LOCUS       NM_006773               3753 bp    mRNA    linear   PRI 01-AUG-2024
DEFINITION  Homo sapiens DEAD-box helicase 18 (DDX18), mRNA.
ACCESSION   NM_006773
VERSION     NM_006773.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3753)
  AUTHORS   Feng,B., Wang,X., Qiu,D., Sun,H., Deng,J., Tan,Y., Ji,K., Xu,S.,
            Zhang,S. and Tang,C.
  TITLE     DDX18 Facilitates the Tumorigenesis of Lung Adenocarcinoma by
            Promoting Cell Cycle Progression through the Upregulation of CDK4
  JOURNAL   Int J Mol Sci 25 (9), 4953 (2024)
   PUBMED   38732173
  REMARK    GeneRIF: DDX18 Facilitates the Tumorigenesis of Lung Adenocarcinoma
            by Promoting Cell Cycle Progression through the Upregulation of
            CDK4.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3753)
  AUTHORS   Guo,C., Liu,Z. and Zhang,H.
  TITLE     DNA 6mA demethylase ALKBH1 regulates DDX18 expression to promote
            proliferation of human head and neck squamous cell carcinoma
  JOURNAL   Cell Oncol (Dordr) 46 (4), 1097-1111 (2023)
   PUBMED   36976498
  REMARK    GeneRIF: DNA 6mA demethylase ALKBH1 regulates DDX18 expression to
            promote proliferation of human head and neck squamous cell
            carcinoma.
REFERENCE   3  (bases 1 to 3753)
  AUTHORS   Redmond,A.M., Byrne,C., Bane,F.T., Brown,G.D., Tibbitts,P.,
            O'Brien,K., Hill,A.D., Carroll,J.S. and Young,L.S.
  TITLE     Genomic interaction between ER and HMGB2 identifies DDX18 as a
            novel driver of endocrine resistance in breast cancer cells
  JOURNAL   Oncogene 34 (29), 3871-3880 (2015)
   PUBMED   25284587
  REMARK    GeneRIF: Data show that odulation of RNA helicase DDX18 directly
            affects growth of tamoxifen-resistant cells, suggesting that it may
            be a critical downstream effector of the estrogen receptors (ERs)
            and high mobility group box 2 (HMGB2) complex.
REFERENCE   4  (bases 1 to 3753)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   5  (bases 1 to 3753)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   6  (bases 1 to 3753)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   7  (bases 1 to 3753)
  AUTHORS   Dubaele,S. and Chene,P.
  TITLE     Cellular studies of MrDb (DDX18)
  JOURNAL   Oncol Res 16 (12), 549-556 (2007)
   PUBMED   18351129
  REMARK    GeneRIF: findings suggest that MrDb is important for cell
            proliferation and that its inhibition could prevent tumor cell
            proliferation.
REFERENCE   8  (bases 1 to 3753)
  AUTHORS   Sekiguchi,T., Hayano,T., Yanagida,M., Takahashi,N. and Nishimoto,T.
  TITLE     NOP132 is required for proper nucleolus localization of DEAD-box
            RNA helicase DDX47
  JOURNAL   Nucleic Acids Res 34 (16), 4593-4608 (2006)
   PUBMED   16963496
REFERENCE   9  (bases 1 to 3753)
  AUTHORS   Gevaert,K., Goethals,M., Martens,L., Van Damme,J., Staes,A.,
            Thomas,G.R. and Vandekerckhove,J.
  TITLE     Exploring proteomes and analyzing protein processing by mass
            spectrometric identification of sorted N-terminal peptides
  JOURNAL   Nat Biotechnol 21 (5), 566-569 (2003)
   PUBMED   12665801
REFERENCE   10 (bases 1 to 3753)
  AUTHORS   Grandori,C., Mac,J., Siebelt,F., Ayer,D.E. and Eisenman,R.N.
  TITLE     Myc-Max heterodimers activate a DEAD box gene and interact with
            multiple E box-related sites in vivo
  JOURNAL   EMBO J 15 (16), 4344-4357 (1996)
   PUBMED   8861962
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BU599536.1, BC024739.1 and
            AK091227.1.
            
            On Nov 22, 2018 this sequence version replaced NM_006773.3.
            
            Summary: DEAD box proteins, characterized by the conserved motif
            Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are
            implicated in a number of cellular processes involving alteration
            of RNA secondary structure such as translation initiation, nuclear
            and mitochondrial splicing, and ribosome and spliceosome assembly.
