RNAh"
                     /inference="alignment:Splign:2.1.0"
     exon            1299..1490
                     /gene="DDX19B"
                     /gene_synonym="DBP5; DDX19; RNAh"
                     /inference="alignment:Splign:2.1.0"
     exon            1491..3275
                     /gene="DDX19B"
                     /gene_synonym="DBP5; DDX19; RNAh"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1773..1778
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DDX19B"
                     /gene_synonym="DBP5; DDX19; RNAh"
                     /note="hexamer: AATACA"
     polyA_site      1798
                     /gene="DDX19B"
                     /gene_synonym="DBP5; DDX19; RNAh"
                     /note="major polyA site"
     regulatory      2584..2589
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DDX19B"
                     /gene_synonym="DBP5; DDX19; RNAh"
                     /note="hexamer: TATAAA"
     polyA_site      2602
                     /gene="DDX19B"
                     /gene_synonym="DBP5; DDX19; RNAh"
     regulatory      3170..3175
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DDX19B"
                     /gene_synonym="DBP5; DDX19; RNAh"
                     /note="hexamer: AAGAAA"
     polyA_site      3183
                     /gene="DDX19B"
                     /gene_synonym="DBP5; DDX19; RNAh"
     regulatory      3226..3231
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DDX19B"
                     /gene_synonym="DBP5; DDX19; RNAh"
                     /note="hexamer: ACTAAA"
     regulatory      3232..3237
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DDX19B"
                     /gene_synonym="DBP5; DDX19; RNAh"
                     /note="hexamer: AACAAG"
     regulatory      3245..3250
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DDX19B"
                     /gene_synonym="DBP5; DDX19; RNAh"
                     /note="hexamer: ATTAAA"
     polyA_site      3245
                     /gene="DDX19B"
                     /gene_synonym="DBP5; DDX19; RNAh"
     polyA_site      3250
                     /gene="DDX19B"
                     /gene_synonym="DBP5; DDX19; RNAh"
     polyA_site      3275
                     /gene="DDX19B"
                     /gene_synonym="DBP5; DDX19; RNAh"
ORIGIN      
        1 gcagccttgt agtggggctg gagcagagcc tgccgcgaac ccccggagcc cacgatccct
       61 cgtgccatcc ctcgaatcca ccagcacgag cgtcccaccc gcgcctggga ccatggccac
      121 tgactcatgg gccctggcgg tggacgagca ggaagctgcg gctgagtcgt tgagcaactt
      181 gcatcttaag gaagagaaaa tcaaaccaga taccaatggt gctgttgtca agaccaatgc
      241 caatgcagag aagacagatg aagaagagaa agaggacaga gctgcccagt ccttactcaa
      301 caagctgatc agaagcaacc ttgttgataa cacaaaccaa gtggaagtcc tgcagcggga
      361 tccaaactcc cctctgtact cggtgaagtc ttttgaagag cttcggctga aaccacagct
      421 tctccaagga gtctatgcca tgggtttcaa tcgtccatcc aagatacaag agaacgcatt
      481 gccactgatg cttgctgagc ccccacagaa cttaattgcc caatctcagt ctggtactgg
      541 taaaacagct gccttcgtgc tggccatgct tagccaagta gaacctgcaa acaaataccc
      601 ccagtgtcta tgtctctccc caacgtatga gctcgccctc caaacaggaa aagtgattga
      661 acaaatgggc aaattttacc ctgaactgaa gctagcttat gctgttcgag gcaataaatt
