LOCUS       NM_018332               2923 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens DEAD-box helicase 19A (DDX19A), transcript variant 1,
            mRNA.
ACCESSION   NM_018332 NM_001015047
VERSION     NM_018332.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2923)
  AUTHORS   Chevalier,B., Baatallah,N., Najm,M., Castanier,S., Jung,V.,
            Pranke,I., Golec,A., Stoven,V., Marullo,S., Antigny,F.,
            Guerrera,I.C., Sermet-Gaudelus,I., Edelman,A. and Hinzpeter,A.
  TITLE     Differential CFTR-Interactome Proximity Labeling Procedures
            Identify Enrichment in Multiple SLC Transporters
  JOURNAL   Int J Mol Sci 23 (16), 8937 (2022)
   PUBMED   36012204
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2923)
  AUTHORS   Lim,S.H., Snider,J., Birimberg-Schwartz,L., Ip,W., Serralha,J.C.,
            Botelho,H.M., Lopes-Pacheco,M., Pinto,M.C., Moutaoufik,M.T.,
            Zilocchi,M., Laselva,O., Esmaeili,M., Kotlyar,M., Lyakisheva,A.,
            Tang,P., Lopez Vazquez,L., Akula,I., Aboualizadeh,F., Wong,V.,
            Grozavu,I., Opacak-Bernardi,T., Yao,Z., Mendoza,M., Babu,M.,
            Jurisica,I., Gonska,T., Bear,C.E., Amaral,M.D. and Stagljar,I.
  TITLE     CFTR interactome mapping using the mammalian membrane two-hybrid
            high-throughput screening system
  JOURNAL   Mol Syst Biol 18 (2), e10629 (2022)
   PUBMED   35156780
REFERENCE   3  (bases 1 to 2923)
  AUTHORS   Huang,X., Dong,H., Liu,Y., Yu,F., Yang,S., Chen,Z. and Li,J.
  TITLE     Silencing of let-7b-5p inhibits ovarian cancer cell proliferation
            and stemness characteristics by Asp-Glu-Ala-Asp-box helicase 19A
  JOURNAL   Bioengineered 12 (1), 7666-7677 (2021)
   PUBMED   34612147
  REMARK    GeneRIF: Silencing of let-7b-5p inhibits ovarian cancer cell
            proliferation and stemness characteristics by Asp-Glu-Ala-Asp-box
            helicase 19A.
REFERENCE   4  (bases 1 to 2923)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 2923)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 2923)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2923)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   8  (bases 1 to 2923)
  AUTHORS   Li,J., Hu,L., Liu,Y., Huang,L., Mu,Y., Cai,X. and Weng,C.
  TITLE     DDX19A Senses Viral RNA and Mediates NLRP3-Dependent Inflammasome
            Activation
  JOURNAL   J Immunol 195 (12), 5732-5749 (2015)
   PUBMED   26538395
REFERENCE   9  (bases 1 to 2923)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB074731.1, BC005162.2 and AI863086.1.
            
            On Nov 22, 2018 this sequence version replaced NM_018332.4.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.263269.1,
                                           SRR1660807.45549.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000302243.12/ ENSP00000306117.7
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                DB074731.1         75-92
            19-2921             BC005162.2         1-2903
            2922-2923           AI863086.1         18-19               c
FEATURES             Location/Qualifiers
     source          1..2923
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q22.1"
     gene            1..2923
                     /gene="DDX19A"
                     /gene_synonym="DDX19-DDX19L; DDX19L"
                     /note="DEAD-box helicase 19A"
                     /db_xref="GeneID:55308"
                     /db_xref="HGNC:HGNC:25628"
     exon            1..146
                     /gene="DDX19A"
                     /gene_synonym="DDX19-DDX19L; DDX19L"
                     /inference="alignment:Splign:2.1.0"
     CDS             90..1526
                     /gene="DDX19A"