            Based on their distribution patterns, some members of this family
            are believed to be involved in embryogenesis, spermatogenesis, and
            cellular growth and division. This gene encodes a DEAD box protein,
            and it is activated by Myc protein. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC024739.1, SRR1803613.252788.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000263239.7/ ENSP00000263239.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-426               BU599536.1         31-456
            427-2439            BC024739.1         413-2425
            2440-3132           AK091227.1         1879-2571
            3133-3753           AK091227.1         2573-3193
FEATURES             Location/Qualifiers
     source          1..3753
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q14.1"
     gene            1..3753
                     /gene="DDX18"
                     /gene_synonym="Has1; MrDb"
                     /note="DEAD-box helicase 18"
                     /db_xref="GeneID:8886"
                     /db_xref="HGNC:HGNC:2741"
                     /db_xref="MIM:606355"
     exon            1..172
                     /gene="DDX18"
                     /gene_synonym="Has1; MrDb"
                     /inference="alignment:Splign:2.1.0"
     CDS             88..2100
                     /gene="DDX18"
                     /gene_synonym="Has1; MrDb"
                     /EC_number="3.6.4.13"
                     /note="DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 18
                     (Myc-regulated); Myc-regulated DEAD box protein; DEAD box
                     protein 18; DEAD (Asp-Glu-Ala-Asp) box polypeptide 18;
                     Helicase Associated with Set1 homolog"
                     /codon_start=1
                     /product="ATP-dependent RNA helicase DDX18"
                     /protein_id="NP_006764.3"
                     /db_xref="CCDS:CCDS2120.1"
                     /db_xref="GeneID:8886"
                     /db_xref="HGNC:HGNC:2741"
                     /db_xref="MIM:606355"
                     /translation="MSHLPMKLLRKKIEKRNLKLRQRNLKFQGASNLTLSETQNGDVS
                     EETMGSRKVKKSKQKPMNVGLSETQNGGMSQEAVGNIKVTKSPQKSTVLTNGEAAMQS
                     SNSESKKKKKKKRKMVNDAEPDTKKAKTENKGKSEEESAETTKETENNVEKPDNDEDE
                     SEVPSLPLGLTGAFEDTSFASLCNLVNENTLKAIKEMGFTNMTEIQHKSIRPLLEGRD
                     LLAAAKTGSGKTLAFLIPAVELIVKLRFMPRNGTGVLILSPTRELAMQTFGVLKELMT
                     HHVHTYGLIMGGSNRSAEAQKLGNGINIIVATPGRLLDHMQNTPGFMYKNLQCLVIDE
                     ADRILDVGFEEELKQIIKLLPTRRQTMLFSATQTRKVEDLARISLKKEPLYVGVDDDK
                     ANATVDGLEQGYVVCPSEKRFLLLFTFLKKNRKKKLMVFFSSCMSVKYHYELLNYIDL
                     PVLAIHGKQKQNKRTTTFFQFCNADSGTLLCTDVAARGLDIPEVDWIVQYDPPDDPKE
                     YIHRVGRTARGLNGRGHALLILRPEELGFLRYLKQSKVPLSEFDFSWSKISDIQSQLE
                     KLIEKNYFLHKSAQEAYKSYIRAYDSHSLKQIFNVNNLNLPQVALSFGFKVPPFVDLN
                     VNSNEGKQKKRGGGGGFGYQKTKKVEKSKIFKHISKKSSDSRQFSH"
     exon            173..457
                     /gene="DDX18"
                     /gene_synonym="Has1; MrDb"
                     /inference="alignment:Splign:2.1.0"
     exon            458..601
                     /gene="DDX18"
                     /gene_synonym="Has1; MrDb"
                     /inference="alignment:Splign:2.1.0"
     exon            602..737
                     /gene="DDX18"
                     /gene_synonym="Has1; MrDb"
                     /inference="alignment:Splign:2.1.0"
     exon            738..838
                     /gene="DDX18"
                     /gene_synonym="Has1; MrDb"