      721 ggaaagaggc cagaagatca gtgagcagat tgtcattggc acccctggga ctgtgctgga
      781 ctggtgctcc aagctcaagt tcattgatcc caagaaaatc aaggtgtttg ttctggatga
      841 ggctgatgtc atgatagcca ctcagggcca ccaagatcag agcatccgca tccagaggat
      901 gctgcccagg aactgccaga tgctgctttt ctccgccacc tttgaagact ctgtgtggaa
      961 gtttgcccag aaagtggtcc cagacccaaa cgttatcaaa ctgaagcgtg aggaagagac
     1021 cctggacacc atcaagcagt actatgtcct gtgcagcagc agagacgaga agttccaggc
     1081 cttgtgtaac ctctacgggg ccatcaccat tgctcaagcc atgatcttct gccatactcg
     1141 caaaacagct agttggctgg cagcagagct ctcaaaagaa ggccaccagg tggctctgct
     1201 gagtggggag atgatggtgg aacagagggc tgcagtgatt gagcgcttcc gagagggcaa
     1261 agagaaggtt ttggtgacca ccaacgtgtg tgcccgcggc attgatgttg aacaagtgtc
     1321 tgtcgtcatc aactttgatc ttcccgtgga caaggacggg aatcctgaca atgagaccta
     1381 cctgcaccgg atcgggcgca cgggccgctt tggcaagagg ggcctggcag tgaacatggt
     1441 ggacagcaag cacagcatga acatcctgaa cagaatccag gagcatttta ataagaagat
     1501 agaaagattg gacacagatg atttggacga gattgagaaa atagccaact gagaagctcc
     1561 accagccact gatgccagcc ctggcactgc ccctgcacag gagacaagtg cgttcagggc
     1621 acaggccccg acatcacccc aaggacaacg gcacaagtag agagaaacta cctacctcac
     1681 ttcaaattat gtttggactt gacaaaaatg tatgcaaatg atgggggatg gtagaaaaaa
     1741 attatttaca caaccttgga agattaggca tgaatacaca gagatttacc ttttggaagt
     1801 ttcatctttt aatttggcca gtgtttcctt catgctaatc tagatgctgt ggctgattac
     1861 ttgcccagga tctcctgtgg cagcctctgc ttgttctctg gcttggagtg gatggggcag
     1921 cctccagctc ctgtggaagt aatggaatag tggtggaaag ggaacacaga gagggaggct
     1981 tccagtaaga taggtgtgta agcccagcca tcatgtttgg aatggcatga ggcagcagag
     2041 gaggcctgag agctgctgct ttggacttgg gggtgggaca gctcatctga gtattgccag
     2101 ccccctgtcc tagtgcccac agcagaaggg aatttgttaa ataagcatgg accaaaatgc
     2161 caacctctcg gttgtgtata tgggtttgtg tcacaggact gtgacctgtt ctcggtgggt
     2221 gcagtctgtg tagagtgcac atctgattat tggtgggtcc tgtgcctgtg cttaagcaag
     2281 tcctgtggag aagtcatcat ggagaattag tggtggccct agcgtgccac aaaacctggt
     2341 ctcatgagca tttgcaacat cccttttaca tccttaatat ccccttaccc cacagtagcc
     2401 ccaaacaaat gtgatctgag gtttagatcc tcagtgaaaa ttgtggtttc aagtcttcat
     2461 ggccagcctc aaggcagttc tagatgtgat cagcagtagt cacaaattct tgttttgtct
     2521 ccacacccag aaggcaagtt ttgtcagagc tggggaataa tttcagatat ttgacatctt
     2581 gattataaag ggcttctgaa catctgtgtt tactgccttt ggaatacaaa caggtgcaac
     2641 tgagggacta gctacactac caccatttat ctgtccaagg caagagtatc accaaggcct
     2701 ttgctccagc cttacttggc atctttgcgc aagatagtca gagcaaacaa tagtaatgga
     2761 cacttctcac acctggccaa ggctgttggt acccacgaaa tgacagcaaa gatgagagga
     2821 aactgaattg caagagcaat atgaaacccc aaccaagagg agtactctgc agttctttgg
     2881 ctttggtata gagtggccac tttctctagg acctggaaga agagtttgat ggctaagaac
     2941 gattgtgatc ctaggtcttc tttgtacgca tctccgtatt taggccagat ctgcctcctg
     3001 ggaagggaag gggccaatgt cagcctccag gtgatttctt taatctgaca ttacaaagag
     3061 accaacagac tgccaattct accacattcc cctggtgggt actcgactat gtagttttct
     3121 ctatgcttct ggtcaactct gacacatctt ggaattcttg taataagaaa agaaattttt
     3181 atactttttt ctccttccct gagtcctgtg gaccaaccct gaaatactaa aaacaagggc
     3241 aataattaaa gaagtataga ctctttagta ggcca
//