                     /gene_synonym="DDX19-DDX19L; DDX19L"
                     /EC_number="3.6.4.13"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ATP-dependent RNA helicase DDX19A; DDX19-like protein;
                     DEAD box protein 19A; DEAD (Asp-Glu-Ala-As) box
                     polypeptide 19A; DEAD (Asp-Glu-Ala-Asp) box polypeptide
                     19A"
                     /codon_start=1
                     /product="ATP-dependent RNA helicase DDX19A isoform 1"
                     /protein_id="NP_060802.1"
                     /db_xref="CCDS:CCDS10889.1"
                     /db_xref="GeneID:55308"
                     /db_xref="HGNC:HGNC:25628"
                     /translation="MATDSWALAVDEQEAAVKSMTNLQIKEEKVKADTNGIIKTSTTA
                     EKTDEEEKEDRAAQSLLNKLIRSNLVDNTNQVEVLQRDPNSPLYSVKSFEELRLKPQL
                     LQGVYAMGFNRPSKIQENALPMMLAEPPQNLIAQSQSGTGKTAAFVLAMLSRVEPSDR
                     YPQCLCLSPTYELALQTGKVIEQMGKFYPELKLAYAVRGNKLERGQKISEQIVIGTPG
                     TVLDWCSKLKFIDPKKIKVFVLDEADVMIATQGHQDQSIRIQRMLPRNCQMLLFSATF
                     EDSVWKFAQKVVPDPNVIKLKREEETLDTIKQYYVLCSSRDEKFQALCNLYGAITIAQ
                     AMIFCHTRKTASWLAAELSKEGHQVALLSGEMMVEQRAAVIERFREGKEKVLVTTNVC
                     ARGIDVEQVSVVINFDLPVDKDGNPDNETYLHRIGRTGRFGKRGLAVNMVDSKHSMNI
                     LNRIQEHFNKKIERLDTDDLDEIEKIAN"
     exon            147..195
                     /gene="DDX19A"
                     /gene_synonym="DDX19-DDX19L; DDX19L"
                     /inference="alignment:Splign:2.1.0"
     exon            196..246
                     /gene="DDX19A"
                     /gene_synonym="DDX19-DDX19L; DDX19L"
                     /inference="alignment:Splign:2.1.0"
     exon            247..382
                     /gene="DDX19A"
                     /gene_synonym="DDX19-DDX19L; DDX19L"
                     /inference="alignment:Splign:2.1.0"
     exon            383..475
                     /gene="DDX19A"
                     /gene_synonym="DDX19-DDX19L; DDX19L"
                     /inference="alignment:Splign:2.1.0"
     exon            476..578
                     /gene="DDX19A"
                     /gene_synonym="DDX19-DDX19L; DDX19L"
                     /inference="alignment:Splign:2.1.0"
     exon            579..693
                     /gene="DDX19A"
                     /gene_synonym="DDX19-DDX19L; DDX19L"
                     /inference="alignment:Splign:2.1.0"
     exon            694..871
                     /gene="DDX19A"
                     /gene_synonym="DDX19-DDX19L; DDX19L"
                     /inference="alignment:Splign:2.1.0"
     exon            872..1109
                     /gene="DDX19A"
                     /gene_synonym="DDX19-DDX19L; DDX19L"
                     /inference="alignment:Splign:2.1.0"
     exon            1110..1272
                     /gene="DDX19A"
                     /gene_synonym="DDX19-DDX19L; DDX19L"
                     /inference="alignment:Splign:2.1.0"
     exon            1273..1464
                     /gene="DDX19A"
                     /gene_synonym="DDX19-DDX19L; DDX19L"
                     /inference="alignment:Splign:2.1.0"
     exon            1465..2923
                     /gene="DDX19A"
                     /gene_synonym="DDX19-DDX19L; DDX19L"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2901..2906
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DDX19A"
                     /gene_synonym="DDX19-DDX19L; DDX19L"
                     /note="hexamer: AATATA"
     polyA_site      2923
                     /gene="DDX19A"
                     /gene_synonym="DDX19-DDX19L; DDX19L"
                     /note="major polyA site"