                     /inference="alignment:Splign:2.1.0"
     exon            839..1038
                     /gene="DDX18"
                     /gene_synonym="Has1; MrDb"
                     /inference="alignment:Splign:2.1.0"
     exon            1039..1153
                     /gene="DDX18"
                     /gene_synonym="Has1; MrDb"
                     /inference="alignment:Splign:2.1.0"
     exon            1154..1293
                     /gene="DDX18"
                     /gene_synonym="Has1; MrDb"
                     /inference="alignment:Splign:2.1.0"
     exon            1294..1455
                     /gene="DDX18"
                     /gene_synonym="Has1; MrDb"
                     /inference="alignment:Splign:2.1.0"
     exon            1456..1608
                     /gene="DDX18"
                     /gene_synonym="Has1; MrDb"
                     /inference="alignment:Splign:2.1.0"
     exon            1609..1722
                     /gene="DDX18"
                     /gene_synonym="Has1; MrDb"
                     /inference="alignment:Splign:2.1.0"
     exon            1723..1779
                     /gene="DDX18"
                     /gene_synonym="Has1; MrDb"
                     /inference="alignment:Splign:2.1.0"
     exon            1780..1957
                     /gene="DDX18"
                     /gene_synonym="Has1; MrDb"
                     /inference="alignment:Splign:2.1.0"
     exon            1958..3753
                     /gene="DDX18"
                     /gene_synonym="Has1; MrDb"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2211..2216
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DDX18"
                     /gene_synonym="Has1; MrDb"
                     /note="hexamer: TATAAA"
     polyA_site      2232
                     /gene="DDX18"
                     /gene_synonym="Has1; MrDb"
                     /note="major polyA site"
     regulatory      2404..2409
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DDX18"
                     /gene_synonym="Has1; MrDb"
                     /note="hexamer: AATATA"
     polyA_site      2426
                     /gene="DDX18"
                     /gene_synonym="Has1; MrDb"
                     /note="major polyA site"
     regulatory      3731..3736
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DDX18"
                     /gene_synonym="Has1; MrDb"
                     /note="hexamer: ATTAAA"
     polyA_site      3753
                     /gene="DDX18"
                     /gene_synonym="Has1; MrDb"
                     /note="major polyA site"
ORIGIN      
        1 acgtgcggcc ggaagggaag taacgtcagc ctgagaactg agtagctgta ctgtgtggcg
       61 ccttattcta ggcacttgtt gggcagaatg tcacacctgc cgatgaaact cctgcgtaag
      121 aagatcgaga agcggaacct caaattgcgg cagcggaacc taaagtttca gggggcctca
      181 aatctgaccc tatcggaaac tcaaaatgga gatgtatctg aagaaacaat gggaagtaga
      241 aaggttaaaa aatcaaaaca aaagcccatg aatgtgggct tatcagaaac tcaaaatgga
      301 ggcatgtctc aagaagcagt gggaaatata aaagttacaa agtctcccca gaaatccact
      361 gtattaacca atggagaagc agcaatgcag tcttccaatt cagaatcaaa aaagaaaaag
      421 aagaaaaaga gaaaaatggt gaatgatgct gagcctgata cgaaaaaagc aaaaactgaa
      481 aacaaaggga aatctgaaga agaaagtgcc gagactacta aagaaacaga aaataatgtg
      541 gagaagccag ataatgatga agatgagagt gaggtgccca gtctgcccct gggactgaca
      601 ggagcttttg aggatacttc gtttgcttct ctatgtaatc ttgtcaatga aaacactctg
      661 aaggcaataa aagaaatggg ttttacaaac atgactgaaa ttcagcataa aagtatcaga
      721 ccacttctgg aaggcaggga tcttctagca gctgcaaaaa caggcagtgg taaaaccctg
      781 gcttttctca tccctgcagt tgaactcatt gttaagttaa ggttcatgcc caggaatgga