ORIGIN      
        1 gcattctcgc gccggtggcg aggttagggc ccgcgttgcg acgtggtgca gcgcatattt
       61 tcacaagtgg gtctcccttg tccgggacta tggccaccga ctcgtgggcc ctggcggtgg
      121 acgagcagga agcggctgtc aagtcgatga ccaatttgca gatcaaggaa gagaaagtca
      181 aagcagatac caatggtatt atcaaaacca gtaccactgc cgagaaaaca gatgaagagg
      241 agaaagagga cagagctgcc cagtccttac tcaacaagct gatcagaagc aaccttgttg
      301 ataacacaaa ccaagtggaa gtcctgcaac gggatccaaa ctcccctctg tactcggtga
      361 agtcgtttga agagcttcgg ctgaaaccac agcttctcca gggagtctat gccatgggct
      421 tcaatcgacc ctccaagata caagagaacg cattacccat gatgcttgct gaacccccac
      481 agaatctgat tgcccagtct cagtctggca ctggtaaaac agctgccttt gtcttagcca
      541 tgctcagccg agtggagcca tcagacagat acccccagtg tctgtgcctc tccccaacat
      601 atgagctggc gcttcaaaca ggaaaagtga ttgagcagat gggcaaattt tacccagaac
      661 tgaagcttgc ctatgccgtt cgaggcaata aattggaaag aggccagaag atcagtgagc
      721 agattgtcat tggcacccct gggaccgtgc tggactggtg ctccaagctc aagttcattg
      781 atcccaagaa aatcaaggtg tttgttctgg atgaggctga tgtcatgata gccactcagg
      841 gccaccaaga tcagagcatc cgcatccaga ggatgctgcc caggaactgc cagatgctgc
      901 ttttctccgc cacctttgaa gactctgtgt ggaagtttgc ccagaaagtg gtcccagacc
      961 caaatgttat caaactgaag cgtgaggaag agaccctgga taccatcaag cagtactatg
     1021 tcctgtgcag cagcagagac gagaagttcc aggccttgtg taacctctac ggggccatca
     1081 ccattgctca agccatgatc ttctgccata ctcgcaaaac agctagttgg ctggcagcag
     1141 agctctcaaa agaaggccac caggtggctc tgctgagtgg ggagatgatg gtggagcaga
     1201 gggctgcggt gattgagcgc ttccgagagg gcaaagagaa ggttttggtg accaccaacg
     1261 tgtgtgcccg cggcattgat gttgaacaag tgtctgtcgt catcaacttt gatcttcccg
     1321 tggacaagga cgggaatcct gacaatgaga cctacctgca ccggatcggg cgcacgggcc
     1381 gctttggcaa gaggggcctg gcagtgaaca tggtggacag caagcacagc atgaacatcc
     1441 tgaacagaat ccaggagcat tttaataaga agatagaaag attggacaca gatgatttgg
     1501 acgagattga gaaaatagcc aactgagaag ctccaccagc cactgatgcc agccctggca
     1561 ctgcccctgc acaggagaca agtgcattta gggcacaggc cccgacatca ccccaaggac
     1621 aacggcagaa gtagagagaa actacctacc tcacttcaaa ttatgtttgg acttgacaaa
     1681 aataggtgca aatgatgggg ggcaatagaa gaaaaaattt gcattttgga aaattgggtc
     1741 ctttccccac ttttttaaag ccacattccc ccatctttat aataatctgg tcacagtggt
     1801 agtcgctggc cccaggaccc cctcctgatt ttggctaggc atcgtggaac cagctccagc
     1861 ccctgaagaa acgatagatg tgcaggttgt gcggaagagg ctgagtggaa aatggtgtga
     1921 gccccaccgc tgtgcatcga atgagggaag tggcagcaga gaggccagag ctgccccctc
     1981 tctgtctctt caatggaccc ttcacaagtg tttctcctgc ccttggggct gtcttccttc
     2041 tcctgaaatc cagagacttt cttgctcatc ccttctccct ttcacttctg ttctctgctg
     2101 cagaaagcag acttgcatat ccctgatgag cagctcggct acttttgtaa acttcagatt
     2161 tggagagaaa cacgaaagtc tgaatcctga ccccttgaga gagagtgatc tggcgagggc
     2221 cgatgaaggg gctgggcctg gtcttgcctt ctcttctctc ggttgctccc tctgcctagg
     2281 cccctggtac tcagtcacgg cagccaggag accccaggtg agtttctgag cgcatacgta
     2341 gttggttctt acccccaggt gtcacacggg gccgagagct gagcaagaat ttggaatgga
     2401 agttatgacc aagggaatta tgctgttcat ttataatagt ggacattatg gagagctctg
     2461 attcctacat aatatgaata aggatggata ggccgggcgt ggtggctcat gcctataatc
     2521 ccagcacgtt gggaggctga ggcgggcgga tcggttgagc tcaggcgttc gggaccagcc
     2581 tggccaacat gatgaaaccc cgtctctacc aaaaatagaa aaaaatatag ccgggcctgg
     2641 tggcgcacgc ctgtagtccc agctactcgg gaggctgagg taggaggatc gcttgagcct
     2701 gggtagaggc tgctgtgagc tgaaatggcg ccactgcact ccagcctggg taacagagcg
     2761 agaccccgac tcaataaata aataaggatg gataaattgt agcgtatgca ccattcatta
     2821 tgctaagaca ttttaaagta attatgagaa acgctctact aatgatttgt ttttatttgt
     2881 atttttctgc ttattagaca aatatatact cattttaaaa agg
//