      841 acaggagtcc ttattctctc acctactaga gaactagcca tgcaaacctt tggtgttctt
      901 aaggagctga tgactcacca cgtgcatacc tatggcttga taatgggtgg cagtaacaga
      961 tctgctgaag cacagaaact tggtaatggg atcaacatca ttgtggccac accaggccgt
     1021 ctgctggacc atatgcagaa taccccagga tttatgtata aaaacctgca gtgtctggtt
     1081 attgatgaag ctgatcgtat cttggatgtg gggtttgaag aggaattaaa gcaaattatt
     1141 aaacttttgc caacacgtag acagactatg ctcttttctg ccacccaaac tcgaaaagtt
     1201 gaagacctgg caaggatttc tctgaaaaag gagccattgt atgttggcgt tgatgatgat
     1261 aaagcgaatg caacagtgga tggtcttgaa cagggatatg ttgtttgtcc ttctgaaaag
     1321 agattccttc tgctctttac attccttaag aagaaccgaa agaagaagct tatggtcttc
     1381 ttttcatctt gtatgtctgt gaaataccac tatgagttgc tgaactacat tgatttgccc
     1441 gtcttggcca ttcatggaaa gcaaaagcaa aataagcgta caaccacatt cttccagttc
     1501 tgcaatgcag attcgggaac actattgtgt acggatgtgg cagcgagagg actagacatt
     1561 cctgaagtcg actggattgt tcagtatgac cctccggatg accctaagga atatattcat
     1621 cgtgtgggta gaacagccag aggcctaaat gggagagggc atgccttgct cattttgcgc
     1681 ccagaagaat tgggttttct tcgctacttg aaacaatcca aggttccatt aagtgaattt
     1741 gacttttcct ggtctaaaat ttctgacatt cagtctcagc ttgagaaatt gattgaaaag
     1801 aattactttc ttcataagtc agcccaggaa gcatataagt catacatacg agcctatgat
     1861 tcccattctc tgaaacagat ctttaatgtt aataacctaa atttgcctca ggttgctctg
     1921 tcatttggtt tcaaggtgcc tcccttcgtt gatctgaacg tcaacagtaa tgaaggcaag
     1981 cagaaaaagc gaggaggtgg tggtggattt ggctaccaga aaaccaagaa agttgagaaa
     2041 tccaaaatct ttaaacacat tagcaagaaa tcatctgaca gcaggcagtt ctctcactga
     2101 acacatgcct tcctttcatc ttgaataact ttgtcctaaa atgaattttt tttccccttg
     2161 atttaacagg atttttgtag actttagaat ttggacttac ctaacaagag tataaattga
     2221 cttgggttgc aagcactgag cactgttact tctatcacgt ctctctttta tttctgggat
     2281 ataaaacagg ctttaagttt cttggttgcc caagggcaga gcaaggaata tctggtgttt
     2341 cttgtgatga taatatttta attttaaata tccctccctc atacaagtgt atgttaccat
     2401 tttaatataa ttctttttgt acctttcctt cttgttttgc gaagattttt gtggcatgga
     2461 ttgctgtgct cactgctgta aaaggtgacc tagtgtactg ggcagctggt ggcggtgcag
     2521 aaaagagtct caggttattt tttgttttta gttatttctt ggaccttgac agtatctaat
     2581 gactcctcct gaaaatgctg cagtataaaa gagcaaagag ctttgggaaa tacctaagaa
     2641 gcaccttaag attagggtgg cattgctttt atagattctt gattttaaag caacaggcct
     2701 ttctcaggtg ttgcattttt tggagcaaaa actatgggtt gtaatttgaa taaagtgtca
     2761 ctaagcagtt ataacgtttg atggctgggg ggtaggaaga ggatggaatt gagatgtttg
     2821 agcctcattt acatcaatag aggtgtaatg tactgcattt cttcatttgg taacataaca
     2881 aagactttca tacaaagaac gatgatgctc ctcattaaga tttgtttaat tcaaggtggt
     2941 ttggatttgg taagcctttg cactctgtag agtacttaga agacaagggc aacttacttg
     3001 gagttagagc caagctgtca gacggtgccc agcacacatt aatgttagct tctttctgag
     3061 aaaaaaatac ctcttccagg ccctgaaaca aaaaatacat ttgctgtgaa gattgaaaat
     3121 gaacaaagtt agaaaaaaaa acagcaaaat cagtgattta gtcagatgag tttttcgttg
     3181 taggagcact tgatttctag tgtgttttgt acagtatata actacaagat agtacatttt
     3241 gtagcagttc aaagccaaag ttgctagcat cattttgctg ttgtgccagt taatcatagg
     3301 atcccattaa ataagtgtgc taacatcgaa tatagagaaa actggtaaag aacattccag
     3361 taggaaaaga aaagaacaat cttccatttc tgggcttggc caccatcacc ctggtcggac
     3421 ctgtcctgga cttccaacct tgactgctga gctcctggct tagcttcttg ggttcctaat
     3481 tcctggtgtt taataattct ctccacgatc atgtttttct gatttttttt ttcagaaata
     3541 atgtttttta aaagacaaaa acaaagggaa gaatatttaa ttactgagca gaagtaaata
     3601 ctgttggcat tttgtacata atctaatttt tatatgcatg ttcatgcttt ttaatttttt
     3661 tatcaaaaat taagtcatct acctactact tgtaaccagc ttgtttcata acatgttatt
     3721 ttcctgtgtc attaaataat tacttcaatg ttg
//
